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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 6 of 60, showing 100 records out of 5973 total, starting on record 501
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP02385
(
show subtarget assignments
)
1
cloned
No
Cj0755
15792094
cfrA
putative iron uptake protein [Campylobac...
696
Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate
Phase 3: June 2008
2HDF
29.8%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP04394
(
show subtarget assignments
)
1
cloned
No
CPF_2117
110800208
spoVD
stage V sporulation protein D [Clostridi...
695
conserved gene; putative drug target function;
Phase 4: April 2009
1PYY
24.8%
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP05192
(
show subtarget assignments
)
1
cloned
No
CD0332
126697904
bclA1
putative exosporium glycoprotein [Clostr...
693
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3HQV
24.4%
Clostridium difficile
Unclassified: Role category not yet assigned
IDP05323
(
show subtarget assignments
)
1
cloned
No
lmo1275
16803315
topA
DNA topoisomerase I [Listeria monocytoge...
692
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2GAI
38.4%
Listeria monocytogenes
DNA metabolism: DNA replication, recombination, and repair
IDP90616
(
show subtarget assignments
)
8
selected
No
VC1054
15641067
DNA polymerase III subunits gamma and ta...
692
Predicted Essential
Community Requests
1JR3
34.5%
Vibrio cholerae
IDP05535
(
show subtarget assignments
)
1
cloned
No
CD3071
126700688
glycosyl hydrolase [Clostridium difficil...
692
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2XVG
22.3%
Clostridium difficile
Unknown function: Enzymes of unknown specificity
IDP04275
(
show subtarget assignments
)
1
cloned
No
BAS3684
49186683
DNA topoisomerase I [Bacillus anthracis ...
692
Proposed to be essential proteins
Phase 4: April 2009
2GAI
38.2%
Bacillus anthracis
IDP05729
(
show subtarget assignments
)
1
soluble
No
CD0263
126697835
flhA
flagellar biosynthesis protein FlhA [Clo...
691
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3MIX
22.6%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP01247
(
show subtarget assignments
)
1
soluble
No
BA_3214
30257780
penicillin-binding protein, putative
691
Drug Target Function
Phase 2: March 2008
2QMI
14.2%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05220
(
show subtarget assignments
)
1
cloned
No
Cj1101
6968529
-
putative integral membrane protein [Camp...
670
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1PJR
36.6%
Campylobacter jejuni
DNA metabolism: DNA replication, recombination, and repair
IDP00720
(
show subtarget assignments
)
1
cloned
No
SACOL1609
57286131
pbp3
penicillin-binding protein 3
691
Drug Target Function
Phase 2: March 2008
2WAF
32.6%
Staphylococcus aureus
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00205
(
show subtarget assignments
)
1
cloned
No
YPO1705
16121965
-
tail-specific protease precursor
690
Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...
Phase 1: October 2007
1FC6
15.8%
Yersinia pestis
IDP90610
(
show subtarget assignments
)
8
soluble
No
YPO4071
16124184
glyS
glycyl-tRNA synthetase subunit beta [Yer...
689
Predicted Essential
Community Requests
Yersinia pestis
IDP05226
(
show subtarget assignments
)
1
cloned
No
lmo0460
16802504
-
putative membrane associated lipoprotein...
689
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3RGX
11.8%
Listeria monocytogenes
Hypothetical proteins: Conserved
IDP02567
(
show subtarget assignments
)
1
cloned
No
Cj1414c
15792732
polysaccharide modification protein [Cam...
689
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
Campylobacter jejuni
Central intermediary metabolism
Other
IDP04221
(
show subtarget assignments
)
1
expressed
No
STM4262_1_688
16767512
putative ABC-type bacteriocin/lantibioti...
688
Salmonella essential protein
Phase 4: April 2009
3G5U
21.5%
Salmonella enterica
IDP02491
(
show subtarget assignments
)
1
cloned
No
YPO1811
16122063
short chain dehydrogenase [Yersinia pest...
688
Conserved; CD; Drug target functions
Phase 3: June 2008
3U0B
14.8%
Yersinia pestis
Central intermediary metabolism
Other
IDP04277
(
show subtarget assignments
)
1
cloned
No
BAS3960
49186958
PTS system, glucose-specific IIABC compo...
687
Proposed to be essential proteins
Phase 4: April 2009
1AX3
14.7%
Bacillus anthracis
IDP91634
(
show subtarget assignments
)
8
selected
No
AAC16023
2429143
exoU
ExoU [Pseudomonas aeruginosa]
687
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
4AKX
95.8%
Pseudomonas aeruginosa
IDP02100
(
show subtarget assignments
)
1
soluble
No
STM3610
16766896
yhjG
putative inner membrane protein [Salmone...
686
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP00221
(
show subtarget assignments
)
1
soluble
No
YPO0164
16120507
-
putative membrane receptor protein
686
Virulence
Phase 1: October 2007
2HDF
20.1%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP04184
(
show subtarget assignments
)
1
expressed
No
VCA0522
15601282
sensor histidine kinase/response regulat...
686
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
10.9%
Vibrio cholerae
Regulatory functions
Other
IDP04348
(
show subtarget assignments
)
1
cloned
No
CPF_2547
110801206
two component regulator [Clostridium per...
686
viruelnce factor;
Phase 4: April 2009
Clostridium perfringens
Unknown function
General
IDP02720
(
show subtarget assignments
)
1
cloned
No
GBAA3950
47529240
infB
translation initiation factor IF-2 [Baci...
686
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
1ZO1
42%
Bacillus anthracis
Protein synthesis
Translation factors
IDP91317
(
show subtarget assignments
)
8
cloned
No
VV2_0843
27367249
Outer membrane receptor protein [Vibrio ...
685
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP90960
(
show subtarget assignments
)
8
expressed
No
VC0658
81545351
C-di-GMP phosphodiesterase A-related pro...
685
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3PJW
18.7%
Vibrio cholerae
IDP04180
(
show subtarget assignments
)
1
expressed
No
VCA0141
15600911
C4-dicarboxylate transport sensor protei...
684
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3JZ3
9.9%
Vibrio cholerae
Regulatory functions
Other
IDP90951
(
show subtarget assignments
)
8
purified
No
VC0653
81545356
C-di-GMP phosphodiesterase A-related pro...
684
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3PJW
15.5%
Vibrio cholerae
IDP00976
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM1879
16765221
ptrB
protease 2
683
Drug Target Function
Phase 2: March 2008
2XE4
37.6%
Salmonella enterica
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP01252
(
show subtarget assignments
)
1
cloned
No
BA_5623
30260075
penicillin-binding protein
683
Drug Target Function
Phase 2: March 2008
3UDF
28.7%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01805
(
show subtarget assignments
)
1
soluble
No
CBU_1084
29541658
sensory box sensor histidine kinase/resp...
683
Conserved; Drug target functions
Phase 3: June 2008
2C2A
12.4%
Coxiella burnetii
Signal transduction
Two-component systems
IDP04440
(
show subtarget assignments
)
1
cloned
No
YPO0266
115346083
secretion system apparatus protein [Yers...
682
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
2X49
15.4%
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP05559
(
show subtarget assignments
)
1
soluble
No
lmo1811
16803851
-
hypothetical protein lmo1811 [Listeria m...
697
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1GM5
40.3%
Listeria monocytogenes
DNA metabolism: DNA replication, recombination, and repair
IDP04153
(
show subtarget assignments
)
1
cloned
No
YPO3975
218930970
opdA
oligopeptidase A [Yersinia pestis CO92]
680
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1S4B
30.7%
Yersinia pestis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP00202
(
show subtarget assignments
)
1
soluble
No
YPO2731
16122935
-
putative membrane protein
679
Virulence
Phase 1: October 2007
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP90963
(
show subtarget assignments
)
8
cloned
No
VP2446
81727013
C-di-GMP phosphodiesterase A-related pro...
679
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3PJW
15.5%
Vibrio parahaemolyticus
IDP00345
(
show subtarget assignments
)
1
cloned
No
lmo0441
16802485
hypothetical protein lmo0441
678
Drug Target Function
Phase 2: March 2008
1MWR
35.3%
Listeria monocytogenes
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP04271
(
show subtarget assignments
)
1
expressed
No
CPF_2241
110798635
sensor histidine kinase [Clostridium per...
678
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
12.4%
Clostridium perfringens
Signal transduction
Two-component systems
IDP04165
(
show subtarget assignments
)
1
expressed
No
VC1521
15641529
sensor histidine kinase [Vibrio cholerae...
677
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
11.7%
Vibrio cholerae
Regulatory functions
Other
IDP05346
(
show subtarget assignments
)
1
soluble
No
CD1036
126698620
cell surface protein (putative N-acetylm...
677
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3NE8
8.4%
Clostridium difficile
Cell envelope: Other
IDP00563
(
show subtarget assignments
)
1
purified
No
YPO0283
16120622
hmuR
hemin receptor precursor
676
Conserved Gene / Pathway
Phase 2: March 2008
3FHH
66.3%
Yersinia pestis
Transport and binding proteins
Other
IDP05532
(
show subtarget assignments
)
1
soluble
No
CD2784
126700400
cell surface protein [Clostridium diffic...
675
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3NE8
9.6%
Clostridium difficile
Cell envelope: Other
IDP90218
(
show subtarget assignments
)
8
soluble
No
MYXV_gp151
9633783
m148R
m148R
675
ankyrin motif, similar to VACV-Cop:B4R
Community Requests
2J8S
6.1%
Myxoma virus
host range factor
0
IDP90593
(
show subtarget assignments
)
8
soluble
No
YPO1522
16121795
metG
methionyl-tRNA synthetase [Yersinia pest...
675
Predicted Essential
Community Requests
1F4L
69.6%
Yersinia pestis
IDP02703
(
show subtarget assignments
)
1
crystallized
No
GBAA3432
47528718
tkt-1
transketolase [Bacillus anthracis str. '...
674
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3HYL
58.1%
Bacillus anthracis
Energy metabolism
Pentose phosphate pathway
IDP01934
(
show subtarget assignments
)
1
soluble
No
GBAA0385
47525656
chitinase B [Bacillus anthracis str. 'Am...
674
Drug target motif; Drug target functions
Phase 3: June 2008
1ITX
37.4%
Bacillus anthracis
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP01241
(
show subtarget assignments
)
1
expressed
No
BA_1474
30255405
penicillin-binding protein
673
Drug Target Function
Phase 2: March 2008
2JCH
28.8%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05549
(
show subtarget assignments
)
1
soluble
No
lmo0549
16802592
-
hypothetical protein lmo0549 [Listeria m...
673
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1M9S
14.6%
Listeria monocytogenes
Transport and binding proteins: Amino acids, peptides and amines
IDP00551
(
show subtarget assignments
)
1
soluble
No
YPO0589
16120918
fadH
2,4-dienoyl-CoA reductase
673
Virulence Associated Factor
Phase 2: March 2008
1PS9
72.5%
Yersinia pestis
Fatty acid and phospholipid metabolism
Degradation
IDP91015
(
show subtarget assignments
)
8
selected
No
y2404
22126288
psn
pesticin/yersiniabactin outer membrane r...
673
TonB-dependent outer membrane receptor (yersiniabactin-binding)
Community Requests
1NQF
23.8%
Yersinia pestis
IDP91013
(
show subtarget assignments
)
8
selected
No
y2358
22126242
hmsF
outer membrane N-deacetylase [Yersinia p...
673
interesting protein in the context of biofilm formation in Y pestis
Community Requests
Yersinia pestis
IDP90169
(
show subtarget assignments
)
8
expressed
No
AAM13454.1
20152993
CPXV008 CDS
CPXV008 protein
672
Potential drug target. Shikimate pathway enzyme
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP01051
(
show subtarget assignments
)
1
expressed
No
STM3219
16766518
fadH
2,4-dieonyl-CoA reductase
672
Drug Target Function
Phase 2: March 2008
1PS9
85.6%
Salmonella enterica
Fatty acid and phospholipid metabolism
Degradation
IDP00444
(
show subtarget assignments
)
1
cloned
No
YPO0342
16120677
putative oxidoreductase Fe-S binding sub...
671
Drug Target Function
Phase 2: March 2008
2VDC
28.8%
Yersinia pestis
Amino acid biosynthesis
Glutamate family
IDP91562
(
show subtarget assignments
)
8
expressed
No
BAB34299
13360335
ECs0876
hypothetical protein [Escherichia coli O...
670
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3NAW
19.6%
Escherichia coli
IDP90632
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO2989
16123170
ligA
NAD-dependent DNA ligase LigA [Yersinia ...
670
Predicted Essential
Community Requests
2OWO
78.5%
Yersinia pestis
IDP90769
(
show subtarget assignments
)
8
purified
No
VC0971
15640987
ligA
NAD-dependent DNA ligase LigA [Vibrio ch...
669
Predicted Essential
Community Requests
2OWO
65.8%
Vibrio cholerae
IDP91724
(
show subtarget assignments
)
8
selected
No
NP_115805
45331215
LZTS2
leucine zipper putative tumor suppressor...
669
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2I1J
10.9%
Homo sapiens
IDP90178
(
show subtarget assignments
)
8
purified
No
AAM13472.1
20153011
VHR1
VHR1 or CPXV025 protein
668
ankyrin-like protein, CP77
Community Requests
1N11
10%
Cowpox virus
host range protein
0
IDP91928
(
show subtarget assignments
)
8
selected
No
SpneCM_010100008890
298255690
ABC transporter membrane-spanning permea...
668
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP90257
(
show subtarget assignments
)
8
purified
No
SAR1996
49484145
lig
DNA ligase [Staphylococcus aureus subsp....
667
(From requester) potential drug target for S. aureus
Community Requests
3JSL
46.3%
Staphylococcus aureus
IDP91002
(
show subtarget assignments
)
8
selected
No
y1919
22125812
bifunctional UDP-glucuronic acid decarbo...
667
virulence/pathogenesis /
-
Community Requests
1Z7E
70.2%
Yersinia pestis
IDP02454
(
show subtarget assignments
)
1
in_pdb
3HYL
3M49
No
GBAA3744
47529034
tkt-2
transketolase [Bacillus anthracis str. '...
666
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3HYL
100%
Bacillus anthracis
Energy metabolism
Pentose phosphate pathway
IDP01438
(
show subtarget assignments
)
1
expressed
No
VC1993
15641995
2,4-dienoyl-CoA reductase
666
Drug Target Function
Phase 2: March 2008
1PS9
56.6%
Vibrio cholerae
Fatty acid and phospholipid metabolism
Degradation
IDP01420
(
show subtarget assignments
)
1
cloned
No
VC1496
15641505
carboxy-terminal protease
665
Drug Target Function
Phase 2: March 2008
1FC6
16.1%
Vibrio cholerae
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP91021
(
show subtarget assignments
)
8
cloned
No
y2872
22126749
yiuR
putative outer membrane receptor [Yersin...
665
other biological interest /
putative iron-binding TonB-dependent outer membrane receptor
Community Requests
2HDF
38%
Yersinia pestis
IDP01470
(
show subtarget assignments
)
1
purified
No
VC2608
15642603
ABC transporter, ATP-binding protein
664
Conserved Gene / Pathway
Phase 2: March 2008
2IW3
23.8%
Vibrio cholerae
Transport and binding proteins
Unknown substrate
IDP00550
(
show subtarget assignments
)
1
purified
No
YPO3488
16123634
deaD
ATP-dependent RNA helicase DeaD
664
Virulence Associated Factor
Phase 2: March 2008
1HV8
23.3%
Yersinia pestis
Transcription
Other
IDP05320
(
show subtarget assignments
)
1
cloned
No
lmo0177
16802223
metS
methionyl-tRNA synthetase [Listeria mono...
630
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2CSX
35.4%
Listeria monocytogenes
Protein synthesis: tRNA aminoacylation
IDP00346
(
show subtarget assignments
)
1
cloned
No
lmo0489
16802532
hypothetical protein lmo0489
664
Drug Target Function
Phase 2: March 2008
3K30
26.6%
Listeria monocytogenes
Energy metabolism
Electron transport
IDP91391
(
show subtarget assignments
)
8
cloned
No
VV1_1292
27364692
mutL
DNA mismatch repair protein [Vibrio vuln...
664
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1B62
36.4%
Vibrio vulnificus
IDP90596
(
show subtarget assignments
)
8
cloned
No
Cj1234
15792558
glyS
glycyl-tRNA synthetase subunit beta [Cam...
664
Predicted Essential
Community Requests
Campylobacter jejuni
IDP90276
(
show subtarget assignments
)
8
cloned
No
TGME49_032600
211965793
patatin-like phospholipase domain-contai...
664
Signature-tagged mutagenesis (STM) has identified this patatin-like phospholipas...
Community Requests
Toxoplasma gondii
IDP91903
(
show subtarget assignments
)
8
selected
No
SpneCM_010100005798
298255108
hypothetical protein SpneCM_05798 [Strep...
663
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2DHR
40.7%
Streptococcus pneumoniae
IDP02310
(
show subtarget assignments
)
1
in_pdb
3KOM
No
FTT1369c
56708422
tktA
transketolase [Francisella tularensis su...
663
Conserved; Drug target functions
Phase 3: June 2008
3KOM
99.7%
Francisella tularensis
Energy metabolism
Pentose phosphate pathway
IDP91735
(
show subtarget assignments
)
8
selected
No
Q4W8J9_STAAU
0
663
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2A1D
29.9%
Staphylococcus aureus
IDP90954
(
show subtarget assignments
)
8
purified
No
UTI89_C4061
122421980
Hypothetical protein yhjK
662
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3PJW
16.2%
Escherichia coli
IDP00613
(
show subtarget assignments
)
1
soluble
No
SACOL1377
57284532
tkt
transketolase
662
Drug Target Function
Phase 2: March 2008
3HYL
61.2%
Staphylococcus aureus
Energy metabolism
Pentose phosphate pathway
IDP90956
(
show subtarget assignments
)
8
cloned
No
UTI89_C1558
122423881
Hypothetical protein yciR
661
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3HVB
15.9%
Escherichia coli
IDP01258
(
show subtarget assignments
)
1
soluble
No
BA_2238
30256883
pbpC
penicillin-binding protein 3
661
Drug Target Function
Phase 2: March 2008
1MWR
34.9%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP91745
(
show subtarget assignments
)
8
selected
No
Q846V4_STAAU
0
660
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2A1D
45.6%
Staphylococcus aureus
IDP01898
(
show subtarget assignments
)
1
expressed
No
STM1669
16765012
invasin-like protein [Salmonella typhimu...
660
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unclassified
Role category not yet assigned
IDP90289
(
show subtarget assignments
)
8
purified
No
TGME49_094270
211967870
arginine methyltransferase protein, puta...
660
Epigenetic is an emerging field in Toxoplasma biology that will provide new targ...
Community Requests
2Y1W
24.5%
Toxoplasma gondii
IDP90110
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_015
68449089
ankyrin-like protein [Monkeypox virus]
660
similar to CPXV-GRI-C9L,CPXV-BR-V024, MPXV-ZAI96-D7L
Community Requests
1N0Q
4.4%
Monkeypox virus
IDP04575
(
show subtarget assignments
)
1
cloned
No
BAS0037
49183072
methionyl-tRNA synthetase [Bacillus anth...
660
Proposed to be essential proteins
Phase 4: April 2009
4DLP
36.2%
Bacillus anthracis
IDP90091
(
show subtarget assignments
)
8
expressed
No
ZZZ_0007
660
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
2P5Z
15.6%
Escherichia coli
IDP91954
(
show subtarget assignments
)
8
in_crystallization_trials
No
SpneCM_010100003495
298254664
oligopeptide binding protein [Streptococ...
660
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3O9P
21.2%
Streptococcus pneumoniae
IDP91952
(
show subtarget assignments
)
8
selected
No
SpneCM_010100008682
298255656
AmiA protein [Streptococcus pneumoniae s...
659
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
1B05
23.4%
Streptococcus pneumoniae
IDP90170
(
show subtarget assignments
)
8
selected
No
AAM13458.1
20152997
CPXV011 CDS
CPXV011 protein
658
ankyrin repeat protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP90891
(
show subtarget assignments
)
8
cloned
No
YPO3122
16123287
dnaX
DNA polymerase III subunits gamma and ta...
658
Predicted Essential
Community Requests
1JR3
46.7%
Yersinia pestis
IDP02415
(
show subtarget assignments
)
1
soluble
No
CBU_1761
29542318
sensory box sensor histidine kinase/resp...
657
Conserved; Drug target functions
Phase 3: June 2008
2C2A
11.6%
Coxiella burnetii
Signal transduction
Two-component systems
IDP05574
(
show subtarget assignments
)
1
soluble
No
SACOL0533
57651372
metS
methionyl-tRNA synthetase [Staphylococcu...
657
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2CSX
35.3%
Staphylococcus aureus
Protein synthesis: tRNA aminoacylation
IDP05216
(
show subtarget assignments
)
1
cloned
No
CD3349
126700969
bclA3
putative exosporium glycoprotein [Clostr...
657
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3HQV
35.6%
Clostridium difficile
Unknown function: General
IDP02646
(
show subtarget assignments
)
1
expressed
No
CBU_1290
29541858
dnaK
chaperone protein dnak [Coxiella burneti...
656
Conserved; Drug target functions
Phase 3: June 2008
2KHO
68.9%
Coxiella burnetii
Protein fate
Protein folding and stabilization
IDP05196
(
show subtarget assignments
)
1
cloned
No
CD0961
126698545
putative phage cell wall hydrolase [Clos...
656
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3H41
8.1%
Clostridium difficile
Unknown function: Enzymes of unknown specificity
IDP02613
(
show subtarget assignments
)
1
expressed
No
YPO3530
16123676
cpdB
bifunctional 2',3'-cyclic nucleotide 2'-...
656
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
3JYF
40.5%
Yersinia pestis
Purines, pyrimidines, nucleosides, and nucleotides
Other
IDP01900
(
show subtarget assignments
)
1
purified
No
STM0570
16763947
apeE
outer membrane esterase [Salmonella typh...
656
Drug target functions
Phase 3: June 2008
3KVN
25.5%
Salmonella enterica
Unclassified
Role category not yet assigned
IDP05353
(
show subtarget assignments
)
1
cloned
No
CD2903
126700520
putative phage cell wall hydrolase [Clos...
656
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3H41
8.1%
Clostridium difficile
Unknown function: Enzymes of unknown specificity
IDP92057
(
show subtarget assignments
)
8
selected
No
TGME49_061030
237831917
mitochondrial NADPH:adrenodoxin oxidored...
656
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1CJC
25%
Toxoplasma gondii
IDP90344
(
show subtarget assignments
)
8
cloned
No
CT105
15604824
hypothetical protein CT105 [Chlamydia tr...
656
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
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