Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04439 (show subtarget assignments)	1	cloned	No	YPO0185	115346005	ssiD	putative taurine dioxygenase [Yersinia p...	282	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GQW	75.9%	Yersinia pestis	Energy metabolism	Other

IDP01701 (show subtarget assignments)	1	soluble	No	CBU_1970	29542525	dapF	diaminopimelate epimerase [Coxiella burn...	276	Conserved; Drug target functions	Phase 3: June 2008	1GQZ	48.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP00477 (show subtarget assignments)	1	purified	No	YPO3845	16123980	dapF	diaminopimelate epimerase	274	Conserved Gene / Pathway	Phase 2: March 2008	1GQZ	75.9%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP02341 (show subtarget assignments)	1	cloned	No	FTT1313c	56708370	greA	transcriptional elongation factor [Franc...	160	Conserved; Drug target functions	Phase 3: June 2008	1GRJ	63.1%	Francisella tularensis	Regulatory functions	Other

IDP01077 (show subtarget assignments)	0	work_stopped	No	STM4122	161353577	argB	acetylglutamate kinase	257	Conserved Gene / Pathway	Phase 2: March 2008	1GS5	94.2%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP90620 (show subtarget assignments)	8	expressed	No	VC0275	15640304		phosphoribosylamine--glycine ligase [Vib...	429	Predicted Essential	Community Requests	1GSO	77.9%	Vibrio cholerae

IDP02246 (show subtarget assignments)	1	expressed	No	FTT0649c	56707771	rnfB	Iron-sulfur cluster-binding protein [Fra...	209	Drug Target	Phase 3: June 2008	1GT8	12.9%	Francisella tularensis	Energy metabolism	Electron transport

IDP00452 (show subtarget assignments)	1	purified	No	YPO2245	16122473		electron transport complex protein RnfB ...	188	Conserved Gene / Pathway	Phase 2: March 2008	1GT8	14.4%	Yersinia pestis	Unknown function	General

IDP00562 (show subtarget assignments)	1	purified	No	YPO2908	16123099	hmp	nitric oxide dioxygenase	396	Virulence Associated Factor	Phase 2: March 2008	1GVH	63.1%	Yersinia pestis	Energy metabolism	Electron transport

IDP01381 (show subtarget assignments)	1	purified	No	VC0529	15640551	ispF	2-C-methyl-D-erythritol 2,4-cyclodiphosp...	158	Drug Target Function	Phase 2: March 2008	1GX1	74.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP05659 (show subtarget assignments)	1	cloned	No	lmo0236	16802282	-	2-C-methyl-D-erythritol 2,4-cyclodiphosp...	157	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GX1	61.8%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Other

IDP00300 (show subtarget assignments)	1	cloned	No	CBU_1153				548	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 2: March 2008	1GXB	10.4%	Coxiella burnetii

IDP91929 (show subtarget assignments)	8	selected	No	SpneCM_010100004422	298254845		formate acetyltransferase [Streptococcus...	774	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1H16	43.6%	Streptococcus pneumoniae

IDP00554 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1549	16121822	hisG	ATP phosphoribosyltransferase	299	Virulence Associated Factor	Phase 2: March 2008	1H3D	88%	Yersinia pestis	Amino acid biosynthesis	Histidine family

IDP04049 (show subtarget assignments)	1	soluble	No	VC1132	15641145	hisG	ATP phosphoribosyltransferase [Vibrio ch...	304	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1H3D	65.8%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP90801 (show subtarget assignments)	8	soluble	No	Cj1597	15792902	hisG	ATP phosphoribosyltransferase [Campyloba...	299	Predicted Essential	Community Requests	1H3D	66.2%	Campylobacter jejuni

IDP90605 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1271c	15792595	tyrS	tyrosyl-tRNA synthetase [Campylobacter j...	401	Predicted Essential	Community Requests	1H3E	38.8%	Campylobacter jejuni

IDP05300 (show subtarget assignments)	1	cloned	No	VC_0631	9655066		tyrosyl-tRNA synthetase [Vibrio cholerae...	395	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1H3E	47.8%	Vibrio cholerae	Protein synthesis: tRNA aminoacylation

IDP00339 (show subtarget assignments)	1	expressed	No	FTT0711	56707830	ispD	2-C-methyl-D-erythritol 4-phosphate cyti...	229	Drug Target Function	Phase 2: March 2008	1H3M	37.1%	Francisella tularensis

IDP90579 (show subtarget assignments)	8	soluble	No	VC0528	15640550	ispD	2-C-methyl-D-erythritol 4-phosphate cyti...	232	We have identified the methylerythritol phosphate (MEP) pathway enzymes, novel d...	Community Requests	1H3M	53.9%	Vibrio cholerae

IDP90580 (show subtarget assignments)	8	cloned	No	Cj1091c	15792416	leuS	leucyl-tRNA synthetase [Campylobacter je...	809	Predicted Essential	Community Requests	1H3N	42.1%	Campylobacter jejuni

IDP05334 (show subtarget assignments)	1	soluble	No	SACOL1808	57652056	leuS	leucyl-tRNA synthetase [Staphylococcus a...	805	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1H3N	46.4%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP04027 (show subtarget assignments)	1	cloned	No	BAS4637	49187628		leucyl-tRNA synthetase [Bacillus anthrac...	802	Proposed to be essential proteins	Phase 4: April 2009	1H3N	45.9%	Bacillus anthracis

IDP92141 (show subtarget assignments)	8	selected	No	TGME49_066730	237838909		leucyl-tRNA synthetase, putative [Toxopl...	1465	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1H3N	22.7%	Toxoplasma gondii

IDP90575 (show subtarget assignments)	8	soluble	No	YPO2610	16122823	leuS	leucyl-tRNA synthetase [Yersinia pestis ...	860	Predicted Essential	Community Requests	1H3N	46.7%	Yersinia pestis

IDP02728 (show subtarget assignments)	1	purified	No	lmo1660	16803700	leuS	leucyl-tRNA synthetase [Listeria monocyt...	803	DNA binding Motifs; Drug Target Homologs	Phase 3: June 2008	1H3N	44.1%	Listeria monocytogenes	Protein synthesis	tRNA aminoacylation

IDP90897 (show subtarget assignments)	8	expressed	No	VC0956	15640972	leuS	leucyl-tRNA synthetase [Vibrio cholerae ...	894	Predicted Essential	Community Requests	1H3N	46.3%	Vibrio cholerae

IDP05140 (show subtarget assignments)	1	soluble	No	BAS0382	49183410	-	prolyl-tRNA synthetase [Bacillus anthrac...	508	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1H4Q	48.2%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP92033 (show subtarget assignments)	8	selected	No	TGME49_019850	237842879		prolyl-tRNA synthetase, putative [Toxopl...	711	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1H4Q	30.2%	Toxoplasma gondii

IDP05297 (show subtarget assignments)	1	cloned	No	CD2188	126699804	mapA	maltose phosphorylase [Clostridium diffi...	761	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1H54	51.9%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02569 (show subtarget assignments)	1	cloned	No	lmo0264	16802310	inlE	internalin E [Listeria monocytogenes EGD...	499	Known virulence-Invasion; Predicted virulence-Invasion; PMID:11432815 ; Predicte...	Phase 3: June 2008	1H6U	44.9%	Listeria monocytogenes	Cellular processes	Pathogenesis

IDP05423 (show subtarget assignments)	1	cloned	No	lmo0263	16802309	inlH	internalin H [Listeria monocytogenes EGD...	548	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1H6U	55.7%	Listeria monocytogenes	Cellular processes: Pathogenesis

IDP02400 (show subtarget assignments)	1	purified	No	YPO3454	16123600	nrdD	anaerobic ribonucleoside triphosphate re...	712	Conserved; CD; Drug target functions	Phase 3: June 2008	1H78	48.2%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP01795 (show subtarget assignments)	1	expressed	No	GBAA0792	47526077	celA-1	PTS system, cellobiose-specific IIB comp...	101	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	41.6%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP05707 (show subtarget assignments)	1	expressed	No	lmo2762	16804799	-	hypothetical protein lmo2762 [Listeria m...	100	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1H9C	44%	Listeria monocytogenes	Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP05643 (show subtarget assignments)	1	soluble	No	CD3082	126700699		PTS system, IIB component [Clostridium d...	114	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1H9C	29.8%	Clostridium difficile	Signal transduction: PTS

IDP01818 (show subtarget assignments)	1	soluble	No	GBAA5444	47530758	celA-2	PTS system, cellobiose-specific IIB comp...	100	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	42%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01852 (show subtarget assignments)	1	cloned	No	GBAA5449	47530763	celA-3	PTS system, cellobiose-specific IIB comp...	100	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	41%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP05281 (show subtarget assignments)	1	in_crystallization_trials	No	CD0136	126697708		PTS system, IIB component [Clostridium d...	108	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1H9C	42.2%	Clostridium difficile	Signal transduction: PTS

IDP02049 (show subtarget assignments)	1	expressed	No	STM3122	16766422		putative arylsulfatase [Salmonella typhi...	579	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1HDH	36.1%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP04087 (show subtarget assignments)	1	cloned	No	CPF_2394	110799648	minC	septum formation inhibitor [Clostridium ...	211	conserved gene; putative drug target function;	Phase 4: April 2009	1HF2	29.7%	Clostridium perfringens	Cellular processes	Cell division

IDP91211 (show subtarget assignments)	8	purified	No	BLIJ_0365	189439940	aroG1	phospho-2-dehydro-3-deoxyheptonate aldol...	410	potential drug target / Shikimate pathway enzyme	Community Requests	1HFB	44.1%	Bifidobacterium longum

IDP90516 (show subtarget assignments)	8	expressed	No	Cj0535	15791896	oorD	2-oxoglutarate-acceptor oxidoreductase s...	103	Predicted Essential	Community Requests	1HFE	31.1%	Campylobacter jejuni

IDP04602 (show subtarget assignments)	1	in_crystallization_trials	No	BAS3667	49186666		transcription elongation factor NusA [Ba...	368	Proposed to be essential proteins	Phase 4: April 2009	1HH2	44%	Bacillus anthracis

IDP90599 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0460	15791824	nusA	transcription elongation factor NusA [Ca...	362	Predicted Essential	Community Requests	1HH2	33.4%	Campylobacter jejuni

IDP90723 (show subtarget assignments)	8	purified	No	Cj0821	15792159	glmU	UDP-N-acetylglucosamine pyrophosphorylas...	429	Predicted Essential	Community Requests	1HM0	40.1%	Campylobacter jejuni

IDP00356 (show subtarget assignments)	1	purified	No	lmo0198	16802244	gcaD	hypothetical protein lmo0198	457	Predicted involvement in glycosyl group metabolism; Drug Target Homologs	Phase 2: March 2008	1HM0	54.3%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91291 (show subtarget assignments)	8	expressed	No	SPA1658	56413821	fabH	3-oxoacyl-(acyl carrier protein) synthas...	317	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1HN9	94.6%	Salmonella enterica

IDP00541 (show subtarget assignments)	1	purified	No	YPO1597	16121865	fabH	3-oxoacyl-(acyl carrier protein) synthas...	316	Conserved Gene / Pathway	Phase 2: March 2008	1HN9	81.1%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP91237 (show subtarget assignments)	8	cloned	No	NT04EC1409	26107632	fabH	3-oxoacyl-[acyl-carrier-protein] synthas...	317	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1HN9	100%	Escherichia coli	Fatty acid and phospholipid metabolism: Biosynthesis

IDP91296 (show subtarget assignments)	8	cloned	No	STM1193	16764548	fabH	3-oxoacyl-(acyl carrier protein) synthas...	317	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1HN9	94.6%	Salmonella enterica

IDP00310 (show subtarget assignments)	1	expressed	No	CBU_0493	29653835	fabH	3-oxoacyl-(acyl-carrier-protein) synthas...	319	Drug Target Function	Phase 2: March 2008	1HN9	54.4%	Coxiella burnetii	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01503 (show subtarget assignments)	1	soluble	No	VCA0978	15601731		amino acid ABC transporter, periplasmic ...	243	Conserved Gene / Pathway	Phase 2: March 2008	1HPB	26.3%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP91481 (show subtarget assignments)	8	expressed	No	VPA1321	28901176		cytotoxic necrotizing factor [Vibrio par...	368	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1HQ0	18.2%	Vibrio parahaemolyticus

IDP04216 (show subtarget assignments)	1	cloned	No	STM1894_1_336	16765236	ruvB	Holliday junction DNA helicase B [Salmon...	336	Salmonella essential protein	Phase 4: April 2009	1HQC	53%	Salmonella enterica

IDP90519 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0383c	15791750	ribH	riboflavin synthase subunit beta [Campyl...	154	Predicted Essential	Community Requests	1HQK	51.9%	Campylobacter jejuni

IDP04728 (show subtarget assignments)	1	selected	No	BAS0102	49183136		DNA-directed RNA polymerase subunit beta...	1177	Proposed to be essential proteins	Phase 4: April 2009	1HQM	49.2%	Bacillus anthracis

IDP02423 (show subtarget assignments)	1	cloned	No	FTT1138	56708213	hemH	ferrochelatase [Francisella tularensis s...	333	Drug Target	Phase 3: June 2008	1HRK	27.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00015 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4048	47605856		UDP-N-acetylenolpyruvoylglucosamine redu...	301	Drug Target Homolog	Phase 1: October 2007	1HSK	39.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00020 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5315	47605857		UDP-N-acetylenolpyruvoylglucosamine redu...	305	Drug Target Homolog	Phase 1: October 2007	1HSK	59.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00658 (show subtarget assignments)	0	work_stopped	No	SACOL0801	57285762	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	307	Drug Target Function	Phase 2: March 2008	1HSK	99.3%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00550 (show subtarget assignments)	1	purified	No	YPO3488	16123634	deaD	ATP-dependent RNA helicase DeaD	664	Virulence Associated Factor	Phase 2: March 2008	1HV8	23.3%	Yersinia pestis	Transcription	Other

IDP01477 (show subtarget assignments)	1	purified	No	VC2762	15642755	glmU	bifunctional N-acetylglucosamine-1-phosp...	453	Drug Target Function	Phase 2: March 2008	1HV9	67.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00318 (show subtarget assignments)	1	cloned	No	CBU_1947	29655231	glmU	UDP-N-acetylglucosamine pyrophosphorylas...	455	Drug Target Function	Phase 2: March 2008	1HV9	51.4%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02450 (show subtarget assignments)	1	expressed	No	FTT1475	56708515	galT	galactose-1-phosphate uridylyltransferas...	341	Drug Target	Phase 3: June 2008	1HXQ	51.6%	Francisella tularensis	Energy metabolism	Sugars

IDP01890 (show subtarget assignments)	1	cloned	No	Cj0063c	15791455		ATPase, ParA family [Campylobacter jejun...	288	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1HYQ	25.7%	Campylobacter jejuni	Cell envelope	Other

IDP05191 (show subtarget assignments)	1	purified	No	CD0265	126697837	fleN	flagellar number regulator [Clostridium ...	292	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1HYQ	27.4%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP01119 (show subtarget assignments)	1	purified	No	BA_0344	30253882	ahpF	alkyl hydroperoxide reductase, F subunit...	508	Conserved Gene / Pathway	Phase 2: March 2008	1HYU	55.7%	Bacillus anthracis	Cellular processes	Detoxification

IDP00653 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0451	57286824	ahpF	alkyl hydroperoxide reductase, subunit F...	507	Conserved Gene / Pathway	Phase 2: March 2008	1HYU	53.8%	Staphylococcus aureus	Cellular processes	Detoxification

IDP02091 (show subtarget assignments)	1	expressed	No	STM3515	16766803	malT	transcriptional regulator MalT [Salmonel...	901	Conserved; Drug target functions	Phase 3: June 2008	1HZ4	36.6%	Salmonella enterica	Energy metabolism	Other

IDP90968 (show subtarget assignments)	8	selected	No					427	Planet Biotechnology company is currently developing an anthrax anti-toxin with ...	Community Requests	1HZH	62.3%	synthetic construct

IDP91290 (show subtarget assignments)	8	soluble	No	SPA1656	56413819	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	244	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I01	95.9%	Salmonella enterica

IDP90545 (show subtarget assignments)	8	soluble	No	YPO1599	16121867	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	244	Predicted Essential	Community Requests	1I01	86.9%	Yersinia pestis

IDP91297 (show subtarget assignments)	8	cloned	No	STM1195	16764550	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	244	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I01	95.9%	Salmonella enterica

IDP01413 (show subtarget assignments)	1	purified	No	VC1174	15641187		anthranilate synthase component I	523	Drug Target Function	Phase 2: March 2008	1I1Q	59.3%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP91223 (show subtarget assignments)	8	purified	No	SF1267	24112663	trpE	anthranilate synthase component I [Shige...	520	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	89.2%	Shigella flexneri

IDP91232 (show subtarget assignments)	8	expressed	No	NT04EC1776	26107995	trpE	Anthranilate synthase component I [Esche...	520	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	89.6%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP91300 (show subtarget assignments)	8	soluble	No	STM1723	16765067	trpE	anthranilate synthase component I	520	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	99.8%	Salmonella enterica

IDP01512 (show subtarget assignments)	1	soluble	No	VC1173	15641186		anthranilate synthase component II	203	Drug Target Function	Phase 2: March 2008	1I1Q	57.1%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP00349 (show subtarget assignments)	1	expressed	No	lmo1632	16803672	trpG	hypothetical protein lmo1632	201	Predicted involvement in glycosyl group metabolism; Drug Target Homologs	Phase 2: March 2008	1I1Q	39.3%	Listeria monocytogenes	Amino acid biosynthesis	Aromatic amino acid family

IDP00342 (show subtarget assignments)	1	cloned	No	FTT1802c	56708788	trpE	anthranilate synthase component I	514	Drug Target Function	Phase 2: March 2008	1I1Q	51.1%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP91286 (show subtarget assignments)	8	expressed	No	SPA1154	56413352	trpE	anthranilate synthase component I [Salmo...	520	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	99%	Salmonella enterica

IDP91238 (show subtarget assignments)	8	cloned	No	HP1282	2314448		anthranilate synthase component I (trpE)...	500	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	46.8%	Helicobacter pylori	Amino acid biosynthesis: Aromatic amino acid family

IDP02062 (show subtarget assignments)	1	soluble	No	CBU_1357	29541922	csdB	selenocysteine lyase [Coxiella burnetii ...	405	Conserved; Drug target functions	Phase 3: June 2008	1I29	50.9%	Coxiella burnetii	Central intermediary metabolism	Other

IDP01912 (show subtarget assignments)	1	soluble	No	STM2984	16766288	csdA	cysteine sulfinate desulfinase [Salmonel...	401	Conserved; Essential; Drug target functions	Phase 3: June 2008	1I29	44.8%	Salmonella enterica	Unknown function	General

IDP91007 (show subtarget assignments)	8	expressed	No	y1938	22125830		bifunctional cysteine desulfurase/seleno...	410	potential drug target / part of iron-sulfur cluster assembly system active under stress conditions	Community Requests	1I29	69.8%	Yersinia pestis

IDP92140 (show subtarget assignments)	8	selected	No	TGME49_072740	237833217		DNA-directed RNA polymerase III subunit,...	1332	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1I3Q	34.5%	Toxoplasma gondii

IDP92094 (show subtarget assignments)	8	selected	No	TGME49_038190	237834427		DNA-directed RNA polymerase II, putative...	484	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1I3Q	20.7%	Toxoplasma gondii

IDP91682 (show subtarget assignments)	8	selected	No	MuHV4gp74	9629629	ORF73	nuclear antigen LANA [Murid herpesvirus ...	314	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1I3Q	13.1%	Murid herpesvirus

IDP91449 (show subtarget assignments)	8	expressed	No	VV1_0390	27363858		SOS-response transcriptional repressor L...	137	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1I4V	34.3%	Vibrio vulnificus

IDP02518 (show subtarget assignments)	1	purified	No	GBAA5557	47530877	upp	uracil phosphoribosyltransferase [Bacill...	209	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1I5E	84.7%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP90977 (show subtarget assignments)	8	soluble	No	y0320	22124237	oxyR	DNA-binding transcriptional regulator Ox...	305	other biological interest / important global regulator	Community Requests	1I6A	59.7%	Yersinia pestis

IDP91526 (show subtarget assignments)	8	in_crystallization_trials	No	lpg1815	52842042	oxyR	hydrogen peroxide-inducible genes activa...	296	other biological interest / The Legionella pneumophila OxyR is a member of the LysR family that is no longer...	Community Requests	1I6A	28.4%	Legionella pneumophila

IDP01713 (show subtarget assignments)	1	soluble	No	YPO3407	16123556		putative carbonic anhydrase [Yersinia pe...	220	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1I6O	70.5%	Yersinia pestis	Central intermediary metabolism	Other

IDP00469 (show subtarget assignments)	1	cloned	No	YPO0139	16120482	hslO	Hsp33-like chaperonin	293	Conserved Gene / Pathway	Phase 2: March 2008	1I7F	71%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP00441 (show subtarget assignments)	1	expressed	No	YPO2207	16122435	trpG	anthranilate synthase component II	192	Drug Target Function	Phase 2: March 2008	1I7Q	87.5%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP00440 (show subtarget assignments)	1	purified	No	YPO2208	16122436	trpE	anthranilate synthase component I	521	Conserved Gene / Pathway	Phase 2: March 2008	1I7Q	79.7%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP91738 (show subtarget assignments)	8	selected	No	Q5YB85_STRSG	0			598	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1I84	15.1%	Streptococcus sp.

IDP00013 (show subtarget assignments)	1	soluble	No	BA_3254	30257811		LPXTG-motif cell wall anchor domain prot...	372	Drug Target Homolog	Phase 1: October 2007	1I84	18.3%	Bacillus anthracis	Cell envelope	Other

IDP91741 (show subtarget assignments)	8	selected	No	Q6V4L4_STRPY	0			397	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1I84	22.4%	Streptococcus pyogenes

IDP04439
(show subtarget assignments)

1

cloned

No

YPO0185

115346005

ssiD

putative taurine dioxygenase [Yersinia p...

282

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GQW

75.9%

Yersinia pestis

Energy metabolism

Other

IDP01701
(show subtarget assignments)

1

soluble

No

CBU_1970

29542525

dapF

diaminopimelate epimerase [Coxiella burn...

276

Conserved; Drug target functions

Phase 3: June 2008

1GQZ

48.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP00477
(show subtarget assignments)

1

purified

No

YPO3845

16123980

dapF

diaminopimelate epimerase

274

Conserved Gene / Pathway

Phase 2: March 2008

1GQZ

75.9%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP02341
(show subtarget assignments)

1

cloned

No

FTT1313c

56708370

greA

transcriptional elongation factor [Franc...

160

Conserved; Drug target functions

Phase 3: June 2008

1GRJ

63.1%

Francisella tularensis

Regulatory functions

Other

IDP01077
(show subtarget assignments)

0

work_stopped

No

STM4122

161353577

argB

acetylglutamate kinase

257

Conserved Gene / Pathway

Phase 2: March 2008

1GS5

94.2%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP90620
(show subtarget assignments)

8

expressed

No

VC0275

15640304

phosphoribosylamine--glycine ligase [Vib...

429

Predicted Essential

Community Requests

1GSO

77.9%

Vibrio cholerae

IDP02246
(show subtarget assignments)

1

expressed

No

FTT0649c

56707771

rnfB

Iron-sulfur cluster-binding protein [Fra...

209

Drug Target

Phase 3: June 2008

1GT8

12.9%

Francisella tularensis

Energy metabolism

Electron transport

IDP00452
(show subtarget assignments)

1

purified

No

YPO2245

16122473

electron transport complex protein RnfB ...

188

Conserved Gene / Pathway

Phase 2: March 2008

1GT8

14.4%

Yersinia pestis

Unknown function

General

IDP00562
(show subtarget assignments)

1

purified

No

YPO2908

16123099

hmp

nitric oxide dioxygenase

396

Virulence Associated Factor

Phase 2: March 2008

1GVH

63.1%

Yersinia pestis

Energy metabolism

Electron transport

IDP01381
(show subtarget assignments)

1

purified

No

VC0529

15640551

ispF

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

158

Drug Target Function

Phase 2: March 2008

1GX1

74.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP05659
(show subtarget assignments)

1

cloned

No

lmo0236

16802282

-

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

157

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GX1

61.8%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Other

IDP00300
(show subtarget assignments)

1

cloned

No

CBU_1153

548

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 2: March 2008

1GXB

10.4%

Coxiella burnetii

IDP91929
(show subtarget assignments)

8

selected

No

SpneCM_010100004422

298254845

formate acetyltransferase [Streptococcus...

774

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1H16

43.6%

Streptococcus pneumoniae

IDP00554
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1549

16121822

hisG

ATP phosphoribosyltransferase

299

Virulence Associated Factor

Phase 2: March 2008

1H3D

88%

Yersinia pestis

Amino acid biosynthesis

Histidine family

IDP04049
(show subtarget assignments)

1

soluble

No

VC1132

15641145

hisG

ATP phosphoribosyltransferase [Vibrio ch...

304

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1H3D

65.8%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP90801
(show subtarget assignments)

8

soluble

No

Cj1597

15792902

hisG

ATP phosphoribosyltransferase [Campyloba...

299

Predicted Essential

Community Requests

1H3D

66.2%

Campylobacter jejuni

IDP90605
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1271c

15792595

tyrS

tyrosyl-tRNA synthetase [Campylobacter j...

401

Predicted Essential

Community Requests

1H3E

38.8%

Campylobacter jejuni

IDP05300
(show subtarget assignments)

1

cloned

No

VC_0631

9655066

tyrosyl-tRNA synthetase [Vibrio cholerae...

395

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1H3E

47.8%

Vibrio cholerae

Protein synthesis: tRNA aminoacylation

IDP00339
(show subtarget assignments)

1

expressed

No

FTT0711

56707830

ispD

2-C-methyl-D-erythritol 4-phosphate cyti...

229

Drug Target Function

Phase 2: March 2008

1H3M

37.1%

Francisella tularensis

IDP90579
(show subtarget assignments)

8

soluble

No

VC0528

15640550

ispD

2-C-methyl-D-erythritol 4-phosphate cyti...

232

We have identified the methylerythritol phosphate (MEP) pathway enzymes, novel d...

Community Requests

1H3M

53.9%

Vibrio cholerae

IDP90580
(show subtarget assignments)

8

cloned

No

Cj1091c

15792416

leuS

leucyl-tRNA synthetase [Campylobacter je...

809

Predicted Essential

Community Requests

1H3N

42.1%

Campylobacter jejuni

IDP05334
(show subtarget assignments)

1

soluble

No

SACOL1808

57652056

leuS

leucyl-tRNA synthetase [Staphylococcus a...

805

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1H3N

46.4%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP04027
(show subtarget assignments)

1

cloned

No

BAS4637

49187628

leucyl-tRNA synthetase [Bacillus anthrac...

802

Proposed to be essential proteins

Phase 4: April 2009

1H3N

45.9%

Bacillus anthracis

IDP92141
(show subtarget assignments)

8

selected

No

TGME49_066730

237838909

leucyl-tRNA synthetase, putative [Toxopl...

1465

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1H3N

22.7%

Toxoplasma gondii

IDP90575
(show subtarget assignments)

8

soluble

No

YPO2610

16122823

leuS

leucyl-tRNA synthetase [Yersinia pestis ...

860

Predicted Essential

Community Requests

1H3N

46.7%

Yersinia pestis

IDP02728
(show subtarget assignments)

1

purified

No

lmo1660

16803700

leuS

leucyl-tRNA synthetase [Listeria monocyt...

803

DNA binding Motifs; Drug Target Homologs

Phase 3: June 2008

1H3N

44.1%

Listeria monocytogenes

Protein synthesis

tRNA aminoacylation

IDP90897
(show subtarget assignments)

8

expressed

No

VC0956

15640972

leuS

leucyl-tRNA synthetase [Vibrio cholerae ...

894

Predicted Essential

Community Requests

1H3N

46.3%

Vibrio cholerae

IDP05140
(show subtarget assignments)

1

soluble

No

BAS0382

49183410

-

prolyl-tRNA synthetase [Bacillus anthrac...

508

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1H4Q

48.2%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP92033
(show subtarget assignments)

8

selected

No

TGME49_019850

237842879

prolyl-tRNA synthetase, putative [Toxopl...

711

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1H4Q

30.2%

Toxoplasma gondii

IDP05297
(show subtarget assignments)

1

cloned

No

CD2188

126699804

mapA

maltose phosphorylase [Clostridium diffi...

761

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1H54

51.9%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02569
(show subtarget assignments)

1

cloned

No

lmo0264

16802310

inlE

internalin E [Listeria monocytogenes EGD...

499

Known virulence-Invasion; Predicted virulence-Invasion; PMID:11432815 ; Predicte...

Phase 3: June 2008

1H6U

44.9%

Listeria monocytogenes

Cellular processes

Pathogenesis

IDP05423
(show subtarget assignments)

1

cloned

No

lmo0263

16802309

inlH

internalin H [Listeria monocytogenes EGD...

548

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1H6U

55.7%

Listeria monocytogenes

Cellular processes: Pathogenesis

IDP02400
(show subtarget assignments)

1

purified

No

YPO3454

16123600

nrdD

anaerobic ribonucleoside triphosphate re...

712

Conserved; CD; Drug target functions

Phase 3: June 2008

1H78

48.2%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP01795
(show subtarget assignments)

1

expressed

No

GBAA0792

47526077

celA-1

PTS system, cellobiose-specific IIB comp...

101

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

41.6%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP05707
(show subtarget assignments)

1

expressed

No

lmo2762

16804799

-

hypothetical protein lmo2762 [Listeria m...

100

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1H9C

44%

Listeria monocytogenes

Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP05643
(show subtarget assignments)

1

soluble

No

CD3082

126700699

PTS system, IIB component [Clostridium d...

114

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1H9C

29.8%

Clostridium difficile

Signal transduction: PTS

IDP01818
(show subtarget assignments)

1

soluble

No

GBAA5444

47530758

celA-2

PTS system, cellobiose-specific IIB comp...

100

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

42%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01852
(show subtarget assignments)

1

cloned

No

GBAA5449

47530763

celA-3

PTS system, cellobiose-specific IIB comp...

100

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

41%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP05281
(show subtarget assignments)

1

in_crystallization_trials

No

CD0136

126697708

PTS system, IIB component [Clostridium d...

108

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1H9C

42.2%

Clostridium difficile

Signal transduction: PTS

IDP02049
(show subtarget assignments)

1

expressed

No

STM3122

16766422

putative arylsulfatase [Salmonella typhi...

579

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1HDH

36.1%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP04087
(show subtarget assignments)

1

cloned

No

CPF_2394

110799648

minC

septum formation inhibitor [Clostridium ...

211

conserved gene; putative drug target function;

Phase 4: April 2009

1HF2

29.7%

Clostridium perfringens

Cellular processes

Cell division

IDP91211
(show subtarget assignments)

8

purified

No

BLIJ_0365

189439940

aroG1

phospho-2-dehydro-3-deoxyheptonate aldol...

410

potential drug target / Shikimate pathway enzyme

Community Requests

1HFB

44.1%

Bifidobacterium longum

IDP90516
(show subtarget assignments)

8

expressed

No

Cj0535

15791896

oorD

2-oxoglutarate-acceptor oxidoreductase s...

103

Predicted Essential

Community Requests

1HFE

31.1%

Campylobacter jejuni

IDP04602
(show subtarget assignments)

1

in_crystallization_trials

No

BAS3667

49186666

transcription elongation factor NusA [Ba...

368

Proposed to be essential proteins

Phase 4: April 2009

1HH2

44%

Bacillus anthracis

IDP90599
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0460

15791824

nusA

transcription elongation factor NusA [Ca...

362

Predicted Essential

Community Requests

1HH2

33.4%

Campylobacter jejuni

IDP90723
(show subtarget assignments)

8

purified

No

Cj0821

15792159

glmU

UDP-N-acetylglucosamine pyrophosphorylas...

429

Predicted Essential

Community Requests

1HM0

40.1%

Campylobacter jejuni

IDP00356
(show subtarget assignments)

1

purified

No

lmo0198

16802244

gcaD

hypothetical protein lmo0198

457

Predicted involvement in glycosyl group metabolism; Drug Target Homologs

Phase 2: March 2008

1HM0

54.3%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91291
(show subtarget assignments)

8

expressed

No

SPA1658

56413821

fabH

3-oxoacyl-(acyl carrier protein) synthas...

317

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1HN9

94.6%

Salmonella enterica

IDP00541
(show subtarget assignments)

1

purified

No

YPO1597

16121865

fabH

3-oxoacyl-(acyl carrier protein) synthas...

316

Conserved Gene / Pathway

Phase 2: March 2008

1HN9

81.1%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP91237
(show subtarget assignments)

8

cloned

No

NT04EC1409

26107632

fabH

3-oxoacyl-[acyl-carrier-protein] synthas...

317

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1HN9

100%

Escherichia coli

Fatty acid and phospholipid metabolism: Biosynthesis

IDP91296
(show subtarget assignments)

8

cloned

No

STM1193

16764548

fabH

3-oxoacyl-(acyl carrier protein) synthas...

317

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1HN9

94.6%

Salmonella enterica

IDP00310
(show subtarget assignments)

1

expressed

No

CBU_0493

29653835

fabH

3-oxoacyl-(acyl-carrier-protein) synthas...

319

Drug Target Function

Phase 2: March 2008

1HN9

54.4%

Coxiella burnetii

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01503
(show subtarget assignments)

1

soluble

No

VCA0978

15601731

amino acid ABC transporter, periplasmic ...

243

Conserved Gene / Pathway

Phase 2: March 2008

1HPB

26.3%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP91481
(show subtarget assignments)

8

expressed

No

VPA1321

28901176

cytotoxic necrotizing factor [Vibrio par...

368

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1HQ0

18.2%

Vibrio parahaemolyticus

IDP04216
(show subtarget assignments)

1

cloned

No

STM1894_1_336

16765236

ruvB

Holliday junction DNA helicase B [Salmon...

336

Salmonella essential protein

Phase 4: April 2009

1HQC

53%

Salmonella enterica

IDP90519
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0383c

15791750

ribH

riboflavin synthase subunit beta [Campyl...

154

Predicted Essential

Community Requests

1HQK

51.9%

Campylobacter jejuni

IDP04728
(show subtarget assignments)

1

selected

No

BAS0102

49183136

DNA-directed RNA polymerase subunit beta...

1177

Proposed to be essential proteins

Phase 4: April 2009

1HQM

49.2%

Bacillus anthracis

IDP02423
(show subtarget assignments)

1

cloned

No

FTT1138

56708213

hemH

ferrochelatase [Francisella tularensis s...

333

Drug Target

Phase 3: June 2008

1HRK

27.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00015
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4048

47605856

UDP-N-acetylenolpyruvoylglucosamine redu...

301

Drug Target Homolog

Phase 1: October 2007

1HSK

39.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00020
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5315

47605857

UDP-N-acetylenolpyruvoylglucosamine redu...

305

Drug Target Homolog

Phase 1: October 2007

1HSK

59.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00658
(show subtarget assignments)

0

work_stopped

No

SACOL0801

57285762

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

307

Drug Target Function

Phase 2: March 2008

1HSK

99.3%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00550
(show subtarget assignments)

1

purified

No

YPO3488

16123634

deaD

ATP-dependent RNA helicase DeaD

664

Virulence Associated Factor

Phase 2: March 2008

1HV8

23.3%

Yersinia pestis

Transcription

Other

IDP01477
(show subtarget assignments)

1

purified

No

VC2762

15642755

glmU

bifunctional N-acetylglucosamine-1-phosp...

453

Drug Target Function

Phase 2: March 2008

1HV9

67.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00318
(show subtarget assignments)

1

cloned

No

CBU_1947

29655231

glmU

UDP-N-acetylglucosamine pyrophosphorylas...

455

Drug Target Function

Phase 2: March 2008

1HV9

51.4%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02450
(show subtarget assignments)

1

expressed

No

FTT1475

56708515

galT

galactose-1-phosphate uridylyltransferas...

341

Drug Target

Phase 3: June 2008

1HXQ

51.6%

Francisella tularensis

Energy metabolism

Sugars

IDP01890
(show subtarget assignments)

1

cloned

No

Cj0063c

15791455

ATPase, ParA family [Campylobacter jejun...

288

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1HYQ

25.7%

Campylobacter jejuni

Cell envelope

Other

IDP05191
(show subtarget assignments)

1

purified

No

CD0265

126697837

fleN

flagellar number regulator [Clostridium ...

292

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1HYQ

27.4%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP01119
(show subtarget assignments)

1

purified

No

BA_0344

30253882

ahpF

alkyl hydroperoxide reductase, F subunit...

508

Conserved Gene / Pathway

Phase 2: March 2008

1HYU

55.7%

Bacillus anthracis

Cellular processes

Detoxification

IDP00653
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0451

57286824

ahpF

alkyl hydroperoxide reductase, subunit F...

507

Conserved Gene / Pathway

Phase 2: March 2008

1HYU

53.8%

Staphylococcus aureus

Cellular processes

Detoxification

IDP02091
(show subtarget assignments)

1

expressed

No

STM3515

16766803

malT

transcriptional regulator MalT [Salmonel...

901

Conserved; Drug target functions

Phase 3: June 2008

1HZ4

36.6%

Salmonella enterica

Energy metabolism

Other

IDP90968
(show subtarget assignments)

8

selected

No

427

Planet Biotechnology company is currently developing an anthrax anti-toxin with ...

Community Requests

1HZH

62.3%

synthetic construct

IDP91290
(show subtarget assignments)

8

soluble

No

SPA1656

56413819

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

244

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I01

95.9%

Salmonella enterica

IDP90545
(show subtarget assignments)

8

soluble

No

YPO1599

16121867

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

244

Predicted Essential

Community Requests

1I01

86.9%

Yersinia pestis

IDP91297
(show subtarget assignments)

8

cloned

No

STM1195

16764550

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

244

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I01

95.9%

Salmonella enterica

IDP01413
(show subtarget assignments)

1

purified

No

VC1174

15641187

anthranilate synthase component I

523

Drug Target Function

Phase 2: March 2008

1I1Q

59.3%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP91223
(show subtarget assignments)

8

purified

No

SF1267

24112663

trpE

anthranilate synthase component I [Shige...

520

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

89.2%

Shigella flexneri

IDP91232
(show subtarget assignments)

8

expressed

No

NT04EC1776

26107995

trpE

Anthranilate synthase component I [Esche...

520

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

89.6%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP91300
(show subtarget assignments)

8

soluble

No

STM1723

16765067

trpE

anthranilate synthase component I

520

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

99.8%

Salmonella enterica

IDP01512
(show subtarget assignments)

1

soluble

No

VC1173

15641186

anthranilate synthase component II

203

Drug Target Function

Phase 2: March 2008

1I1Q

57.1%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP00349
(show subtarget assignments)

1

expressed

No

lmo1632

16803672

trpG

hypothetical protein lmo1632

201

Predicted involvement in glycosyl group metabolism; Drug Target Homologs

Phase 2: March 2008

1I1Q

39.3%

Listeria monocytogenes

Amino acid biosynthesis

Aromatic amino acid family

IDP00342
(show subtarget assignments)

1

cloned

No

FTT1802c

56708788

trpE

anthranilate synthase component I

514

Drug Target Function

Phase 2: March 2008

1I1Q

51.1%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP91286
(show subtarget assignments)

8

expressed

No

SPA1154

56413352

trpE

anthranilate synthase component I [Salmo...

520

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

99%

Salmonella enterica

IDP91238
(show subtarget assignments)

8

cloned

No

HP1282

2314448

anthranilate synthase component I (trpE)...

500

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

46.8%

Helicobacter pylori

Amino acid biosynthesis: Aromatic amino acid family

IDP02062
(show subtarget assignments)

1

soluble

No

CBU_1357

29541922

csdB

selenocysteine lyase [Coxiella burnetii ...

405

Conserved; Drug target functions

Phase 3: June 2008

1I29

50.9%

Coxiella burnetii

Central intermediary metabolism

Other

IDP01912
(show subtarget assignments)

1

soluble

No

STM2984

16766288

csdA

cysteine sulfinate desulfinase [Salmonel...

401

Conserved; Essential; Drug target functions

Phase 3: June 2008

1I29

44.8%

Salmonella enterica

Unknown function

General

IDP91007
(show subtarget assignments)

8

expressed

No

y1938

22125830

bifunctional cysteine desulfurase/seleno...

410

potential drug target / part of iron-sulfur cluster assembly system active under stress conditions

Community Requests

1I29

69.8%

Yersinia pestis

IDP92140
(show subtarget assignments)

8

selected

No

TGME49_072740

237833217

DNA-directed RNA polymerase III subunit,...

1332

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1I3Q

34.5%

Toxoplasma gondii

IDP92094
(show subtarget assignments)

8

selected

No

TGME49_038190

237834427

DNA-directed RNA polymerase II, putative...

484

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1I3Q

20.7%

Toxoplasma gondii

IDP91682
(show subtarget assignments)

8

selected

No

MuHV4gp74

9629629

ORF73

nuclear antigen LANA [Murid herpesvirus ...

314

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1I3Q

13.1%

Murid herpesvirus

IDP91449
(show subtarget assignments)

8

expressed

No

VV1_0390

27363858

SOS-response transcriptional repressor L...

137

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1I4V

34.3%

Vibrio vulnificus

IDP02518
(show subtarget assignments)

1

purified

No

GBAA5557

47530877

upp

uracil phosphoribosyltransferase [Bacill...

209

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1I5E

84.7%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP90977
(show subtarget assignments)

8

soluble

No

y0320

22124237

oxyR

DNA-binding transcriptional regulator Ox...

305

other biological interest / important global regulator

Community Requests

1I6A

59.7%

Yersinia pestis

IDP91526
(show subtarget assignments)

8

in_crystallization_trials

No

lpg1815

52842042

oxyR

hydrogen peroxide-inducible genes activa...

296

other biological interest / The Legionella pneumophila OxyR is a member of the LysR family that is no longer...

Community Requests

1I6A

28.4%

Legionella pneumophila

IDP01713
(show subtarget assignments)

1

soluble

No

YPO3407

16123556

putative carbonic anhydrase [Yersinia pe...

220

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1I6O

70.5%

Yersinia pestis

Central intermediary metabolism

Other

IDP00469
(show subtarget assignments)

1

cloned

No

YPO0139

16120482

hslO

Hsp33-like chaperonin

293

Conserved Gene / Pathway

Phase 2: March 2008

1I7F

71%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP00441
(show subtarget assignments)

1

expressed

No

YPO2207

16122435

trpG

anthranilate synthase component II

192

Drug Target Function

Phase 2: March 2008

1I7Q

87.5%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP00440
(show subtarget assignments)

1

purified

No

YPO2208

16122436

trpE

anthranilate synthase component I

521

Conserved Gene / Pathway

Phase 2: March 2008

1I7Q

79.7%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP91738
(show subtarget assignments)

8

selected

No

Q5YB85_STRSG

0

598

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1I84

15.1%

Streptococcus sp.

IDP00013
(show subtarget assignments)

1

soluble

No

BA_3254

30257811

LPXTG-motif cell wall anchor domain prot...

372

Drug Target Homolog

Phase 1: October 2007

1I84

18.3%

Bacillus anthracis

Cell envelope

Other

IDP91741
(show subtarget assignments)

8

selected

No

Q6V4L4_STRPY

0

397

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1I84

22.4%

Streptococcus pyogenes