Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05285 (show subtarget assignments)	1	selected	No	CD0663	126698240	tcdA	toxin A [Clostridium difficile 630]	2710	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3SRZ	20%	Clostridium difficile	Cellular processes: Pathogenesis

IDP01422 (show subtarget assignments)	1	expressed	No	VC1549	15641557		glycerol-3-phosphate ABC transporter, pe...	434	Conserved Gene / Pathway	Phase 2: March 2008	2HEU	20%	Vibrio cholerae	Transport and binding proteins	Other

IDP01253 (show subtarget assignments)	1	cloned	No	BA_2575	30257197		penicillin-binding protein, putative	481	Drug Target Function	Phase 2: March 2008	2QMI	20%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02356 (show subtarget assignments)	1	cloned	No	FTT1296	56708355	ubiE	menaquinone biosynthesis methyltransfera...	250	Conserved; Drug target functions	Phase 3: June 2008	2AVN	20%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP91190 (show subtarget assignments)	1	in_crystallization_trials	No	EF_A0061	29345308		6'-aminoglycoside N-acetyltransferase [E...	479	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3R6Z	20%	Enterococcus faecalis

IDP00675 (show subtarget assignments)	1	cloned	No	SACOL1455	57284564		carboxyl-terminal protease	496	Drug Target Function	Phase 2: March 2008	1FC6	20%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05314 (show subtarget assignments)	1	soluble	No	BA_4986	30259478	gerHC	spore germination protein GerHC [Bacillu...	359	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3N54	20.1%	Bacillus anthracis	Cellular processes: Sporulation and germination

IDP00221 (show subtarget assignments)	1	soluble	No	YPO0164	16120507	-	putative membrane receptor protein	686	Virulence	Phase 1: October 2007	2HDF	20.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02827 (show subtarget assignments)	1	cloned	No	FTT1508c	56708546	relA	GTP pyrophosphokinase [Francisella tular...	647	Drug Target	Phase 3: June 2008	1VJ7	20.1%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP91633 (show subtarget assignments)	8	purified	No	BAB35418	13361460	ECs1995	hypothetical protein [Escherichia coli O...	209	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2KKX	20.1%	Escherichia coli

IDP91466 (show subtarget assignments)	8	soluble	No	VV1_0078	27363563		site-specific recombinase XerC [Vibrio v...	234	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1A0P	20.1%	Vibrio vulnificus

IDP90210 (show subtarget assignments)	8	expressed	No	MYXV_gp140	9633772	m136R	m136R	179	unknown, similar to VACV-Cop:A52R	Community Requests	2VVW	20.1%	Myxoma virus	unknown, conserved protein	0

IDP91261 (show subtarget assignments)	8	soluble	No	NT05BA0041	49176992		DNA polymerase III, delta prime subunit ...	327	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1A5T	20.2%	Bacillus anthracis	DNA metabolism: DNA replication, recombination, and repair

IDP91572 (show subtarget assignments)	8	soluble	No	BAB35419	13361461	ECs1996	hypothetical protein [Escherichia coli O...	213	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2KKX	20.2%	Escherichia coli

IDP91642 (show subtarget assignments)	8	cloned	No	NP_216895	15609516		peptide synthetase MBTF (peptide synthas...	1461	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	2VSQ	20.2%	Mycobacterium tuberculosis

IDP04448 (show subtarget assignments)	1	cloned	No	YPO0810	218927990		general secretion pathway protein J [Yer...	198	putative drug target function;	Phase 4: April 2009	2RET	20.2%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP05056 (show subtarget assignments)	1	soluble	No	CD0257	126697829	motB	chemotaxis protein [Clostridium difficil...	231	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2K1S	20.3%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP04357 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0894	56707995	purCD	fusion protein PurC/PurD [Francisella tu...	770	conserved gene; putative drug target function;	Phase 4: April 2009	2YRW	20.3%	Francisella tularensis

IDP02134 (show subtarget assignments)	1	soluble	No	CBU_0597	29541198		oxygen-independent coproporphyrinogen II...	375	Conserved; Drug target functions	Phase 3: June 2008	1OLT	20.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP92048 (show subtarget assignments)	8	selected	No	TGME49_049270	237835927		thioredoxin, putative [Toxoplasma gondii...	428	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3IDV	20.3%	Toxoplasma gondii

IDP92066 (show subtarget assignments)	8	selected	No	ABO93620	144228223	GAPDH2	apicoplast glyceraldehyde-3-phosphate de...	995	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3STH	20.3%	Toxoplasma gondii

IDP91341 (show subtarget assignments)	8	cloned	No	VV2_0101	27366558		lipase [Vibrio vulnificus CMCP6]	265	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2ORY	20.4%	Vibrio vulnificus

IDP05207 (show subtarget assignments)	1	cloned	No	CD2365	126699980		putative sulfonate ABC transporter,solut...	363	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3QSL	20.4%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP91487 (show subtarget assignments)	8	soluble	No	VP1697	28898471		putative type III export apparatus prote...	142	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1XKP	20.4%	Vibrio parahaemolyticus

IDP01169 (show subtarget assignments)	1	cloned	No	GBAA_pXO1_0146	47566458	atxA	transcriptional activator atxa, (pxo1-11...	475	Virulence Associated Factor	Phase 2: March 2008	3SQN	20.4%	Bacillus anthracis

IDP05524 (show subtarget assignments)	1	cloned	No	CD2402	126700017		putative cell wall hydrolase [Clostridiu...	396	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3H41	20.5%	Clostridium difficile	Cellular processes: Sporulation and germination

IDP02020 (show subtarget assignments)	1	crystallized	No	FTT0245	56707402	usp	universal stress protein [Francisella tu...	278	Drug Target	Phase 3: June 2008	2PFS	20.5%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP04678 (show subtarget assignments)	1	cloned	No	GBAA2560	47527849		sensor histidine kinase [Bacillus anthra...	385	putative drug target function;	Phase 4: April 2009	3DGE	20.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04703 (show subtarget assignments)	1	expressed	No	YPO0273	115346091		putative type III secretion apparatus pr...	355	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	3BZP	20.6%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP90959 (show subtarget assignments)	8	cloned	No	PP2258	81441302		Sensory box protein	562	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	2R6O	20.6%	Pseudomonas putida

IDP02658 (show subtarget assignments)	1	cloned	No	STM2648	16765968	yfiF	putative methyltransferase [Salmonella t...	345	Conserved; Essential; Drug target functions	Phase 3: June 2008	1X7O	20.6%	Salmonella enterica	Unknown function	General

IDP91668 (show subtarget assignments)	8	selected	No	Q914E0_9ENTO	0			2194	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2IJD	20.6%	Human echovirus

IDP02515 (show subtarget assignments)	1	cloned	No	YPO2567	16122785	pta	phosphate acetyltransferase [Yersinia pe...	717	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	1TD9	20.6%	Yersinia pestis	Energy metabolism	Fermentation

IDP05294 (show subtarget assignments)	1	cloned	No	CD1418	126699021		putative drug/sodium antiporter [Clostri...	451	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	3MKT	20.6%	Clostridium difficile	Transport and binding proteins: Other

IDP04188 (show subtarget assignments)	1	expressed	No	VCA0939	15601692		sensory box/GGDEF family protein [Vibrio...	321	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3BRE	20.6%	Vibrio cholerae	Regulatory functions	Other

IDP92135 (show subtarget assignments)	8	selected	No	TGME49_045670	211964661		pyruvate dehydrogenase, putative [Toxopl...	635	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1NI4	20.6%	Toxoplasma gondii

IDP05024 (show subtarget assignments)	1	soluble	No	BAS4675	49187666	-	ABC transporter, substrate-binding prote...	325	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IX1	20.6%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP91953 (show subtarget assignments)	8	cloned	No	SpneCM_010100002215	298254414		extracellular solute-binding lipoprotein...	442	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3QUF	20.6%	Streptococcus pneumoniae

IDP00322 (show subtarget assignments)	1	expressed	No	Cj0346	15791714	trpD	anthranilate synthase component II	533	Drug Target Function	Phase 2: March 2008	1VQU	20.6%	Campylobacter jejuni	Amino acid biosynthesis	Aromatic amino acid family

IDP91667 (show subtarget assignments)	8	selected	No	POLG_CXB3W	0			2185	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2IJD	20.7%	Coxsackievirus B3

IDP90709 (show subtarget assignments)	8	cloned	No	YPO1215	16121506	ubiG	3-demethylubiquinone-9 3-methyltransfera...	242	Predicted Essential	Community Requests	3JWH	20.7%	Yersinia pestis

IDP92094 (show subtarget assignments)	8	selected	No	TGME49_038190	237834427		DNA-directed RNA polymerase II, putative...	484	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1I3Q	20.7%	Toxoplasma gondii

IDP05126 (show subtarget assignments)	1	expressed	No	BA_4346	30258846	cpdB	2',3'-cyclic-nucleotide 2'-phosphodieste...	774	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3JYF	20.7%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides: Other

IDP91996 (show subtarget assignments)	8	purified	No	SpneCM_010100000832	298254145		membrane-fusion protein [Streptococcus p...	399	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3FPP	20.8%	Streptococcus pneumoniae

IDP05210 (show subtarget assignments)	1	cloned	No	CD2464	126700081	hemN	oxygen-independent coproporphyrinogen II...	380	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1OLT	20.8%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP02173 (show subtarget assignments)	1	expressed	No	Cj1136	15792461		putative galactosyltransferase [Campylob...	390	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3L7I	20.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91958 (show subtarget assignments)	8	expressed	No	SpneCM_010100004562	298254871		Trk family potassium uptake protein [Str...	221	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1LSU	20.8%	Streptococcus pneumoniae

IDP02394 (show subtarget assignments)	1	cloned	No	YPO1633	16121901	phoQ	sensor protein PhoQ [Yersinia pestis CO9...	484	Conserved; CD; Drug target functions	Phase 3: June 2008	1ID0	20.9%	Yersinia pestis	Regulatory functions	Other

IDP01409 (show subtarget assignments)	1	purified	No	VC0972	15640988		porin, putative	349	Conserved Gene / Pathway	Phase 2: March 2008	1PHO	20.9%	Vibrio cholerae	Transport and binding proteins	Porins

IDP91904 (show subtarget assignments)	8	selected	No	SpneCM_010100000777	298254134		endo-beta-N-acetylglucosaminidase, parti...	573	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2WW5	20.9%	Streptococcus pneumoniae

IDP02410 (show subtarget assignments)	1	in_crystallization_trials	No	Cj1328	15792651	neuC2	putative N-acetylglucosamine-6-phosphate...	384	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008	3BEO	20.9%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91554 (show subtarget assignments)	8	expressed	No	BAB38444	13364498	ECs5021	hypothetical protein [Escherichia coli O...	526	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3NAW	20.9%	Escherichia coli

IDP01695 (show subtarget assignments)	1	expressed	No	GBAA0228	47525485		ABC transporter ATP-binding protein [Bac...	626	Conserved; Drug target functions	Phase 3: June 2008	1YQT	20.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP04692 (show subtarget assignments)	1	expressed	No	GBAA5105	47778363		sensor histidine kinase [Bacillus anthra...	368	putative drug target function;	Phase 4: April 2009	2C2A	20.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01857 (show subtarget assignments)	1	soluble	No	FTT1034c	56708121	ndh	NADH dehydrogenase [Francisella tularens...	420	Drug Target	Phase 3: June 2008	1XHC	21%	Francisella tularensis	Energy metabolism	Electron transport

IDP91719 (show subtarget assignments)	8	selected	No	NP_066925	10863909	SPINT2	kunitz-type protease inhibitor 2 isoform...	252	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2ODY	21%	Homo sapiens

IDP02010 (show subtarget assignments)	1	soluble	No	lmo1829	16803869		hypothetical protein lmo1829 [Listeria m...	570	Known virulence-adherence; PMID:15228540	Phase 3: June 2008	3DOA	21.1%	Listeria monocytogenes	Cell envelope	Surface structures

IDP05111 (show subtarget assignments)	1	cloned	No	CD2187	126699803		putative phage-related cell wall hydrola...	297	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3FI7	21.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91880 (show subtarget assignments)	8	soluble	No	NP_464280	16802795		hypothetical protein lmo0753 [Listeria m...	226	essential/virulence/pathogenesis / lmo0753 (681-nt, 226-aa) is one of the few Crp/Fnr family transcription factors ...	Community Requests	3D0S	21.2%	Listeria monocytogenes

IDP91378 (show subtarget assignments)	8	cloned	No	VV1_1552	27364921		2-octaprenyl-6-methoxyphenyl hydroxylase...	391	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2X3N	21.2%	Vibrio vulnificus

IDP92131 (show subtarget assignments)	8	selected	No	TGME49_019540	237842821		alanyl-tRNA synthetase, putative [Toxopl...	1037	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2ZZF	21.2%	Toxoplasma gondii

IDP04125 (show subtarget assignments)	1	cloned	No	YPO2847	115348521	yegM	putitive HlyD family secretion protein [...	444	conserved gene; putative drug target function;	Phase 4: April 2009	3FPP	21.2%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00817 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2098	57286314	atpH	ATP synthase F1, delta subunit	179	Drug Target Function	Phase 2: March 2008	2WSS	21.2%	Staphylococcus aureus	Energy metabolism	ATP-proton motive force interconversion

IDP91954 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100003495	298254664		oligopeptide binding protein [Streptococ...	660	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3O9P	21.2%	Streptococcus pneumoniae

IDP05098 (show subtarget assignments)	1	purified	No	CD0569	126698147		putative outer membrane lipoprotein [Clo...	334	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2FQW	21.3%	Clostridium difficile	Cell envelope: Other

IDP05694 (show subtarget assignments)	1	soluble	No	lmo2007	16804046	-	hypothetical protein lmo2007 [Listeria m...	485	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3OMB	21.3%	Listeria monocytogenes	Transport and binding proteins: Unknown substrate

IDP00208 (show subtarget assignments)	1	expressed	No	YPO1979	16122221	-	putative dehydrogenase	338	Virulence	Phase 1: October 2007	2PK3	21.3%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP05411 (show subtarget assignments)	1	purified	No	BA_2793	30257397		putative chitin binding protein [Bacillu...	455	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2XWX	21.3%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP91793 (show subtarget assignments)	8	in_crystallization_trials	No	BAA03776	807707	mphA	macrolide 2'-phosphotransferase I [Esche...	301	other biological interest / Kinase	Community Requests	3TDV	21.3%	Escherichia coli

IDP01721 (show subtarget assignments)	1	cloned	No	Cj1031	15792358		putative outer membrane component of eff...	424	Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...	Phase 3: June 2008	2VDD	21.4%	Campylobacter jejuni	Regulatory functions	Other

IDP02259 (show subtarget assignments)	1	cloned	No	GBAA2164	47527458		ABC transporter ATP-binding protein [Bac...	631	Conserved; Drug target functions	Phase 3: June 2008	1YQT	21.4%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP90975 (show subtarget assignments)	8	cloned	No	y0011	22123933		hypothetical protein y0011 [Yersinia pes...	229	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests	2DI3	21.4%	Yersinia pestis

IDP91673 (show subtarget assignments)	8	selected	No	CD44_HUMAN	0			742	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1POZ	21.4%	Homo sapiens

IDP01007 (show subtarget assignments)	1	cloned	No	STM2531	16765851	pbpC	penicillin-binding protein 1C	771	Drug Target Function	Phase 2: March 2008	2OLU	21.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90929 (show subtarget assignments)	8	cloned	No	STM3714	16766999	rfaK	putative hexose transferase [Salmonella ...	381	Predicted Essential	Community Requests	2BIS	21.5%	Salmonella enterica

IDP90116 (show subtarget assignments)	8	cloned	No	MPXV_ZAI1979_005_025	68449099		kelch-like protein [Monkeypox virus]	107	similar to MPXV-ZAI96-D18L, part of VACV-COP-C2L	Community Requests	3HVE	21.5%	Monkeypox virus

IDP02442 (show subtarget assignments)	1	soluble	No	GBAA4092	47778244		prophage LambdaBa02, Clp protease family...	251	Drug target motif; Drug target functions	Phase 3: June 2008	2F6I	21.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04221 (show subtarget assignments)	1	expressed	No	STM4262_1_688	16767512		putative ABC-type bacteriocin/lantibioti...	688	Salmonella essential protein	Phase 4: April 2009	3G5U	21.5%	Salmonella enterica

IDP92556 (show subtarget assignments)	8	selected	No	VV1_1076	27360618		HTH-type transcriptional regulator ilvY ...	296	potential drug target / Proteins are in a pathway we are investigating for playing a role in symbiont nu...	Community Requests	2H99	21.6%	Vibrio vulnificus

IDP02198 (show subtarget assignments)	1	cloned	No	YPO1273	16121558		putative substrate-binding transport pro...	602	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1XOC	21.6%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00034 (show subtarget assignments)	1	expressed	No	BA_1346	30255285		internalin, putative	542	Virulence	Phase 1: October 2007	2OMT	21.6%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP02544 (show subtarget assignments)	1	cloned	No	Cj1142	15792467	neuC1	putative N-acetylglucosamine-6-phosphate...	371	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	3OT5	21.6%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05359 (show subtarget assignments)	1	soluble	No	BA_1311	30255254		putative lipoprotein [Bacillus anthracis...	324	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1L0Q	21.6%	Bacillus anthracis	Cell envelope: Other

IDP90126 (show subtarget assignments)	8	expressed	No	MPXV_ZAI1979_005_044	68449118		unknown [Monkeypox virus]	212	thiol substrate, similar to VACV-COP-F9L, MPXV-ZAI96-C15L	Community Requests	1YPY	21.7%	Monkeypox virus

IDP05233 (show subtarget assignments)	1	cloned	No	lmo1455	16803495	dnaG	DNA primase [Listeria monocytogenes EGD-...	626	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2AU3	21.7%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP91911 (show subtarget assignments)	8	selected	No	SpneCM_010100005012	298254959		G5 domain family protein, partial [Strep...	974	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3HQV	21.7%	Streptococcus pneumoniae

IDP92118 (show subtarget assignments)	8	selected	No	TGME49_015480	237843139		adenosine/AMP deaminase domain containin...	515	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3OU8	21.7%	Toxoplasma gondii

IDP00703 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0250	57286711		PTS system, IIA component	263	Conserved Gene / Pathway	Phase 2: March 2008	1AX3	21.7%	Staphylococcus aureus	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01936 (show subtarget assignments)	1	cloned	No	Cj0720c	15792069	flaC	flagellin subunit protein FlaC [Campylob...	249	Known Predicted virulence-flagella; Predicted virulence-Adhesion of Campylobacte...	Phase 3: June 2008	3K8V	21.7%	Campylobacter jejuni	Protein synthesis	Ribosomal proteins: synthesis and modification

IDP05398 (show subtarget assignments)	1	soluble	No	BA_3750	30258269		putative phosphonate ABC transporter, ph...	312	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3N5L	21.8%	Bacillus anthracis	Transport and binding proteins: Other

IDP01188 (show subtarget assignments)	1	expressed	No	BA_0502	30254030		penicillin-binding protein, putative	412	Drug Target Function	Phase 2: March 2008	2QMI	21.8%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01489 (show subtarget assignments)	1	cloned	No	VCA0591	15601350		peptide ABC transporter, periplasmic pep...	611	Conserved Gene / Pathway	Phase 2: March 2008	1ZTY	21.8%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP00756 (show subtarget assignments)	1	soluble	No	SACOL0115	57286664		glycosyl transferase, group 1 family pro...	388	Conserved Gene / Pathway	Phase 2: March 2008	3C48	21.8%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04417 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0033	56707213	nuoC	NADH dehydrogenase I [Francisella tulare...	216	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2FUG	21.8%	Francisella tularensis

IDP00506 (show subtarget assignments)	1	expressed	No	YPO2491	16122712		putative hemolysin activator protein	562	Conserved Gene / Pathway	Phase 2: March 2008	2QDZ	21.9%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00472 (show subtarget assignments)	1	expressed	No	YPO0598	16120927		putative hemolysin activator protein	562	Virulence Associated Factor	Phase 2: March 2008	2QDZ	21.9%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP92089 (show subtarget assignments)	8	selected	No	TGME49_118320	237840947		ATP-dependent Clp protease proteolytic s...	310	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3QWD	21.9%	Toxoplasma gondii

IDP90893 (show subtarget assignments)	8	expressed	No	YPO3781	16123915	ubiE	ubiquinone/menaquinone biosynthesis meth...	251	Predicted Essential	Community Requests	2AVN	21.9%	Yersinia pestis

IDP01167 (show subtarget assignments)	1	expressed	No	GBAA_pXO2_0060	47566729		capsule synthesis trans-acting positive ...	482	Virulence Associated Factor	Phase 2: March 2008	3SQN	22%	Bacillus anthracis

IDP92003 (show subtarget assignments)	8	selected	No	SpneCM_010100002775	298254522		sensor histidine kinase [Streptococcus p...	350	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2C2A	22%	Streptococcus pneumoniae

IDP05285
(show subtarget assignments)

1

selected

No

CD0663

126698240

tcdA

toxin A [Clostridium difficile 630]

2710

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3SRZ

20%

Clostridium difficile

Cellular processes: Pathogenesis

IDP01422
(show subtarget assignments)

1

expressed

No

VC1549

15641557

glycerol-3-phosphate ABC transporter, pe...

434

Conserved Gene / Pathway

Phase 2: March 2008

2HEU

20%

Vibrio cholerae

Transport and binding proteins

Other

IDP01253
(show subtarget assignments)

1

cloned

No

BA_2575

30257197

penicillin-binding protein, putative

481

Drug Target Function

Phase 2: March 2008

2QMI

20%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02356
(show subtarget assignments)

1

cloned

No

FTT1296

56708355

ubiE

menaquinone biosynthesis methyltransfera...

250

Conserved; Drug target functions

Phase 3: June 2008

2AVN

20%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP91190
(show subtarget assignments)

1

in_crystallization_trials

No

EF_A0061

29345308

6'-aminoglycoside N-acetyltransferase [E...

479

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3R6Z

20%

Enterococcus faecalis

IDP00675
(show subtarget assignments)

1

cloned

No

SACOL1455

57284564

carboxyl-terminal protease

496

Drug Target Function

Phase 2: March 2008

1FC6

20%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05314
(show subtarget assignments)

1

soluble

No

BA_4986

30259478

gerHC

spore germination protein GerHC [Bacillu...

359

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3N54

20.1%

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP00221
(show subtarget assignments)

1

soluble

No

YPO0164

16120507

-

putative membrane receptor protein

686

Virulence

Phase 1: October 2007

2HDF

20.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02827
(show subtarget assignments)

1

cloned

No

FTT1508c

56708546

relA

GTP pyrophosphokinase [Francisella tular...

647

Drug Target

Phase 3: June 2008

1VJ7

20.1%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP91633
(show subtarget assignments)

8

purified

No

BAB35418

13361460

ECs1995

hypothetical protein [Escherichia coli O...

209

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2KKX

20.1%

Escherichia coli

IDP91466
(show subtarget assignments)

8

soluble

No

VV1_0078

27363563

site-specific recombinase XerC [Vibrio v...

234

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1A0P

20.1%

Vibrio vulnificus

IDP90210
(show subtarget assignments)

8

expressed

No

MYXV_gp140

9633772

m136R

179

unknown, similar to VACV-Cop:A52R

Community Requests

2VVW

20.1%

Myxoma virus

unknown, conserved protein

0

IDP91261
(show subtarget assignments)

8

soluble

No

NT05BA0041

49176992

DNA polymerase III, delta prime subunit ...

327

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1A5T

20.2%

Bacillus anthracis

DNA metabolism: DNA replication, recombination, and repair

IDP91572
(show subtarget assignments)

8

soluble

No

BAB35419

13361461

ECs1996

hypothetical protein [Escherichia coli O...

213

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2KKX

20.2%

Escherichia coli

IDP91642
(show subtarget assignments)

8

cloned

No

NP_216895

15609516

peptide synthetase MBTF (peptide synthas...

1461

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

2VSQ

20.2%

Mycobacterium tuberculosis

IDP04448
(show subtarget assignments)

1

cloned

No

YPO0810

218927990

general secretion pathway protein J [Yer...

198

putative drug target function;

Phase 4: April 2009

2RET

20.2%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP05056
(show subtarget assignments)

1

soluble

No

CD0257

126697829

motB

chemotaxis protein [Clostridium difficil...

231

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2K1S

20.3%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP04357
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0894

56707995

purCD

fusion protein PurC/PurD [Francisella tu...

770

conserved gene; putative drug target function;

Phase 4: April 2009

2YRW

20.3%

Francisella tularensis

IDP02134
(show subtarget assignments)

1

soluble

No

CBU_0597

29541198

oxygen-independent coproporphyrinogen II...

375

Conserved; Drug target functions

Phase 3: June 2008

1OLT

20.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP92048
(show subtarget assignments)

8

selected

No

TGME49_049270

237835927

thioredoxin, putative [Toxoplasma gondii...

428

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3IDV

20.3%

Toxoplasma gondii

IDP92066
(show subtarget assignments)

8

selected

No

ABO93620

144228223

GAPDH2

apicoplast glyceraldehyde-3-phosphate de...

995

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3STH

20.3%

Toxoplasma gondii

IDP91341
(show subtarget assignments)

8

cloned

No

VV2_0101

27366558

lipase [Vibrio vulnificus CMCP6]

265

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2ORY

20.4%

Vibrio vulnificus

IDP05207
(show subtarget assignments)

1

cloned

No

CD2365

126699980

putative sulfonate ABC transporter,solut...

363

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3QSL

20.4%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP91487
(show subtarget assignments)

8

soluble

No

VP1697

28898471

putative type III export apparatus prote...

142

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1XKP

20.4%

Vibrio parahaemolyticus

IDP01169
(show subtarget assignments)

1

cloned

No

GBAA_pXO1_0146

47566458

atxA

transcriptional activator atxa, (pxo1-11...

475

Virulence Associated Factor

Phase 2: March 2008

3SQN

20.4%

Bacillus anthracis

IDP05524
(show subtarget assignments)

1

cloned

No

CD2402

126700017

putative cell wall hydrolase [Clostridiu...

396

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3H41

20.5%

Clostridium difficile

Cellular processes: Sporulation and germination

IDP02020
(show subtarget assignments)

1

crystallized

No

FTT0245

56707402

usp

universal stress protein [Francisella tu...

278

Drug Target

Phase 3: June 2008

2PFS

20.5%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP04678
(show subtarget assignments)

1

cloned

No

GBAA2560

47527849

sensor histidine kinase [Bacillus anthra...

385

putative drug target function;

Phase 4: April 2009

3DGE

20.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04703
(show subtarget assignments)

1

expressed

No

YPO0273

115346091

putative type III secretion apparatus pr...

355

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

3BZP

20.6%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP90959
(show subtarget assignments)

8

cloned

No

PP2258

81441302

Sensory box protein

562

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

2R6O

20.6%

Pseudomonas putida

IDP02658
(show subtarget assignments)

1

cloned

No

STM2648

16765968

yfiF

putative methyltransferase [Salmonella t...

345

Conserved; Essential; Drug target functions

Phase 3: June 2008

1X7O

20.6%

Salmonella enterica

Unknown function

General

IDP91668
(show subtarget assignments)

8

selected

No

Q914E0_9ENTO

0

2194

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2IJD

20.6%

Human echovirus

IDP02515
(show subtarget assignments)

1

cloned

No

YPO2567

16122785

pta

phosphate acetyltransferase [Yersinia pe...

717

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

1TD9

20.6%

Yersinia pestis

Energy metabolism

Fermentation

IDP05294
(show subtarget assignments)

1

cloned

No

CD1418

126699021

putative drug/sodium antiporter [Clostri...

451

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

3MKT

20.6%

Clostridium difficile

Transport and binding proteins: Other

IDP04188
(show subtarget assignments)

1

expressed

No

VCA0939

15601692

sensory box/GGDEF family protein [Vibrio...

321

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3BRE

20.6%

Vibrio cholerae

Regulatory functions

Other

IDP92135
(show subtarget assignments)

8

selected

No

TGME49_045670

211964661

pyruvate dehydrogenase, putative [Toxopl...

635

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1NI4

20.6%

Toxoplasma gondii

IDP05024
(show subtarget assignments)

1

soluble

No

BAS4675

49187666

-

ABC transporter, substrate-binding prote...

325

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IX1

20.6%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP91953
(show subtarget assignments)

8

cloned

No

SpneCM_010100002215

298254414

extracellular solute-binding lipoprotein...

442

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3QUF

20.6%

Streptococcus pneumoniae

IDP00322
(show subtarget assignments)

1

expressed

No

Cj0346

15791714

trpD

anthranilate synthase component II

533

Drug Target Function

Phase 2: March 2008

1VQU

20.6%

Campylobacter jejuni

Amino acid biosynthesis

Aromatic amino acid family

IDP91667
(show subtarget assignments)

8

selected

No

POLG_CXB3W

0

2185

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2IJD

20.7%

Coxsackievirus B3

IDP90709
(show subtarget assignments)

8

cloned

No

YPO1215

16121506

ubiG

3-demethylubiquinone-9 3-methyltransfera...

242

Predicted Essential

Community Requests

3JWH

20.7%

Yersinia pestis

IDP92094
(show subtarget assignments)

8

selected

No

TGME49_038190

237834427

DNA-directed RNA polymerase II, putative...

484

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1I3Q

20.7%

Toxoplasma gondii

IDP05126
(show subtarget assignments)

1

expressed

No

BA_4346

30258846

cpdB

2',3'-cyclic-nucleotide 2'-phosphodieste...

774

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3JYF

20.7%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides: Other

IDP91996
(show subtarget assignments)

8

purified

No

SpneCM_010100000832

298254145

membrane-fusion protein [Streptococcus p...

399

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3FPP

20.8%

Streptococcus pneumoniae

IDP05210
(show subtarget assignments)

1

cloned

No

CD2464

126700081

hemN

oxygen-independent coproporphyrinogen II...

380

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1OLT

20.8%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP02173
(show subtarget assignments)

1

expressed

No

Cj1136

15792461

putative galactosyltransferase [Campylob...

390

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3L7I

20.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91958
(show subtarget assignments)

8

expressed

No

SpneCM_010100004562

298254871

Trk family potassium uptake protein [Str...

221

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1LSU

20.8%

Streptococcus pneumoniae

IDP02394
(show subtarget assignments)

1

cloned

No

YPO1633

16121901

phoQ

sensor protein PhoQ [Yersinia pestis CO9...

484

Conserved; CD; Drug target functions

Phase 3: June 2008

1ID0

20.9%

Yersinia pestis

Regulatory functions

Other

IDP01409
(show subtarget assignments)

1

purified

No

VC0972

15640988

porin, putative

349

Conserved Gene / Pathway

Phase 2: March 2008

1PHO

20.9%

Vibrio cholerae

Transport and binding proteins

Porins

IDP91904
(show subtarget assignments)

8

selected

No

SpneCM_010100000777

298254134

endo-beta-N-acetylglucosaminidase, parti...

573

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2WW5

20.9%

Streptococcus pneumoniae

IDP02410
(show subtarget assignments)

1

in_crystallization_trials

No

Cj1328

15792651

neuC2

putative N-acetylglucosamine-6-phosphate...

384

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

3BEO

20.9%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91554
(show subtarget assignments)

8

expressed

No

BAB38444

13364498

ECs5021

hypothetical protein [Escherichia coli O...

526

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3NAW

20.9%

Escherichia coli

IDP01695
(show subtarget assignments)

1

expressed

No

GBAA0228

47525485

ABC transporter ATP-binding protein [Bac...

626

Conserved; Drug target functions

Phase 3: June 2008

1YQT

20.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP04692
(show subtarget assignments)

1

expressed

No

GBAA5105

47778363

sensor histidine kinase [Bacillus anthra...

368

putative drug target function;

Phase 4: April 2009

2C2A

20.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01857
(show subtarget assignments)

1

soluble

No

FTT1034c

56708121

ndh

NADH dehydrogenase [Francisella tularens...

420

Drug Target

Phase 3: June 2008

1XHC

21%

Francisella tularensis

Energy metabolism

Electron transport

IDP91719
(show subtarget assignments)

8

selected

No

NP_066925

10863909

SPINT2

kunitz-type protease inhibitor 2 isoform...

252

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2ODY

21%

Homo sapiens

IDP02010
(show subtarget assignments)

1

soluble

No

lmo1829

16803869

hypothetical protein lmo1829 [Listeria m...

570

Known virulence-adherence; PMID:15228540

Phase 3: June 2008

3DOA

21.1%

Listeria monocytogenes

Cell envelope

Surface structures

IDP05111
(show subtarget assignments)

1

cloned

No

CD2187

126699803

putative phage-related cell wall hydrola...

297

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3FI7

21.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91880
(show subtarget assignments)

8

soluble

No

NP_464280

16802795

hypothetical protein lmo0753 [Listeria m...

226

essential/virulence/pathogenesis / lmo0753 (681-nt, 226-aa) is one of the few Crp/Fnr family transcription factors ...

Community Requests

3D0S

21.2%

Listeria monocytogenes

IDP91378
(show subtarget assignments)

8

cloned

No

VV1_1552

27364921

2-octaprenyl-6-methoxyphenyl hydroxylase...

391

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2X3N

21.2%

Vibrio vulnificus

IDP92131
(show subtarget assignments)

8

selected

No

TGME49_019540

237842821

alanyl-tRNA synthetase, putative [Toxopl...

1037

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2ZZF

21.2%

Toxoplasma gondii

IDP04125
(show subtarget assignments)

1

cloned

No

YPO2847

115348521

yegM

putitive HlyD family secretion protein [...

444

conserved gene; putative drug target function;

Phase 4: April 2009

3FPP

21.2%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP00817
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2098

57286314

atpH

ATP synthase F1, delta subunit

179

Drug Target Function

Phase 2: March 2008

2WSS

21.2%

Staphylococcus aureus

Energy metabolism

ATP-proton motive force interconversion

IDP91954
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100003495

298254664

oligopeptide binding protein [Streptococ...

660

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3O9P

21.2%

Streptococcus pneumoniae

IDP05098
(show subtarget assignments)

1

purified

No

CD0569

126698147

putative outer membrane lipoprotein [Clo...

334

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2FQW

21.3%

Clostridium difficile

Cell envelope: Other

IDP05694
(show subtarget assignments)

1

soluble

No

lmo2007

16804046

-

hypothetical protein lmo2007 [Listeria m...

485

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3OMB

21.3%

Listeria monocytogenes

Transport and binding proteins: Unknown substrate

IDP00208
(show subtarget assignments)

1

expressed

No

YPO1979

16122221

-

putative dehydrogenase

338

Virulence

Phase 1: October 2007

2PK3

21.3%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP05411
(show subtarget assignments)

1

purified

No

BA_2793

30257397

putative chitin binding protein [Bacillu...

455

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2XWX

21.3%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP91793
(show subtarget assignments)

8

in_crystallization_trials

No

BAA03776

807707

mphA

macrolide 2'-phosphotransferase I [Esche...

301

other biological interest / Kinase

Community Requests

3TDV

21.3%

Escherichia coli

IDP01721
(show subtarget assignments)

1

cloned

No

Cj1031

15792358

putative outer membrane component of eff...

424

Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...

Phase 3: June 2008

2VDD

21.4%

Campylobacter jejuni

Regulatory functions

Other

IDP02259
(show subtarget assignments)

1

cloned

No

GBAA2164

47527458

ABC transporter ATP-binding protein [Bac...

631

Conserved; Drug target functions

Phase 3: June 2008

1YQT

21.4%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP90975
(show subtarget assignments)

8

cloned

No

y0011

22123933

hypothetical protein y0011 [Yersinia pes...

229

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

2DI3

21.4%

Yersinia pestis

IDP91673
(show subtarget assignments)

8

selected

No

CD44_HUMAN

0

742

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1POZ

21.4%

Homo sapiens

IDP01007
(show subtarget assignments)

1

cloned

No

STM2531

16765851

pbpC

penicillin-binding protein 1C

771

Drug Target Function

Phase 2: March 2008

2OLU

21.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90929
(show subtarget assignments)

8

cloned

No

STM3714

16766999

rfaK

putative hexose transferase [Salmonella ...

381

Predicted Essential

Community Requests

2BIS

21.5%

Salmonella enterica

IDP90116
(show subtarget assignments)

8

cloned

No

MPXV_ZAI1979_005_025

68449099

kelch-like protein [Monkeypox virus]

107

similar to MPXV-ZAI96-D18L, part of VACV-COP-C2L

Community Requests

3HVE

21.5%

Monkeypox virus

IDP02442
(show subtarget assignments)

1

soluble

No

GBAA4092

47778244

prophage LambdaBa02, Clp protease family...

251

Drug target motif; Drug target functions

Phase 3: June 2008

2F6I

21.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04221
(show subtarget assignments)

1

expressed

No

STM4262_1_688

16767512

putative ABC-type bacteriocin/lantibioti...

688

Salmonella essential protein

Phase 4: April 2009

3G5U

21.5%

Salmonella enterica

IDP92556
(show subtarget assignments)

8

selected

No

VV1_1076

27360618

HTH-type transcriptional regulator ilvY ...

296

potential drug target / Proteins are in a pathway we are investigating for playing a role in symbiont nu...

Community Requests

2H99

21.6%

Vibrio vulnificus

IDP02198
(show subtarget assignments)

1

cloned

No

YPO1273

16121558

putative substrate-binding transport pro...

602

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1XOC

21.6%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00034
(show subtarget assignments)

1

expressed

No

BA_1346

30255285

internalin, putative

542

Virulence

Phase 1: October 2007

2OMT

21.6%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP02544
(show subtarget assignments)

1

cloned

No

Cj1142

15792467

neuC1

putative N-acetylglucosamine-6-phosphate...

371

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

3OT5

21.6%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05359
(show subtarget assignments)

1

soluble

No

BA_1311

30255254

putative lipoprotein [Bacillus anthracis...

324

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1L0Q

21.6%

Bacillus anthracis

Cell envelope: Other

IDP90126
(show subtarget assignments)

8

expressed

No

MPXV_ZAI1979_005_044

68449118

unknown [Monkeypox virus]

212

thiol substrate, similar to VACV-COP-F9L, MPXV-ZAI96-C15L

Community Requests

1YPY

21.7%

Monkeypox virus

IDP05233
(show subtarget assignments)

1

cloned

No

lmo1455

16803495

dnaG

DNA primase [Listeria monocytogenes EGD-...

626

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2AU3

21.7%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP91911
(show subtarget assignments)

8

selected

No

SpneCM_010100005012

298254959

G5 domain family protein, partial [Strep...

974

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3HQV

21.7%

Streptococcus pneumoniae

IDP92118
(show subtarget assignments)

8

selected

No

TGME49_015480

237843139

adenosine/AMP deaminase domain containin...

515

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3OU8

21.7%

Toxoplasma gondii

IDP00703
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0250

57286711

PTS system, IIA component

263

Conserved Gene / Pathway

Phase 2: March 2008

1AX3

21.7%

Staphylococcus aureus

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01936
(show subtarget assignments)

1

cloned

No

Cj0720c

15792069

flaC

flagellin subunit protein FlaC [Campylob...

249

Known Predicted virulence-flagella; Predicted virulence-Adhesion of Campylobacte...

Phase 3: June 2008

3K8V

21.7%

Campylobacter jejuni

Protein synthesis

Ribosomal proteins: synthesis and modification

IDP05398
(show subtarget assignments)

1

soluble

No

BA_3750

30258269

putative phosphonate ABC transporter, ph...

312

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3N5L

21.8%

Bacillus anthracis

Transport and binding proteins: Other

IDP01188
(show subtarget assignments)

1

expressed

No

BA_0502

30254030

penicillin-binding protein, putative

412

Drug Target Function

Phase 2: March 2008

2QMI

21.8%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01489
(show subtarget assignments)

1

cloned

No

VCA0591

15601350

peptide ABC transporter, periplasmic pep...

611

Conserved Gene / Pathway

Phase 2: March 2008

1ZTY

21.8%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP00756
(show subtarget assignments)

1

soluble

No

SACOL0115

57286664

glycosyl transferase, group 1 family pro...

388

Conserved Gene / Pathway

Phase 2: March 2008

3C48

21.8%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04417
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0033

56707213

nuoC

NADH dehydrogenase I [Francisella tulare...

216

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2FUG

21.8%

Francisella tularensis

IDP00506
(show subtarget assignments)

1

expressed

No

YPO2491

16122712

putative hemolysin activator protein

562

Conserved Gene / Pathway

Phase 2: March 2008

2QDZ

21.9%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP00472
(show subtarget assignments)

1

expressed

No

YPO0598

16120927

putative hemolysin activator protein

562

Virulence Associated Factor

Phase 2: March 2008

2QDZ

21.9%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP92089
(show subtarget assignments)

8

selected

No

TGME49_118320

237840947

ATP-dependent Clp protease proteolytic s...

310

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3QWD

21.9%

Toxoplasma gondii

IDP90893
(show subtarget assignments)

8

expressed

No

YPO3781

16123915

ubiE

ubiquinone/menaquinone biosynthesis meth...

251

Predicted Essential

Community Requests

2AVN

21.9%

Yersinia pestis

IDP01167
(show subtarget assignments)

1

expressed

No

GBAA_pXO2_0060

47566729

capsule synthesis trans-acting positive ...

482

Virulence Associated Factor

Phase 2: March 2008

3SQN

22%

Bacillus anthracis

IDP92003
(show subtarget assignments)

8

selected

No

SpneCM_010100002775

298254522

sensor histidine kinase [Streptococcus p...

350

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2C2A

22%

Streptococcus pneumoniae