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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 7 of 60, showing 100 records out of 5973 total, starting on record 601
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP04209
(
show subtarget assignments
)
1
soluble
No
Z5142
15804250
hypothetical protein Z5142 [Escherichia ...
398
Effector protein
Phase 4: April 2009
3PCR
89.7%
Escherichia coli
IDP04381
(
show subtarget assignments
)
8
selected
No
CAC05791
12329060
unnamed protein product [Shigella flexne...
296
Shigella effector protein
Community Requests
3MKL
8.4%
Shigella flexneri
IDP04383
(
show subtarget assignments
)
1
purified
No
BAS4455
49187450
phenylalanyl-tRNA synthetase subunit bet...
806
Proposed to be essential proteins
Phase 4: April 2009
2RHS
49.8%
Bacillus anthracis
IDP05041
(
show subtarget assignments
)
1
purified
No
BA_2335
30256973
hypothetical protein BA_2335 [Bacillus a...
64
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05046
(
show subtarget assignments
)
1
expressed
No
BA_3529
30258064
hypothetical protein BA_3529 [Bacillus a...
117
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04038
(
show subtarget assignments
)
1
expressed
No
YPCD1.65
5832485
YPCD1.65
putative transposase [Yersinia pestis CO...
102
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04221
(
show subtarget assignments
)
1
expressed
No
STM4262_1_688
16767512
putative ABC-type bacteriocin/lantibioti...
688
Salmonella essential protein
Phase 4: April 2009
3G5U
21.5%
Salmonella enterica
IDP91005
(
show subtarget assignments
)
8
soluble
No
y1936
22125828
ATP-binding component of a transport sys...
257
potential drug target /
part of iron-sulfur cluster assembly system active under stress conditions
Community Requests
2ZU0
80.9%
Yersinia pestis
IDP04215
(
show subtarget assignments
)
1
cloned
No
STM1574_1_495
16764918
smvA
methyl viologen resistance [Salmonella t...
495
Salmonella essential protein
Phase 4: April 2009
2GFP
17%
Salmonella enterica
IDP91193
(
show subtarget assignments
)
8
cloned
No
BAS4092
49187090
-
Stage III sporulation protein AF
210
essential/virulence/pathogenesis /
Essential proteins
Community Requests
Bacillus anthracis
IDP04046
(
show subtarget assignments
)
1
cloned
No
YPCD1.78c
16082765
tap
repA translation protein [Yersinia pesti...
24
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04395
(
show subtarget assignments
)
1
cloned
No
FTT0076
56707255
sucA
2-oxoglutarate dehydrogenase E1 componen...
941
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2JGD
47.8%
Francisella tularensis
IDP91045
(
show subtarget assignments
)
8
cloned
No
ECH0010
15799700
hypothetical protein Z0021 [Escherichia ...
108
virulence/pathogenesis /
Hypothetical protein Z0021 is involved in regulation of swimming motility in E. ...
Community Requests
Escherichia coli
IDP91364
(
show subtarget assignments
)
8
expressed
No
VV1_2716
27366006
Outer membrane protein [Vibrio vulnificu...
421
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1EK9
23.8%
Vibrio vulnificus
IDP04214
(
show subtarget assignments
)
1
expressed
No
STM1473_1_377
16764819
ompN
outer membrane protein N precursor [Salm...
377
Salmonella essential protein
Phase 4: April 2009
1OSM
66%
Salmonella enterica
IDP91024
(
show subtarget assignments
)
8
cloned
No
y2983
22126860
outer membrane protein C2 [Yersinia pest...
371
drug resistance /
anion-specific outer membrane porin
Community Requests
3HW9
59.9%
Yersinia pestis
IDP04212
(
show subtarget assignments
)
1
cloned
No
STM0646_1_343
16764023
holA
DNA polymerase III subunit delta [Salmon...
343
Salmonella essential protein
Phase 4: April 2009
1JQJ
89.8%
Salmonella enterica
IDP91368
(
show subtarget assignments
)
8
expressed
No
VV1_2596
27365892
hypothetical protein VV1_2596 [Vibrio vu...
194
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04213
(
show subtarget assignments
)
1
cloned
No
STM1003_1_478
16764363
putative transcriptional regulator [Salm...
478
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP05087
(
show subtarget assignments
)
1
cloned
No
BA_0335
30253873
hypothetical protein BA_0335 [Bacillus a...
184
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05094
(
show subtarget assignments
)
1
purified
No
BA_3160
30257733
hypothetical protein BA_3160 [Bacillus a...
257
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP91004
(
show subtarget assignments
)
8
soluble
No
y1935
22125827
cysteine desulfurase activator complex s...
503
potential drug target /
part of iron-sulfur cluster assembly system active under stress conditions
Community Requests
4DN7
18.7%
Yersinia pestis
IDP04219
(
show subtarget assignments
)
1
cloned
No
STM3148_1_392
16766448
hybB
putative hydrogenase 2 b cytochrome subu...
392
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04216
(
show subtarget assignments
)
1
cloned
No
STM1894_1_336
16765236
ruvB
Holliday junction DNA helicase B [Salmon...
336
Salmonella essential protein
Phase 4: April 2009
1HQC
53%
Salmonella enterica
IDP91059
(
show subtarget assignments
)
8
soluble
No
FTT_1472c
56708512
ppiC
peptidyl-prolyl cis-trans isomerase [Fra...
92
virulence/pathogenesis /
Gene encodes a SurA orthologue which has shown to be important for virulence in ...
Community Requests
1JNS
47.8%
Francisella tularensis
IDP91012
(
show subtarget assignments
)
8
expressed
No
y2259
22126145
hypothetical protein y2259 [Yersinia pes...
271
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
Yersinia pestis
IDP91006
(
show subtarget assignments
)
8
soluble
No
y1937
22125829
cysteine desulfurase activator complex s...
441
potential drug target /
part of iron-sulfur cluster assembly system active under stress conditions
Community Requests
1VH4
56%
Yersinia pestis
IDP91052
(
show subtarget assignments
)
8
in_crystallization_trials
No
PSA0001
116063829
rmtD
16S rRNA methylase [Pseudomonas aerugino...
247
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3B89
42.5%
Pseudomonas aeruginosa
IDP91007
(
show subtarget assignments
)
8
expressed
No
y1938
22125830
bifunctional cysteine desulfurase/seleno...
410
potential drug target /
part of iron-sulfur cluster assembly system active under stress conditions
Community Requests
1I29
69.8%
Yersinia pestis
IDP91195
(
show subtarget assignments
)
8
cloned
No
BAS4091
49187089
-
Stage III sporulation protein AG
220
essential/virulence/pathogenesis /
Essential proteins
Community Requests
Bacillus anthracis
IDP04217
(
show subtarget assignments
)
1
cloned
No
STM2619_1_203
16765939
hypothetical protein STM2619 [Salmonella...
203
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04218
(
show subtarget assignments
)
1
expressed
No
STM2996_1_1123
16766298
recC
exonuclease V subunit gamma [Salmonella ...
1123
Salmonella essential protein
Phase 4: April 2009
1W36
88.4%
Salmonella enterica
IDP05162
(
show subtarget assignments
)
1
soluble
No
BA_1701
30255991
hypothetical protein BA_1701 [Bacillus a...
225
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP91008
(
show subtarget assignments
)
8
soluble
No
y1951
22125843
sodB
superoxide dismutase [Yersinia pestis KI...
206
other biological interest /
iron-regulated oxidative stress enzyme
Community Requests
1ISA
75.2%
Yersinia pestis
IDP91010
(
show subtarget assignments
)
8
cloned
No
y2245
22126131
hypothetical protein y2245 [Yersinia pes...
341
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
3ETN
12.3%
Yersinia pestis
IDP91064
(
show subtarget assignments
)
1
cloned
No
y2422
21959284
144
other biological interest /
Identified in a mutant screen
Community Requests
Yersinia pestis
IDP05175
(
show subtarget assignments
)
1
expressed
No
lmo1656
16803696
-
hypothetical protein lmo1656 [Listeria m...
143
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP91190
(
show subtarget assignments
)
1
in_crystallization_trials
No
EF_A0061
29345308
6'-aminoglycoside N-acetyltransferase [E...
479
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3R6Z
20%
Enterococcus faecalis
IDP04572
(
show subtarget assignments
)
1
soluble
No
BAS0005
49183044
DNA gyrase subunit B [Bacillus anthracis...
640
Proposed to be essential proteins
Phase 4: April 2009
1EI1
34.4%
Bacillus anthracis
IDP04077
(
show subtarget assignments
)
1
crystallized
No
FTT1793c
56708781
pepN
aminopeptidase N [Francisella tularensis...
864
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2DQ6
48.9%
Francisella tularensis
IDP04590
(
show subtarget assignments
)
1
expressed
No
BAS0136
49183170
30S ribosomal protein S11 [Bacillus anth...
129
Proposed to be essential proteins
Phase 4: April 2009
1VS5
65.9%
Bacillus anthracis
IDP04589
(
show subtarget assignments
)
1
expressed
No
BAS0135
49183169
30S ribosomal protein S13 [Bacillus anth...
121
Proposed to be essential proteins
Phase 4: April 2009
1FJG
63.9%
Bacillus anthracis
IDP91058
(
show subtarget assignments
)
8
soluble
No
FTT_0468
56707610
surA
peptidyl-prolyl cis-trans isomerase (PPI...
473
virulence/pathogenesis /
Gene encodes a SurA orthologue which has shown to be important for virulence in ...
Community Requests
1M5Y
19.5%
Francisella tularensis
IDP05275
(
show subtarget assignments
)
1
soluble
No
lmo2686
16804723
-
hypothetical protein lmo2686 [Listeria m...
177
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP91380
(
show subtarget assignments
)
8
soluble
No
VV1_1472
27364856
hypothetical protein VV1_1472 [Vibrio vu...
390
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP05221
(
show subtarget assignments
)
1
expressed
No
BA_4349
30258849
hypothetical protein BA_4349 [Bacillus a...
62
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP91050
(
show subtarget assignments
)
8
in_crystallization_trials
No
EFE0001
1209531
vanB
D-Ala:D-Lac ligase [Enterococcus faecali...
342
drug resistance /
D-lactate D-ala ligase; generates vancomycin resistant cell wall
Community Requests
1E4E
75.1%
Enterococcus faecalis
IDP04066
(
show subtarget assignments
)
8
selected
No
CAC05819
12329088
mxiE
MxiE, similarities to transcriptional ac...
210
Shigella effector protein
Community Requests
Shigella flexneri
IDP05242
(
show subtarget assignments
)
1
cloned
No
lmo2079
16804118
-
hypothetical protein lmo2079 [Listeria m...
380
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP05237
(
show subtarget assignments
)
1
soluble
No
lmo1653
16803693
-
putative cellsurface protein [Listeria m...
201
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP05273
(
show subtarget assignments
)
1
soluble
No
lmo1752
16803792
-
hypothetical protein lmo1752 [Listeria m...
251
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP91076
(
show subtarget assignments
)
8
cloned
No
CGSHiII_09046
145639651
fused lipid transporter subunits of ABC ...
587
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3B5W
65.9%
Haemophilus influenzae
IDP05256
(
show subtarget assignments
)
1
cloned
No
BA_1805
30256080
hypothetical protein BA_1805 [Bacillus a...
44
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05272
(
show subtarget assignments
)
1
in_crystallization_trials
No
lmo1649
16803689
-
hypothetical protein lmo1649 [Listeria m...
171
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP04225
(
show subtarget assignments
)
8
cloned
No
CAC05803
12329072
ipaB
IpaB, secreted by the Mxi-Spa secretion ...
580
Shigella effector protein
Community Requests
3U0C
34.3%
Shigella flexneri
IDP91023
(
show subtarget assignments
)
8
cloned
No
y2980
22126857
hypothetical protein y2980 [Yersinia pes...
180
other biological interest /
-
Community Requests
Yersinia pestis
IDP05278
(
show subtarget assignments
)
1
cloned
No
BA_5456
30259924
hypothetical protein BA_5456 [Bacillus a...
49
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP91016
(
show subtarget assignments
)
8
selected
No
y2451
22126334
hypothetical protein y2451 [Yersinia pes...
384
other biological interest /
putative iron transport protein
Community Requests
3AT7
40.9%
Yersinia pestis
IDP04098
(
show subtarget assignments
)
1
cloned
No
YPCD1.50
5832470
YPCD1.50
hypothetical protein YPCD1.50 [Yersinia ...
32
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04064
(
show subtarget assignments
)
1
expressed
No
BAS0127
49183161
30S ribosomal protein S5 [Bacillus anthr...
166
Proposed to be essential proteins
Phase 4: April 2009
1PKP
75.3%
Bacillus anthracis
IDP91382
(
show subtarget assignments
)
8
purified
No
VV1_1470
27364854
histone acetyltransferase HPA2 [Vibrio v...
164
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1YX0
18.9%
Vibrio vulnificus
IDP91383
(
show subtarget assignments
)
8
soluble
No
VV1_1467
27364851
arginine deiminase [Vibrio vulnificus CM...
406
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1RXX
45.3%
Vibrio vulnificus
IDP91039
(
show subtarget assignments
)
8
selected
No
Sd1012_5151
194431100
hdeB
HdeB protein [Shigella dysenteriae 1012]...
108
potential drug target /
A protein that is important for acid resistance in some enteropathogens; it is a...
Community Requests
2XUV
65.7%
Shigella dysenteriae
IDP04224
(
show subtarget assignments
)
8
selected
No
CAC05802
12329071
ipaC
IpaC, secreted by the Mxi-Spa secretion ...
363
Shigella effector protein
Community Requests
Shigella flexneri
IDP04060
(
show subtarget assignments
)
8
selected
No
CAC05813
12329082
mxiI
MxiI, component of the Mxi-Spa secretion...
97
Shigella effector protein
Community Requests
Shigella flexneri
IDP91022
(
show subtarget assignments
)
8
cloned
No
y2966
22126843
ompC
outer membrane porin protein C [Yersinia...
374
drug resistance /
outer membrane porin
Community Requests
2IXX
67.9%
Yersinia pestis
IDP91071
(
show subtarget assignments
)
8
cloned
No
NGO2165
59719354
putative ABC transporter, ATP-binding pr...
622
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3B5Y
34.2%
Neisseria gonorrhoeae
IDP05363
(
show subtarget assignments
)
1
soluble
No
BA_2032
30256684
hypothetical protein BA_2032 [Bacillus a...
148
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP91385
(
show subtarget assignments
)
8
soluble
No
VV1_1465
27364849
pyrB
aspartate carbamoyltransferase catalytic...
309
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2BE7
76.4%
Vibrio vulnificus
IDP05365
(
show subtarget assignments
)
1
expressed
No
BA_2909
30257501
hypothetical protein BA_2909 [Bacillus a...
56
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04069
(
show subtarget assignments
)
1
in_pdb
3R3T
Yes
BAS5327
49188311
30S ribosomal protein S6 [Bacillus anthr...
96
Proposed to be essential proteins
Phase 4: April 2009
3R3T
100%
Bacillus anthracis
IDP91051
(
show subtarget assignments
)
8
in_crystallization_trials
No
PRM0001
81687074
rmtC
16S rRNA methylase [Proteus mirabilis]
281
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3B89
29.2%
Proteus mirabilis
IDP04436
(
show subtarget assignments
)
1
expressed
No
YPCD1.97c
5832512
YPCD1.97c
putative transposase [Yersinia pestis CO...
308
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04576
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0076
49183111
lysyl-tRNA synthetase [Bacillus anthraci...
499
Proposed to be essential proteins
Phase 4: April 2009
3A74
77.6%
Bacillus anthracis
IDP05376
(
show subtarget assignments
)
1
cloned
No
BA_4131
30258637
hypothetical protein BA_4131 [Bacillus a...
44
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05375
(
show subtarget assignments
)
1
expressed
No
BA_4118
30258624
hypothetical protein BA_4118 [Bacillus a...
57
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05373
(
show subtarget assignments
)
1
cloned
No
BA_3146
30257723
hypothetical protein BA_3146 [Bacillus a...
47
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05374
(
show subtarget assignments
)
1
cloned
No
BA_3570
30258098
hypothetical protein BA_3570 [Bacillus a...
63
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04068
(
show subtarget assignments
)
1
expressed
No
YPCD1.94n
40548799
hypothetical protein YPCD1.94n [Yersinia...
251
virulence factor;
Phase 4: April 2009
1A5V
15.1%
Yersinia pestis
IDP04414
(
show subtarget assignments
)
8
selected
No
CAC05786
12329055
sepA
SepA, extracellular serine protease of t...
1364
Shigella effector protein
Community Requests
1WXR
34.9%
Shigella flexneri
IDP05377
(
show subtarget assignments
)
1
soluble
No
BA_3611
30258139
hypothetical protein BA_3611 [Bacillus a...
61
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05378
(
show subtarget assignments
)
1
soluble
No
BA_4133
30258639
hypothetical protein BA_4133 [Bacillus a...
81
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05386
(
show subtarget assignments
)
1
soluble
No
BA_2029
30256682
hypothetical protein BA_2029 [Bacillus a...
168
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04067
(
show subtarget assignments
)
1
purified
No
BAS4417
49187412
thioredoxin [Bacillus anthracis str. Ste...
104
Proposed to be essential proteins
Phase 4: April 2009
2GZY
75%
Bacillus anthracis
IDP05389
(
show subtarget assignments
)
1
cloned
No
BA_2660
30257276
hypothetical protein BA_2660 [Bacillus a...
31
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05388
(
show subtarget assignments
)
1
soluble
No
BA_2383
30257018
hypothetical protein BA_2383 [Bacillus a...
191
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04070
(
show subtarget assignments
)
1
cloned
No
FTT0073
56707252
sdhD
succinate dehydrogenase hydrophobic memb...
122
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1NEK
26.2%
Francisella tularensis
IDP05396
(
show subtarget assignments
)
1
cloned
No
BA_3329
30257874
hypothetical protein BA_3329 [Bacillus a...
41
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04075
(
show subtarget assignments
)
8
selected
No
CAC05807
12329076
icsB
IcsB, function unknown [Shigella flexner...
494
Shigella effector protein
Community Requests
Shigella flexneri
IDP04416
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS4049
49187047
ribonuclease Z [Bacillus anthracis str. ...
307
Proposed to be essential proteins
Phase 4: April 2009
1Y44
61.2%
Bacillus anthracis
IDP04415
(
show subtarget assignments
)
8
selected
No
CAC05837
12329106
icsA (virG)
IcsA (VirG), outermembrane protein expos...
1102
Shigella effector protein
Community Requests
3ML3
15.2%
Shigella flexneri
IDP05400
(
show subtarget assignments
)
1
cloned
No
BA_0243
30253741
hypothetical protein BA_0243 [Bacillus a...
36
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05410
(
show subtarget assignments
)
1
soluble
No
BA_2500
30257128
hypothetical protein BA_2500 [Bacillus a...
156
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05401
(
show subtarget assignments
)
1
expressed
No
BA_4365
30258863
hypothetical protein BA_4365 [Bacillus a...
83
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04417
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0033
56707213
nuoC
NADH dehydrogenase I [Francisella tulare...
216
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2FUG
21.8%
Francisella tularensis
IDP91019
(
show subtarget assignments
)
8
selected
No
y2821
22126698
poxB
pyruvate dehydrogenase [Yersinia pestis ...
573
potential drug target /
alternative pathway for aerobic energy metabolism
Community Requests
3EY9
79.2%
Yersinia pestis
IDP04074
(
show subtarget assignments
)
1
cloned
No
BAS4469
49187464
50S ribosomal protein L20 [Bacillus anth...
118
Proposed to be essential proteins
Phase 4: April 2009
1VS6
55.1%
Bacillus anthracis
IDP91293
(
show subtarget assignments
)
8
soluble
No
SPA3343
56415395
cysG
siroheme synthase [Salmonella enterica s...
457
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1PJQ
99.6%
Salmonella enterica
IDP91531
(
show subtarget assignments
)
8
soluble
No
VC1887
15641889
hypothetical protein VC1887 [Vibrio chol...
266
potential drug target /
Vc1887 was found in a knockout screen for determinants of cell shape by action o...
Community Requests
Vibrio cholerae
IDP91530
(
show subtarget assignments
)
8
purified
No
VC1268
15641281
hypothetical protein VC1268 [Vibrio chol...
524
other biological interest /
We have recently established that D-amino acids are important signal molecules t...
Community Requests
Vibrio cholerae
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