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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 7 of 60, showing 100 records out of 5973 total, starting on record 601
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP00339
(
show subtarget assignments
)
1
expressed
No
FTT0711
56707830
ispD
2-C-methyl-D-erythritol 4-phosphate cyti...
229
Drug Target Function
Phase 2: March 2008
1H3M
37.1%
Francisella tularensis
IDP90273
(
show subtarget assignments
)
8
cloned
No
TGME49_013900
211968791
regulator of chromosome condensation, pu...
1155
Signature-tagged mutagenesis (STM) has identified the regulator of chromosome co...
Community Requests
3MVD
11.1%
Toxoplasma gondii
IDP90272
(
show subtarget assignments
)
8
cloned
No
TGME49_111670
211962063
hypothetical protein TGME49_111670 [Toxo...
440
Unpublished data from signature-tagged mutagenesis (STM) has identified this sur...
Community Requests
Toxoplasma gondii
IDP90402
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_635
3329083
hypothetical protein [Chlamydia trachoma...
144
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00341
(
show subtarget assignments
)
1
cloned
No
FTT1305c
56708363
murA
UDP-N-acetylglucosamine 1-carboxyvinyltr...
444
Drug Target Function
Phase 2: March 2008
3SG1
32.7%
Francisella tularensis
IDP90267
(
show subtarget assignments
)
8
purified
No
TP_0326
3322602
Treponema pallidum subsp. pallidum str. ...
853
From requestor: The structural characterization of Tp0326 will be helpful in at ...
Community Requests
3EFC
11.6%
Treponema pallidum
IDP90511
(
show subtarget assignments
)
8
purified
No
Q9KPV6
42560015
RecName: Full=Undecaprenyl pyrophosphate...
250
Predicted Essential
Community Requests
1JP3
56%
Vibrio cholerae
IDP90405
(
show subtarget assignments
)
8
cloned
No
CT_651
3329100
hypothetical protein [Chlamydia trachoma...
608
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90537
(
show subtarget assignments
)
8
purified
No
Q9KL24
21542209
RecName: Full=Dihydroorotase; Short=DHOa...
342
Predicted Essential
Community Requests
1XGE
55%
Vibrio cholerae
IDP90595
(
show subtarget assignments
)
8
expressed
No
YPO2298
16122522
phoA
alkaline phosphatase [Yersinia pestis CO...
481
Predicted Essential
Community Requests
1B8J
70.7%
Yersinia pestis
IDP90277
(
show subtarget assignments
)
8
soluble
No
TGME49_059690
211962827
orotidine-monophosphate-decarboxylase, p...
320
The orotidine monophosphate decarboxylase (TgODCase) is the last step in de novo...
Community Requests
3QW3
39.1%
Toxoplasma gondii
IDP90278
(
show subtarget assignments
)
8
crystallized
No
TGME49_003450
211965291
hypothetical protein, conserved [Toxopla...
227
Unpublished data from signature-tagged mutagenesis (STM) has identified this nov...
Community Requests
2PD0
41.9%
Toxoplasma gondii
IDP90636
(
show subtarget assignments
)
8
purified
No
Cj0432c
15791799
murD
UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...
402
Predicted Essential
Community Requests
1E0D
27.6%
Campylobacter jejuni
IDP90276
(
show subtarget assignments
)
8
cloned
No
TGME49_032600
211965793
patatin-like phospholipase domain-contai...
664
Signature-tagged mutagenesis (STM) has identified this patatin-like phospholipas...
Community Requests
Toxoplasma gondii
IDP90699
(
show subtarget assignments
)
8
cloned
No
Cj0478
15791842
rpoB
DNA-directed RNA polymerase subunit beta...
1378
Predicted Essential
Community Requests
3IYD
47.9%
Campylobacter jejuni
IDP90291
(
show subtarget assignments
)
8
soluble
No
TGME49_081900
211969063
high mobility group (HMG) box domain-con...
880
The newly described histone lysine methyl-transferase KMTox targets histones H4 ...
Community Requests
Toxoplasma gondii
IDP90592
(
show subtarget assignments
)
8
in_crystallization_trials
No
VC2389
15642386
carB
carbamoyl phosphate synthase large subun...
1076
Predicted Essential
Community Requests
1BXR
85.6%
Vibrio cholerae
IDP90282
(
show subtarget assignments
)
8
selected
No
TGME49_013640
211968765
splicing factor, arginine/serine-rich 4,...
1461
Unpublished data from a differentiation mutagenesis screen indicate that the spl...
Community Requests
Toxoplasma gondii
IDP90280
(
show subtarget assignments
)
8
selected
No
TGME49_004420
211965378
oocyst wall protein COWP, putative [Toxo...
499
Unpublished data from a differentiation mutagenesis screen indicate that the ooc...
Community Requests
1N7D
19%
Toxoplasma gondii
IDP90283
(
show subtarget assignments
)
8
cloned
No
TGME49_075440
211969603
GRA6
granule antigen protein GRA6 [Toxoplasma...
224
GRA6 is a secreted dense granule protein that generates protective immunity, e.g...
Community Requests
Toxoplasma gondii
IDP90590
(
show subtarget assignments
)
8
cloned
No
Cj0770c
15792108
lipoprotein, NLPA family [Campylobacter ...
258
Predicted Essential
Community Requests
1P99
35.7%
Campylobacter jejuni
IDP90412
(
show subtarget assignments
)
8
expressed
No
CT_657
3329107
hypothetical protein [Chlamydia trachoma...
105
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90290
(
show subtarget assignments
)
8
purified
No
TGME49_019520
211968370
arginine N-methyltransferase 1 [Toxoplas...
392
The histone arginine methyl-transferase TgPRMT1 methylates histone 4 (R3). Whe...
Community Requests
1OR8
44.9%
Toxoplasma gondii
IDP01101
(
show subtarget assignments
)
1
expressed
No
GBAA_pXO1_0119
47566439
hypothetical protein GBAA_pXO1_0119
82
Virulence Associated Factor
Phase 2: March 2008
3SIK
52.4%
Bacillus anthracis
IDP90286
(
show subtarget assignments
)
8
in_pdb
3UKS
No
TGME49_035700
211966629
sedoheptulose-1,7 bisphosphatase, putati...
330
Unpublished data indicate that the Calvin cycle enzyme sedoheptulose-1,7-bisphos...
Community Requests
3UKS
100%
Toxoplasma gondii
IDP90408
(
show subtarget assignments
)
8
expressed
No
CT_631
3329079
hypothetical protein [Chlamydia trachoma...
84
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90285
(
show subtarget assignments
)
8
soluble
No
TGME49_083850
211966798
peptidyl-prolyl isomerase, putative [Tox...
521
The immunophilin TgFBCP57 uniquely contains domains for both immunosuppressant d...
Community Requests
1KT0
23.2%
Toxoplasma gondii
IDP90407
(
show subtarget assignments
)
8
expressed
No
CT_656
3329106
hypothetical protein [Chlamydia trachoma...
97
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90406
(
show subtarget assignments
)
8
soluble
No
CT_668
3329119
hypothetical protein [Chlamydia trachoma...
223
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90284
(
show subtarget assignments
)
8
expressed
No
TGME49_070250
211963365
dense granule protein 1 / major antigenp...
190
GRA1 is secreted from dense granule as one of the few soluble proteins that can ...
Community Requests
Toxoplasma gondii
IDP90287
(
show subtarget assignments
)
8
purified
No
TGME49_021210
211967615
18 kDa cyclophilin [Toxoplasma gondii ME...
179
Parasite cyclophilin 18 (TgC18) is an agonist of chemokine receptor CCR5 on T c...
Community Requests
1AK4
53.6%
Toxoplasma gondii
IDP90594
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO0644
16120969
dnaG
DNA primase [Yersinia pestis CO92]
582
Predicted Essential
Community Requests
1DD9
45.7%
Yersinia pestis
IDP90429
(
show subtarget assignments
)
8
cloned
No
CT_860
3329334
hypothetical protein [Chlamydia trachoma...
493
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90707
(
show subtarget assignments
)
8
purified
No
Cj0233c
15791605
pyrE
orotate phosphoribosyltransferase [Campy...
202
Predicted Essential
Community Requests
2YZK
22.3%
Campylobacter jejuni
IDP90288
(
show subtarget assignments
)
0
work_stopped
No
TGME49_093690
211967835
profilin family protein [Toxoplasma gond...
163
Parasite profilin is indispensable for gliding motility, host cell invasion, act...
Community Requests
3NEC
100%
Toxoplasma gondii
IDP90409
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_667
3329118
hypothetical protein [Chlamydia trachoma...
149
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90289
(
show subtarget assignments
)
8
purified
No
TGME49_094270
211967870
arginine methyltransferase protein, puta...
660
Epigenetic is an emerging field in Toxoplasma biology that will provide new targ...
Community Requests
2Y1W
24.5%
Toxoplasma gondii
IDP90410
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_663
3329114
hypothetical protein [Chlamydia trachoma...
133
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90092
(
show subtarget assignments
)
8
purified
No
ZZZ_0008
155
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90310
(
show subtarget assignments
)
8
expressed
No
CT_716
3329172
hypothetical protein [Chlamydia trachoma...
121
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90007
(
show subtarget assignments
)
8
cloned
No
Z4378
12517596
qseC
quorum sensing Escherichia coli regulato...
449
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3JZ3
47%
Escherichia coli
IDP90297
(
show subtarget assignments
)
8
purified
No
TGME49_065450
211966338
hexokinase [Toxoplasma gondii ME49]
468
Hexokinase (TgHK) is one of 5 major glycolytic enzymes characterized in Toxoplas...
Community Requests
1CZA
34.7%
Toxoplasma gondii
IDP90294
(
show subtarget assignments
)
8
expressed
No
TGME49_113230
211962198
eukaryotic translation initiation factor...
347
Under stress conditions, the initiation factor 2a (TgIF2a) is phosphorylated to ...
Community Requests
1Q8K
40.3%
Toxoplasma gondii
IDP90598
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO3443
16123591
valS
valyl-tRNA synthetase [Yersinia pestis C...
965
Predicted Essential
Community Requests
1GAX
40.5%
Yersinia pestis
IDP90295
(
show subtarget assignments
)
8
cloned
No
TGME49_005290
211965425
dual-specificity phosphatase laforin, pu...
523
Human Lafora disease is one of five major progressive myoclonus epilepsies that ...
Community Requests
Toxoplasma gondii
IDP90296
(
show subtarget assignments
)
8
purified
No
TGME49_068850
211963242
enolase 2 [Toxoplasma gondii ME49]
475
Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...
Community Requests
3OTR
68.8%
Toxoplasma gondii
IDP90299
(
show subtarget assignments
)
8
selected
No
TGME49_007160
211969665
Toxoplasma gondii bradyzoite SAG2 relate...
364
The Toxoplasma gondii surface is dominated by a large class of GPI-anchored prot...
Community Requests
2JKS
14%
Toxoplasma gondii
IDP90302
(
show subtarget assignments
)
0
work_stopped
No
BB_0420
2688313
sensory transduction histidine kinase, p...
1494
Mutational studies suggest that Hk1 is required for the survival of the Lyme dis...
Community Requests
3A0R
5.6%
Borrelia burgdorferi
IDP90298
(
show subtarget assignments
)
8
selected
No
TGME49_120190
211967550
bradyzoite-specific surface protein, put...
398
TgSRS9 is one of the few in the SAG1 family that is expressed only in bradyzoite...
Community Requests
2JKS
37.7%
Toxoplasma gondii
IDP90304
(
show subtarget assignments
)
8
soluble
No
CT_671
3329122
hypothetical protein [Chlamydia trachoma...
283
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90676
(
show subtarget assignments
)
8
expressed
No
Cj0533
15791894
sucC
succinyl-CoA synthase, beta subunit [Cam...
387
Predicted Essential
Community Requests
1CQI
45.5%
Campylobacter jejuni
IDP90301
(
show subtarget assignments
)
8
selected
No
TGME49_025290
211963866
nucleoside-triphosphatase, putative [Tox...
642
The T. gondii nucleoside triphosphate hydrolases (NTPase) are ecto ATPases with ...
Community Requests
3AGR
38.6%
Toxoplasma gondii
IDP90300
(
show subtarget assignments
)
8
in_pdb
4EIV
3QYQ
Yes
TGME49_118750
211967477
deoxyribose-phosphate aldolase, putative...
286
The deoxyribose phosphate aldolase-like gene TgPDA is recently described to be s...
Community Requests
3QYQ
96.5%
Toxoplasma gondii
IDP90657
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO0556
16120884
murC
UDP-N-acetylmuramate--L-alanine ligase [...
491
Predicted Essential
Community Requests
2F00
86.2%
Yersinia pestis
IDP90305
(
show subtarget assignments
)
8
cloned
No
CT_681
3329133
ompA
Major Outer Membrane Protein [Chlamydia ...
393
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90417
(
show subtarget assignments
)
8
cloned
No
CT_504
3328941
hypothetical protein [Chlamydia trachoma...
288
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90324
(
show subtarget assignments
)
8
expressed
No
CT088
15604807
sycE
secretion chaperone [Chlamydia trachomat...
146
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90416
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_538
3328976
hypothetical protein [Chlamydia trachoma...
238
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP01168
(
show subtarget assignments
)
1
expressed
No
GBAA_pXO2_0084
47566748
capsule synthesis trans-acting positive ...
483
Virulence Associated Factor
Phase 2: March 2008
3SQN
8.5%
Bacillus anthracis
IDP90428
(
show subtarget assignments
)
8
cloned
No
CT_849
3329321
hypothetical protein [Chlamydia trachoma...
159
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90005
(
show subtarget assignments
)
8
soluble
No
Z4377
12517595
qseB
quorum sensing Escherichia coli regulato...
219
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3Q9S
41.1%
Escherichia coli
IDP01166
(
show subtarget assignments
)
1
cloned
No
GBAA_pXO1_0190
47566502
hypothetical protein GBAA_pXO1_0190
410
Virulence Associated Factor
Phase 2: March 2008
Bacillus anthracis
IDP90003
(
show subtarget assignments
)
8
crystallized
No
FTT1103
56708183
conserved hypothetical lipoprotein
365
(Community Request)
Community Requests
3GYK
12.3%
Francisella tularensis
IDP90308
(
show subtarget assignments
)
8
cloned
No
CT_700
3329154
hypothetical protein [Chlamydia trachoma...
441
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1NA0
6.3%
Chlamydia trachomatis
IDP90415
(
show subtarget assignments
)
8
cloned
No
CT_443
3328874
omcB
60kDa Cysteine-Rich OMP [Chlamydia trach...
553
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90339
(
show subtarget assignments
)
8
cloned
No
CT050
15604769
hypothetical protein CT050 [Chlamydia tr...
536
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3H0G
10.8%
Chlamydia trachomatis
IDP01167
(
show subtarget assignments
)
1
expressed
No
GBAA_pXO2_0060
47566729
capsule synthesis trans-acting positive ...
482
Virulence Associated Factor
Phase 2: March 2008
3SQN
22%
Bacillus anthracis
IDP90001
(
show subtarget assignments
)
8
cloned
No
FTT0094c
56603762
qseC
sensor histidine kinase
475
Drug Target (Community Request)
Community Requests
3A0R
15.8%
Francisella tularensis
IDP90306
(
show subtarget assignments
)
8
cloned
No
CT_694
3329148
hypothetical protein [Chlamydia trachoma...
323
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP01109
(
show subtarget assignments
)
1
soluble
No
GBAA_pXO1_0148
47566460
hypothetical protein GBAA_pXO1_0148
150
Virulence Associated Factor
Phase 2: March 2008
3PMD
100%
Bacillus anthracis
IDP90313
(
show subtarget assignments
)
8
cloned
No
CT_713
3329169
ompB
Outer Membrane Protein Analog [Chlamydia...
340
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90081
(
show subtarget assignments
)
8
cloned
No
ABD79034.1
89892477
M2
matrix protein 2 [Influenza A virus (A/U...
96
Influenza matrix protein 2 (M2) is a validated therapeutic target whose on-marke...
Community Requests
2L0J
42.7%
Influenza A
IDP90091
(
show subtarget assignments
)
8
expressed
No
ZZZ_0007
660
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
2P5Z
15.6%
Escherichia coli
IDP90085
(
show subtarget assignments
)
8
purified
No
ZZZ_0001
158
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90312
(
show subtarget assignments
)
8
expressed
No
CT_712
3329168
hypothetical protein [Chlamydia trachoma...
390
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90548
(
show subtarget assignments
)
8
cloned
No
Cj0960c
15792289
rnpA
ribonuclease P protein component [Campyl...
108
Predicted Essential
Community Requests
1A6F
27.9%
Campylobacter jejuni
IDP90311
(
show subtarget assignments
)
8
cloned
No
CT_734
3329192
hypothetical protein [Chlamydia trachoma...
221
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90423
(
show subtarget assignments
)
8
cloned
No
CT_444
3328876
omcA
9kDa-Cysteine-Rich Lipoprotein [Chlamydi...
88
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90084
(
show subtarget assignments
)
8
soluble
No
ZP_01795673
145640079
hypothetical protein CGSHiII_00674 [Haem...
148
The protein we would like structure analyzed is from Haemophilus influenzae. Pri...
Community Requests
2XM6
28.4%
Haemophilus influenzae
IDP90314
(
show subtarget assignments
)
8
soluble
No
CT_733
3329191
hypothetical protein [Chlamydia trachoma...
448
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP01169
(
show subtarget assignments
)
1
cloned
No
GBAA_pXO1_0146
47566458
atxA
transcriptional activator atxa, (pxo1-11...
475
Virulence Associated Factor
Phase 2: March 2008
3SQN
20.4%
Bacillus anthracis
IDP01530
(
show subtarget assignments
)
1
in_pdb
3EFV
3ETF
No
STM1524
16764869
yneI
putative succinate-semialdehyde dehydrog...
462
It is an essential gene in Salmonella which is important in energy metabolism.
Phase 3: June 2008
3EFV
100%
Salmonella enterica
IDP90083
(
show subtarget assignments
)
8
cloned
No
ZP_01795671
145640077
hypothetical protein CGSHiII_00664 [Haem...
219
The protein we would like structure analyzed is from Haemophilus influenzae. Pri...
Community Requests
2XM6
35.6%
Haemophilus influenzae
IDP90315
(
show subtarget assignments
)
8
cloned
No
CT_744
3329204
CHLTR possible phosphoprotein [Chlamydia...
821
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90323
(
show subtarget assignments
)
8
cloned
No
CT082
15604801
hypothetical protein CT082 [Chlamydia tr...
560
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90082
(
show subtarget assignments
)
8
purified
No
P03493.2
85681917
RecName: Full=Matrix protein 2; AltName:...
109
Influenza matrix protein 2 (M2) is a validated therapeutic target whose on-marke...
Community Requests
2KJ1
64.2%
Influenza B
IDP01174
(
show subtarget assignments
)
1
expressed
No
BA_2823
30257425
hypothetical protein BA_2823
375
Drug Target Function
Phase 2: March 2008
Bacillus anthracis
IDP90318
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_718
3329174
hypothetical protein [Chlamydia trachoma...
174
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90090
(
show subtarget assignments
)
8
expressed
No
ZZZ_0006
310
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90320
(
show subtarget assignments
)
8
cloned
No
CT_779
3329243
hypothetical protein [Chlamydia trachoma...
229
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00175
(
show subtarget assignments
)
1
soluble
No
YPO1471
16121746
-
putative ATPase subunit of ATP-dependent...
880
Virulence
Phase 1: October 2007
1QVR
36.9%
Yersinia pestis
IDP90319
(
show subtarget assignments
)
8
cloned
No
CT_753
3329214
hypothetical protein [Chlamydia trachoma...
74
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90722
(
show subtarget assignments
)
8
in_pdb
3OUZ
3OUU
No
Cj1290c
15792613
accC
biotin carboxylase [Campylobacter jejuni...
443
Predicted Essential
Community Requests
3OUU
100%
Campylobacter jejuni
IDP90721
(
show subtarget assignments
)
8
crystallized
No
YPO1610
16121878
aroE
shikimate 5-dehydrogenase [Yersinia pest...
292
Predicted Essential
Community Requests
1NPY
52.4%
Yersinia pestis
IDP90086
(
show subtarget assignments
)
8
expressed
No
ZZZ_0002
492
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90089
(
show subtarget assignments
)
8
expressed
No
ZZZ_0005
600
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90419
(
show subtarget assignments
)
8
cloned
No
CT_446
3328878
euo
CHLPS Euo Protein [Chlamydia trachomatis...
183
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90420
(
show subtarget assignments
)
8
cloned
No
CT_465
3328899
hypothetical protein [Chlamydia trachoma...
213
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90902
(
show subtarget assignments
)
8
in_crystallization_trials
No
STM2641
16765961
nadB
L-aspartate oxidase [Salmonella typhimur...
540
Predicted Essential
Community Requests
1CHU
89.6%
Salmonella enterica
IDP90901
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO3273
16123430
pssA
phosphatidylserine synthase [Yersinia pe...
452
Predicted Essential
Community Requests
3HSI
50.3%
Yersinia pestis
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