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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 7 of 60, showing 100 records out of 5973 total, starting on record 601
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP05098
(
show subtarget assignments
)
1
purified
No
CD0569
126698147
putative outer membrane lipoprotein [Clo...
334
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2FQW
21.3%
Clostridium difficile
Cell envelope: Other
IDP05067
(
show subtarget assignments
)
1
cloned
No
CD2664
126700278
murE
UDP-N-acetylmuramoylalanyl-D-glutamate--...
484
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2WTZ
36.2%
Clostridium difficile
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP04634
(
show subtarget assignments
)
1
in_pdb
3MSU
No
FTT0071c
56707250
gltA
citrate synthase [Francisella tularensis...
424
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3MSU
100%
Francisella tularensis
IDP04635
(
show subtarget assignments
)
1
soluble
No
FTT0101
56603768
conserved membrane hypothetical protein ...
337
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
4E94
25.5%
Francisella tularensis
IDP04636
(
show subtarget assignments
)
1
soluble
No
FTT0238
56707395
aroE1
shikimate 5-dehydrogenase [Francisella t...
257
drug target; conserved gene;
Phase 4: April 2009
3O8Q
36.8%
Francisella tularensis
IDP04081
(
show subtarget assignments
)
1
purified
No
BAS0361
49183389
DNA topoisomerase III [Bacillus anthraci...
729
Proposed to be essential proteins
Phase 4: April 2009
1D6M
27.7%
Bacillus anthracis
IDP05180
(
show subtarget assignments
)
1
soluble
No
BA_3644
30258169
putative oligopeptide ABC transporter, o...
568
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3TCF
29.6%
Bacillus anthracis
Transport and binding proteins: Amino acids, peptides and amines
IDP05075
(
show subtarget assignments
)
1
cloned
No
lmo0466
16802510
-
hypothetical protein lmo0466 [Listeria m...
576
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
Listeria monocytogenes
DNA metabolism: DNA replication, recombination, and repair
IDP04638
(
show subtarget assignments
)
1
expressed
No
FTT0372c
56707523
accD
Acetyl-CoA carboxylase beta subunit [Fra...
302
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2F9Y
60.3%
Francisella tularensis
IDP05143
(
show subtarget assignments
)
1
cloned
No
BAS4423
49187418
-
triple helix repeat-containing collagen ...
312
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1WCK
27.6%
Bacillus anthracis
Unknown function: General
IDP04026
(
show subtarget assignments
)
1
expressed
No
FTT0456c
56707598
hypothetical protein FTT_0456c [Francise...
97
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1YHD
39.2%
Francisella tularensis
IDP04211
(
show subtarget assignments
)
1
expressed
No
STM0408_1_323
16763788
secF
preprotein translocase subunit SecF [Sal...
323
Salmonella essential protein
Phase 4: April 2009
3AQP
35.3%
Salmonella enterica
IDP04339
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0115
49183149
50S ribosomal protein L22 [Bacillus anth...
113
Proposed to be essential proteins
Phase 4: April 2009
1BXE
59.3%
Bacillus anthracis
IDP04591
(
show subtarget assignments
)
1
cloned
No
BAS0138
49183172
50S ribosomal protein L17 [Bacillus anth...
120
Proposed to be essential proteins
Phase 4: April 2009
1NKW
50.8%
Bacillus anthracis
IDP04045
(
show subtarget assignments
)
1
soluble
No
FTT1747
56708745
outer membrane protein [Francisella tula...
191
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Francisella tularensis
IDP05071
(
show subtarget assignments
)
1
cloned
No
CD3291
126700910
hypothetical protein CD3291 [Clostridium...
174
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP04025
(
show subtarget assignments
)
1
expressed
No
YPCD1.36c
16082724
yscX
hypothetical protein YPCD1.36c [Yersinia...
122
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP05070
(
show subtarget assignments
)
1
cloned
No
CD3246
126700865
putative surface protein [Clostridium di...
709
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Cell envelope: Surface structures
IDP05028
(
show subtarget assignments
)
1
purified
No
BA_0331
30253869
polysaccharide deacetylase-like protein ...
367
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Unknown function: General
IDP05102
(
show subtarget assignments
)
1
cloned
No
CD1130
126698724
putative transglycosylase [Clostridium d...
164
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1QSA
28.7%
Clostridium difficile
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP04647
(
show subtarget assignments
)
1
purified
No
FTT1127
56604696
Rhodanese-like family protein [Francisel...
252
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1YT8
18.3%
Francisella tularensis
IDP05339
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL1622
57651958
glyS
glycyl-tRNA synthetase [Staphylococcus a...
463
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1ATI
41.9%
Staphylococcus aureus
Protein synthesis: tRNA aminoacylation
IDP05026
(
show subtarget assignments
)
1
cloned
No
BA_0025
30253539
putative csfB protein [Bacillus anthraci...
59
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Unknown function: General
IDP05074
(
show subtarget assignments
)
1
cloned
No
lmo0135
16802183
-
hypothetical protein lmo0135 [Listeria m...
524
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1XOC
32.4%
Listeria monocytogenes
Transport and binding proteins: Amino acids, peptides and amines
IDP05072
(
show subtarget assignments
)
1
cloned
No
CD3564
126701190
spoIIR
stage II sporulation protein [Clostridiu...
198
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Cellular processes: Sporulation and germination
IDP05338
(
show subtarget assignments
)
1
cloned
No
lmo1598
16803638
tyrS
tyrosyl-tRNA synthetase [Listeria monocy...
419
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2TS1
62.8%
Listeria monocytogenes
Protein synthesis: tRNA aminoacylation
IDP04210
(
show subtarget assignments
)
1
expressed
No
ZZZ_0017
243
Effector protein
Phase 4: April 2009
2KXC
18.5%
Escherichia coli
IDP04646
(
show subtarget assignments
)
1
soluble
No
FTT1085
56708168
hypothetical protein FTT_1085 [Francisel...
332
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1QXN
9.3%
Francisella tularensis
IDP05027
(
show subtarget assignments
)
1
purified
No
BA_0231
30253731
putative oligopeptide ABC transporter, o...
555
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3DRF
27.3%
Bacillus anthracis
Transport and binding proteins: Amino acids, peptides and amines
IDP05101
(
show subtarget assignments
)
1
in_crystallization_trials
No
CD1058
126698642
hbd
3-hydroxybutyryl-CoA dehydrogenase [Clos...
281
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1F0Y
43.9%
Clostridium difficile
Fatty acid and phospholipid metabolism: Degradation
IDP05073
(
show subtarget assignments
)
1
expressed
No
Cj0562
6968026
dnaB
gamma-glutamyl phosphate reductase [Camp...
439
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2VYE
37.1%
Campylobacter jejuni
DNA metabolism: DNA replication, recombination, and repair
IDP04336
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAC05790
12329059
ospC1
OspC1, secreted by the Mxi-Spa secretion...
470
Shigella effector protein
Community Requests
Shigella flexneri
IDP04209
(
show subtarget assignments
)
1
soluble
No
Z5142
15804250
hypothetical protein Z5142 [Escherichia ...
398
Effector protein
Phase 4: April 2009
3PCR
89.7%
Escherichia coli
IDP05100
(
show subtarget assignments
)
1
soluble
No
CD0876
126698453
ABC transporter, substrate-binding lipop...
345
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3LFT
32.2%
Clostridium difficile
Transport and binding proteins: Amino acids, peptides and amines
IDP04098
(
show subtarget assignments
)
1
cloned
No
YPCD1.50
5832470
YPCD1.50
hypothetical protein YPCD1.50 [Yersinia ...
32
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04642
(
show subtarget assignments
)
1
expressed
No
FTT0716
56707835
upp
uracil phosphoribosyltransferase [Franci...
214
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2EHJ
69.2%
Francisella tularensis
IDP04640
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0559c
56707689
cmk
cytidylate kinase [Francisella tularensi...
221
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1CKE
47.1%
Francisella tularensis
IDP04335
(
show subtarget assignments
)
1
cloned
No
STM1543_1_428
16764888
putative transport protein [Salmonella t...
428
Salmonella essential protein
Phase 4: April 2009
1PW4
23.4%
Salmonella enterica
IDP04728
(
show subtarget assignments
)
1
selected
No
BAS0102
49183136
DNA-directed RNA polymerase subunit beta...
1177
Proposed to be essential proteins
Phase 4: April 2009
1HQM
49.2%
Bacillus anthracis
IDP04598
(
show subtarget assignments
)
1
cloned
No
BAS1442
49184459
dihydrodipicolinate reductase [Bacillus ...
266
Proposed to be essential proteins
Phase 4: April 2009
1C3V
40.6%
Bacillus anthracis
IDP04658
(
show subtarget assignments
)
1
purified
No
FTT1736c
56708739
kdpD
two component sensor protein kdpD [Franc...
893
conserved gene;
Phase 4: April 2009
2R8R
11.4%
Francisella tularensis
IDP05079
(
show subtarget assignments
)
1
cloned
No
lmo1438
16803478
-
hypothetical protein lmo1438 [Listeria m...
721
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2WAE
32.6%
Listeria monocytogenes
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP04115
(
show subtarget assignments
)
1
expressed
No
STM2352_1_235
16765679
hisM
histidine/lysine/arginine/ornithine tran...
235
Salmonella essential protein
Phase 4: April 2009
3DHW
23.8%
Salmonella enterica
IDP05267
(
show subtarget assignments
)
1
soluble
No
lmo0255
16802301
-
hypothetical protein lmo0255 [Listeria m...
167
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
Viral functions: General
IDP05199
(
show subtarget assignments
)
1
soluble
No
CD1556
126699160
putative polysaccharide deacetylase [Clo...
277
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2C1G
22.7%
Clostridium difficile
Energy metabolism: Biosynthesis and degradation of polysaccharides
IDP04292
(
show subtarget assignments
)
1
cloned
No
YPO0812
218927992
general secretion pathway protein H [Yer...
180
conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04530
(
show subtarget assignments
)
1
soluble
No
STM2519_1_490
16765839
engA
GTP-binding protein EngA [Salmonella typ...
490
Salmonella essential protein
Phase 4: April 2009
2HJG
36.1%
Salmonella enterica
IDP04055
(
show subtarget assignments
)
1
cloned
No
STM0301_1_836
16763684
safC
putative fimbrial usher [Salmonella typh...
836
Salmonella essential protein
Phase 4: April 2009
3RFZ
37%
Salmonella enterica
IDP05044
(
show subtarget assignments
)
1
expressed
No
BA_3338
30257881
putative S-layer protein [Bacillus anthr...
360
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3PYW
15.6%
Bacillus anthracis
Cell envelope: Surface structures
IDP05106
(
show subtarget assignments
)
1
cloned
No
CD1469
126699073
cell surface protein (putative penicilli...
990
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2QMI
10%
Clostridium difficile
Cell envelope: Other
IDP04573
(
show subtarget assignments
)
1
crystallized
No
BAS0006
49183045
DNA gyrase subunit A [Bacillus anthracis...
823
Proposed to be essential proteins
Phase 4: April 2009
2XCO
42.9%
Bacillus anthracis
IDP04030
(
show subtarget assignments
)
1
cloned
No
YPO2532
115348229
hypothetical protein [Yersinia pestis CO...
70
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP05130
(
show subtarget assignments
)
1
cloned
No
CD0119
126697691
phosphoglucomutase/phosphomannomutase mu...
454
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3PDK
50.2%
Clostridium difficile
Central intermediary metabolism: Amino sugars
IDP04592
(
show subtarget assignments
)
1
expressed
No
BAS0143
49183177
50S ribosomal protein L13 [Bacillus anth...
145
Proposed to be essential proteins
Phase 4: April 2009
1P85
56.6%
Bacillus anthracis
IDP04276
(
show subtarget assignments
)
1
soluble
No
FTT0312c
56707465
folA
dihydrofolate reductase type I [Francise...
166
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3JW3
41.6%
Francisella tularensis
IDP04654
(
show subtarget assignments
)
1
purified
No
FTT1526c
56708560
idh
isocitrate dehydrogenase [Francisella tu...
747
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1ITW
62.7%
Francisella tularensis
IDP05046
(
show subtarget assignments
)
1
expressed
No
BA_3529
30258064
hypothetical protein BA_3529 [Bacillus a...
117
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04575
(
show subtarget assignments
)
1
cloned
No
BAS0037
49183072
methionyl-tRNA synthetase [Bacillus anth...
660
Proposed to be essential proteins
Phase 4: April 2009
4DLP
36.2%
Bacillus anthracis
IDP04215
(
show subtarget assignments
)
1
cloned
No
STM1574_1_495
16764918
smvA
methyl viologen resistance [Salmonella t...
495
Salmonella essential protein
Phase 4: April 2009
2GFP
17%
Salmonella enterica
IDP04214
(
show subtarget assignments
)
1
expressed
No
STM1473_1_377
16764819
ompN
outer membrane protein N precursor [Salm...
377
Salmonella essential protein
Phase 4: April 2009
1OSM
66%
Salmonella enterica
IDP04651
(
show subtarget assignments
)
1
cloned
No
FTT1417
56708464
carbon-nitrogen hydrolase [Francisella t...
261
drug target; conserved gene;
Phase 4: April 2009
2E11
34.3%
Francisella tularensis
IDP04608
(
show subtarget assignments
)
1
soluble
No
BAS3704
49186703
putative glycerol-3-phosphate acyltransf...
330
Proposed to be essential proteins
Phase 4: April 2009
1VI1
66.4%
Bacillus anthracis
IDP04107
(
show subtarget assignments
)
1
purified
No
BAS0120
49183154
50S ribosomal protein L14 [Bacillus anth...
122
Proposed to be essential proteins
Phase 4: April 2009
1C04
86.9%
Bacillus anthracis
IDP05241
(
show subtarget assignments
)
1
cloned
No
lmo1955
16803994
-
hypothetical protein lmo1955 [Listeria m...
297
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1A0P
43.8%
Listeria monocytogenes
Mobile and extrachromosomal element functions: Prophage functions
IDP04116
(
show subtarget assignments
)
1
expressed
No
Z5122
15804232
sepZ
hypothetical protein Z5122 [Escherichia ...
99
Effector protein
Phase 4: April 2009
Escherichia coli
IDP04652
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT1432c
56708477
ppnK
inorganic phosphate/ATP-NAD kinase [Fran...
296
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2AN1
41.6%
Francisella tularensis
IDP05030
(
show subtarget assignments
)
1
soluble
No
BA_0898
30254646
N-acetylmuramoyl-L-alanine amidase, fami...
529
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3PYW
18.1%
Bacillus anthracis
Cell envelope: Surface structures
IDP05349
(
show subtarget assignments
)
1
cloned
No
CD2487
126700104
PTS system, IIB component [Clostridium d...
105
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2KYR
67.6%
Clostridium difficile
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
IDP04526
(
show subtarget assignments
)
1
expressed
No
STM1637_1_516
16764981
putative inner membrane protein [Salmone...
516
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP05240
(
show subtarget assignments
)
1
expressed
No
CD0233
126697804
hypothetical protein CD0233 [Clostridium...
130
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2AJ7
33.1%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP05147
(
show subtarget assignments
)
1
cloned
No
BAS4903
49187891
-
methionyl-tRNA synthetase [Bacillus anth...
544
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1RQG
38.7%
Bacillus anthracis
Protein synthesis: tRNA aminoacylation
IDP04596
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS1099
49184119
tryptophanyl-tRNA synthetase [Bacillus a...
329
Proposed to be essential proteins
Phase 4: April 2009
3PRH
73.9%
Bacillus anthracis
IDP04217
(
show subtarget assignments
)
1
cloned
No
STM2619_1_203
16765939
hypothetical protein STM2619 [Salmonella...
203
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP05129
(
show subtarget assignments
)
1
cloned
No
CD0091
126697661
adk
adenylate kinase [Clostridium difficile ...
221
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3FB4
57.9%
Clostridium difficile
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
IDP05078
(
show subtarget assignments
)
1
soluble
No
lmo1340
16803380
-
hypothetical protein lmo1340 [Listeria m...
363
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
Transport and binding proteins: Unknown substrate
IDP04520
(
show subtarget assignments
)
1
purified
No
Z0985
15800520
hypothetical protein Z0985 [Escherichia ...
326
Effector protein
Phase 4: April 2009
Escherichia coli
IDP05108
(
show subtarget assignments
)
1
in_pdb
4DUN
No
CD1761
126699370
hypothetical protein CD1761 [Clostridium...
260
virulence/pathogenesis /
Targets associated with virulence and/or pathogenesis
Phase 5: 2010
4DUN
100%
Clostridium difficile
Cellular processes: Toxin production and resistance
IDP05392
(
show subtarget assignments
)
1
cloned
No
BA_3222
30257786
hypothetical protein BA_3222 [Bacillus a...
56
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05245
(
show subtarget assignments
)
1
soluble
No
lmo2349
16804387
-
hypothetical protein lmo2349 [Listeria m...
269
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2O1M
71%
Listeria monocytogenes
Transport and binding proteins: Unknown substrate
IDP05132
(
show subtarget assignments
)
1
cloned
No
CD0262
126697834
flhB
bifunctional flagellar biosynthesis prot...
604
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2JLH
7.9%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP04216
(
show subtarget assignments
)
1
cloned
No
STM1894_1_336
16765236
ruvB
Holliday junction DNA helicase B [Salmon...
336
Salmonella essential protein
Phase 4: April 2009
1HQC
53%
Salmonella enterica
IDP05246
(
show subtarget assignments
)
1
soluble
No
lmo2439
16804477
-
hypothetical protein lmo2439 [Listeria m...
113
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2K5Q
33.6%
Listeria monocytogenes
Unclassified: Role category not yet assigned
IDP04275
(
show subtarget assignments
)
1
cloned
No
BAS3684
49186683
DNA topoisomerase I [Bacillus anthracis ...
692
Proposed to be essential proteins
Phase 4: April 2009
2GAI
38.2%
Bacillus anthracis
IDP05045
(
show subtarget assignments
)
1
soluble
No
BA_3418
30257959
putative lipoprotein [Bacillus anthracis...
131
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP04663
(
show subtarget assignments
)
1
cloned
No
BAS5325
49188309
30S ribosomal protein S18 [Bacillus anth...
77
Proposed to be essential proteins
Phase 4: April 2009
1P6G
50.6%
Bacillus anthracis
IDP04350
(
show subtarget assignments
)
1
cloned
No
STM1338_1_795
16764689
pheT
phenylalanyl-tRNA synthetase subunit bet...
795
Salmonella essential protein
Phase 4: April 2009
3PCO
92.6%
Salmonella enterica
IDP05146
(
show subtarget assignments
)
1
cloned
No
BAS4784
49187774
-
glycyl-tRNA synthetase [Bacillus anthrac...
458
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1ATI
43.2%
Bacillus anthracis
Protein synthesis: tRNA aminoacylation
IDP04595
(
show subtarget assignments
)
1
soluble
No
BAS0565
49183590
nicotinate phosphoribosyltransferase [Ba...
487
Proposed to be essential proteins
Phase 4: April 2009
2F7F
61.4%
Bacillus anthracis
IDP04218
(
show subtarget assignments
)
1
expressed
No
STM2996_1_1123
16766298
recC
exonuclease V subunit gamma [Salmonella ...
1123
Salmonella essential protein
Phase 4: April 2009
1W36
88.4%
Salmonella enterica
IDP04525
(
show subtarget assignments
)
1
cloned
No
STM1556_1_483
16764900
putative Na+/H+ antiporter [Salmonella t...
483
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP05050
(
show subtarget assignments
)
1
purified
No
BA_5330
30259806
iron compound ABC transporter, iron comp...
333
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3GFV
26.4%
Bacillus anthracis
Transport and binding proteins: Cations and iron carrying compounds
IDP05082
(
show subtarget assignments
)
1
cloned
No
lmo2179
16804218
-
peptidoglycan binding protein [Listeria ...
1152
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2KT7
2.3%
Listeria monocytogenes
Regulatory functions: Other
IDP04223
(
show subtarget assignments
)
8
selected
No
CAC05808
12329077
ipgD
IpgD, secreted by the Mxi-Spa machinery,...
538
Shigella effector protein
Community Requests
Shigella flexneri
IDP05452
(
show subtarget assignments
)
1
cloned
No
BAS5207
49188193
-
collagen adhesion protein, C-terminal [B...
882
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3KPT
12.6%
Bacillus anthracis
Protein fate: Degradation of proteins, peptides, and glycopeptides
IDP04222
(
show subtarget assignments
)
8
selected
No
CAC05827
12329096
spa33
Spa33, component of the Mxi-Spa secretio...
293
Shigella effector protein
Community Requests
Shigella flexneri
IDP04349
(
show subtarget assignments
)
1
expressed
No
STM0557_1_550
16763935
putative inner membrane protein [Salmone...
550
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP05253
(
show subtarget assignments
)
1
cloned
No
CD0259
126697831
putative flagellar protein [Clostridium ...
107
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP04524
(
show subtarget assignments
)
1
in_pdb
3Q58
Yes
STM1129_1_226
16764486
N-acetylmannosamine-6-phosphate 2-epimer...
226
Salmonella essential protein
Phase 4: April 2009
3Q58
100%
Salmonella enterica
IDP05499
(
show subtarget assignments
)
1
soluble
No
BA_4322
30258823
5'-nucleotidase family protein [Bacillus...
529
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2Z1A
30.2%
Bacillus anthracis
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
IDP05498
(
show subtarget assignments
)
1
cloned
No
CD0249
126697820
fliG
flagellar motor switch protein [Clostrid...
356
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3PKR
28.4%
Clostridium difficile
Cellular processes: Chemotaxis and motility
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