Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP91952 (show subtarget assignments)	8	selected	No	SpneCM_010100008682	298255656		AmiA protein [Streptococcus pneumoniae s...	659	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1B05	23.4%	Streptococcus pneumoniae

IDP05166 (show subtarget assignments)	1	soluble	No	BA_1921	30256579		amidase family protein [Bacillus anthrac...	536	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M21	36%	Bacillus anthracis	Unknown function: Enzymes of unknown specificity

IDP05552 (show subtarget assignments)	1	soluble	No	lmo0849	16802890	-	amidase [Listeria monocytogenes EGD-e]	616	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M21	27.6%	Listeria monocytogenes	Central intermediary metabolism: Other

IDP00665 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1079	57285865	purF	amidophosphoribosyltransferase	494	Drug Target Function	Phase 2: March 2008	1AO0	51%	Staphylococcus aureus	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02568 (show subtarget assignments)	1	cloned	No	GBAA0295	47525558	purF	amidophosphoribosyltransferase [Bacillus...	471	Drug target motif; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1AO0	69.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90700 (show subtarget assignments)	8	soluble	No	Cj0196c	15791583	purF	amidophosphoribosyltransferase [Campylob...	445	Predicted Essential	Community Requests	1AO0	46.3%	Campylobacter jejuni

IDP04541 (show subtarget assignments)	1	cloned	No	CPF_0674	110800675	purF	amidophosphoribosyltransferase [Clostrid...	473	conserved gene; putative drug target function;	Phase 4: April 2009	1AO0	44.6%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04657 (show subtarget assignments)	1	expressed	No	FTT1721c	56708727	purF	amidophosphoribosyltransferase [Francise...	496	conserved gene; putative drug target function;	Phase 4: April 2009	1ECB	55.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04344 (show subtarget assignments)	1	in_crystallization_trials	No	VC1004	15641019		amidophosphoribosyltransferase [Vibrio c...	504	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1ECB	76.1%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04475 (show subtarget assignments)	1	cloned	No	YPO2772	115348455	purF	amidophosphoribosyltransferase [Yersinia...	505	drug target; virulence factor; conserved gene; putative drug target function;...	Phase 4: April 2009	1ECB	86.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04502 (show subtarget assignments)	1	purified	No	VC1136	9655608		amidotransferase HisH [Vibrio cholerae O...	203	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KA9	36.9%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP05579 (show subtarget assignments)	1	soluble	No	BA_0855	30254440		amino acid ABC transporter, amino acid-b...	265	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2YLN	40.8%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP02641 (show subtarget assignments)	1	purified	No	GBAA0640	47525919		amino acid ABC transporter amino acid-bi...	276	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2V25	33.3%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP04366 (show subtarget assignments)	1	purified	No	CPF_1531	110800274		amino acid ABC transporter, amino acid-b...	262	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HV1	36.6%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP04547 (show subtarget assignments)	1	cloned	No	CPF_0581	110800184		amino acid ABC transporter, amino acid-b...	278	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2PVU	30.2%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP91898 (show subtarget assignments)	8	selected	No	SpneCM_010100003105	298254588		amino acid ABC transporter, amino acid-b...	521	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3I6V	13.4%	Streptococcus pneumoniae

IDP91947 (show subtarget assignments)	8	selected	No	SpneCM_010100001889	298254350		amino acid ABC transporter, amino acid-b...	721	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3HV1	10.4%	Streptococcus pneumoniae

IDP91962 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100007760	298255480		amino acid ABC transporter, amino acid-b...	266	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	4EQ9	40.6%	Streptococcus pneumoniae

IDP01414 (show subtarget assignments)	1	purified	No	VC1359	15641371		amino acid ABC transporter, ATP-binding ...	251	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	55.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01113 (show subtarget assignments)	1	expressed	No	BA_0368	30253903		amino acid ABC transporter, ATP-binding ...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	65.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01505 (show subtarget assignments)	1	expressed	No	VCA1037	15601788		amino acid ABC transporter, ATP-binding ...	239	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	52.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01147 (show subtarget assignments)	1	expressed	No	BA_0639	30254242		amino acid ABC transporter, ATP-binding ...	243	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	60.5%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01355 (show subtarget assignments)	1	soluble	No	VC0008	15640040		amino acid ABC transporter, ATP-binding ...	245	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	51.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP00730 (show subtarget assignments)	1	soluble	No	SACOL2453	57286449		amino acid ABC transporter, ATP-binding ...	408	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	27.5%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP00696 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2410	57285141		amino acid ABC transporter, ATP-binding ...	243	Drug Target Function	Phase 2: March 2008	2OLJ	52.3%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP01431 (show subtarget assignments)	1	purified	No	VC1864	15641866		amino acid ABC transporter, ATP-binding ...	256	Conserved Gene / Pathway	Phase 2: March 2008	1B0U	62.9%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP02474 (show subtarget assignments)	1	cloned	No	Cj0922c	15792251	pebC	amino acid ABC transporter ATP-binding p...	242	Predicted virulence-Adhesion of Campylobacter	Phase 3: June 2008	2OLJ	52.5%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01641 (show subtarget assignments)	1	cloned	No	CBU_0481	29541087	artP	amino acid ABC transporter, ATP-binding ...	250	Conserved; Drug target functions	Phase 3: June 2008	2OLJ	48%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP01356 (show subtarget assignments)	1	soluble	No	VC0010	15640042		amino acid ABC transporter, periplasmic ...	248	Conserved Gene / Pathway	Phase 2: March 2008	1GGG	31.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01430 (show subtarget assignments)	1	in_crystallization_trials	No	VC1863	15641865		amino acid ABC transporter, periplasmic ...	260	Conserved Gene / Pathway	Phase 2: March 2008	1LAF	39.2%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP02749 (show subtarget assignments)	1	soluble	No	CBU_0482	29541088		amino acid ABC transporter, periplasmic ...	269	Conserved; Drug target functions	Phase 3: June 2008	3TQL	84.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP01503 (show subtarget assignments)	1	soluble	No	VCA0978	15601731		amino acid ABC transporter, periplasmic ...	243	Conserved Gene / Pathway	Phase 2: March 2008	1HPB	26.3%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP91967 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100008960	298255704		amino acid ABC transporter, periplasmic ...	268	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1XT8	28.7%	Streptococcus pneumoniae

IDP91901 (show subtarget assignments)	8	selected	No	SpneCM_010100002026	298254377		amino acid ABC transporter, permease pro...	227	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP05139 (show subtarget assignments)	1	soluble	No	BAS0353	49183381	-	amino acid ABC transporter, solute bindi...	264	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TQL	30.3%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP05630 (show subtarget assignments)	1	soluble	No	CD1774	126699383		amino acid ABC transporter, substrate-bi...	267	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HV1	36%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP05633 (show subtarget assignments)	1	purified	No	CD2177	126699793		amino-acid ABC transporter,substrate-bin...	267	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2IEE	32.6%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP05634 (show subtarget assignments)	1	soluble	No	CD2174	126699790		amino-acid ABC transporter,substrate-bin...	270	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2IEE	29.3%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP04386 (show subtarget assignments)	1	cloned	No	YPO3230	218930257	pepD	aminoacyl-histidine dipeptidase [Yersini...	486	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3MRU	63%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91192 (show subtarget assignments)	1	in_crystallization_trials	No	BAD95814	62857277	neoU	aminoglycoside 3'-phosphotransferase [St...	268	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3R78	38.1%	Streptomyces fradiae

IDP00039 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1960	30256617		aminoglycoside 6-adenylyltransferase, pu...	290	Virulence	Phase 1: October 2007	2PBE	37.9%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP91868 (show subtarget assignments)	8	in_pdb 4F0Y 4EVY	No	AAA21889	455437	aac(6')-Ig	aminoglycoside 6'-N-acetyltransferase [A...	145	drug resistance / confers resistance to aminoglycoside antibiotics by acetylation	Community Requests	4EVY	100%	Acinetobacter haemolyticus

IDP91798 (show subtarget assignments)	8	purified	No	AAX82592	62422020	aph(6)-Ia	aminoglycoside-6-phosphotransferase Ia [...	307	other biological interest / Kinase	Community Requests			Streptomyces griseus

IDP92558 (show subtarget assignments)	8	selected	No	CAA87463	1065719	aadB	aminoglycoside adenylyltransferase [Esch...	177	drug resistance / This enzyme is one of the most clinically widespread aminogylcoside-deactivating...	Community Requests			Escherichia coli

IDP04529 (show subtarget assignments)	1	crystallized	No	STM2481_1_1037	16765801	acrD	aminoglycoside/multidrug efflux system [...	1037	Salmonella essential protein	Phase 4: April 2009	1IWG	66.2%	Salmonella enterica

IDP00044 (show subtarget assignments)	1	in_pdb 3SLB 3SLF 3E4F 3IJW 3N0S 3KZL 3N0M	Yes	BA_2930	30257522	aacC7	aminoglycoside N3-acetyltransferase	265	Virulence	Phase 1: October 2007	3E4F	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP91783 (show subtarget assignments)	8	in_pdb 4EBK 4EBJ	No	AAM76670	30171089	ant4'-IIb	aminoglycoside nucleotidyltransferase [P...	251	drug resistance / Aminoglycoside nucleotidyltransferase (ant4'-IIb) gene (aminoglycoside resistanc...	Community Requests	4EBJ	98.8%	Pseudomonas aeruginosa

IDP91191 (show subtarget assignments)	1	in_pdb 4EJ7 3R78	No	CAJ77079	90265397	aphA1	Aminoglycoside phosphotransferase [Acine...	271	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3R78	100%	Acinetobacter baumannii

IDP91187 (show subtarget assignments)	1	in_pdb 3UZR 4DCA	Yes	AF207840_1	10130002	aph(2')-Ib	aminoglycoside phosphotransferase [Enter...	299	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3HAM	100%	Enterococcus faecium

IDP00063 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4952	30259447		aminoglycoside phosphotransferase family...	263	Virulence	Phase 1: October 2007	3I0O	14.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00045 (show subtarget assignments)	1	purified	No	BA_3111	30257692		aminoglycoside phosphotransferase family...	292	Virulence	Phase 1: October 2007	3LZH	17.8%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01496 (show subtarget assignments)	1	soluble	No	VCA0813	15601568		aminopeptidase	501	Drug Target Function	Phase 2: March 2008	1RTQ	43.9%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01397 (show subtarget assignments)	1	purified	No	VC0755	161582019		aminopeptidase B	429	Drug Target Function	Phase 2: March 2008	3H8E	32.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04077 (show subtarget assignments)	1	crystallized	No	FTT1793c	56708781	pepN	aminopeptidase N [Francisella tularensis...	864	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2DQ6	48.9%	Francisella tularensis

IDP92127 (show subtarget assignments)	8	selected	No	TGME49_021310	237841325		aminopeptidase N, putative [Toxoplasma g...	966	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2GTQ	33.6%	Toxoplasma gondii

IDP04359 (show subtarget assignments)	1	cloned	No	YPO1414	218928562	pepN	aminopeptidase N [Yersinia pestis CO92]	871	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2DQ6	77.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01761 (show subtarget assignments)	1	cloned	No	GBAA5606	47530928		aminopeptidase, putative [Bacillus anthr...	466	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2EK8	33%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00424 (show subtarget assignments)	1	purified	No	YPO2975	16123156		aminotransferase	411	Conserved Gene / Pathway	Phase 2: March 2008	2X5D	88.6%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP01639 (show subtarget assignments)	1	cloned	No	GBAA4225	47529518		aminotransferase A [Bacillus anthracis s...	387	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1GD9	39.5%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01705 (show subtarget assignments)	1	in_pdb 3N5M	No	BAS1519	49184534		aminotransferase [Bacillus anthracis str...	449	CONSERVED GENE/PATHWAY	Phase 3: June 2008	3N5M	99.6%	Bacillus anthracis	N/A	N/A

IDP01723 (show subtarget assignments)	1	in_pdb 3KAX	No	GBAA5138	47530443		aminotransferase, classes I and II [Baci...	383	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3KAX	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01704 (show subtarget assignments)	1	expressed	No	GBAA5215	47530521		aminotransferase, class V [Bacillus anth...	406	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1T3I	51%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01602 (show subtarget assignments)	1	expressed	No	YPO2288	16122512	amn	AMP nucleosidase [Yersinia pestis CO92]	546	CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...	Phase 3: June 2008	1T8R	63.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP02559 (show subtarget assignments)	1	cloned	No	YPO3325	16123478	dmsA	anaerobic dimethyl sulfoxide reductase c...	816	Conserved; CD; Drug target functions	Phase 3: June 2008	1E60	28.7%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02285 (show subtarget assignments)	1	soluble	No	FTT0132	56707303	glpA	anaerobic glycerol-3-phosphate dehydroge...	510	Drug Target	Phase 3: June 2008	3DA1	33.1%	Francisella tularensis	Energy metabolism	Other

IDP02006 (show subtarget assignments)	1	expressed	No	STM2285	16765612	glpB	anaerobic glycerol-3-phosphate dehydroge...	419	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Energy metabolism	Anaerobic

IDP02653 (show subtarget assignments)	1	in_crystallization_trials	No	STM2840	16766146		anaerobic nitric oxide reductase flavoru...	479	Conserved; Drug target functions	Phase 3: June 2008	1YCF	33.8%	Salmonella enterica	Energy metabolism	Electron transport

IDP02400 (show subtarget assignments)	1	purified	No	YPO3454	16123600	nrdD	anaerobic ribonucleoside triphosphate re...	712	Conserved; CD; Drug target functions	Phase 3: June 2008	1H78	48.2%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP01841 (show subtarget assignments)	1	purified	No	STM2549	16765869	asrB	anaerobic sulfite reductase subunit B [S...	272	Conserved; Drug target functions	Phase 3: June 2008	1KRH	18.8%	Salmonella enterica	Energy metabolism	Anaerobic

IDP90111 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_017	68449091		ankyrin-like protein [Monkeypox virus]	630	similar to VACV-COP-C9L, MPXV-ZAI96-D9L	Community Requests	3NOC	5.1%	Monkeypox virus

IDP90119 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_029	68449103		ankyrin-like protein [Monkeypox virus]	442	similar to VACV-COP-M1L, MPXV-ZAI96-O1L	Community Requests	1N11	16.3%	Monkeypox virus

IDP90121 (show subtarget assignments)	8	purified	No	MPXV_ZAI1979_005_031	68449105		ankyrin-like protein [Monkeypox virus]	284	similar to VACV-COP-K1L, MPXV-ZAI96-C1L	Community Requests	3KEA	94.7%	Monkeypox virus

IDP90137 (show subtarget assignments)	8	cloned	No	MPXV_ZAI1979_005_179	68449250		ankyrin-like protein [Monkeypox virus]	561	similar to VACV-COP-B4R, MPXV-ZAI96-B5R	Community Requests	1N11	11.2%	Monkeypox virus

IDP90104 (show subtarget assignments)	8	expressed	No	MPXV_ZAI1979_005_004	68449081		ankyrin-like protein [Monkeypox virus]	437	similar to CPXV-GRI-C1L, MPXV-ZAI96-D1L/N4R	Community Requests	2Y1L	9.6%	Monkeypox virus

IDP90110 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_015	68449089		ankyrin-like protein [Monkeypox virus]	660	similar to CPXV-GRI-C9L,CPXV-BR-V024, MPXV-ZAI96-D7L	Community Requests	1N0Q	4.4%	Monkeypox virus

IDP90103 (show subtarget assignments)	8	cloned	No	MPXV_ZAI1979_005_003	68449080		ankyrin-like protein [Monkeypox virus]	587	similar to VACV-COP-B25R/C19L, MPXV-ZAI96-J3L/J1R	Community Requests			Monkeypox virus

IDP90146 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_193	68449265		ankyrin-like protein [Monkeypox virus]	789	similar to VACV-COP-B20R, MPXV-ZAI96-B17R	Community Requests	1MJ0	5.2%	Monkeypox virus

IDP90138 (show subtarget assignments)	8	cloned	No	MPXV_ZAI1979_005_181	68449252		ankyrin-like protein [Monkeypox virus]	119	similar to VACV-COP-B6R, MPXV-ZAI96-B7R	Community Requests			Monkeypox virus

IDP91301 (show subtarget assignments)	8	expressed	No	STM1724	16765068	trpD	anthranilate phosphoribosyltransferase	531	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	47.1%	Salmonella enterica

IDP02501 (show subtarget assignments)	1	cloned	No	GBAA1250	47526516	trpD	anthranilate phosphoribosyltransferase [...	341	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VQU	39.6%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP91257 (show subtarget assignments)	8	soluble	No	NT02SA1359	14247140	trpD	anthranilate phosphoribosyltransferase [...	332	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1VQU	33.8%	Staphylococcus aureus	Amino acid biosynthesis: Aromatic amino acid family

IDP04161 (show subtarget assignments)	1	cloned	No	VC1172	9655648		anthranilate phosphoribosyltransferase [...	353	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KGZ	59.5%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP91300 (show subtarget assignments)	8	soluble	No	STM1723	16765067	trpE	anthranilate synthase component I	520	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	99.8%	Salmonella enterica

IDP01196 (show subtarget assignments)	1	expressed	No	BA_1248	30255197	trpE	anthranilate synthase component I	471	Drug Target Function	Phase 2: March 2008	1QDL	38.4%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP00440 (show subtarget assignments)	1	purified	No	YPO2208	16122436	trpE	anthranilate synthase component I	521	Conserved Gene / Pathway	Phase 2: March 2008	1I7Q	79.7%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP00350 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1633	16803673	trpE	anthranilate synthase component I	454	Drug Target Function	Phase 2: March 2008	1QDL	35.7%	Listeria monocytogenes	Amino acid biosynthesis	Aromatic amino acid family

IDP00342 (show subtarget assignments)	1	cloned	No	FTT1802c	56708788	trpE	anthranilate synthase component I	514	Drug Target Function	Phase 2: March 2008	1I1Q	51.1%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP00799 (show subtarget assignments)	1	expressed	No	SACOL1403	57284557	trpE	anthranilate synthase component I	468	Drug Target Function	Phase 2: March 2008	1QDL	33.3%	Staphylococcus aureus	Amino acid biosynthesis	Aromatic amino acid family

IDP01413 (show subtarget assignments)	1	purified	No	VC1174	15641187		anthranilate synthase component I	523	Drug Target Function	Phase 2: March 2008	1I1Q	59.3%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP00316 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1152	29654458	trpE	anthranilate synthase component I	463	Drug Target Function	Phase 2: March 2008	1QDL	34.3%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP91232 (show subtarget assignments)	8	expressed	No	NT04EC1776	26107995	trpE	Anthranilate synthase component I [Esche...	520	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	89.6%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP00441 (show subtarget assignments)	1	expressed	No	YPO2207	16122435	trpG	anthranilate synthase component II	192	Drug Target Function	Phase 2: March 2008	1I7Q	87.5%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP00337 (show subtarget assignments)	1	expressed	No	FTT0946	56708043	trpG	anthranilate synthase component II	184	Drug Target Function	Phase 2: March 2008	1QDL	40.7%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP00322 (show subtarget assignments)	1	expressed	No	Cj0346	15791714	trpD	anthranilate synthase component II	533	Drug Target Function	Phase 2: March 2008	1VQU	20.6%	Campylobacter jejuni	Amino acid biosynthesis	Aromatic amino acid family

IDP01512 (show subtarget assignments)	1	soluble	No	VC1173	15641186		anthranilate synthase component II	203	Drug Target Function	Phase 2: March 2008	1I1Q	57.1%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP91233 (show subtarget assignments)	8	expressed	No	NT04EC1775	26107994	trpD	Anthranilate synthase component II [Esch...	531	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	47.3%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP91286 (show subtarget assignments)	8	expressed	No	SPA1154	56413352	trpE	anthranilate synthase component I [Salmo...	520	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	99%	Salmonella enterica

IDP91223 (show subtarget assignments)	8	purified	No	SF1267	24112663	trpE	anthranilate synthase component I [Shige...	520	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	89.2%	Shigella flexneri

IDP91238 (show subtarget assignments)	8	cloned	No	HP1282	2314448		anthranilate synthase component I (trpE)...	500	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	46.8%	Helicobacter pylori	Amino acid biosynthesis: Aromatic amino acid family

IDP00847 (show subtarget assignments)	1	expressed	No	SACOL1404	57284558	trpG	anthranilate synthase, glutamine amidotr...	188	Drug Target Function	Phase 2: March 2008	1QDL	34.2%	Staphylococcus aureus	Amino acid biosynthesis	Aromatic amino acid family

IDP91952
(show subtarget assignments)

8

selected

No

SpneCM_010100008682

298255656

AmiA protein [Streptococcus pneumoniae s...

659

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1B05

23.4%

Streptococcus pneumoniae

IDP05166
(show subtarget assignments)

1

soluble

No

BA_1921

30256579

amidase family protein [Bacillus anthrac...

536

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M21

36%

Bacillus anthracis

Unknown function: Enzymes of unknown specificity

IDP05552
(show subtarget assignments)

1

soluble

No

lmo0849

16802890

-

amidase [Listeria monocytogenes EGD-e]

616

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M21

27.6%

Listeria monocytogenes

Central intermediary metabolism: Other

IDP00665
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1079

57285865

purF

amidophosphoribosyltransferase

494

Drug Target Function

Phase 2: March 2008

1AO0

51%

Staphylococcus aureus

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02568
(show subtarget assignments)

1

cloned

No

GBAA0295

47525558

purF

amidophosphoribosyltransferase [Bacillus...

471

Drug target motif; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1AO0

69.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90700
(show subtarget assignments)

8

soluble

No

Cj0196c

15791583

purF

amidophosphoribosyltransferase [Campylob...

445

Predicted Essential

Community Requests

1AO0

46.3%

Campylobacter jejuni

IDP04541
(show subtarget assignments)

1

cloned

No

CPF_0674

110800675

purF

amidophosphoribosyltransferase [Clostrid...

473

conserved gene; putative drug target function;

Phase 4: April 2009

1AO0

44.6%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04657
(show subtarget assignments)

1

expressed

No

FTT1721c

56708727

purF

amidophosphoribosyltransferase [Francise...

496

conserved gene; putative drug target function;

Phase 4: April 2009

1ECB

55.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04344
(show subtarget assignments)

1

in_crystallization_trials

No

VC1004

15641019

amidophosphoribosyltransferase [Vibrio c...

504

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1ECB

76.1%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04475
(show subtarget assignments)

1

cloned

No

YPO2772

115348455

purF

amidophosphoribosyltransferase [Yersinia...

505

drug target; virulence factor; conserved gene; putative drug target function;...

Phase 4: April 2009

1ECB

86.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04502
(show subtarget assignments)

1

purified

No

VC1136

9655608

amidotransferase HisH [Vibrio cholerae O...

203

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KA9

36.9%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP05579
(show subtarget assignments)

1

soluble

No

BA_0855

30254440

amino acid ABC transporter, amino acid-b...

265

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2YLN

40.8%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP02641
(show subtarget assignments)

1

purified

No

GBAA0640

47525919

amino acid ABC transporter amino acid-bi...

276

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2V25

33.3%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP04366
(show subtarget assignments)

1

purified

No

CPF_1531

110800274

amino acid ABC transporter, amino acid-b...

262

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HV1

36.6%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP04547
(show subtarget assignments)

1

cloned

No

CPF_0581

110800184

amino acid ABC transporter, amino acid-b...

278

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2PVU

30.2%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP91898
(show subtarget assignments)

8

selected

No

SpneCM_010100003105

298254588

amino acid ABC transporter, amino acid-b...

521

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3I6V

13.4%

Streptococcus pneumoniae

IDP91947
(show subtarget assignments)

8

selected

No

SpneCM_010100001889

298254350

amino acid ABC transporter, amino acid-b...

721

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3HV1

10.4%

Streptococcus pneumoniae

IDP91962
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100007760

298255480

amino acid ABC transporter, amino acid-b...

266

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

4EQ9

40.6%

Streptococcus pneumoniae

IDP01414
(show subtarget assignments)

1

purified

No

VC1359

15641371

amino acid ABC transporter, ATP-binding ...

251

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

55.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01113
(show subtarget assignments)

1

expressed

No

BA_0368

30253903

amino acid ABC transporter, ATP-binding ...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

65.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01505
(show subtarget assignments)

1

expressed

No

VCA1037

15601788

amino acid ABC transporter, ATP-binding ...

239

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

52.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01147
(show subtarget assignments)

1

expressed

No

BA_0639

30254242

amino acid ABC transporter, ATP-binding ...

243

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

60.5%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01355
(show subtarget assignments)

1

soluble

No

VC0008

15640040

amino acid ABC transporter, ATP-binding ...

245

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

51.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP00730
(show subtarget assignments)

1

soluble

No

SACOL2453

57286449

amino acid ABC transporter, ATP-binding ...

408

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

27.5%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP00696
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2410

57285141

amino acid ABC transporter, ATP-binding ...

243

Drug Target Function

Phase 2: March 2008

2OLJ

52.3%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP01431
(show subtarget assignments)

1

purified

No

VC1864

15641866

amino acid ABC transporter, ATP-binding ...

256

Conserved Gene / Pathway

Phase 2: March 2008

1B0U

62.9%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP02474
(show subtarget assignments)

1

cloned

No

Cj0922c

15792251

pebC

amino acid ABC transporter ATP-binding p...

242

Predicted virulence-Adhesion of Campylobacter

Phase 3: June 2008

2OLJ

52.5%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01641
(show subtarget assignments)

1

cloned

No

CBU_0481

29541087

artP

amino acid ABC transporter, ATP-binding ...

250

Conserved; Drug target functions

Phase 3: June 2008

2OLJ

48%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP01356
(show subtarget assignments)

1

soluble

No

VC0010

15640042

amino acid ABC transporter, periplasmic ...

248

Conserved Gene / Pathway

Phase 2: March 2008

1GGG

31.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01430
(show subtarget assignments)

1

in_crystallization_trials

No

VC1863

15641865

amino acid ABC transporter, periplasmic ...

260

Conserved Gene / Pathway

Phase 2: March 2008

1LAF

39.2%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP02749
(show subtarget assignments)

1

soluble

No

CBU_0482

29541088

amino acid ABC transporter, periplasmic ...

269

Conserved; Drug target functions

Phase 3: June 2008

3TQL

84.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP01503
(show subtarget assignments)

1

soluble

No

VCA0978

15601731

amino acid ABC transporter, periplasmic ...

243

Conserved Gene / Pathway

Phase 2: March 2008

1HPB

26.3%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP91967
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100008960

298255704

amino acid ABC transporter, periplasmic ...

268

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1XT8

28.7%

Streptococcus pneumoniae

IDP91901
(show subtarget assignments)

8

selected

No

SpneCM_010100002026

298254377

amino acid ABC transporter, permease pro...

227

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP05139
(show subtarget assignments)

1

soluble

No

BAS0353

49183381

-

amino acid ABC transporter, solute bindi...

264

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TQL

30.3%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP05630
(show subtarget assignments)

1

soluble

No

CD1774

126699383

amino acid ABC transporter, substrate-bi...

267

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HV1

36%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP05633
(show subtarget assignments)

1

purified

No

CD2177

126699793

amino-acid ABC transporter,substrate-bin...

267

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2IEE

32.6%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP05634
(show subtarget assignments)

1

soluble

No

CD2174

126699790

amino-acid ABC transporter,substrate-bin...

270

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2IEE

29.3%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP04386
(show subtarget assignments)

1

cloned

No

YPO3230

218930257

pepD

aminoacyl-histidine dipeptidase [Yersini...

486

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3MRU

63%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91192
(show subtarget assignments)

1

in_crystallization_trials

No

BAD95814

62857277

neoU

aminoglycoside 3'-phosphotransferase [St...

268

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3R78

38.1%

Streptomyces fradiae

IDP00039
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1960

30256617

aminoglycoside 6-adenylyltransferase, pu...

290

Virulence

Phase 1: October 2007

2PBE

37.9%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP91868
(show subtarget assignments)

8

in_pdb
4F0Y
4EVY

No

AAA21889

455437

aac(6')-Ig

aminoglycoside 6'-N-acetyltransferase [A...

145

drug resistance / confers resistance to aminoglycoside antibiotics by acetylation

Community Requests

4EVY

100%

Acinetobacter haemolyticus

IDP91798
(show subtarget assignments)

8

purified

No

AAX82592

62422020

aph(6)-Ia

aminoglycoside-6-phosphotransferase Ia [...

307

other biological interest / Kinase

Community Requests

Streptomyces griseus

IDP92558
(show subtarget assignments)

8

selected

No

CAA87463

1065719

aadB

aminoglycoside adenylyltransferase [Esch...

177

drug resistance / This enzyme is one of the most clinically widespread aminogylcoside-deactivating...

Community Requests

Escherichia coli

IDP04529
(show subtarget assignments)

1

crystallized

No

STM2481_1_1037

16765801

acrD

aminoglycoside/multidrug efflux system [...

1037

Salmonella essential protein

Phase 4: April 2009

1IWG

66.2%

Salmonella enterica

IDP00044
(show subtarget assignments)

1

in_pdb
3SLB
3SLF
3E4F
3IJW
3N0S
3KZL
3N0M

Yes

BA_2930

30257522

aacC7

aminoglycoside N3-acetyltransferase

265

Virulence

Phase 1: October 2007

3E4F

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP91783
(show subtarget assignments)

8

in_pdb
4EBK
4EBJ

No

AAM76670

30171089

ant4'-IIb

aminoglycoside nucleotidyltransferase [P...

251

drug resistance / Aminoglycoside nucleotidyltransferase (ant4'-IIb) gene (aminoglycoside resistanc...

Community Requests

4EBJ

98.8%

Pseudomonas aeruginosa

IDP91191
(show subtarget assignments)

1

in_pdb
4EJ7
3R78

No

CAJ77079

90265397

aphA1

Aminoglycoside phosphotransferase [Acine...

271

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3R78

100%

Acinetobacter baumannii

IDP91187
(show subtarget assignments)

1

in_pdb
3UZR
4DCA

Yes

AF207840_1

10130002

aph(2')-Ib

aminoglycoside phosphotransferase [Enter...

299

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3HAM

100%

Enterococcus faecium

IDP00063
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4952

30259447

aminoglycoside phosphotransferase family...

263

Virulence

Phase 1: October 2007

3I0O

14.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00045
(show subtarget assignments)

1

purified

No

BA_3111

30257692

aminoglycoside phosphotransferase family...

292

Virulence

Phase 1: October 2007

3LZH

17.8%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01496
(show subtarget assignments)

1

soluble

No

VCA0813

15601568

aminopeptidase

501

Drug Target Function

Phase 2: March 2008

1RTQ

43.9%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01397
(show subtarget assignments)

1

purified

No

VC0755

161582019

aminopeptidase B

429

Drug Target Function

Phase 2: March 2008

3H8E

32.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04077
(show subtarget assignments)

1

crystallized

No

FTT1793c

56708781

pepN

aminopeptidase N [Francisella tularensis...

864

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2DQ6

48.9%

Francisella tularensis

IDP92127
(show subtarget assignments)

8

selected

No

TGME49_021310

237841325

aminopeptidase N, putative [Toxoplasma g...

966

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2GTQ

33.6%

Toxoplasma gondii

IDP04359
(show subtarget assignments)

1

cloned

No

YPO1414

218928562

pepN

aminopeptidase N [Yersinia pestis CO92]

871

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2DQ6

77.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01761
(show subtarget assignments)

1

cloned

No

GBAA5606

47530928

aminopeptidase, putative [Bacillus anthr...

466

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2EK8

33%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00424
(show subtarget assignments)

1

purified

No

YPO2975

16123156

aminotransferase

411

Conserved Gene / Pathway

Phase 2: March 2008

2X5D

88.6%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP01639
(show subtarget assignments)

1

cloned

No

GBAA4225

47529518

aminotransferase A [Bacillus anthracis s...

387

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1GD9

39.5%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01705
(show subtarget assignments)

1

in_pdb
3N5M

No

BAS1519

49184534

aminotransferase [Bacillus anthracis str...

449

CONSERVED GENE/PATHWAY

Phase 3: June 2008

3N5M

99.6%

Bacillus anthracis

N/A

IDP01723
(show subtarget assignments)

1

in_pdb
3KAX

No

GBAA5138

47530443

aminotransferase, classes I and II [Baci...

383

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3KAX

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01704
(show subtarget assignments)

1

expressed

No

GBAA5215

47530521

aminotransferase, class V [Bacillus anth...

406

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1T3I

51%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01602
(show subtarget assignments)

1

expressed

No

YPO2288

16122512

amn

AMP nucleosidase [Yersinia pestis CO92]

546

CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...

Phase 3: June 2008

1T8R

63.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP02559
(show subtarget assignments)

1

cloned

No

YPO3325

16123478

dmsA

anaerobic dimethyl sulfoxide reductase c...

816

Conserved; CD; Drug target functions

Phase 3: June 2008

1E60

28.7%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02285
(show subtarget assignments)

1

soluble

No

FTT0132

56707303

glpA

anaerobic glycerol-3-phosphate dehydroge...

510

Drug Target

Phase 3: June 2008

3DA1

33.1%

Francisella tularensis

Energy metabolism

Other

IDP02006
(show subtarget assignments)

1

expressed

No

STM2285

16765612

glpB

anaerobic glycerol-3-phosphate dehydroge...

419

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Energy metabolism

Anaerobic

IDP02653
(show subtarget assignments)

1

in_crystallization_trials

No

STM2840

16766146

anaerobic nitric oxide reductase flavoru...

479

Conserved; Drug target functions

Phase 3: June 2008

1YCF

33.8%

Salmonella enterica

Energy metabolism

Electron transport

IDP02400
(show subtarget assignments)

1

purified

No

YPO3454

16123600

nrdD

anaerobic ribonucleoside triphosphate re...

712

Conserved; CD; Drug target functions

Phase 3: June 2008

1H78

48.2%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP01841
(show subtarget assignments)

1

purified

No

STM2549

16765869

asrB

anaerobic sulfite reductase subunit B [S...

272

Conserved; Drug target functions

Phase 3: June 2008

1KRH

18.8%

Salmonella enterica

Energy metabolism

Anaerobic

IDP90111
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_017

68449091

ankyrin-like protein [Monkeypox virus]

630

similar to VACV-COP-C9L, MPXV-ZAI96-D9L

Community Requests

3NOC

5.1%

Monkeypox virus

IDP90119
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_029

68449103

ankyrin-like protein [Monkeypox virus]

442

similar to VACV-COP-M1L, MPXV-ZAI96-O1L

Community Requests

1N11

16.3%

Monkeypox virus

IDP90121
(show subtarget assignments)

8

purified

No

MPXV_ZAI1979_005_031

68449105

ankyrin-like protein [Monkeypox virus]

284

similar to VACV-COP-K1L, MPXV-ZAI96-C1L

Community Requests

3KEA

94.7%

Monkeypox virus

IDP90137
(show subtarget assignments)

8

cloned

No

MPXV_ZAI1979_005_179

68449250

ankyrin-like protein [Monkeypox virus]

561

similar to VACV-COP-B4R, MPXV-ZAI96-B5R

Community Requests

1N11

11.2%

Monkeypox virus

IDP90104
(show subtarget assignments)

8

expressed

No

MPXV_ZAI1979_005_004

68449081

ankyrin-like protein [Monkeypox virus]

437

similar to CPXV-GRI-C1L, MPXV-ZAI96-D1L/N4R

Community Requests

2Y1L

9.6%

Monkeypox virus

IDP90110
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_015

68449089

ankyrin-like protein [Monkeypox virus]

660

Community Requests

1N0Q

4.4%

Monkeypox virus

IDP90103
(show subtarget assignments)

8

cloned

No

MPXV_ZAI1979_005_003

68449080

ankyrin-like protein [Monkeypox virus]

587

Community Requests

Monkeypox virus

IDP90146
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_193

68449265

ankyrin-like protein [Monkeypox virus]

789

similar to VACV-COP-B20R, MPXV-ZAI96-B17R

Community Requests

1MJ0

5.2%

Monkeypox virus

IDP90138
(show subtarget assignments)

8

cloned

No

MPXV_ZAI1979_005_181

68449252

ankyrin-like protein [Monkeypox virus]

119

similar to VACV-COP-B6R, MPXV-ZAI96-B7R

Community Requests

Monkeypox virus

IDP91301
(show subtarget assignments)

8

expressed

No

STM1724

16765068

trpD

anthranilate phosphoribosyltransferase

531

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

47.1%

Salmonella enterica

IDP02501
(show subtarget assignments)

1

cloned

No

GBAA1250

47526516

trpD

anthranilate phosphoribosyltransferase [...

341

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VQU

39.6%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP91257
(show subtarget assignments)

8

soluble

No

NT02SA1359

14247140

trpD

anthranilate phosphoribosyltransferase [...

332

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1VQU

33.8%

Staphylococcus aureus

Amino acid biosynthesis: Aromatic amino acid family

IDP04161
(show subtarget assignments)

1

cloned

No

VC1172

9655648

anthranilate phosphoribosyltransferase [...

353

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KGZ

59.5%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP91300
(show subtarget assignments)

8

soluble

No

STM1723

16765067

trpE

anthranilate synthase component I

520

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

99.8%

Salmonella enterica

IDP01196
(show subtarget assignments)

1

expressed

No

BA_1248

30255197

trpE

anthranilate synthase component I

471

Drug Target Function

Phase 2: March 2008

1QDL

38.4%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP00440
(show subtarget assignments)

1

purified

No

YPO2208

16122436

trpE

anthranilate synthase component I

521

Conserved Gene / Pathway

Phase 2: March 2008

1I7Q

79.7%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP00350
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1633

16803673

trpE

anthranilate synthase component I

454

Drug Target Function

Phase 2: March 2008

1QDL

35.7%

Listeria monocytogenes

Amino acid biosynthesis

Aromatic amino acid family

IDP00342
(show subtarget assignments)

1

cloned

No

FTT1802c

56708788

trpE

anthranilate synthase component I

514

Drug Target Function

Phase 2: March 2008

1I1Q

51.1%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP00799
(show subtarget assignments)

1

expressed

No

SACOL1403

57284557

trpE

anthranilate synthase component I

468

Drug Target Function

Phase 2: March 2008

1QDL

33.3%

Staphylococcus aureus

Amino acid biosynthesis

Aromatic amino acid family

IDP01413
(show subtarget assignments)

1

purified

No

VC1174

15641187

anthranilate synthase component I

523

Drug Target Function

Phase 2: March 2008

1I1Q

59.3%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP00316
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1152

29654458

trpE

anthranilate synthase component I

463

Drug Target Function

Phase 2: March 2008

1QDL

34.3%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP91232
(show subtarget assignments)

8

expressed

No

NT04EC1776

26107995

trpE

Anthranilate synthase component I [Esche...

520

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

89.6%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP00441
(show subtarget assignments)

1

expressed

No

YPO2207

16122435

trpG

anthranilate synthase component II

192

Drug Target Function

Phase 2: March 2008

1I7Q

87.5%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP00337
(show subtarget assignments)

1

expressed

No

FTT0946

56708043

trpG

anthranilate synthase component II

184

Drug Target Function

Phase 2: March 2008

1QDL

40.7%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP00322
(show subtarget assignments)

1

expressed

No

Cj0346

15791714

trpD

anthranilate synthase component II

533

Drug Target Function

Phase 2: March 2008

1VQU

20.6%

Campylobacter jejuni

Amino acid biosynthesis

Aromatic amino acid family

IDP01512
(show subtarget assignments)

1

soluble

No

VC1173

15641186

anthranilate synthase component II

203

Drug Target Function

Phase 2: March 2008

1I1Q

57.1%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP91233
(show subtarget assignments)

8

expressed

No

NT04EC1775

26107994

trpD

Anthranilate synthase component II [Esch...

531

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

47.3%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP91286
(show subtarget assignments)

8

expressed

No

SPA1154

56413352

trpE

anthranilate synthase component I [Salmo...

520

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

99%

Salmonella enterica

IDP91223
(show subtarget assignments)

8

purified

No

SF1267

24112663

trpE

anthranilate synthase component I [Shige...

520

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

89.2%

Shigella flexneri

IDP91238
(show subtarget assignments)

8

cloned

No

HP1282

2314448

anthranilate synthase component I (trpE)...

500

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

46.8%

Helicobacter pylori

Amino acid biosynthesis: Aromatic amino acid family

IDP00847
(show subtarget assignments)

1

expressed

No

SACOL1404

57284558

trpG

anthranilate synthase, glutamine amidotr...

188

Drug Target Function

Phase 2: March 2008

1QDL

34.2%

Staphylococcus aureus

Amino acid biosynthesis

Aromatic amino acid family