Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP90946 (show subtarget assignments)	8	cloned	No	BP1878	33592926	bvgA	virulence factors transcription regulato...	209	BvgA is the transcriptional activator for all known virulence genes in the human...	Community Requests	3C3W	31.6%	Bordetella pertussis

IDP91219 (show subtarget assignments)	1	cloned	No	SAOUHSC_01359	110810462		RecName: Full=Phosphatidylglycerol lysyl...	840	virulence/pathogenesis / Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound...	Community Requests			Staphylococcus aureus

IDP90189 (show subtarget assignments)	8	cloned	No	AAM13616.1	20153155	CPXV175 CDS	CPXV175 protein	277	CD47-like putative membrane protein	Community Requests	2JJS	13%	Cowpox virus	host defense modulator	0

IDP90212 (show subtarget assignments)	8	cloned	No	MYXV_gp067	9633699	m063R	m063R, m63R	215	CD47-like	Community Requests			Myxoma virus	host range factor, host defense modulator	0

IDP01643 (show subtarget assignments)	1	crystallized	No	YPO2892	16123083	hscA	chaperone protein HscA [Yersinia pestis ...	650	CD; Drug target functions	Phase 3: June 2008	2KHO	37.8%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP02636 (show subtarget assignments)	1	expressed	No	YPO3722	16123860	metH	B12-dependent methionine synthase [Yersi...	1231	CD; Drug target functions	Phase 3: June 2008	1K7Y	40.1%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP02460 (show subtarget assignments)	1	cloned	No	YPO1675	16121939	cheD	methyl-accepting chemotaxis protein [Yer...	557	CD; Drug target functions	Phase 3: June 2008	3ZX6	43.3%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP02339 (show subtarget assignments)	1	expressed	No	YPO2647	16122856	proV	glycine betaine/L-proline transport ATP-...	399	CD; Drug target functions	Phase 3: June 2008	3FVQ	25.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP90967 (show subtarget assignments)	8	cloned	No	UTI89_C2819	122422922		Hypothetical protein yfgF	747	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3HVB	14.2%	Escherichia coli

IDP90965 (show subtarget assignments)	8	purified	No	VF0094	75354809		Sensory box/GGDEF family protein	852	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3PJW	11.2%	Vibrio fischeri

IDP90966 (show subtarget assignments)	8	purified	No	UTI89_C3683	122422243		Hypothetical protein yhdA	646	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3HVB	15.8%	Escherichia coli

IDP90958 (show subtarget assignments)	8	cloned	No	UTI89_C1702	122423767		Hypothetical protein	807	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	1V9Y	18%	Escherichia coli

IDP90959 (show subtarget assignments)	8	cloned	No	PP2258	81441302		Sensory box protein	562	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	2R6O	20.6%	Pseudomonas putida

IDP90956 (show subtarget assignments)	8	cloned	No	UTI89_C1558	122423881		Hypothetical protein yciR	661	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3HVB	15.9%	Escherichia coli

IDP90957 (show subtarget assignments)	8	cloned	No	PFL_1902	123656875		Sensory box-containing diguanylate cycla...	572	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3PJW	18.4%	Pseudomonas fluorescens

IDP90960 (show subtarget assignments)	8	expressed	No	VC0658	81545351		C-di-GMP phosphodiesterase A-related pro...	685	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3PJW	18.7%	Vibrio cholerae

IDP90953 (show subtarget assignments)	8	expressed	No	VF0985	75354249		Sensory box/GGDEF family protein	827	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3HVB	12.1%	Vibrio fischeri

IDP90952 (show subtarget assignments)	8	soluble	No	UTI89_C2726	122422986		Hypothetical protein yfeA	749	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3PJW	13.4%	Escherichia coli

IDP90954 (show subtarget assignments)	8	purified	No	UTI89_C4061	122421980		Hypothetical protein yhjK	662	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3PJW	16.2%	Escherichia coli

IDP90951 (show subtarget assignments)	8	purified	No	VC0653	81545356		C-di-GMP phosphodiesterase A-related pro...	684	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3PJW	15.5%	Vibrio cholerae

IDP90955 (show subtarget assignments)	8	purified	No	PA14_07500	122261554		Hypothetical protein	1245	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	2R6O	10.6%	Pseudomonas aeruginosa

IDP90961 (show subtarget assignments)	8	purified	No	VP0117	81728759		GGDEF family protein	848	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3PJW	12.3%	Vibrio parahaemolyticus

IDP90945 (show subtarget assignments)	8	purified	No	VP0092	28896866		hypothetical protein VP0092 [Vibrio para...	811	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3HVB	13.7%	Vibrio parahaemolyticus

IDP90962 (show subtarget assignments)	8	purified	No	VC2750	81544306		GGDEF family protein	849	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	2R6O	13%	Vibrio cholerae

IDP90963 (show subtarget assignments)	8	cloned	No	VP2446	81727013		C-di-GMP phosphodiesterase A-related pro...	679	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3PJW	15.5%	Vibrio parahaemolyticus

IDP90964 (show subtarget assignments)	8	purified	No	VC0072	81545617		Sensory box/GGDEF family protein	768	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3PJW	15.4%	Vibrio cholerae

IDP01669 (show subtarget assignments)	1	cloned	No	YPO3048	16123225		ABC transporter ATP-binding protein [Yer...	356	CD; Involved in virulence; Drug target functions	Phase 3: June 2008	1Z47	36.8%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01648 (show subtarget assignments)	1	cloned	No	YPO2944	16123127		putative pili chaperone protein [Yersini...	259	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	32.8%	Yersinia pestis	Cell envelope	Surface structures

IDP02503 (show subtarget assignments)	1	cloned	No	YPO2502	16122723	gutB	putative zinc-binding dehydrogenase [Yer...	408	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	2D8A	30.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Chlorophyll and bacteriochlorphyll

IDP02464 (show subtarget assignments)	1	cloned	No	YPO1708	16121968		putative chaperone protein [Yersinia pes...	259	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	33.2%	Yersinia pestis	Cell envelope	Surface structures

IDP02064 (show subtarget assignments)	1	cloned	No	YPO3878	16124011		putative fimbrial chaperone [Yersinia pe...	243	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	32.5%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP01665 (show subtarget assignments)	1	soluble	No	YPO3001	16123182		putative pyridine nucleotide-disulphide ...	548	CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...	Phase 3: June 2008	3ICR	58%	Yersinia pestis	Cellular processes	Detoxification

IDP01602 (show subtarget assignments)	1	expressed	No	YPO2288	16122512	amn	AMP nucleosidase [Yersinia pestis CO92]	546	CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...	Phase 3: June 2008	1T8R	63.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP90225 (show subtarget assignments)	8	in_pdb 3K29	No	CT670	3329121		Hypothetical	168	Chlamydia type III secretion associated protein CT670	Community Requests	3K29	100%	Chlamydia trachomatis

IDP91785 (show subtarget assignments)	8	purified	No	ABQ00063	145974708	cfr	Cfr [Staphylococcus aureus]	349	drug resistance / Chloramphenicol-florfenicol resistance protein	Community Requests	3RF9	33.5%	Staphylococcus aureus

IDP90003 (show subtarget assignments)	8	crystallized	No	FTT1103	56708183		conserved hypothetical lipoprotein	365	(Community Request)	Community Requests	3GYK	12.3%	Francisella tularensis

IDP92247 (show subtarget assignments)	8	selected	No	ABA71730	77380198	vanWG	VanWG [Enterococcus faecalis]	281	drug resistance / Community-requested targets (Patrice Courvalin, Pasteur Institute). Gene is foun...	Community Requests			Enterococcus faecalis

IDP92246 (show subtarget assignments)	8	selected	No	EF_2296	2499116		RecName: Full=Vancomycin B-type resistan...	275	drug resistance / Community-requested targets (Patrice Courvalin, Pasteur Institute). Gene is foun...	Community Requests			Enterococcus faecalis

IDP90293 (show subtarget assignments)	8	in_pdb 3OTR	No	TGME49_068860	211963243		enolase 1 [Toxoplasma gondii ME49]	444	Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...	Community Requests	3OTR	100%	Toxoplasma gondii

IDP90296 (show subtarget assignments)	8	purified	No	TGME49_068850	211963242		enolase 2 [Toxoplasma gondii ME49]	475	Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...	Community Requests	3OTR	68.8%	Toxoplasma gondii

IDP91047 (show subtarget assignments)	8	in_crystallization_trials	No	EFA0003	5353563	vanRD	response regulator [Enterococcus faecium...	232	drug resistance / Component of regulatory system of transcription of vancomycin resistance genes	Community Requests	2GWR	37.1%	Enterococcus faecium

IDP91043 (show subtarget assignments)	8	in_crystallization_trials	No	EFE0003	33355848	vanRG	response regulator [Enterococcus faecali...	235	drug resistance / Component of regulatory system of transcription of vancomycin resistance genes	Community Requests	1P2F	37%	Enterococcus faecalis

IDP91869 (show subtarget assignments)	8	in_pdb 4E8O	No	AAC41391	547387	aac(6')-Ih	aac(6')-Ih [Acinetobacter baumannii]	146	drug resistance / confers resistance to aminoglycoside antibiotics by acetylation	Community Requests	4E8O	100%	Acinetobacter baumannii

IDP91868 (show subtarget assignments)	8	in_pdb 4F0Y 4EVY	No	AAA21889	455437	aac(6')-Ig	aminoglycoside 6'-N-acetyltransferase [A...	145	drug resistance / confers resistance to aminoglycoside antibiotics by acetylation	Community Requests	4EVY	100%	Acinetobacter haemolyticus

IDP91870 (show subtarget assignments)	8	selected	No	CAA30578	38663		unnamed protein product [Acinetobacter b...	259	drug resistance / confers resistance to aminoglycoside antibiotics by phosphorylation	Community Requests	2BKK	34.4%	Acinetobacter baumannii

IDP91871 (show subtarget assignments)	8	selected	No	AAB05624	1209528	vanYB	D,D-carboxypeptidase [Enterococcus faeca...	268	drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...	Community Requests			Enterococcus faecalis

IDP91872 (show subtarget assignments)	8	selected	No	ACM47285	222159812	vanYD	D,D-carboxypeptidase VanYD [Enterococcus...	363	drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...	Community Requests	1ES4	24%	Enterococcus faecium

IDP91649 (show subtarget assignments)	8	cloned	No	NP_217311	15609932		hypothetical protein Rv2795c [Mycobacter...	324	drug target / Confirmed essential by targeted genetic disruption and complementation studies, ...	Community Requests			Mycobacterium tuberculosis

IDP01670 (show subtarget assignments)	1	cloned	No	GBAA0156	47525414		hypothetical protein GBAA0156 [Bacillus ...	496	Conserved;	Phase 3: June 2008	2KQ1	6.7%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02799 (show subtarget assignments)	1	cloned	No	GBAA4787	47778326		hypothetical protein GBAA4787 [Bacillus ...	885	Conserved;	Phase 3: June 2008	3SIK	7.6%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02534 (show subtarget assignments)	1	cloned	No	GBAA4614	47529912		Holliday junction resolvase-like protein...	137	Conserved;	Phase 3: June 2008	1VHX	70.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02513 (show subtarget assignments)	1	soluble	No	GBAA0258	47525517		hypothetical protein GBAA0258 [Bacillus ...	157	Conserved;	Phase 3: June 2008	1FL9	30.6%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02267 (show subtarget assignments)	1	soluble	No	GBAA0987	47526266		hypothetical protein GBAA0987 [Bacillus ...	66	Conserved;	Phase 3: June 2008			Bacillus anthracis	Hypothetical proteins	Conserved

IDP01874 (show subtarget assignments)	1	cloned	No	GBAA0062	47525316		hypothetical protein GBAA0062 [Bacillus ...	476	Conserved;	Phase 3: June 2008	3A2K	46.6%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01616 (show subtarget assignments)	1	in_pdb 3EG7	No	VC_A0947	9658384		spermidine n1-acetyltransferase [Vibrio ...	173	CONSERVED	Phase 3: June 2008	3EG7	100%	Vibrio cholerae	N/A	N/A

IDP01540 (show subtarget assignments)	1	in_pdb 3EC6	No	GBAA0418	47525694		general stress protein 26 [Bacillus anth...	138	CONSERVED	Phase 3: June 2008	3EC6	100%	Bacillus anthracis

IDP01725 (show subtarget assignments)	0	work_stopped	No	GBAA2534	47527824		acetyltransferase [Bacillus anthracis st...	168	CONSERVED	Phase 3: June 2008	3FBU	100%	Bacillus anthracis	N/A	N/A

IDP01712 (show subtarget assignments)	1	in_pdb 3EFE	No	GBAA2657	47551781		thiJ/pfpI family protein [Bacillus anthr...	210	CONSERVED	Phase 3: June 2008	3EFE	100%	Bacillus anthracis	N/A	N/A

IDP02040 (show subtarget assignments)	1	expressed	No	GBAA4637	47529935	relA	GTP pyrophosphokinase [Bacillus anthraci...	727	CONSERVED. Additional information: It is responsible for a down-regulation of RN...	Phase 3: June 2008	1VJ7	31.2%	Bacillus anthracis	Cellular processes: Adaptations to atypical conditions	N/A

IDP01671 (show subtarget assignments)	1	cloned	No	YPO3012	16123191	cysA	sulfate/thiosulfate transporter subunit ...	363	Conserved; CD; Drug target functions	Phase 3: June 2008	1Z47	39.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00099 (show subtarget assignments)	0	work_stopped	No	NT02SF1983	30041448	ynhD	putative ATP-binding component of a tran...	248	Conserved; CD; Drug target functions	Phase 1: October 2007	2D3W	99.6%	Shigella flexneri	Transport and binding proteins	Unknown substrate

IDP02593 (show subtarget assignments)	1	expressed	No	YPO3426	16123575	hofB	hypothetical protein YPO3426 [Yersinia p...	512	Conserved; CD; Drug target functions	Phase 3: June 2008	1P9R	34.2%	Yersinia pestis	Cell envelope	Surface structures

IDP02559 (show subtarget assignments)	1	cloned	No	YPO3325	16123478	dmsA	anaerobic dimethyl sulfoxide reductase c...	816	Conserved; CD; Drug target functions	Phase 3: June 2008	1E60	28.7%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02491 (show subtarget assignments)	1	cloned	No	YPO1811	16122063		short chain dehydrogenase [Yersinia pest...	688	Conserved; CD; Drug target functions	Phase 3: June 2008	3U0B	14.8%	Yersinia pestis	Central intermediary metabolism	Other

IDP02422 (show subtarget assignments)	1	cloned	No	YPO1666	16121930	cheA	chemotaxis protein CheA [Yersinia pestis...	723	Conserved; CD; Drug target functions	Phase 3: June 2008	1B3Q	22.7%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP02400 (show subtarget assignments)	1	purified	No	YPO3454	16123600	nrdD	anaerobic ribonucleoside triphosphate re...	712	Conserved; CD; Drug target functions	Phase 3: June 2008	1H78	48.2%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP02394 (show subtarget assignments)	1	cloned	No	YPO1633	16121901	phoQ	sensor protein PhoQ [Yersinia pestis CO9...	484	Conserved; CD; Drug target functions	Phase 3: June 2008	1ID0	20.9%	Yersinia pestis	Regulatory functions	Other

IDP02238 (show subtarget assignments)	1	expressed	No	YPO0815	16121126		general secretion pathway protein E [Yer...	503	Conserved; CD; Drug target functions	Phase 3: June 2008	1P9R	48.3%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP02155 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0239	16120577	trkA	potassium transporter peripheral membran...	458	Conserved; CD; Drug target functions	Phase 3: June 2008	1LSS	12.2%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP02039 (show subtarget assignments)	1	expressed	No	YPO1198	16121491		putative ABC transport ATP-binding subun...	312	Conserved; CD; Drug target functions	Phase 3: June 2008	1V43	34%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01778 (show subtarget assignments)	1	cloned	No	YPO3689	16123828		putative ribonuclease [Yersinia pestis C...	152	Conserved; CD; Drug target functions	Phase 3: June 2008	1BNE	42.1%	Yersinia pestis	Transcription	Degradation of RNA

IDP01757 (show subtarget assignments)	1	purified	No	YPO3509	16123655	obgE	GTPase ObgE [Yersinia pestis CO92]	390	Conserved; CD; Drug target functions	Phase 3: June 2008	1LNZ	40.8%	Yersinia pestis	Unknown function	General

IDP01763 (show subtarget assignments)	1	cloned	No	YPO3627	16123769	ssuB	aliphatic sulfonates transport ATP-bindi...	271	Conserved; CD; Drug target functions	Phase 3: June 2008	2IT1	35.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP02581 (show subtarget assignments)	1	purified	No	YPO3372	16123521	cysJ	sulfite reductase subunit alpha [Yersini...	606	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	1DDG	47.9%	Yersinia pestis	Central intermediary metabolism	Sulfur metabolism

IDP02281 (show subtarget assignments)	1	cloned	No	YPO1305	16121587	psaC	outer membrane usher protein PsaC precur...	837	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	3RFZ	36.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP02086 (show subtarget assignments)	1	cloned	No	YPO3557	161486860	gltB	glutamate synthase subunit alpha [Yersin...	1538	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	1EA0	45%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP01991 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0108	16120455	cytR	DNA-binding transcriptional regulator Cy...	342	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	3OQO	35.7%	Yersinia pestis	Regulatory functions	Other

IDP02003 (show subtarget assignments)	1	cloned	No	YPO0190	16120529		glutathione-regulated potassium-efflux s...	183	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	3EYW	38.3%	Yersinia pestis	Energy metabolism	Electron transport

IDP00226 (show subtarget assignments)	1	soluble	No	YPO3938	16124066	glgP	glycogen phosphorylase	815	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 1: October 2007	1EM6	49.9%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02700 (show subtarget assignments)	1	cloned	No	YPO3419	16123568	aceE	pyruvate dehydrogenase subunit E1 [Yersi...	887	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1L8A	89.1%	Yersinia pestis	Energy metabolism	Pyruvate dehydrogenase

IDP02688 (show subtarget assignments)	0	work_stopped	No	YPO0921	16121226	pgk	phosphoglycerate kinase [Yersinia pestis...	387	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1ZMR	88.6%	Yersinia pestis	Energy metabolism	Glycolysis/gluconeogenesis

IDP01614 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2581	16122794		putative sugar-binding periplasmic prote...	309	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2IOY	29.5%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02650 (show subtarget assignments)	1	expressed	No	YPO3962	16124090		sugar-binding transport protein [Yersini...	314	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2IOY	34.7%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02638 (show subtarget assignments)	1	in_pdb 3LG3	No	YPO3725	16123862	aceA	isocitrate lyase [Yersinia pestis CO92]	435	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3LG3	100%	Yersinia pestis	Energy metabolism	TCA cycle

IDP02550 (show subtarget assignments)	1	in_pdb 3RF0	Yes	YPO2837	16123032	ppx	exopolyphosphatase [Yersinia pestis CO92...	519	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1U6Z	76.3%	Yersinia pestis	Central intermediary metabolism	Phosphorus compounds

IDP02539 (show subtarget assignments)	1	cloned	No	YPO3200	16123361	malZ	maltodextrin glucosidase [Yersinia pesti...	609	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1EA9	33.5%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP02536 (show subtarget assignments)	1	in_pdb 3KUU	No	YPO3076	16123253	purE	phosphoribosylaminoimidazole carboxylase...	174	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3KUU	99.4%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02449 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1775	16122029	purT	phosphoribosylglycinamide formyltransfer...	393	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1EYZ	78.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02445 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3411	16123560	speE	spermidine synthase [Yersinia pestis CO9...	296	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3ADN	78%	Yersinia pestis	Central intermediary metabolism	Polyamine biosynthesis

IDP02355 (show subtarget assignments)	1	in_pdb 3JTJ	Yes	YPO1400	16121680	kdsB	3-deoxy-manno-octulosonate cytidylyltran...	250	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3JTJ	100%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02336 (show subtarget assignments)	1	expressed	No	YPO2533	16122751	edd	phosphogluconate dehydratase [Yersinia p...	625	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2GP4	63.8%	Yersinia pestis	Energy metabolism	Entner-Doudoroff

IDP02350 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2977	16123158	glk	glucokinase [Yersinia pestis CO92]	323	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1Q18	78.6%	Yersinia pestis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02353 (show subtarget assignments)	1	soluble	No	YPO1374	16121654	trxB	thioredoxin reductase [Yersinia pestis C...	320	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1CL0	85%	Yersinia pestis	Energy metabolism	Electron transport

IDP02274 (show subtarget assignments)	1	in_pdb 3IJ5	Yes	YPO3578	16123722		3-deoxy-D-manno-octulosonate 8-phosphate...	187	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3IJ5	100%	Yersinia pestis	Hypothetical proteins	Conserved

IDP02223 (show subtarget assignments)	1	expressed	No	YPO0550	16120878	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	490	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1E8C	76.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02203 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0442	16120773	serB	phosphoserine phosphatase [Yersinia pest...	326	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3N28	46.3%	Yersinia pestis	Amino acid biosynthesis	Serine family

IDP02197 (show subtarget assignments)	1	cloned	No	YPO0405	16120739		putative phosphoenolpyruvate-protein pho...	852	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2KX9	24.6%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02220 (show subtarget assignments)	1	cloned	No	YPO2221	16122450	acnA	aconitate hydratase [Yersinia pestis CO9...	890	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3SN2	52.2%	Yersinia pestis	Energy metabolism	TCA cycle

IDP02201 (show subtarget assignments)	1	soluble	No	YPO0461	16120790	thrC	threonine synthase [Yersinia pestis CO92...	429	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1VB3	82.3%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP02190 (show subtarget assignments)	1	expressed	No	YPO0360	16120695	frdA	fumarate reductase flavoprotein subunit ...	607	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1KF6	85.2%	Yersinia pestis	Energy metabolism	Anaerobic

IDP90946
(show subtarget assignments)

8

cloned

No

BP1878

33592926

bvgA

virulence factors transcription regulato...

209

BvgA is the transcriptional activator for all known virulence genes in the human...

Community Requests

3C3W

31.6%

Bordetella pertussis

IDP91219
(show subtarget assignments)

1

cloned

No

SAOUHSC_01359

110810462

RecName: Full=Phosphatidylglycerol lysyl...

840

virulence/pathogenesis / Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound...

Community Requests

Staphylococcus aureus

IDP90189
(show subtarget assignments)

8

cloned

No

AAM13616.1

20153155

CPXV175 CDS

CPXV175 protein

277

CD47-like putative membrane protein

Community Requests

2JJS

13%

Cowpox virus

host defense modulator

0

IDP90212
(show subtarget assignments)

8

cloned

No

MYXV_gp067

9633699

m063R

m063R, m63R

215

CD47-like

Community Requests

Myxoma virus

host range factor, host defense modulator

0

IDP01643
(show subtarget assignments)

1

crystallized

No

YPO2892

16123083

hscA

chaperone protein HscA [Yersinia pestis ...

650

CD; Drug target functions

Phase 3: June 2008

2KHO

37.8%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP02636
(show subtarget assignments)

1

expressed

No

YPO3722

16123860

metH

B12-dependent methionine synthase [Yersi...

1231

CD; Drug target functions

Phase 3: June 2008

1K7Y

40.1%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP02460
(show subtarget assignments)

1

cloned

No

YPO1675

16121939

cheD

methyl-accepting chemotaxis protein [Yer...

557

CD; Drug target functions

Phase 3: June 2008

3ZX6

43.3%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP02339
(show subtarget assignments)

1

expressed

No

YPO2647

16122856

proV

glycine betaine/L-proline transport ATP-...

399

CD; Drug target functions

Phase 3: June 2008

3FVQ

25.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP90967
(show subtarget assignments)

8

cloned

No

UTI89_C2819

122422922

Hypothetical protein yfgF

747

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3HVB

14.2%

Escherichia coli

IDP90965
(show subtarget assignments)

8

purified

No

VF0094

75354809

Sensory box/GGDEF family protein

852

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3PJW

11.2%

Vibrio fischeri

IDP90966
(show subtarget assignments)

8

purified

No

UTI89_C3683

122422243

Hypothetical protein yhdA

646

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3HVB

15.8%

Escherichia coli

IDP90958
(show subtarget assignments)

8

cloned

No

UTI89_C1702

122423767

Hypothetical protein

807

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

1V9Y

18%

Escherichia coli

IDP90959
(show subtarget assignments)

8

cloned

No

PP2258

81441302

Sensory box protein

562

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

2R6O

20.6%

Pseudomonas putida

IDP90956
(show subtarget assignments)

8

cloned

No

UTI89_C1558

122423881

Hypothetical protein yciR

661

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3HVB

15.9%

Escherichia coli

IDP90957
(show subtarget assignments)

8

cloned

No

PFL_1902

123656875

Sensory box-containing diguanylate cycla...

572

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3PJW

18.4%

Pseudomonas fluorescens

IDP90960
(show subtarget assignments)

8

expressed

No

VC0658

81545351

C-di-GMP phosphodiesterase A-related pro...

685

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3PJW

18.7%

Vibrio cholerae

IDP90953
(show subtarget assignments)

8

expressed

No

VF0985

75354249

Sensory box/GGDEF family protein

827

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3HVB

12.1%

Vibrio fischeri

IDP90952
(show subtarget assignments)

8

soluble

No

UTI89_C2726

122422986

Hypothetical protein yfeA

749

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3PJW

13.4%

Escherichia coli

IDP90954
(show subtarget assignments)

8

purified

No

UTI89_C4061

122421980

Hypothetical protein yhjK

662

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3PJW

16.2%

Escherichia coli

IDP90951
(show subtarget assignments)

8

purified

No

VC0653

81545356

C-di-GMP phosphodiesterase A-related pro...

684

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3PJW

15.5%

Vibrio cholerae

IDP90955
(show subtarget assignments)

8

purified

No

PA14_07500

122261554

Hypothetical protein

1245

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

2R6O

10.6%

Pseudomonas aeruginosa

IDP90961
(show subtarget assignments)

8

purified

No

VP0117

81728759

GGDEF family protein

848

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3PJW

12.3%

Vibrio parahaemolyticus

IDP90945
(show subtarget assignments)

8

purified

No

VP0092

28896866

hypothetical protein VP0092 [Vibrio para...

811

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3HVB

13.7%

Vibrio parahaemolyticus

IDP90962
(show subtarget assignments)

8

purified

No

VC2750

81544306

GGDEF family protein

849

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

2R6O

13%

Vibrio cholerae

IDP90963
(show subtarget assignments)

8

cloned

No

VP2446

81727013

C-di-GMP phosphodiesterase A-related pro...

679

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3PJW

15.5%

Vibrio parahaemolyticus

IDP90964
(show subtarget assignments)

8

purified

No

VC0072

81545617

Sensory box/GGDEF family protein

768

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3PJW

15.4%

Vibrio cholerae

IDP01669
(show subtarget assignments)

1

cloned

No

YPO3048

16123225

ABC transporter ATP-binding protein [Yer...

356

CD; Involved in virulence; Drug target functions

Phase 3: June 2008

1Z47

36.8%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01648
(show subtarget assignments)

1

cloned

No

YPO2944

16123127

putative pili chaperone protein [Yersini...

259

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

32.8%

Yersinia pestis

Cell envelope

Surface structures

IDP02503
(show subtarget assignments)

1

cloned

No

YPO2502

16122723

gutB

putative zinc-binding dehydrogenase [Yer...

408

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

2D8A

30.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Chlorophyll and bacteriochlorphyll

IDP02464
(show subtarget assignments)

1

cloned

No

YPO1708

16121968

putative chaperone protein [Yersinia pes...

259

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

33.2%

Yersinia pestis

Cell envelope

Surface structures

IDP02064
(show subtarget assignments)

1

cloned

No

YPO3878

16124011

putative fimbrial chaperone [Yersinia pe...

243

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

32.5%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP01665
(show subtarget assignments)

1

soluble

No

YPO3001

16123182

putative pyridine nucleotide-disulphide ...

548

CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...

Phase 3: June 2008

3ICR

58%

Yersinia pestis

Cellular processes

Detoxification

IDP01602
(show subtarget assignments)

1

expressed

No

YPO2288

16122512

amn

AMP nucleosidase [Yersinia pestis CO92]

546

CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...

Phase 3: June 2008

1T8R

63.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP90225
(show subtarget assignments)

8

in_pdb
3K29

No

CT670

3329121

Hypothetical

168

Chlamydia type III secretion associated protein CT670

Community Requests

3K29

100%

Chlamydia trachomatis

IDP91785
(show subtarget assignments)

8

purified

No

ABQ00063

145974708

cfr

Cfr [Staphylococcus aureus]

349

drug resistance / Chloramphenicol-florfenicol resistance protein

Community Requests

3RF9

33.5%

Staphylococcus aureus

IDP90003
(show subtarget assignments)

8

crystallized

No

FTT1103

56708183

conserved hypothetical lipoprotein

365

(Community Request)

Community Requests

3GYK

12.3%

Francisella tularensis

IDP92247
(show subtarget assignments)

8

selected

No

ABA71730

77380198

vanWG

VanWG [Enterococcus faecalis]

281

drug resistance / Community-requested targets (Patrice Courvalin, Pasteur Institute). Gene is foun...

Community Requests

Enterococcus faecalis

IDP92246
(show subtarget assignments)

8

selected

No

EF_2296

2499116

RecName: Full=Vancomycin B-type resistan...

275

drug resistance / Community-requested targets (Patrice Courvalin, Pasteur Institute). Gene is foun...

Community Requests

Enterococcus faecalis

IDP90293
(show subtarget assignments)

8

in_pdb
3OTR

No

TGME49_068860

211963243

enolase 1 [Toxoplasma gondii ME49]

444

Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...

Community Requests

3OTR

100%

Toxoplasma gondii

IDP90296
(show subtarget assignments)

8

purified

No

TGME49_068850

211963242

enolase 2 [Toxoplasma gondii ME49]

475

Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...

Community Requests

3OTR

68.8%

Toxoplasma gondii

IDP91047
(show subtarget assignments)

8

in_crystallization_trials

No

EFA0003

5353563

vanRD

response regulator [Enterococcus faecium...

232

drug resistance / Component of regulatory system of transcription of vancomycin resistance genes

Community Requests

2GWR

37.1%

Enterococcus faecium

IDP91043
(show subtarget assignments)

8

in_crystallization_trials

No

EFE0003

33355848

vanRG

response regulator [Enterococcus faecali...

235

drug resistance / Component of regulatory system of transcription of vancomycin resistance genes

Community Requests

1P2F

37%

Enterococcus faecalis

IDP91869
(show subtarget assignments)

8

in_pdb
4E8O

No

AAC41391

547387

aac(6')-Ih

aac(6')-Ih [Acinetobacter baumannii]

146

drug resistance / confers resistance to aminoglycoside antibiotics by acetylation

Community Requests

4E8O

100%

Acinetobacter baumannii

IDP91868
(show subtarget assignments)

8

in_pdb
4F0Y
4EVY

No

AAA21889

455437

aac(6')-Ig

aminoglycoside 6'-N-acetyltransferase [A...

145

drug resistance / confers resistance to aminoglycoside antibiotics by acetylation

Community Requests

4EVY

100%

Acinetobacter haemolyticus

IDP91870
(show subtarget assignments)

8

selected

No

CAA30578

38663

unnamed protein product [Acinetobacter b...

259

drug resistance / confers resistance to aminoglycoside antibiotics by phosphorylation

Community Requests

2BKK

34.4%

Acinetobacter baumannii

IDP91871
(show subtarget assignments)

8

selected

No

AAB05624

1209528

vanYB

D,D-carboxypeptidase [Enterococcus faeca...

268

drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...

Community Requests

Enterococcus faecalis

IDP91872
(show subtarget assignments)

8

selected

No

ACM47285

222159812

vanYD

D,D-carboxypeptidase VanYD [Enterococcus...

363

drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...

Community Requests

1ES4

24%

Enterococcus faecium

IDP91649
(show subtarget assignments)

8

cloned

No

NP_217311

15609932

hypothetical protein Rv2795c [Mycobacter...

324

drug target / Confirmed essential by targeted genetic disruption and complementation studies, ...

Community Requests

Mycobacterium tuberculosis

IDP01670
(show subtarget assignments)

1

cloned

No

GBAA0156

47525414

hypothetical protein GBAA0156 [Bacillus ...

496

Conserved;

Phase 3: June 2008

2KQ1

6.7%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02799
(show subtarget assignments)

1

cloned

No

GBAA4787

47778326

hypothetical protein GBAA4787 [Bacillus ...

885

Conserved;

Phase 3: June 2008

3SIK

7.6%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02534
(show subtarget assignments)

1

cloned

No

GBAA4614

47529912

Holliday junction resolvase-like protein...

137

Conserved;

Phase 3: June 2008

1VHX

70.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02513
(show subtarget assignments)

1

soluble

No

GBAA0258

47525517

hypothetical protein GBAA0258 [Bacillus ...

157

Conserved;

Phase 3: June 2008

1FL9

30.6%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02267
(show subtarget assignments)

1

soluble

No

GBAA0987

47526266

hypothetical protein GBAA0987 [Bacillus ...

66

Conserved;

Phase 3: June 2008

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01874
(show subtarget assignments)

1

cloned

No

GBAA0062

47525316

hypothetical protein GBAA0062 [Bacillus ...

476

Conserved;

Phase 3: June 2008

3A2K

46.6%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01616
(show subtarget assignments)

1

in_pdb
3EG7

No

VC_A0947

9658384

spermidine n1-acetyltransferase [Vibrio ...

173

CONSERVED

Phase 3: June 2008

3EG7

100%

Vibrio cholerae

N/A

IDP01540
(show subtarget assignments)

1

in_pdb
3EC6

No

GBAA0418

47525694

general stress protein 26 [Bacillus anth...

138

CONSERVED

Phase 3: June 2008

3EC6

100%

Bacillus anthracis

IDP01725
(show subtarget assignments)

0

work_stopped

No

GBAA2534

47527824

acetyltransferase [Bacillus anthracis st...

168

CONSERVED

Phase 3: June 2008

3FBU

100%

Bacillus anthracis

N/A

IDP01712
(show subtarget assignments)

1

in_pdb
3EFE

No

GBAA2657

47551781

thiJ/pfpI family protein [Bacillus anthr...

210

CONSERVED

Phase 3: June 2008

3EFE

100%

Bacillus anthracis

N/A

IDP02040
(show subtarget assignments)

1

expressed

No

GBAA4637

47529935

relA

GTP pyrophosphokinase [Bacillus anthraci...

727

CONSERVED. Additional information: It is responsible for a down-regulation of RN...

Phase 3: June 2008

1VJ7

31.2%

Bacillus anthracis

Cellular processes: Adaptations to atypical conditions

N/A

IDP01671
(show subtarget assignments)

1

cloned

No

YPO3012

16123191

cysA

sulfate/thiosulfate transporter subunit ...

363

Conserved; CD; Drug target functions

Phase 3: June 2008

1Z47

39.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00099
(show subtarget assignments)

0

work_stopped

No

NT02SF1983

30041448

ynhD

putative ATP-binding component of a tran...

248

Conserved; CD; Drug target functions

Phase 1: October 2007

2D3W

99.6%

Shigella flexneri

Transport and binding proteins

Unknown substrate

IDP02593
(show subtarget assignments)

1

expressed

No

YPO3426

16123575

hofB

hypothetical protein YPO3426 [Yersinia p...

512

Conserved; CD; Drug target functions

Phase 3: June 2008

1P9R

34.2%

Yersinia pestis

Cell envelope

Surface structures

IDP02559
(show subtarget assignments)

1

cloned

No

YPO3325

16123478

dmsA

anaerobic dimethyl sulfoxide reductase c...

816

Conserved; CD; Drug target functions

Phase 3: June 2008

1E60

28.7%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02491
(show subtarget assignments)

1

cloned

No

YPO1811

16122063

short chain dehydrogenase [Yersinia pest...

688

Conserved; CD; Drug target functions

Phase 3: June 2008

3U0B

14.8%

Yersinia pestis

Central intermediary metabolism

Other

IDP02422
(show subtarget assignments)

1

cloned

No

YPO1666

16121930

cheA

chemotaxis protein CheA [Yersinia pestis...

723

Conserved; CD; Drug target functions

Phase 3: June 2008

1B3Q

22.7%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP02400
(show subtarget assignments)

1

purified

No

YPO3454

16123600

nrdD

anaerobic ribonucleoside triphosphate re...

712

Conserved; CD; Drug target functions

Phase 3: June 2008

1H78

48.2%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP02394
(show subtarget assignments)

1

cloned

No

YPO1633

16121901

phoQ

sensor protein PhoQ [Yersinia pestis CO9...

484

Conserved; CD; Drug target functions

Phase 3: June 2008

1ID0

20.9%

Yersinia pestis

Regulatory functions

Other

IDP02238
(show subtarget assignments)

1

expressed

No

YPO0815

16121126

general secretion pathway protein E [Yer...

503

Conserved; CD; Drug target functions

Phase 3: June 2008

1P9R

48.3%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP02155
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0239

16120577

trkA

potassium transporter peripheral membran...

458

Conserved; CD; Drug target functions

Phase 3: June 2008

1LSS

12.2%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP02039
(show subtarget assignments)

1

expressed

No

YPO1198

16121491

putative ABC transport ATP-binding subun...

312

Conserved; CD; Drug target functions

Phase 3: June 2008

1V43

34%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01778
(show subtarget assignments)

1

cloned

No

YPO3689

16123828

putative ribonuclease [Yersinia pestis C...

152

Conserved; CD; Drug target functions

Phase 3: June 2008

1BNE

42.1%

Yersinia pestis

Transcription

Degradation of RNA

IDP01757
(show subtarget assignments)

1

purified

No

YPO3509

16123655

obgE

GTPase ObgE [Yersinia pestis CO92]

390

Conserved; CD; Drug target functions

Phase 3: June 2008

1LNZ

40.8%

Yersinia pestis

Unknown function

General

IDP01763
(show subtarget assignments)

1

cloned

No

YPO3627

16123769

ssuB

aliphatic sulfonates transport ATP-bindi...

271

Conserved; CD; Drug target functions

Phase 3: June 2008

2IT1

35.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP02581
(show subtarget assignments)

1

purified

No

YPO3372

16123521

cysJ

sulfite reductase subunit alpha [Yersini...

606

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

1DDG

47.9%

Yersinia pestis

Central intermediary metabolism

Sulfur metabolism

IDP02281
(show subtarget assignments)

1

cloned

No

YPO1305

16121587

psaC

outer membrane usher protein PsaC precur...

837

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

3RFZ

36.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02086
(show subtarget assignments)

1

cloned

No

YPO3557

161486860

gltB

glutamate synthase subunit alpha [Yersin...

1538

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

1EA0

45%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP01991
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0108

16120455

cytR

DNA-binding transcriptional regulator Cy...

342

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

3OQO

35.7%

Yersinia pestis

Regulatory functions

Other

IDP02003
(show subtarget assignments)

1

cloned

No

YPO0190

16120529

glutathione-regulated potassium-efflux s...

183

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

3EYW

38.3%

Yersinia pestis

Energy metabolism

Electron transport

IDP00226
(show subtarget assignments)

1

soluble

No

YPO3938

16124066

glgP

glycogen phosphorylase

815

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 1: October 2007

1EM6

49.9%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02700
(show subtarget assignments)

1

cloned

No

YPO3419

16123568

aceE

pyruvate dehydrogenase subunit E1 [Yersi...

887

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1L8A

89.1%

Yersinia pestis

Energy metabolism

Pyruvate dehydrogenase

IDP02688
(show subtarget assignments)

0

work_stopped

No

YPO0921

16121226

pgk

phosphoglycerate kinase [Yersinia pestis...

387

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1ZMR

88.6%

Yersinia pestis

Energy metabolism

Glycolysis/gluconeogenesis

IDP01614
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2581

16122794

putative sugar-binding periplasmic prote...

309

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2IOY

29.5%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02650
(show subtarget assignments)

1

expressed

No

YPO3962

16124090

sugar-binding transport protein [Yersini...

314

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2IOY

34.7%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02638
(show subtarget assignments)

1

in_pdb
3LG3

No

YPO3725

16123862

aceA

isocitrate lyase [Yersinia pestis CO92]

435

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3LG3

100%

Yersinia pestis

Energy metabolism

TCA cycle

IDP02550
(show subtarget assignments)

1

in_pdb
3RF0

Yes

YPO2837

16123032

ppx

exopolyphosphatase [Yersinia pestis CO92...

519

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1U6Z

76.3%

Yersinia pestis

Central intermediary metabolism

Phosphorus compounds

IDP02539
(show subtarget assignments)

1

cloned

No

YPO3200

16123361

malZ

maltodextrin glucosidase [Yersinia pesti...

609

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1EA9

33.5%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP02536
(show subtarget assignments)

1

in_pdb
3KUU

No

YPO3076

16123253

purE

phosphoribosylaminoimidazole carboxylase...

174

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3KUU

99.4%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02449
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1775

16122029

purT

phosphoribosylglycinamide formyltransfer...

393

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1EYZ

78.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02445
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3411

16123560

speE

spermidine synthase [Yersinia pestis CO9...

296

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3ADN

78%

Yersinia pestis

Central intermediary metabolism

Polyamine biosynthesis

IDP02355
(show subtarget assignments)

1

in_pdb
3JTJ

Yes

YPO1400

16121680

kdsB

3-deoxy-manno-octulosonate cytidylyltran...

250

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3JTJ

100%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02336
(show subtarget assignments)

1

expressed

No

YPO2533

16122751

edd

phosphogluconate dehydratase [Yersinia p...

625

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2GP4

63.8%

Yersinia pestis

Energy metabolism

Entner-Doudoroff

IDP02350
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2977

16123158

glk

glucokinase [Yersinia pestis CO92]

323

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1Q18

78.6%

Yersinia pestis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02353
(show subtarget assignments)

1

soluble

No

YPO1374

16121654

trxB

thioredoxin reductase [Yersinia pestis C...

320

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1CL0

85%

Yersinia pestis

Energy metabolism

Electron transport

IDP02274
(show subtarget assignments)

1

in_pdb
3IJ5

Yes

YPO3578

16123722

3-deoxy-D-manno-octulosonate 8-phosphate...

187

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3IJ5

100%

Yersinia pestis

Hypothetical proteins

Conserved

IDP02223
(show subtarget assignments)

1

expressed

No

YPO0550

16120878

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

490

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1E8C

76.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02203
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0442

16120773

serB

phosphoserine phosphatase [Yersinia pest...

326

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3N28

46.3%

Yersinia pestis

Amino acid biosynthesis

Serine family

IDP02197
(show subtarget assignments)

1

cloned

No

YPO0405

16120739

putative phosphoenolpyruvate-protein pho...

852

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2KX9

24.6%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02220
(show subtarget assignments)

1

cloned

No

YPO2221

16122450

acnA

aconitate hydratase [Yersinia pestis CO9...

890

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3SN2

52.2%

Yersinia pestis

Energy metabolism

TCA cycle

IDP02201
(show subtarget assignments)

1

soluble

No

YPO0461

16120790

thrC

threonine synthase [Yersinia pestis CO92...

429

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1VB3

82.3%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP02190
(show subtarget assignments)

1

expressed

No

YPO0360

16120695

frdA

fumarate reductase flavoprotein subunit ...

607

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1KF6

85.2%

Yersinia pestis

Energy metabolism

Anaerobic

Targets