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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 7 of 60, showing 100 records out of 5973 total, starting on record 601
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP05229
(
show subtarget assignments
)
1
cloned
No
lmo1286
16803326
parE
DNA topoisomerase IV subunit B [Listeria...
655
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1EI1
29.8%
Listeria monocytogenes
DNA metabolism: DNA replication, recombination, and repair
IDP05059
(
show subtarget assignments
)
1
soluble
No
CD0690
126698269
putative nucleotide phosphodiesterase [C...
655
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3GVE
15.3%
Clostridium difficile
Unknown function: Enzymes of unknown specificity
IDP01170
(
show subtarget assignments
)
1
cloned
No
BA_0165
30253674
prolyl oligopeptidase family protein, pu...
654
Drug Target Function
Phase 2: March 2008
1Z68
11.6%
Bacillus anthracis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP91957
(
show subtarget assignments
)
8
selected
No
SpneCM_010100004917
298254940
oligopeptide-binding protein AliB [Strep...
653
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
1DPE
22.2%
Streptococcus pneumoniae
IDP01003
(
show subtarget assignments
)
1
cloned
No
STM2479
16765799
aegA
putative oxidoreductase Fe-S binding sub...
653
Conserved Gene / Pathway
Phase 2: March 2008
2VDC
29.2%
Salmonella enterica
Central intermediary metabolism
Other
IDP05639
(
show subtarget assignments
)
1
soluble
No
CD2713
126700327
cell surface protein [Clostridium diffic...
653
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2V04
14.4%
Clostridium difficile
Cell envelope: Other
IDP02156
(
show subtarget assignments
)
1
soluble
No
YPO0253
16120590
acs
acetyl-CoA synthetase [Yersinia pestis C...
652
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...
Phase 3: June 2008
2P2F
83.9%
Yersinia pestis
Central intermediary metabolism
Other
IDP00153
(
show subtarget assignments
)
1
expressed
No
VC0475
15640502
irgA
enterobactin receptor
652
Virulence
Phase 1: October 2007
2HDF
37.1%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP01643
(
show subtarget assignments
)
1
crystallized
No
YPO2892
16123083
hscA
chaperone protein HscA [Yersinia pestis ...
650
CD; Drug target functions
Phase 3: June 2008
2KHO
37.8%
Yersinia pestis
Protein fate
Protein folding and stabilization
IDP91523
(
show subtarget assignments
)
8
selected
No
TGME49_071960
237833085
hypothetical protein TGME49_071960 [Toxo...
650
virulence/pathogenesis /
Paralog of MIP1 (=MORN1 Interacting Protein 1 or MIP1; GI 237838237) and MLP1 (=...
Community Requests
Toxoplasma gondii
IDP04375
(
show subtarget assignments
)
1
expressed
No
VCA0211
15600980
sensory box sensor histidine kinase [Vib...
648
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3D36
9.7%
Vibrio cholerae
Regulatory functions
Other
IDP05751
(
show subtarget assignments
)
1
soluble
No
lmo0219
16802265
-
hypothetical protein lmo0219 [Listeria m...
648
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
3A2K
27.9%
Listeria monocytogenes
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
IDP01394
(
show subtarget assignments
)
1
soluble
No
VC0700
15640719
soluble lytic murein transglycosylase
648
Drug Target Function
Phase 2: March 2008
1QSA
33.8%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP90753
(
show subtarget assignments
)
8
crystallized
No
Cj0586
15791946
ligA
NAD-dependent DNA ligase LigA [Campyloba...
647
Predicted Essential
Community Requests
2OWO
40.7%
Campylobacter jejuni
IDP02184
(
show subtarget assignments
)
1
expressed
No
CBU_1352
29541917
ftsH
ATP-dependent metalloprotease FtsH [Coxi...
647
Conserved; Drug target functions
Phase 3: June 2008
2CE7
41.6%
Coxiella burnetii
Cellular processes
Cell division
IDP02827
(
show subtarget assignments
)
1
cloned
No
FTT1508c
56708546
relA
GTP pyrophosphokinase [Francisella tular...
647
Drug Target
Phase 3: June 2008
1VJ7
20.1%
Francisella tularensis
Cellular processes
Adaptations to atypical conditions
IDP90413
(
show subtarget assignments
)
8
cloned
No
CT_622
3329069
CHLPN 76kDa Homolog [Chlamydia trachomat...
647
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP92559
(
show subtarget assignments
)
8
selected
No
1MWR_A
24987837
Chain A, Structure Of Semet Penicillin B...
646
potential drug target /
Pptase, FactorXa, HCV NS3/NS4A, Trypsin and Elastase/Subtilisin (see below)] and...
Community Requests
1MWR
97.4%
Staphylococcus aureus
IDP90966
(
show subtarget assignments
)
8
purified
No
UTI89_C3683
122422243
Hypothetical protein yhdA
646
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3HVB
15.8%
Escherichia coli
IDP92117
(
show subtarget assignments
)
8
selected
No
TGME49_073410
237833291
tyrosyl-tRNA synthetase, putative [Toxop...
646
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1TYC
18.7%
Toxoplasma gondii
IDP02606
(
show subtarget assignments
)
1
in_crystallization_trials
No
lmo0006
16802054
gyrB
DNA gyrase subunit B [Listeria monocytog...
646
Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...
Phase 3: June 2008
1EI1
31.4%
Listeria monocytogenes
DNA metabolism
DNA replication, recombination, and repair
IDP91712
(
show subtarget assignments
)
8
selected
No
NP_006588
5729877
HSPA8
heat shock cognate 71 kDa protein isofor...
646
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3C7N
85.8%
Homo sapiens
IDP05076
(
show subtarget assignments
)
1
soluble
No
lmo0801
16802843
-
hypothetical protein lmo0801 [Listeria m...
646
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1M9S
22.1%
Listeria monocytogenes
Cellular processes: Pathogenesis
IDP05712
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS4472
49187467
-
threonyl-tRNA synthetase [Bacillus anthr...
645
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1NYQ
69.5%
Bacillus anthracis
Protein synthesis: tRNA aminoacylation
IDP90563
(
show subtarget assignments
)
8
soluble
No
VC0061
15640093
thiamine biosynthesis protein ThiC [Vibr...
645
Predicted Essential
Community Requests
3EPM
65%
Vibrio cholerae
IDP02575
(
show subtarget assignments
)
1
cloned
No
GBAA5123
47778366
glgB
glycogen branching enzyme [Bacillus anth...
645
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3K1D
43.4%
Bacillus anthracis
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP02605
(
show subtarget assignments
)
1
cloned
No
YPO3502
16123648
hflB
ATP-dependent metalloprotease [Yersinia ...
644
Drug target motif; Conserved; CD; Drug target functions
Phase 3: June 2008
2DHR
40.7%
Yersinia pestis
Cellular processes
Cell division
IDP92113
(
show subtarget assignments
)
8
selected
No
TGME49_118590
237841001
mrp protein, putative [Toxoplasma gondii...
644
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
3KB1
14%
Toxoplasma gondii
IDP00131
(
show subtarget assignments
)
0
work_stopped
No
NT01ST2113
16765046
rnb
exoribonuclease II
644
Essential
Phase 1: October 2007
2ID0
90.7%
Salmonella enterica
Transcription
Degradation of RNA
IDP05542
(
show subtarget assignments
)
1
cloned
No
Cj0508
6967973
pbpA
hypothetical protein Cj0504c [Campylobac...
643
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
3FWL
31.1%
Campylobacter jejuni
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP90301
(
show subtarget assignments
)
8
selected
No
TGME49_025290
211963866
nucleoside-triphosphatase, putative [Tox...
642
The T. gondii nucleoside triphosphate hydrolases (NTPase) are ecto ATPases with ...
Community Requests
3AGR
38.6%
Toxoplasma gondii
IDP02393
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT1269c
56708329
dnaK
heat shock protein DnaK [Francisella tul...
642
Conserved; Drug target functions
Phase 3: June 2008
2KHO
71.3%
Francisella tularensis
Protein fate
Protein folding and stabilization
IDP02248
(
show subtarget assignments
)
1
cloned
No
Cj0548
15791909
fliD
flagellar capping protein [Campylobacter...
642
Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066
Phase 3: June 2008
Campylobacter jejuni
Protein synthesis
tRNA aminoacylation
IDP90813
(
show subtarget assignments
)
8
in_crystallization_trials
No
VCA0287
15601053
threonyl-tRNA synthetase [Vibrio cholera...
642
Predicted Essential
Community Requests
1QF6
75.6%
Vibrio cholerae
IDP05543
(
show subtarget assignments
)
1
cloned
No
CD2628
126700242
hypothetical protein CD2628 [Clostridium...
642
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP90770
(
show subtarget assignments
)
8
soluble
No
YPO2433
16122654
thrS
threonyl-tRNA synthetase [Yersinia pesti...
642
Predicted Essential
Community Requests
1QF6
88.3%
Yersinia pestis
IDP00727
(
show subtarget assignments
)
1
cloned
No
SACOL2036
57284905
ABC transporter, ATP-binding protein
642
Conserved Gene / Pathway
Phase 2: March 2008
2IW3
24.1%
Staphylococcus aureus
Transport and binding proteins
Unknown substrate
IDP91789
(
show subtarget assignments
)
8
purified
No
TETS_LISMO
6094462
RecName: Full=Tetracycline resistance pr...
641
drug resistance /
Tetracycline resistance
Community Requests
1DAR
27.6%
Listeria monocytogenes
IDP00343
(
show subtarget assignments
)
1
expressed
No
lmo2235
16804274
hypothetical protein lmo2235
641
Drug Target Function
Phase 2: March 2008
3K30
29.4%
Listeria monocytogenes
Cellular processes
Detoxification
IDP04572
(
show subtarget assignments
)
1
soluble
No
BAS0005
49183044
DNA gyrase subunit B [Bacillus anthracis...
640
Proposed to be essential proteins
Phase 4: April 2009
1EI1
34.4%
Bacillus anthracis
IDP05080
(
show subtarget assignments
)
1
cloned
No
lmo1559
16803599
thrS
threonyl-tRNA synthetase [Listeria monoc...
640
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1NYQ
72%
Listeria monocytogenes
Protein synthesis: tRNA aminoacylation
IDP04449
(
show subtarget assignments
)
1
cloned
No
YPO0816
218927995
general secretion pathway protein D [Yer...
640
putative drug target function;
Phase 4: April 2009
3EZJ
15.6%
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP90348
(
show subtarget assignments
)
8
expressed
No
CT166
15604885
hypothetical protein CT166 [Chlamydia tr...
639
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3SRZ
15.6%
Chlamydia trachomatis
IDP00171
(
show subtarget assignments
)
1
cloned
No
YPO0452
16120781
-
putative soluble lytic murein transglyco...
639
Similar to Essential SALTY
Phase 1: October 2007
1QSA
61.8%
Yersinia pestis
Hypothetical proteins
Conserved
IDP05335
(
show subtarget assignments
)
1
expressed
No
BAS2222
49185231
-
threonyl-tRNA synthetase [Bacillus anthr...
639
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1NYQ
50.5%
Bacillus anthracis
Protein synthesis: tRNA aminoacylation
IDP91781
(
show subtarget assignments
)
8
purified
No
AAV80411
56155277
tetO
TetO [Enterococcus faecalis]
639
drug resistance /
Tetracycline resistance
Community Requests
1DAR
27.9%
Enterococcus faecalis
IDP91780
(
show subtarget assignments
)
8
cloned
No
CAA27977
48190
unnamed protein product [Enterococcus fa...
639
drug resistance /
Tetracycline resistance
Community Requests
1DAR
28.4%
Enterococcus faecalis
IDP01843
(
show subtarget assignments
)
1
cloned
No
lmo0204
16802250
actA
actin-assembly inducing protein precurso...
639
Known virulence-Nucleation-promoting factor; Predicted virulence-Pathogenicity i...
Phase 3: June 2008
Listeria monocytogenes
Unclassified
Role category not yet assigned
IDP02738
(
show subtarget assignments
)
1
cloned
No
FTT1310c
56708367
hflB
ATP-dependent metalloprotease [Francisel...
638
Conserved; Drug target functions; Drug target motif
Phase 3: June 2008
2DHR
39.3%
Francisella tularensis
N/A
N/A
IDP05755
(
show subtarget assignments
)
1
expressed
No
lmo0732
16802774
-
peptidoglycan binding protein [Listeria ...
638
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3RGX
17.6%
Listeria monocytogenes
Unclassified: Role category not yet assigned
IDP91329
(
show subtarget assignments
)
8
soluble
No
VV2_0264
27366713
signal transduction protein [Vibrio vuln...
638
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3PJW
18.5%
Vibrio vulnificus
IDP01224
(
show subtarget assignments
)
1
cloned
No
BA_4054
30258561
sporulation specific penicillin-binding ...
638
Drug Target Function
Phase 2: March 2008
1PYY
26.4%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP91652
(
show subtarget assignments
)
8
purified
No
NP_218318
15610937
long-chain-fatty-acid--CoA ligase [Mycob...
637
drug target /
Required for synthesis of mycolic acids and confirmed essential, see: Portevin, ...
Community Requests
3PBK
28.9%
Mycobacterium tuberculosis
IDP01728
(
show subtarget assignments
)
1
expressed
No
CBU_0840
29541434
asnB-2
asparagine synthetase B, glutamine-hydro...
637
Conserved; Drug target functions
Phase 3: June 2008
1Q15
13%
Coxiella burnetii
Amino acid biosynthesis
Aspartate family
IDP00762
(
show subtarget assignments
)
1
purified
No
SACOL0209
57286673
staphylocoagulase precursor
636
Conserved Gene / Pathway
Phase 2: March 2008
2A1D
29.4%
Staphylococcus aureus
Cellular processes
Pathogenesis
IDP92135
(
show subtarget assignments
)
8
selected
No
TGME49_045670
211964661
pyruvate dehydrogenase, putative [Toxopl...
635
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1NI4
20.6%
Toxoplasma gondii
IDP04326
(
show subtarget assignments
)
8
purified
No
CAC05800
12329069
ipaA
IpaA, secreted by the Mxi-Spa machinery,...
633
Shigella effector protein
Community Requests
2FM8
10.7%
Shigella flexneri
IDP91603
(
show subtarget assignments
)
8
cloned
No
CBU_1963
29542518
hypothetical protein
633
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP02440
(
show subtarget assignments
)
1
cloned
No
lmo0331
16802376
hypothetical protein lmo0331 [Listeria m...
633
Predicted virulence-Invasion; Predicted involvement or location on the cell wall...
Phase 3: June 2008
3BZ5
28.4%
Listeria monocytogenes
Cellular processes
Pathogenesis
IDP01984
(
show subtarget assignments
)
1
expressed
No
CBU_0831
29541425
asnB-1
asparagine synthetase B, glutamine-hydro...
632
Conserved; Drug target functions
Phase 3: June 2008
1CT9
18.8%
Coxiella burnetii
Amino acid biosynthesis
Aspartate family
IDP91488
(
show subtarget assignments
)
8
cloned
No
VP1696
28898470
putative type III secretion protein YscC...
632
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2Y9K
6.3%
Vibrio parahaemolyticus
IDP91620
(
show subtarget assignments
)
8
expressed
No
BAB35850
13361894
ECs2427
hypothetical protein [Escherichia coli O...
632
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP90180
(
show subtarget assignments
)
8
cloned
No
AAM13474.1
20153013
CPXV027 CDS
CPXV027 protein
632
ankyrin-like protein
Community Requests
3NOC
5.4%
Cowpox virus
conserved hypothetical proteins
0
IDP90564
(
show subtarget assignments
)
8
in_pdb
3L84
3M34
3M6L
3M7I
No
Cj1645
15792950
tkt
transketolase [Campylobacter jejuni subs...
632
Predicted Essential
Community Requests
3L84
100%
Campylobacter jejuni
IDP02494
(
show subtarget assignments
)
1
cloned
No
GBAA0550
47525823
hypothetical protein GBAA0550 [Bacillus ...
631
Drug target motif; Conserved;
Phase 3: June 2008
Bacillus anthracis
Hypothetical proteins
Conserved
IDP02812
(
show subtarget assignments
)
1
cloned
No
FTT1484c
56708523
aceF
dihydrolipoamide acetyltransferase [Fran...
631
Conserved; Drug target functions
Phase 3: June 2008
3DUF
26%
Francisella tularensis
Energy metabolism
Pyruvate dehydrogenase
IDP00417
(
show subtarget assignments
)
1
cloned
No
YPO2604
16122817
pbpA
penicillin-binding protein 2
631
Drug Target Function
Phase 2: March 2008
3OC2
26.1%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05641
(
show subtarget assignments
)
1
soluble
No
CD2799
126700415
cell surface protein [Clostridium diffic...
631
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Cell envelope: Other
IDP02259
(
show subtarget assignments
)
1
cloned
No
GBAA2164
47527458
ABC transporter ATP-binding protein [Bac...
631
Conserved; Drug target functions
Phase 3: June 2008
1YQT
21.4%
Bacillus anthracis
Transport and binding proteins
Unknown substrate
IDP91072
(
show subtarget assignments
)
8
cloned
No
YPO2588
16122801
-
putative ABC transport protein
631
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
2HYD
32.2%
Yersinia pestis
IDP90111
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_017
68449091
ankyrin-like protein [Monkeypox virus]
630
similar to VACV-COP-C9L, MPXV-ZAI96-D9L
Community Requests
3NOC
5.1%
Monkeypox virus
IDP91680
(
show subtarget assignments
)
8
cloned
No
INLB_LISMO
0
630
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1M9S
93.7%
Listeria monocytogenes
IDP04341
(
show subtarget assignments
)
1
expressed
No
CBU_0634
215919011
putative aerobic respiration control sen...
630
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
14.8%
Coxiella burnetii
Regulatory functions
Protein interactions
IDP91936
(
show subtarget assignments
)
8
selected
No
SpneCM_010100003100
298254587
hypothetical protein SpneCM_03100 [Strep...
629
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP90787
(
show subtarget assignments
)
8
purified
No
Cj0838c
15792176
metG
methionyl-tRNA synthetase [Campylobacter...
628
Predicted Essential
Community Requests
2CSX
38.5%
Campylobacter jejuni
IDP02209
(
show subtarget assignments
)
1
cloned
No
Cj1337
15792660
hypothetical protein Cj1337 [Campylobact...
628
Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950
Phase 3: June 2008
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP02344
(
show subtarget assignments
)
1
cloned
No
FTT0356
56707508
htpG
heat shock protein 90 [Francisella tular...
628
Conserved; Drug target functions
Phase 3: June 2008
2IOP
52.4%
Francisella tularensis
Cell envelopeProtein fate
Surface structuresProtein folding and stabilization
IDP91732
(
show subtarget assignments
)
8
selected
No
O67990_VIBMI
0
628
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2Y3U
16.6%
Vibrio mimicus
IDP01796
(
show subtarget assignments
)
1
cloned
No
GBAA5258
47778380
cell wall surface anchor family protein ...
627
Drug target homolog; Drug target functions
Phase 3: June 2008
Bacillus anthracis
Cell envelope
Other
IDP05193
(
show subtarget assignments
)
1
cloned
No
CD0689
126698268
putative nucleotide phosphodiesterase [C...
627
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3GVE
16.4%
Clostridium difficile
Unknown function: Enzymes of unknown specificity
IDP91470
(
show subtarget assignments
)
8
crystallized
No
VPA1355
28901210
putative type III secretion system EscV ...
627
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP05063
(
show subtarget assignments
)
1
in_crystallization_trials
No
CD2190
126699806
cyclomaltodextrinase (maltogenic alpha-a...
627
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1J0H
47.4%
Clostridium difficile
Energy metabolism: Biosynthesis and degradation of polysaccharides
IDP90817
(
show subtarget assignments
)
8
cloned
No
VC2431
15642428
DNA topoisomerase IV subunit B [Vibrio c...
626
Predicted Essential
Community Requests
1S16
49.8%
Vibrio cholerae
IDP05561
(
show subtarget assignments
)
1
cloned
No
lmo2026
16804065
-
peptidoglycan binding protein [Listeria ...
626
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1M0Z
11%
Listeria monocytogenes
Transport and binding proteins: Amino acids, peptides and amines
IDP05233
(
show subtarget assignments
)
1
cloned
No
lmo1455
16803495
dnaG
DNA primase [Listeria monocytogenes EGD-...
626
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2AU3
21.7%
Listeria monocytogenes
DNA metabolism: DNA replication, recombination, and repair
IDP05214
(
show subtarget assignments
)
1
cloned
No
CD2796
126700412
cell surface protein [Clostridium diffic...
626
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Cell envelope: Other
IDP04131
(
show subtarget assignments
)
1
cloned
No
YPO2947
115348609
conserved hypothetical protein [Yersinia...
626
virulence factor;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP01695
(
show subtarget assignments
)
1
expressed
No
GBAA0228
47525485
ABC transporter ATP-binding protein [Bac...
626
Conserved; Drug target functions
Phase 3: June 2008
1YQT
20.9%
Bacillus anthracis
Transport and binding proteins
Unknown substrate
IDP02336
(
show subtarget assignments
)
1
expressed
No
YPO2533
16122751
edd
phosphogluconate dehydratase [Yersinia p...
625
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
2GP4
63.8%
Yersinia pestis
Energy metabolism
Entner-Doudoroff
IDP01911
(
show subtarget assignments
)
1
cloned
No
Cj1422c
15792740
sugar transferase [Campylobacter jejuni ...
625
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
Campylobacter jejuni
Central intermediary metabolism
Sulfur metabolism
IDP00708
(
show subtarget assignments
)
1
expressed
No
SACOL0779
57285742
ABC transporter, ATP-binding protein
625
Conserved Gene / Pathway
Phase 2: March 2008
2IW3
22.2%
Staphylococcus aureus
Transport and binding proteins
Unknown substrate
IDP90734
(
show subtarget assignments
)
8
selected
No
VC0517
15640541
RNA polymerase sigma factor RpoD [Vibrio...
625
Predicted Essential
Community Requests
3IYD
78.1%
Vibrio cholerae
IDP04327
(
show subtarget assignments
)
1
cloned
No
CPF_1243
110801193
sensory box histidine kinase [Clostridiu...
623
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
11.2%
Clostridium perfringens
Regulatory functions
IDP91079
(
show subtarget assignments
)
8
cloned
No
BMA0204
53725011
ABC transporter, ATP-binding/permease pr...
623
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
4AA3
32.8%
Burkholderia mallei
IDP00860
(
show subtarget assignments
)
1
cloned
No
STM1910
16765252
putative penicillin-binding protein
623
Drug Target Function
Phase 2: March 2008
3PBN
25.5%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02580
(
show subtarget assignments
)
1
cloned
No
STM0452
16763833
cypD
peptidyl-prolyl cis-trans isomerase (rot...
623
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
2KGJ
13.2%
Salmonella enterica
Protein fate
Protein folding and stabilization
IDP05260
(
show subtarget assignments
)
1
cloned
No
CD2791
126700407
cell surface protein (putative S-layer p...
623
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Cell envelope: Other
IDP90733
(
show subtarget assignments
)
8
cloned
No
Cj1001
15792328
rpoD
RNA polymerase sigma factor RpoD [Campyl...
622
Predicted Essential
Community Requests
3IYD
35.9%
Campylobacter jejuni
IDP91071
(
show subtarget assignments
)
8
cloned
No
NGO2165
59719354
putative ABC transporter, ATP-binding pr...
622
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3B5Y
34.2%
Neisseria gonorrhoeae
IDP04367
(
show subtarget assignments
)
1
cloned
No
BAS3563
49186564
PTS system, fructose-specific IIABC comp...
622
Proposed to be essential proteins
Phase 4: April 2009
2R4Q
11.4%
Bacillus anthracis
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