Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP92144 (show subtarget assignments)	8	selected	No	TGME49_110960	211962004		vacuolar ATP synthase subunit F, putativ...	127	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2QAI	22%	Toxoplasma gondii

IDP01167 (show subtarget assignments)	1	expressed	No	GBAA_pXO2_0060	47566729		capsule synthesis trans-acting positive ...	482	Virulence Associated Factor	Phase 2: March 2008	3SQN	22%	Bacillus anthracis

IDP02599 (show subtarget assignments)	1	cloned	No	Cj1138	15792463		putative galactosyltransferase [Campylob...	389	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3L7I	22%	Campylobacter jejuni	Energy metabolism	Sugars

IDP02652 (show subtarget assignments)	1	expressed	No	GBAA1422	47526694	leuC	isopropylmalate isomerase large subunit ...	464	Conserved; Drug target functions	Phase 3: June 2008	2B3X	22%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP02379 (show subtarget assignments)	1	expressed	No	FTT1257	56708319	emrA1	HlyD family secretion protein [Francisel...	340	Conserved; Drug target functions	Phase 3: June 2008	4DK0	22.1%	Francisella tularensis	Cellular processesTransport and binding proteins	Toxin production and resistanceOther

IDP05076 (show subtarget assignments)	1	soluble	No	lmo0801	16802843	-	hypothetical protein lmo0801 [Listeria m...	646	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M9S	22.1%	Listeria monocytogenes	Cellular processes: Pathogenesis

IDP01232 (show subtarget assignments)	1	purified	No	BA_5112	30259596	menF	menaquinone-specific isochorismate synth...	464	Drug Target Function	Phase 2: March 2008	3H9M	22.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP91957 (show subtarget assignments)	8	selected	No	SpneCM_010100004917	298254940		oligopeptide-binding protein AliB [Strep...	653	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1DPE	22.2%	Streptococcus pneumoniae

IDP00048 (show subtarget assignments)	1	cloned	No	BA_3330	30257875		beta-lactam antibiotic acylase family pr...	796	Virulence	Phase 1: October 2007	1KEH	22.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00708 (show subtarget assignments)	1	expressed	No	SACOL0779	57285742		ABC transporter, ATP-binding protein	625	Conserved Gene / Pathway	Phase 2: March 2008	2IW3	22.2%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP00628 (show subtarget assignments)	1	cloned	No	SACOL0369	57285482		prophage L54a, Clp protease, putative	257	Drug Target Function	Phase 2: March 2008	1Y7O	22.2%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02193 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0868c	56707972		arsenical restistance operon repressor [...	121	Drug Target	Phase 3: June 2008	3JTH	22.3%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP91955 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100006939	298255319		ABC transporter substrate-binding protei...	341	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3EIW	22.3%	Streptococcus pneumoniae

IDP05535 (show subtarget assignments)	1	cloned	No	CD3071	126700688		glycosyl hydrolase [Clostridium difficil...	692	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2XVG	22.3%	Clostridium difficile	Unknown function: Enzymes of unknown specificity

IDP90707 (show subtarget assignments)	8	purified	No	Cj0233c	15791605	pyrE	orotate phosphoribosyltransferase [Campy...	202	Predicted Essential	Community Requests	2YZK	22.3%	Campylobacter jejuni

IDP05112 (show subtarget assignments)	1	cloned	No	CD2246	126699864	cspC	putative germination-specific protease [...	557	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3EIF	22.3%	Clostridium difficile	Unknown function: General

IDP90909 (show subtarget assignments)	8	in_crystallization_trials	No	YPO0650	16120975	cca	multifunctional tRNA nucleotidyl transfe...	412	Predicted Essential	Community Requests	3AQM	22.3%	Yersinia pestis

IDP91048 (show subtarget assignments)	8	in_crystallization_trials	No	EGA0001	4545123	vanT	serine racemase VanT [Enterococcus galli...	698	drug resistance / Serine racemase involved in synthesis of D-Ala-D-Ser, a component of vancomycin ...	Community Requests	4ECL	22.3%	Enterococcus gallinarum

IDP01301 (show subtarget assignments)	1	expressed	No	VC0170	15640200		peptide ABC transporter, ATP-binding pro...	571	Conserved Gene / Pathway	Phase 2: March 2008	1YQT	22.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP02558 (show subtarget assignments)	1	cloned	No	GBAA4584	47529880	vpR	minor extracellular protease VpR [Bacill...	917	Drug target motif; Drug target functions	Phase 3: June 2008	3EIF	22.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00701 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0149	57285352	cap5N	capsular polysaccharide biosynthesis pro...	295	Conserved Gene / Pathway	Phase 2: March 2008	1Z45	22.4%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91741 (show subtarget assignments)	8	selected	No	Q6V4L4_STRPY	0			397	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1I84	22.4%	Streptococcus pyogenes

IDP05155 (show subtarget assignments)	1	expressed	No	BA_0885	30254634	sap	S-layer protein Sap [Bacillus anthracis ...	814	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PYW	22.4%	Bacillus anthracis	Cell envelope: Surface structures

IDP91281 (show subtarget assignments)	8	expressed	No	NT05BA5437	49182125		RNA polymerase sigma-70 factor, ECF subf...	175	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1OR7	22.5%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP00059 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4013	30258522		fibronectin/fibrinogen-binding protein, ...	569	Virulence	Phase 1: October 2007	3DOA	22.5%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP01175 (show subtarget assignments)	1	expressed	No	BA_2825	30257427		peptidase M3 family protein	548	Drug Target Function	Phase 2: March 2008	3CE2	22.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91033 (show subtarget assignments)	8	cloned	No	SAR0023	49240405	sasH	putative 5'-nucleotidase [Staphylococcus...	786	virulence/pathogenesis / An uncharacterized cell surface protein of staph. aureus with an anchor site for...	Community Requests	2Z1A	22.5%	Staphylococcus aureus

IDP92142 (show subtarget assignments)	8	selected	No	TGME49_112230	237830295		DNA topoisomerase II, putative [Toxoplas...	1687	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3QX3	22.5%	Toxoplasma gondii

IDP90938 (show subtarget assignments)	8	cloned	No	NMPDR 243277.1.peg.3917				218	Predicted Essential	Community Requests	2JGV	22.5%	Vibrio cholerae

IDP00183 (show subtarget assignments)	1	cloned	No	YPO0613	16120939	-	putative permease protein	293	Virulence	Phase 1: October 2007	2R6G	22.5%	Yersinia pestis

IDP00432 (show subtarget assignments)	1	soluble	No	YPCD1.12c	16082702	sopB	putative plasmid-partitioning control pr...	320	Virulence Associated Factor	Phase 2: March 2008	3MKY	22.5%	Yersinia pestis	Cellular processes	Cell division

IDP02138 (show subtarget assignments)	1	expressed	No	Cj0580c	15791940		coproporphyrinogen III oxidase [Campylob...	355	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1OLT	22.5%	Campylobacter jejuni	Amino acid biosynthesis	Pyruvate family

IDP02332 (show subtarget assignments)	1	purified	No	GBAA1462	47526735		UbiE/COQ5 family methlytransferase [Baci...	258	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3UJD	22.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02195 (show subtarget assignments)	1	expressed	No	FTT0084c	56707262	hemN	oxygen-independent coproporphyrinogen II...	380	Conserved; Drug target functions	Phase 3: June 2008	1OLT	22.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP05244 (show subtarget assignments)	1	soluble	No	lmo2203	16804242	-	hypothetical protein lmo2203 [Listeria m...	367	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M9S	22.6%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04686 (show subtarget assignments)	1	expressed	No	GBAA4223	47529516	kinB-3	sporulation kinase B [Bacillus anthracis...	424	putative drug target function;	Phase 4: April 2009	3D36	22.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP05729 (show subtarget assignments)	1	soluble	No	CD0263	126697835	flhA	flagellar biosynthesis protein FlhA [Clo...	691	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3MIX	22.6%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP02634 (show subtarget assignments)	1	cloned	No	Cj1125c	15792450	wlaG	general glycosylation pathway protein [C...	376	Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...	Phase 3: June 2008	2JJM	22.6%	Campylobacter jejuni	Cellular processes	Chemotaxis and motility

IDP01479 (show subtarget assignments)	1	expressed	No	VCA0064	15600835		TonB system receptor, putative	713	Conserved Gene / Pathway	Phase 2: March 2008	1NQF	22.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP92141 (show subtarget assignments)	8	selected	No	TGME49_066730	237838909		leucyl-tRNA synthetase, putative [Toxopl...	1465	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1H3N	22.7%	Toxoplasma gondii

IDP05380 (show subtarget assignments)	1	soluble	No	BA_0633	30254236	gerKC	spore germination protein GerKC [Bacillu...	374	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3N54	22.7%	Bacillus anthracis	Cellular processes: Sporulation and germination

IDP00773 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0569	57285587		ATP:guanido phosphotransferase	335	Drug Target Function	Phase 2: March 2008	3L2D	22.7%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP05199 (show subtarget assignments)	1	soluble	No	CD1556	126699160		putative polysaccharide deacetylase [Clo...	277	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	22.7%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02422 (show subtarget assignments)	1	cloned	No	YPO1666	16121930	cheA	chemotaxis protein CheA [Yersinia pestis...	723	Conserved; CD; Drug target functions	Phase 3: June 2008	1B3Q	22.7%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP91032 (show subtarget assignments)	8	cloned	No	Y1069	31795399		toxin [Yersinia pestis KIM]	587	virulence/pathogenesis / survival factor of Y pestis in the flea	Community Requests	1F0I	22.7%	Yersinia pestis

IDP05488 (show subtarget assignments)	1	cloned	No	BA_4789	30259275		putative LPXTG-motif cell wall anchor do...	237	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2K78	22.8%	Bacillus anthracis	Unknown function: General

IDP02835 (show subtarget assignments)	1	expressed	No	FTT0631	56707756	hflX	protease, GTP-binding subunit [Francisel...	435	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2QTF	22.8%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91730 (show subtarget assignments)	8	selected	No	NP_683513	22538811	CCL28	C-C motif chemokine 28 precursor [Homo s...	127	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2KUM	22.8%	Homo sapiens

IDP91020 (show subtarget assignments)	8	in_crystallization_trials	No	y2842	22126718		hypothetical protein y2842 [Yersinia pes...	378	other biological interest / putative periplasmic iron-binding protein	Community Requests	2ETV	22.8%	Yersinia pestis

IDP02115 (show subtarget assignments)	1	purified	No	FTT0900	56708001		hypothetical protein FTT0900 [Francisell...	123	Drug Target	Community Requests	2GM2	22.8%	Francisella tularensis	Cell envelope	Other

IDP91307 (show subtarget assignments)	8	expressed	No	VP1663	28898437		putative YscY [Vibrio parahaemolyticus R...	114	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2FO7	22.8%	Vibrio parahaemolyticus

IDP02788 (show subtarget assignments)	1	expressed	No	CBU_0140	29540760	ftsA	cell division protein FtsA [Coxiella bur...	410	Conserved; Drug target functions	Phase 3: June 2008	1E4F	22.9%	Coxiella burnetii	Cellular processes	Cell division

IDP01176 (show subtarget assignments)	1	expressed	No	BA_2869	30257466		peptidase, putative	358	Drug Target Function	Phase 2: March 2008	3CE2	22.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01688 (show subtarget assignments)	0	work_stopped	No	Cj1313	15792636		GNAT family acetyltransferase [Campyloba...	157	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008	3EG7	22.9%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP04242 (show subtarget assignments)	1	cloned	No	CPF_1113	110798641		sugar ABC transporter, sugar-binding pro...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3QUF	22.9%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02167 (show subtarget assignments)	1	expressed	No	CBU_0886	29541477	coaBC	phosphopantothenoylcysteine decarboxylas...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	23%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP91636 (show subtarget assignments)	8	cloned	No	NP_217464	15610085		acyl-CoA synthetase [Mycobacterium tuber...	705	virulence/pathogenesis / Required for the synthesis of the phthiocerol dimycocerosates and related compou...	Community Requests	2V7B	23%	Mycobacterium tuberculosis

IDP91432 (show subtarget assignments)	8	cloned	No	VV1_0487	27363951		prephenate dehydratase [Vibrio vulnificu...	392	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2QMX	23%	Vibrio vulnificus

IDP02486 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4209	47529502		Ppx/GppA phosphatase family protein [Bac...	512	Conserved; Drug target functions	Phase 3: June 2008	3HI0	23%	Bacillus anthracis	Central intermediary metabolism	Phosphorus compounds

IDP05282 (show subtarget assignments)	1	soluble	No	CD0228	126697799	fliN	flagellar motor switch protein [Clostrid...	104	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1O6A	23.1%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05271 (show subtarget assignments)	1	cloned	No	lmo1194	16803234	cbiD	cobalt-precorrin-6A synthase [Listeria m...	373	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1SR8	23.1%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04148 (show subtarget assignments)	1	expressed	No	YPO3508	115349133	basS	two-component system sensor protein [Yer...	355	conserved gene; putative drug target function;	Phase 4: April 2009	3JZ3	23.1%	Yersinia pestis	Regulatory functions	Other

IDP05382 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0925	30254668		putative lipoprotein [Bacillus anthracis...	325	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2QPQ	23.1%	Bacillus anthracis	Cell envelope: Other

IDP02538 (show subtarget assignments)	1	soluble	No	FTT1746	56708744		peptidase [Francisella tularensis subsp....	307	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3RST	23.1%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01248 (show subtarget assignments)	1	soluble	No	BA_3554	30258085		penicillin-binding protein, putative	377	Drug Target Function	Phase 2: March 2008	3TG9	23.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02431 (show subtarget assignments)	1	crystallized	No	CBU_1770	29542327		ABC transporter, ATP-binding protein [Co...	432	Conserved; Drug target functions	Phase 3: June 2008	2YYZ	23.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02806 (show subtarget assignments)	1	cloned	No	Cj1133	15792458	waaC	lipopolysaccharide heptosyltransferase I...	342	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	2GT1	23.1%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91316 (show subtarget assignments)	8	purified	No	VV2_1515	27367862		toxin secretion ATP-binding protein [Vib...	717	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3G5U	23.1%	Vibrio vulnificus

IDP04674 (show subtarget assignments)	1	expressed	No	GBAA1956	47527252		sensor histidine kinase [Bacillus anthra...	351	putative drug target function;	Phase 4: April 2009	3A0R	23.1%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP90285 (show subtarget assignments)	8	soluble	No	TGME49_083850	211966798		peptidyl-prolyl isomerase, putative [Tox...	521	The immunophilin TgFBCP57 uniquely contains domains for both immunosuppressant d...	Community Requests	1KT0	23.2%	Toxoplasma gondii

IDP05173 (show subtarget assignments)	1	expressed	No	BA_2528	30257152		N-acetylmuramoyl-L-alanine amidase, fami...	410	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PYW	23.2%	Bacillus anthracis	Cell envelope: Surface structures

IDP02235 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1105c	56708184	msrA1	bifunctional methionine sulfoxide reduct...	284	Drug Target	Phase 3: June 2008	2GT3	23.2%	Francisella tularensis	Cell envelopeProtein fate	Surface structuresProtein modification and repair

IDP91274 (show subtarget assignments)	8	soluble	No	NT05BA4272	49181014		acetyl-CoA carboxylase, biotin carboxyl ...	164	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1A6X	23.2%	Bacillus anthracis	Fatty acid and phospholipid metabolism: Biosynthesis

IDP05081 (show subtarget assignments)	1	expressed	No	lmo2027	16804066	-	putative cell surface protein, internali...	367	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Y5Q	23.2%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP02721 (show subtarget assignments)	1	soluble	No	GBAA4007	47529300	coaBC	bifunctional phosphopantothenoylcysteine...	401	Conserved; Drug target functions	Phase 3: June 2008	1U7U	23.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02626 (show subtarget assignments)	1	cloned	No	Cj1614	15792919	chuA	TonB-dependent heme receptor [Campylobac...	709	Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate	Phase 3: June 2008	3FHH	23.3%	Campylobacter jejuni	Regulatory functions	Other

IDP00550 (show subtarget assignments)	1	purified	No	YPO3488	16123634	deaD	ATP-dependent RNA helicase DeaD	664	Virulence Associated Factor	Phase 2: March 2008	1HV8	23.3%	Yersinia pestis	Transcription	Other

IDP91400 (show subtarget assignments)	8	cloned	No	VV1_1002	27364436		ABC-type amino acid transport system, pe...	223	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3DHW	23.3%	Vibrio vulnificus

IDP02009 (show subtarget assignments)	1	soluble	No	STM2925	16766231	nlpD	lipoprotein NlpD [Salmonella typhimurium...	377	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1QWY	23.3%	Salmonella enterica	Cell envelope	Other

IDP02240 (show subtarget assignments)	1	cloned	No	FTT1572c	56708598	ompH	outer membrane protein OmpH [Francisella...	167	Drug Target	Phase 3: June 2008	1SG2	23.4%	Francisella tularensis	Cell envelopeMobile and extrachromosomal element functions	OtherProphage functions

IDP91952 (show subtarget assignments)	8	selected	No	SpneCM_010100008682	298255656		AmiA protein [Streptococcus pneumoniae s...	659	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1B05	23.4%	Streptococcus pneumoniae

IDP04335 (show subtarget assignments)	1	cloned	No	STM1543_1_428	16764888		putative transport protein [Salmonella t...	428	Salmonella essential protein	Phase 4: April 2009	1PW4	23.4%	Salmonella enterica

IDP91407 (show subtarget assignments)	8	purified	No	VV1_0729	27364183		cAMP-binding proteins - catabolite gene ...	187	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3DN7	23.4%	Vibrio vulnificus

IDP04304 (show subtarget assignments)	1	cloned	No	CPF_2640	110798722		sensor histidine kinase [Clostridium per...	310	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	23.5%	Clostridium perfringens	Signal transduction	Two-component systems

IDP05119 (show subtarget assignments)	1	soluble	No	CD2989	126700610		ABC transporter, substrate-binding prote...	319	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2X7P	23.5%	Clostridium difficile	Transport and binding proteins: Unknown substrate

IDP00161 (show subtarget assignments)	1	soluble	No	VC0835	15640852	tcpT	toxin co-regulated pilus biosynthesis pr...	503	Virulence	Phase 1: October 2007	1P9R	23.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP02036 (show subtarget assignments)	1	cloned	No	GBAA1500	47526774		M23/37 family peptidase [Bacillus anthra...	204	Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...	Phase 3: June 2008	3SLU	23.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05541 (show subtarget assignments)	1	cloned	No	CD3437	126701060	cobS	cobalamin synthase [Clostridium difficil...	257	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RH5	23.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP02477 (show subtarget assignments)	1	cloned	No	YPO2035	16122274		hypothetical protein YPO2035 [Yersinia p...	276	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1ZCC	23.6%	Yersinia pestis	Central intermediary metabolism	Other

IDP01729 (show subtarget assignments)	1	cloned	No	FTT0808	56707919	spoT	guanosine-3',5'-bis(diphosphate) 3'-pyro...	707	Conserved; Drug target functions	Phase 3: June 2008	1VJ7	23.6%	Francisella tularensis	Regulatory functionsAmino acid biosynthesis	OtherHistidine family

IDP00190 (show subtarget assignments)	1	soluble	No	YPO0927	16121232	-	putative lipoprotein	250	Similar to Essential SALTY	Phase 1: October 2007	3C37	23.6%	Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP91017 (show subtarget assignments)	8	expressed	No	y2556	22126437	fcuA	ferrichrome receptor, TonB dependent [Ye...	776	other biological interest / putative iron-binding TonB-dependent outer membrane receptor	Community Requests	3QLB	23.6%	Yersinia pestis

IDP05261 (show subtarget assignments)	1	cloned	No	CD2772	126700388	tuaG	putative teichuronic acid biosynthesis g...	212	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3BCV	23.6%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02695 (show subtarget assignments)	1	soluble	No	Cj0698	15792047	flgG	flagellar basal body rod protein FlgG [C...	263	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	3A69	23.6%	Campylobacter jejuni	Unknown function	Enzymes of unknown specificity

IDP90102 (show subtarget assignments)	8	expressed	No	MPXV_ZAI1979_005_002	68449079		TNF-alpha-receptor-like protein [Monkeyp...	348	similar to VACV-COP-C22L/B28R, MPXV-ZAI96-J2L/J2R	Community Requests	3ON9	23.6%	Monkeypox virus

IDP04014 (show subtarget assignments)	1	purified	No	YPO3173	115348814	thiI	thiamine biosynthesis protein [Yersinia ...	483	conserved gene; putative drug target function;	Phase 4: April 2009	2C5S	23.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP01244 (show subtarget assignments)	1	cloned	No	BA_2504	30257132		penicillin-binding protein	588	Drug Target Function	Phase 2: March 2008	1MWR	23.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02662 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1676	16803716	menF	menaquinone-specific isochorismate synth...	462	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3HWO	23.6%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP05553 (show subtarget assignments)	1	soluble	No	lmo1136	16803176	-	hypothetical protein lmo1136 [Listeria m...	539	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1O6S	23.6%	Listeria monocytogenes	Cellular processes: Pathogenesis

IDP05607 (show subtarget assignments)	1	soluble	No	BA_4862	30259361		putative lipoprotein [Bacillus anthracis...	123	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2JQO	23.6%	Bacillus anthracis	Cell envelope: Other

IDP92144
(show subtarget assignments)

8

selected

No

TGME49_110960

211962004

vacuolar ATP synthase subunit F, putativ...

127

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2QAI

22%

Toxoplasma gondii

IDP01167
(show subtarget assignments)

1

expressed

No

GBAA_pXO2_0060

47566729

capsule synthesis trans-acting positive ...

482

Virulence Associated Factor

Phase 2: March 2008

3SQN

22%

Bacillus anthracis

IDP02599
(show subtarget assignments)

1

cloned

No

Cj1138

15792463

putative galactosyltransferase [Campylob...

389

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3L7I

22%

Campylobacter jejuni

Energy metabolism

Sugars

IDP02652
(show subtarget assignments)

1

expressed

No

GBAA1422

47526694

leuC

isopropylmalate isomerase large subunit ...

464

Conserved; Drug target functions

Phase 3: June 2008

2B3X

22%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP02379
(show subtarget assignments)

1

expressed

No

FTT1257

56708319

emrA1

HlyD family secretion protein [Francisel...

340

Conserved; Drug target functions

Phase 3: June 2008

4DK0

22.1%

Francisella tularensis

Cellular processesTransport and binding proteins

Toxin production and resistanceOther

IDP05076
(show subtarget assignments)

1

soluble

No

lmo0801

16802843

-

hypothetical protein lmo0801 [Listeria m...

646

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M9S

22.1%

Listeria monocytogenes

Cellular processes: Pathogenesis

IDP01232
(show subtarget assignments)

1

purified

No

BA_5112

30259596

menF

menaquinone-specific isochorismate synth...

464

Drug Target Function

Phase 2: March 2008

3H9M

22.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP91957
(show subtarget assignments)

8

selected

No

SpneCM_010100004917

298254940

oligopeptide-binding protein AliB [Strep...

653

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1DPE

22.2%

Streptococcus pneumoniae

IDP00048
(show subtarget assignments)

1

cloned

No

BA_3330

30257875

beta-lactam antibiotic acylase family pr...

796

Virulence

Phase 1: October 2007

1KEH

22.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00708
(show subtarget assignments)

1

expressed

No

SACOL0779

57285742

ABC transporter, ATP-binding protein

625

Conserved Gene / Pathway

Phase 2: March 2008

2IW3

22.2%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP00628
(show subtarget assignments)

1

cloned

No

SACOL0369

57285482

prophage L54a, Clp protease, putative

257

Drug Target Function

Phase 2: March 2008

1Y7O

22.2%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02193
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0868c

56707972

arsenical restistance operon repressor [...

121

Drug Target

Phase 3: June 2008

3JTH

22.3%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP91955
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100006939

298255319

ABC transporter substrate-binding protei...

341

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3EIW

22.3%

Streptococcus pneumoniae

IDP05535
(show subtarget assignments)

1

cloned

No

CD3071

126700688

glycosyl hydrolase [Clostridium difficil...

692

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2XVG

22.3%

Clostridium difficile

Unknown function: Enzymes of unknown specificity

IDP90707
(show subtarget assignments)

8

purified

No

Cj0233c

15791605

pyrE

orotate phosphoribosyltransferase [Campy...

202

Predicted Essential

Community Requests

2YZK

22.3%

Campylobacter jejuni

IDP05112
(show subtarget assignments)

1

cloned

No

CD2246

126699864

cspC

putative germination-specific protease [...

557

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3EIF

22.3%

Clostridium difficile

Unknown function: General

IDP90909
(show subtarget assignments)

8

in_crystallization_trials

No

YPO0650

16120975

cca

multifunctional tRNA nucleotidyl transfe...

412

Predicted Essential

Community Requests

3AQM

22.3%

Yersinia pestis

IDP91048
(show subtarget assignments)

8

in_crystallization_trials

No

EGA0001

4545123

vanT

serine racemase VanT [Enterococcus galli...

698

drug resistance / Serine racemase involved in synthesis of D-Ala-D-Ser, a component of vancomycin ...

Community Requests

4ECL

22.3%

Enterococcus gallinarum

IDP01301
(show subtarget assignments)

1

expressed

No

VC0170

15640200

peptide ABC transporter, ATP-binding pro...

571

Conserved Gene / Pathway

Phase 2: March 2008

1YQT

22.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP02558
(show subtarget assignments)

1

cloned

No

GBAA4584

47529880

vpR

minor extracellular protease VpR [Bacill...

917

Drug target motif; Drug target functions

Phase 3: June 2008

3EIF

22.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00701
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0149

57285352

cap5N

capsular polysaccharide biosynthesis pro...

295

Conserved Gene / Pathway

Phase 2: March 2008

1Z45

22.4%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91741
(show subtarget assignments)

8

selected

No

Q6V4L4_STRPY

0

397

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1I84

22.4%

Streptococcus pyogenes

IDP05155
(show subtarget assignments)

1

expressed

No

BA_0885

30254634

sap

S-layer protein Sap [Bacillus anthracis ...

814

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PYW

22.4%

Bacillus anthracis

Cell envelope: Surface structures

IDP91281
(show subtarget assignments)

8

expressed

No

NT05BA5437

49182125

RNA polymerase sigma-70 factor, ECF subf...

175

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1OR7

22.5%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP00059
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4013

30258522

fibronectin/fibrinogen-binding protein, ...

569

Virulence

Phase 1: October 2007

3DOA

22.5%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP01175
(show subtarget assignments)

1

expressed

No

BA_2825

30257427

peptidase M3 family protein

548

Drug Target Function

Phase 2: March 2008

3CE2

22.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91033
(show subtarget assignments)

8

cloned

No

SAR0023

49240405

sasH

putative 5'-nucleotidase [Staphylococcus...

786

virulence/pathogenesis / An uncharacterized cell surface protein of staph. aureus with an anchor site for...

Community Requests

2Z1A

22.5%

Staphylococcus aureus

IDP92142
(show subtarget assignments)

8

selected

No

TGME49_112230

237830295

DNA topoisomerase II, putative [Toxoplas...

1687

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3QX3

22.5%

Toxoplasma gondii

IDP90938
(show subtarget assignments)

8

cloned

No

NMPDR 243277.1.peg.3917

218

Predicted Essential

Community Requests

2JGV

22.5%

Vibrio cholerae

IDP00183
(show subtarget assignments)

1

cloned

No

YPO0613

16120939

-

putative permease protein

293

Virulence

Phase 1: October 2007

2R6G

22.5%

Yersinia pestis

IDP00432
(show subtarget assignments)

1

soluble

No

YPCD1.12c

16082702

sopB

putative plasmid-partitioning control pr...

320

Virulence Associated Factor

Phase 2: March 2008

3MKY

22.5%

Yersinia pestis

Cellular processes

Cell division

IDP02138
(show subtarget assignments)

1

expressed

No

Cj0580c

15791940

coproporphyrinogen III oxidase [Campylob...

355

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1OLT

22.5%

Campylobacter jejuni

Amino acid biosynthesis

Pyruvate family

IDP02332
(show subtarget assignments)

1

purified

No

GBAA1462

47526735

UbiE/COQ5 family methlytransferase [Baci...

258

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3UJD

22.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02195
(show subtarget assignments)

1

expressed

No

FTT0084c

56707262

hemN

oxygen-independent coproporphyrinogen II...

380

Conserved; Drug target functions

Phase 3: June 2008

1OLT

22.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP05244
(show subtarget assignments)

1

soluble

No

lmo2203

16804242

-

hypothetical protein lmo2203 [Listeria m...

367

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M9S

22.6%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04686
(show subtarget assignments)

1

expressed

No

GBAA4223

47529516

kinB-3

sporulation kinase B [Bacillus anthracis...

424

putative drug target function;

Phase 4: April 2009

3D36

22.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP05729
(show subtarget assignments)

1

soluble

No

CD0263

126697835

flhA

flagellar biosynthesis protein FlhA [Clo...

691

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3MIX

22.6%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP02634
(show subtarget assignments)

1

cloned

No

Cj1125c

15792450

wlaG

general glycosylation pathway protein [C...

376

Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...

Phase 3: June 2008

2JJM

22.6%

Campylobacter jejuni

Cellular processes

Chemotaxis and motility

IDP01479
(show subtarget assignments)

1

expressed

No

VCA0064

15600835

TonB system receptor, putative

713

Conserved Gene / Pathway

Phase 2: March 2008

1NQF

22.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP92141
(show subtarget assignments)

8

selected

No

TGME49_066730

237838909

leucyl-tRNA synthetase, putative [Toxopl...

1465

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1H3N

22.7%

Toxoplasma gondii

IDP05380
(show subtarget assignments)

1

soluble

No

BA_0633

30254236

gerKC

spore germination protein GerKC [Bacillu...

374

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3N54

22.7%

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP00773
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0569

57285587

ATP:guanido phosphotransferase

335

Drug Target Function

Phase 2: March 2008

3L2D

22.7%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP05199
(show subtarget assignments)

1

soluble

No

CD1556

126699160

putative polysaccharide deacetylase [Clo...

277

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

22.7%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02422
(show subtarget assignments)

1

cloned

No

YPO1666

16121930

cheA

chemotaxis protein CheA [Yersinia pestis...

723

Conserved; CD; Drug target functions

Phase 3: June 2008

1B3Q

22.7%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP91032
(show subtarget assignments)

8

cloned

No

Y1069

31795399

toxin [Yersinia pestis KIM]

587

virulence/pathogenesis / survival factor of Y pestis in the flea

Community Requests

1F0I

22.7%

Yersinia pestis

IDP05488
(show subtarget assignments)

1

cloned

No

BA_4789

30259275

putative LPXTG-motif cell wall anchor do...

237

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2K78

22.8%

Bacillus anthracis

Unknown function: General

IDP02835
(show subtarget assignments)

1

expressed

No

FTT0631

56707756

hflX

protease, GTP-binding subunit [Francisel...

435

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2QTF

22.8%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91730
(show subtarget assignments)

8

selected

No

NP_683513

22538811

CCL28

C-C motif chemokine 28 precursor [Homo s...

127

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2KUM

22.8%

Homo sapiens

IDP91020
(show subtarget assignments)

8

in_crystallization_trials

No

y2842

22126718

hypothetical protein y2842 [Yersinia pes...

378

other biological interest / putative periplasmic iron-binding protein

Community Requests

2ETV

22.8%

Yersinia pestis

IDP02115
(show subtarget assignments)

1

purified

No

FTT0900

56708001

hypothetical protein FTT0900 [Francisell...

123

Drug Target

Community Requests

2GM2

22.8%

Francisella tularensis

Cell envelope

Other

IDP91307
(show subtarget assignments)

8

expressed

No

VP1663

28898437

putative YscY [Vibrio parahaemolyticus R...

114

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2FO7

22.8%

Vibrio parahaemolyticus

IDP02788
(show subtarget assignments)

1

expressed

No

CBU_0140

29540760

ftsA

cell division protein FtsA [Coxiella bur...

410

Conserved; Drug target functions

Phase 3: June 2008

1E4F

22.9%

Coxiella burnetii

Cellular processes

Cell division

IDP01176
(show subtarget assignments)

1

expressed

No

BA_2869

30257466

peptidase, putative

358

Drug Target Function

Phase 2: March 2008

3CE2

22.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01688
(show subtarget assignments)

0

work_stopped

No

Cj1313

15792636

GNAT family acetyltransferase [Campyloba...

157

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

3EG7

22.9%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP04242
(show subtarget assignments)

1

cloned

No

CPF_1113

110798641

sugar ABC transporter, sugar-binding pro...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3QUF

22.9%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02167
(show subtarget assignments)

1

expressed

No

CBU_0886

29541477

coaBC

phosphopantothenoylcysteine decarboxylas...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

23%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP91636
(show subtarget assignments)

8

cloned

No

NP_217464

15610085

acyl-CoA synthetase [Mycobacterium tuber...

705

virulence/pathogenesis / Required for the synthesis of the phthiocerol dimycocerosates and related compou...

Community Requests

2V7B

23%

Mycobacterium tuberculosis

IDP91432
(show subtarget assignments)

8

cloned

No

VV1_0487

27363951

prephenate dehydratase [Vibrio vulnificu...

392

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2QMX

23%

Vibrio vulnificus

IDP02486
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4209

47529502

Ppx/GppA phosphatase family protein [Bac...

512

Conserved; Drug target functions

Phase 3: June 2008

3HI0

23%

Bacillus anthracis

Central intermediary metabolism

Phosphorus compounds

IDP05282
(show subtarget assignments)

1

soluble

No

CD0228

126697799

fliN

flagellar motor switch protein [Clostrid...

104

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1O6A

23.1%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05271
(show subtarget assignments)

1

cloned

No

lmo1194

16803234

cbiD

cobalt-precorrin-6A synthase [Listeria m...

373

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1SR8

23.1%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04148
(show subtarget assignments)

1

expressed

No

YPO3508

115349133

basS

two-component system sensor protein [Yer...

355

conserved gene; putative drug target function;

Phase 4: April 2009

3JZ3

23.1%

Yersinia pestis

Regulatory functions

Other

IDP05382
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0925

30254668

putative lipoprotein [Bacillus anthracis...

325

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2QPQ

23.1%

Bacillus anthracis

Cell envelope: Other

IDP02538
(show subtarget assignments)

1

soluble

No

FTT1746

56708744

peptidase [Francisella tularensis subsp....

307

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3RST

23.1%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01248
(show subtarget assignments)

1

soluble

No

BA_3554

30258085

penicillin-binding protein, putative

377

Drug Target Function

Phase 2: March 2008

3TG9

23.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02431
(show subtarget assignments)

1

crystallized

No

CBU_1770

29542327

ABC transporter, ATP-binding protein [Co...

432

Conserved; Drug target functions

Phase 3: June 2008

2YYZ

23.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02806
(show subtarget assignments)

1

cloned

No

Cj1133

15792458

waaC

lipopolysaccharide heptosyltransferase I...

342

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

2GT1

23.1%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91316
(show subtarget assignments)

8

purified

No

VV2_1515

27367862

toxin secretion ATP-binding protein [Vib...

717

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3G5U

23.1%

Vibrio vulnificus

IDP04674
(show subtarget assignments)

1

expressed

No

GBAA1956

47527252

sensor histidine kinase [Bacillus anthra...

351

putative drug target function;

Phase 4: April 2009

3A0R

23.1%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP90285
(show subtarget assignments)

8

soluble

No

TGME49_083850

211966798

peptidyl-prolyl isomerase, putative [Tox...

521

The immunophilin TgFBCP57 uniquely contains domains for both immunosuppressant d...

Community Requests

1KT0

23.2%

Toxoplasma gondii

IDP05173
(show subtarget assignments)

1

expressed

No

BA_2528

30257152

N-acetylmuramoyl-L-alanine amidase, fami...

410

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PYW

23.2%

Bacillus anthracis

Cell envelope: Surface structures

IDP02235
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1105c

56708184

msrA1

bifunctional methionine sulfoxide reduct...

284

Drug Target

Phase 3: June 2008

2GT3

23.2%

Francisella tularensis

Cell envelopeProtein fate

Surface structuresProtein modification and repair

IDP91274
(show subtarget assignments)

8

soluble

No

NT05BA4272

49181014

acetyl-CoA carboxylase, biotin carboxyl ...

164

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1A6X

23.2%

Bacillus anthracis

Fatty acid and phospholipid metabolism: Biosynthesis

IDP05081
(show subtarget assignments)

1

expressed

No

lmo2027

16804066

-

putative cell surface protein, internali...

367

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Y5Q

23.2%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP02721
(show subtarget assignments)

1

soluble

No

GBAA4007

47529300

coaBC

bifunctional phosphopantothenoylcysteine...

401

Conserved; Drug target functions

Phase 3: June 2008

1U7U

23.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02626
(show subtarget assignments)

1

cloned

No

Cj1614

15792919

chuA

TonB-dependent heme receptor [Campylobac...

709

Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate

Phase 3: June 2008

3FHH

23.3%

Campylobacter jejuni

Regulatory functions

Other

IDP00550
(show subtarget assignments)

1

purified

No

YPO3488

16123634

deaD

ATP-dependent RNA helicase DeaD

664

Virulence Associated Factor

Phase 2: March 2008

1HV8

23.3%

Yersinia pestis

Transcription

Other

IDP91400
(show subtarget assignments)

8

cloned

No

VV1_1002

27364436

ABC-type amino acid transport system, pe...

223

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3DHW

23.3%

Vibrio vulnificus

IDP02009
(show subtarget assignments)

1

soluble

No

STM2925

16766231

nlpD

lipoprotein NlpD [Salmonella typhimurium...

377

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1QWY

23.3%

Salmonella enterica

Cell envelope

Other

IDP02240
(show subtarget assignments)

1

cloned

No

FTT1572c

56708598

ompH

outer membrane protein OmpH [Francisella...

167

Drug Target

Phase 3: June 2008

1SG2

23.4%

Francisella tularensis

Cell envelopeMobile and extrachromosomal element functions

OtherProphage functions

IDP91952
(show subtarget assignments)

8

selected

No

SpneCM_010100008682

298255656

AmiA protein [Streptococcus pneumoniae s...

659

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1B05

23.4%

Streptococcus pneumoniae

IDP04335
(show subtarget assignments)

1

cloned

No

STM1543_1_428

16764888

putative transport protein [Salmonella t...

428

Salmonella essential protein

Phase 4: April 2009

1PW4

23.4%

Salmonella enterica

IDP91407
(show subtarget assignments)

8

purified

No

VV1_0729

27364183

cAMP-binding proteins - catabolite gene ...

187

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3DN7

23.4%

Vibrio vulnificus

IDP04304
(show subtarget assignments)

1

cloned

No

CPF_2640

110798722

sensor histidine kinase [Clostridium per...

310

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

23.5%

Clostridium perfringens

Signal transduction

Two-component systems

IDP05119
(show subtarget assignments)

1

soluble

No

CD2989

126700610

ABC transporter, substrate-binding prote...

319

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2X7P

23.5%

Clostridium difficile

Transport and binding proteins: Unknown substrate

IDP00161
(show subtarget assignments)

1

soluble

No

VC0835

15640852

tcpT

toxin co-regulated pilus biosynthesis pr...

503

Virulence

Phase 1: October 2007

1P9R

23.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP02036
(show subtarget assignments)

1

cloned

No

GBAA1500

47526774

M23/37 family peptidase [Bacillus anthra...

204

Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...

Phase 3: June 2008

3SLU

23.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05541
(show subtarget assignments)

1

cloned

No

CD3437

126701060

cobS

cobalamin synthase [Clostridium difficil...

257

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RH5

23.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP02477
(show subtarget assignments)

1

cloned

No

YPO2035

16122274

hypothetical protein YPO2035 [Yersinia p...

276

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1ZCC

23.6%

Yersinia pestis

Central intermediary metabolism

Other

IDP01729
(show subtarget assignments)

1

cloned

No

FTT0808

56707919

spoT

guanosine-3',5'-bis(diphosphate) 3'-pyro...

707

Conserved; Drug target functions

Phase 3: June 2008

1VJ7

23.6%

Francisella tularensis

Regulatory functionsAmino acid biosynthesis

OtherHistidine family

IDP00190
(show subtarget assignments)

1

soluble

No

YPO0927

16121232

-

putative lipoprotein

250

Similar to Essential SALTY

Phase 1: October 2007

3C37

23.6%

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP91017
(show subtarget assignments)

8

expressed

No

y2556

22126437

fcuA

ferrichrome receptor, TonB dependent [Ye...

776

other biological interest / putative iron-binding TonB-dependent outer membrane receptor

Community Requests

3QLB

23.6%

Yersinia pestis

IDP05261
(show subtarget assignments)

1

cloned

No

CD2772

126700388

tuaG

putative teichuronic acid biosynthesis g...

212

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3BCV

23.6%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02695
(show subtarget assignments)

1

soluble

No

Cj0698

15792047

flgG

flagellar basal body rod protein FlgG [C...

263

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

3A69

23.6%

Campylobacter jejuni

Unknown function

Enzymes of unknown specificity

IDP90102
(show subtarget assignments)

8

expressed

No

MPXV_ZAI1979_005_002

68449079

TNF-alpha-receptor-like protein [Monkeyp...

348

Community Requests

3ON9

23.6%

Monkeypox virus

IDP04014
(show subtarget assignments)

1

purified

No

YPO3173

115348814

thiI

thiamine biosynthesis protein [Yersinia ...

483

conserved gene; putative drug target function;

Phase 4: April 2009

2C5S

23.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP01244
(show subtarget assignments)

1

cloned

No

BA_2504

30257132

penicillin-binding protein

588

Drug Target Function

Phase 2: March 2008

1MWR

23.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02662
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1676

16803716

menF

menaquinone-specific isochorismate synth...

462

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3HWO

23.6%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP05553
(show subtarget assignments)

1

soluble

No

lmo1136

16803176

-

hypothetical protein lmo1136 [Listeria m...

539

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1O6S

23.6%

Listeria monocytogenes

Cellular processes: Pathogenesis

IDP05607
(show subtarget assignments)

1

soluble

No

BA_4862

30259361

putative lipoprotein [Bacillus anthracis...

123

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2JQO

23.6%

Bacillus anthracis

Cell envelope: Other