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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 8 of 60, showing 100 records out of 5973 total, starting on record 701
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP91409
(
show subtarget assignments
)
8
cloned
No
VV1_0717
27364172
hypothetical protein VV1_0717 [Vibrio vu...
217
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP91407
(
show subtarget assignments
)
8
purified
No
VV1_0729
27364183
cAMP-binding proteins - catabolite gene ...
187
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3DN7
23.4%
Vibrio vulnificus
IDP04022
(
show subtarget assignments
)
1
cloned
No
BAS0095
49183129
preprotein translocase subunit SecE [Bac...
59
Proposed to be essential proteins
Phase 4: April 2009
3DIN
33.9%
Bacillus anthracis
IDP04436
(
show subtarget assignments
)
1
expressed
No
YPCD1.97c
5832512
YPCD1.97c
putative transposase [Yersinia pestis CO...
308
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04625
(
show subtarget assignments
)
1
cloned
No
BAS5050
49188036
glycosyl transferase, group 4 family pro...
357
Proposed to be essential proteins
Phase 4: April 2009
Bacillus anthracis
IDP05036
(
show subtarget assignments
)
1
cloned
No
BA_1663
30255960
hypothetical protein BA_1663 [Bacillus a...
450
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP90256
(
show subtarget assignments
)
8
crystallized
No
SAR0409
49482642
guaA
bifunctional GMP synthase/glutamine amid...
513
(From requestor) Identified potential S. aureus drug target. Would like to devel...
Community Requests
1GPM
51.2%
Staphylococcus aureus
IDP04611
(
show subtarget assignments
)
1
cloned
No
BAS3754
49186753
sporulation sigma factor SigG [Bacillus ...
289
Proposed to be essential proteins
Phase 4: April 2009
1L0O
37%
Bacillus anthracis
IDP04275
(
show subtarget assignments
)
1
cloned
No
BAS3684
49186683
DNA topoisomerase I [Bacillus anthracis ...
692
Proposed to be essential proteins
Phase 4: April 2009
2GAI
38.2%
Bacillus anthracis
IDP04045
(
show subtarget assignments
)
1
soluble
No
FTT1747
56708745
outer membrane protein [Francisella tula...
191
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Francisella tularensis
IDP90968
(
show subtarget assignments
)
8
selected
No
427
Planet Biotechnology company is currently developing an anthrax anti-toxin with ...
Community Requests
1HZH
62.3%
synthetic construct
IDP90977
(
show subtarget assignments
)
8
soluble
No
y0320
22124237
oxyR
DNA-binding transcriptional regulator Ox...
305
other biological interest /
important global regulator
Community Requests
1I6A
59.7%
Yersinia pestis
IDP04013
(
show subtarget assignments
)
1
cloned
No
STM2913_1_498
16766219
putative permease [Salmonella typhimuriu...
498
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04021
(
show subtarget assignments
)
1
expressed
No
BAS3695
49186694
30S ribosomal protein S16 [Bacillus anth...
90
Proposed to be essential proteins
Phase 4: April 2009
1EMW
42.2%
Bacillus anthracis
IDP90976
(
show subtarget assignments
)
8
cloned
No
y0137
22124057
degQ
protease [Yersinia pestis KIM 10]
463
other biological interest /
bifunctional chaperone / protease
Community Requests
4A8A
67.6%
Yersinia pestis
IDP90972
(
show subtarget assignments
)
8
selected
No
ECO103_4485
260846542
tisB
lexA-regulated toxic peptide [Escherichi...
29
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP90973
(
show subtarget assignments
)
8
selected
No
AND4_00045
163803697
RTX toxin RtxA [Vibrio sp. AND4]
525
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Vibrio sp.
IDP90975
(
show subtarget assignments
)
8
cloned
No
y0011
22123933
hypothetical protein y0011 [Yersinia pes...
229
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
2DI3
21.4%
Yersinia pestis
IDP04024
(
show subtarget assignments
)
1
cloned
No
BAS5319
49188303
DNA-binding response regulator YycF [Bac...
235
Proposed to be essential proteins
Phase 4: April 2009
2OQR
47.7%
Bacillus anthracis
IDP04028
(
show subtarget assignments
)
1
purified
No
BAS0109
49183143
30S ribosomal protein S10 [Bacillus anth...
102
Proposed to be essential proteins
Phase 4: April 2009
1P6G
61.8%
Bacillus anthracis
IDP04614
(
show subtarget assignments
)
1
purified
No
BAS4131
49187128
glycine cleavage system aminomethyltrans...
366
Proposed to be essential proteins
Phase 4: April 2009
1YX2
66.1%
Bacillus anthracis
IDP04080
(
show subtarget assignments
)
1
cloned
No
BAS0123
49183157
30S ribosomal protein S14 [Bacillus anth...
61
Proposed to be essential proteins
Phase 4: April 2009
1FJG
73.8%
Bacillus anthracis
IDP04027
(
show subtarget assignments
)
1
cloned
No
BAS4637
49187628
leucyl-tRNA synthetase [Bacillus anthrac...
802
Proposed to be essential proteins
Phase 4: April 2009
1H3N
45.9%
Bacillus anthracis
IDP04025
(
show subtarget assignments
)
1
expressed
No
YPCD1.36c
16082724
yscX
hypothetical protein YPCD1.36c [Yersinia...
122
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04026
(
show subtarget assignments
)
1
expressed
No
FTT0456c
56707598
hypothetical protein FTT_0456c [Francise...
97
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1YHD
39.2%
Francisella tularensis
IDP90979
(
show subtarget assignments
)
8
cloned
No
y0636
22124550
hypothetical protein y0636 [Yersinia pes...
158
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
2Y75
24.1%
Yersinia pestis
IDP04038
(
show subtarget assignments
)
1
expressed
No
YPCD1.65
5832485
YPCD1.65
putative transposase [Yersinia pestis CO...
102
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP90985
(
show subtarget assignments
)
8
expressed
No
y0964
22124871
hypothetical protein y0964 [Yersinia pes...
421
other biological interest /
-
Community Requests
3MVE
41.8%
Yersinia pestis
IDP90984
(
show subtarget assignments
)
8
cloned
No
y0931
22124839
hypothetical protein y0931 [Yersinia pes...
281
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
3SHO
12.8%
Yersinia pestis
IDP90983
(
show subtarget assignments
)
8
selected
No
y0870
22124781
katG
catalase-peroxidase [Yersinia pestis KIM...
751
virulence/pathogenesis /
stress response protein and antigen in Y pestis
Community Requests
2FXG
59.4%
Yersinia pestis
IDP04035
(
show subtarget assignments
)
1
in_pdb
3P0R
Yes
BAS5262
49188247
azoreductase [Bacillus anthracis str. St...
208
Proposed to be essential proteins
Phase 4: April 2009
3P0R
100%
Bacillus anthracis
IDP90987
(
show subtarget assignments
)
8
crystallized
No
y1125
22125029
hypothetical protein y1125 [Yersinia pes...
297
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
1VP5
57.2%
Yersinia pestis
IDP04034
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0128
49183162
50S ribosomal protein L30 [Bacillus anth...
60
Proposed to be essential proteins
Phase 4: April 2009
1VS6
53.3%
Bacillus anthracis
IDP04030
(
show subtarget assignments
)
1
cloned
No
YPO2532
115348229
hypothetical protein [Yersinia pestis CO...
70
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04046
(
show subtarget assignments
)
1
cloned
No
YPCD1.78c
16082765
tap
repA translation protein [Yersinia pesti...
24
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04276
(
show subtarget assignments
)
1
soluble
No
FTT0312c
56707465
folA
dihydrofolate reductase type I [Francise...
166
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3JW3
41.6%
Francisella tularensis
IDP04057
(
show subtarget assignments
)
1
purified
No
BAS0125
49183159
50S ribosomal protein L6 [Bacillus anthr...
179
Proposed to be essential proteins
Phase 4: April 2009
1C04
74.9%
Bacillus anthracis
IDP04068
(
show subtarget assignments
)
1
expressed
No
YPCD1.94n
40548799
hypothetical protein YPCD1.94n [Yersinia...
251
virulence factor;
Phase 4: April 2009
1A5V
15.1%
Yersinia pestis
IDP04055
(
show subtarget assignments
)
1
cloned
No
STM0301_1_836
16763684
safC
putative fimbrial usher [Salmonella typh...
836
Salmonella essential protein
Phase 4: April 2009
3RFZ
37%
Salmonella enterica
IDP04520
(
show subtarget assignments
)
1
purified
No
Z0985
15800520
hypothetical protein Z0985 [Escherichia ...
326
Effector protein
Phase 4: April 2009
Escherichia coli
IDP91357
(
show subtarget assignments
)
8
soluble
No
VV1_2850
27366131
50S ribosomal protein L25 [Vibrio vulnif...
92
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1B75
56.5%
Vibrio vulnificus
IDP91507
(
show subtarget assignments
)
8
expressed
No
VP1667
28898441
putative outer membrane protein PopN [Vi...
297
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1XKP
29.3%
Vibrio parahaemolyticus
IDP04619
(
show subtarget assignments
)
1
in_pdb
4DIB
No
BAS4478
49187473
glyceraldehyde-3-phosphate dehydrogenase...
342
Proposed to be essential proteins
Phase 4: April 2009
4DIB
100%
Bacillus anthracis
IDP90991
(
show subtarget assignments
)
8
cloned
No
y1282
22125182
formate acetyltransferase [Yersinia pest...
150
other biological interest /
stress-response protein replacind PflA in PflA/PflB complex
Community Requests
1CM5
40%
Yersinia pestis
IDP04079
(
show subtarget assignments
)
1
purified
No
BAS0100
49183134
50S ribosomal protein L7/L12 [Bacillus a...
119
Proposed to be essential proteins
Phase 4: April 2009
1DD3
63.3%
Bacillus anthracis
IDP91512
(
show subtarget assignments
)
8
cloned
No
VV2_0404
27366843
cytolysin [Vibrio vulnificus CMCP6]
468
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1XEZ
25.9%
Vibrio vulnificus
IDP04067
(
show subtarget assignments
)
1
purified
No
BAS4417
49187412
thioredoxin [Bacillus anthracis str. Ste...
104
Proposed to be essential proteins
Phase 4: April 2009
2GZY
75%
Bacillus anthracis
IDP04066
(
show subtarget assignments
)
8
selected
No
CAC05819
12329088
mxiE
MxiE, similarities to transcriptional ac...
210
Shigella effector protein
Community Requests
Shigella flexneri
IDP04064
(
show subtarget assignments
)
1
expressed
No
BAS0127
49183161
30S ribosomal protein S5 [Bacillus anthr...
166
Proposed to be essential proteins
Phase 4: April 2009
1PKP
75.3%
Bacillus anthracis
IDP04060
(
show subtarget assignments
)
8
selected
No
CAC05813
12329082
mxiI
MxiI, component of the Mxi-Spa secretion...
97
Shigella effector protein
Community Requests
Shigella flexneri
IDP04069
(
show subtarget assignments
)
1
in_pdb
3R3T
Yes
BAS5327
49188311
30S ribosomal protein S6 [Bacillus anthr...
96
Proposed to be essential proteins
Phase 4: April 2009
3R3T
100%
Bacillus anthracis
IDP04277
(
show subtarget assignments
)
1
cloned
No
BAS3960
49186958
PTS system, glucose-specific IIABC compo...
687
Proposed to be essential proteins
Phase 4: April 2009
1AX3
14.7%
Bacillus anthracis
IDP04077
(
show subtarget assignments
)
1
crystallized
No
FTT1793c
56708781
pepN
aminopeptidase N [Francisella tularensis...
864
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2DQ6
48.9%
Francisella tularensis
IDP04070
(
show subtarget assignments
)
1
cloned
No
FTT0073
56707252
sdhD
succinate dehydrogenase hydrophobic memb...
122
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1NEK
26.2%
Francisella tularensis
IDP04292
(
show subtarget assignments
)
1
cloned
No
YPO0812
218927992
general secretion pathway protein H [Yer...
180
conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04288
(
show subtarget assignments
)
1
expressed
No
YPCD1.08c
5832431
YPCD1.08c
hypothetical protein YPCD1.08c [Yersinia...
99
virulence factor; conserved gene;
Phase 4: April 2009
3KXE
28.3%
Yersinia pestis
IDP90993
(
show subtarget assignments
)
8
selected
No
y1334
22125233
cysteine desulfurase [Yersinia pestis KI...
409
other biological interest /
enzyme involved in iron-sulfur cluster synthesis
Community Requests
1P3W
87.8%
Yersinia pestis
IDP91001
(
show subtarget assignments
)
8
soluble
No
y1897
22125790
yfeA
periplasmic-binding protein [Yersinia pe...
323
virulence/pathogenesis /
periplasmic iron-binding protein
Community Requests
1XVL
52.9%
Yersinia pestis
IDP04622
(
show subtarget assignments
)
1
soluble
No
BAS4556
49187550
tyrosyl-tRNA synthetase [Bacillus anthra...
418
potential drug target /
Proposed to be essential proteins
Phase 4: April 2009
2TS1
70.6%
Bacillus anthracis
IDP91000
(
show subtarget assignments
)
8
cloned
No
y1726
22125620
hypothetical protein y1726 [Yersinia pes...
334
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
Yersinia pestis
IDP04623
(
show subtarget assignments
)
1
expressed
No
BAS4760
49187751
glucose-1-phosphate adenylyltransferase ...
376
Proposed to be essential proteins
Phase 4: April 2009
3BRK
40%
Bacillus anthracis
IDP90996
(
show subtarget assignments
)
8
in_pdb
4DYU
No
y1677
22125572
dps
DNA starvation/stationary phase protecti...
167
other biological interest /
global stress response protein
Community Requests
4DYU
100%
Yersinia pestis
IDP04075
(
show subtarget assignments
)
8
selected
No
CAC05807
12329076
icsB
IcsB, function unknown [Shigella flexner...
494
Shigella effector protein
Community Requests
Shigella flexneri
IDP04071
(
show subtarget assignments
)
1
cloned
No
BAS0129
49183163
50S ribosomal protein L15 [Bacillus anth...
146
Proposed to be essential proteins
Phase 4: April 2009
1VSA
51.4%
Bacillus anthracis
IDP90998
(
show subtarget assignments
)
8
cloned
No
y1724
22125618
hypothetical protein y1724 [Yersinia pes...
448
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
Yersinia pestis
IDP04074
(
show subtarget assignments
)
1
cloned
No
BAS4469
49187464
50S ribosomal protein L20 [Bacillus anth...
118
Proposed to be essential proteins
Phase 4: April 2009
1VS6
55.1%
Bacillus anthracis
IDP04307
(
show subtarget assignments
)
1
cloned
No
CPF_1812
110799901
putative lipoprotein [Clostridium perfri...
44
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
IDP04106
(
show subtarget assignments
)
1
cloned
No
BAS0124
49183158
30S ribosomal protein S8 [Bacillus anthr...
132
Proposed to be essential proteins
Phase 4: April 2009
1SEI
85.6%
Bacillus anthracis
IDP04528
(
show subtarget assignments
)
1
expressed
No
STM2257_1_289
16765585
napH
quinol dehydrogenase membrane component ...
289
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04646
(
show subtarget assignments
)
1
soluble
No
FTT1085
56708168
hypothetical protein FTT_1085 [Francisel...
332
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1QXN
9.3%
Francisella tularensis
IDP04119
(
show subtarget assignments
)
1
crystallized
No
BAS0131
49183165
adenylate kinase [Bacillus anthracis str...
216
Proposed to be essential proteins
Phase 4: April 2009
1ZIN
74.1%
Bacillus anthracis
IDP04135
(
show subtarget assignments
)
1
cloned
No
BAS4470
49187465
50S ribosomal protein L35 [Bacillus anth...
66
Proposed to be essential proteins
Phase 4: April 2009
1VS6
48.5%
Bacillus anthracis
IDP04335
(
show subtarget assignments
)
1
cloned
No
STM1543_1_428
16764888
putative transport protein [Salmonella t...
428
Salmonella essential protein
Phase 4: April 2009
1PW4
23.4%
Salmonella enterica
IDP05094
(
show subtarget assignments
)
1
purified
No
BA_3160
30257733
hypothetical protein BA_3160 [Bacillus a...
257
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04527
(
show subtarget assignments
)
1
cloned
No
STM1824_1_454
16765165
pabB
para-aminobenzoate synthase component I ...
454
Salmonella essential protein
Phase 4: April 2009
1K0E
76.2%
Salmonella enterica
IDP04633
(
show subtarget assignments
)
1
in_pdb
4EEI
No
FTT0015
56707195
purB
adenylosuccinate lyase [Francisella tula...
432
conserved gene; putative drug target function;
Phase 4: April 2009
4EEI
100%
Francisella tularensis
IDP04530
(
show subtarget assignments
)
1
soluble
No
STM2519_1_490
16765839
engA
GTP-binding protein EngA [Salmonella typ...
490
Salmonella essential protein
Phase 4: April 2009
2HJG
36.1%
Salmonella enterica
IDP91209
(
show subtarget assignments
)
8
expressed
No
BT_2084
29347494
chorismate synthase [Bacteroides thetaio...
358
potential drug target /
Shikimate pathway enzyme
Community Requests
1R52
47.9%
Bacteroides thetaiotaomicron
IDP04306
(
show subtarget assignments
)
8
selected
No
CAC05809
12329078
ipgE
IpgE, cytoplasmic chaperone for IpgD [Sh...
120
Shigella effector protein
Community Requests
1K3S
27.5%
Shigella flexneri
IDP04526
(
show subtarget assignments
)
1
expressed
No
STM1637_1_516
16764981
putative inner membrane protein [Salmone...
516
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04098
(
show subtarget assignments
)
1
cloned
No
YPCD1.50
5832470
YPCD1.50
hypothetical protein YPCD1.50 [Yersinia ...
32
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04574
(
show subtarget assignments
)
1
soluble
No
BAS0015
49183051
seryl-tRNA synthetase [Bacillus anthraci...
424
Proposed to be essential proteins
Phase 4: April 2009
2DQ3
57.8%
Bacillus anthracis
IDP04107
(
show subtarget assignments
)
1
purified
No
BAS0120
49183154
50S ribosomal protein L14 [Bacillus anth...
122
Proposed to be essential proteins
Phase 4: April 2009
1C04
86.9%
Bacillus anthracis
IDP04628
(
show subtarget assignments
)
1
soluble
No
BAS5322
49188306
50S ribosomal protein L9 [Bacillus anthr...
148
Proposed to be essential proteins
Phase 4: April 2009
1DIV
75%
Bacillus anthracis
IDP04529
(
show subtarget assignments
)
1
crystallized
No
STM2481_1_1037
16765801
acrD
aminoglycoside/multidrug efflux system [...
1037
Salmonella essential protein
Phase 4: April 2009
1IWG
66.2%
Salmonella enterica
IDP04117
(
show subtarget assignments
)
8
selected
No
CAC05825
12329094
spa13
spa13, component of the Mxi-Spa secretio...
112
Shigella effector protein
Community Requests
Shigella flexneri
IDP04308
(
show subtarget assignments
)
1
cloned
No
YPCD1.14n
40548797
hypothetical protein YPCD1.14n [Yersinia...
65
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04309
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0050
49183085
peptidyl-tRNA hydrolase [Bacillus anthra...
186
Proposed to be essential proteins
Phase 4: April 2009
3KJZ
40.9%
Bacillus anthracis
IDP91009
(
show subtarget assignments
)
8
soluble
No
y2136
22126024
hypothetical protein y2136 [Yersinia pes...
317
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
Yersinia pestis
IDP91008
(
show subtarget assignments
)
8
soluble
No
y1951
22125843
sodB
superoxide dismutase [Yersinia pestis KI...
206
other biological interest /
iron-regulated oxidative stress enzyme
Community Requests
1ISA
75.2%
Yersinia pestis
IDP04311
(
show subtarget assignments
)
1
purified
No
BAS4340
49187335
50S ribosomal protein L27 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1VSA
55.2%
Bacillus anthracis
IDP04314
(
show subtarget assignments
)
1
purified
No
YPCD1.73c
5832493
YPCD1.73c
hypothetical protein YPCD1.73c [Yersinia...
149
virulence factor; conserved gene;
Phase 4: April 2009
1JSC
40.7%
Yersinia pestis
IDP04116
(
show subtarget assignments
)
1
expressed
No
Z5122
15804232
sepZ
hypothetical protein Z5122 [Escherichia ...
99
Effector protein
Phase 4: April 2009
Escherichia coli
IDP91012
(
show subtarget assignments
)
8
expressed
No
y2259
22126145
hypothetical protein y2259 [Yersinia pes...
271
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
Yersinia pestis
IDP91015
(
show subtarget assignments
)
8
selected
No
y2404
22126288
psn
pesticin/yersiniabactin outer membrane r...
673
TonB-dependent outer membrane receptor (yersiniabactin-binding)
Community Requests
1NQF
23.8%
Yersinia pestis
IDP04115
(
show subtarget assignments
)
1
expressed
No
STM2352_1_235
16765679
hisM
histidine/lysine/arginine/ornithine tran...
235
Salmonella essential protein
Phase 4: April 2009
3DHW
23.8%
Salmonella enterica
IDP91017
(
show subtarget assignments
)
8
expressed
No
y2556
22126437
fcuA
ferrichrome receptor, TonB dependent [Ye...
776
other biological interest /
putative iron-binding TonB-dependent outer membrane receptor
Community Requests
3QLB
23.6%
Yersinia pestis
IDP91016
(
show subtarget assignments
)
8
selected
No
y2451
22126334
hypothetical protein y2451 [Yersinia pes...
384
other biological interest /
putative iron transport protein
Community Requests
3AT7
40.9%
Yersinia pestis
IDP91631
(
show subtarget assignments
)
8
expressed
No
BAB35244
13361286
ECs1821
hypothetical protein [Escherichia coli O...
92
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91630
(
show subtarget assignments
)
8
cloned
No
BAB35233
13361275
ECs1810
hypothetical protein [Escherichia coli O...
88
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
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