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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 8 of 60, showing 100 records out of 5973 total, starting on record 701
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP04578
(
show subtarget assignments
)
1
cloned
No
BAS0089
49183123
cysteinyl-tRNA synthetase [Bacillus anth...
465
Proposed to be essential proteins
Phase 4: April 2009
1LI5
45.6%
Bacillus anthracis
IDP04579
(
show subtarget assignments
)
1
cloned
No
BAS0098
49183132
50S ribosomal protein L1 [Bacillus anthr...
230
Proposed to be essential proteins
Phase 4: April 2009
3QOY
56.3%
Bacillus anthracis
IDP04587
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0118
49183152
50S ribosomal protein L29 [Bacillus anth...
66
Proposed to be essential proteins
Phase 4: April 2009
1R73
45.5%
Bacillus anthracis
IDP05095
(
show subtarget assignments
)
1
soluble
No
BA_5481
30259944
conserved domain protein [Bacillus anthr...
290
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Domain
IDP05014
(
show subtarget assignments
)
1
soluble
No
BA_1972
30256627
putative lipoprotein [Bacillus anthracis...
765
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP04625
(
show subtarget assignments
)
1
cloned
No
BAS5050
49188036
glycosyl transferase, group 4 family pro...
357
Proposed to be essential proteins
Phase 4: April 2009
Bacillus anthracis
IDP05001
(
show subtarget assignments
)
1
purified
No
BA_1090
30254820
putative lipoprotein [Bacillus anthracis...
142
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP04593
(
show subtarget assignments
)
1
cloned
No
BAS0144
49183178
30S ribosomal protein S9 [Bacillus anthr...
130
Proposed to be essential proteins
Phase 4: April 2009
1VS5
55.4%
Bacillus anthracis
IDP05208
(
show subtarget assignments
)
1
cloned
No
CD2373
126699988
putative carbon starvation protein [Clos...
499
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Cellular processes: Adaptations to atypical conditions
IDP04070
(
show subtarget assignments
)
1
cloned
No
FTT0073
56707252
sdhD
succinate dehydrogenase hydrophobic memb...
122
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1NEK
26.2%
Francisella tularensis
IDP05131
(
show subtarget assignments
)
1
cloned
No
CD0260
126697832
fliP
flagellar biosynthesis protein FliP [Clo...
221
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP04663
(
show subtarget assignments
)
1
cloned
No
BAS5325
49188309
30S ribosomal protein S18 [Bacillus anth...
77
Proposed to be essential proteins
Phase 4: April 2009
1P6G
50.6%
Bacillus anthracis
IDP04527
(
show subtarget assignments
)
1
cloned
No
STM1824_1_454
16765165
pabB
para-aminobenzoate synthase component I ...
454
Salmonella essential protein
Phase 4: April 2009
1K0E
76.2%
Salmonella enterica
IDP05015
(
show subtarget assignments
)
1
cloned
No
CD0247
126697818
fliE
flagellar hook-basal body protein FliE [...
105
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP05298
(
show subtarget assignments
)
1
purified
No
CD2189
126699805
pgmB
beta-phosphoglucomutase [Clostridium dif...
226
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3NAS
46.9%
Clostridium difficile
Energy metabolism: Biosynthesis and degradation of polysaccharides
IDP05101
(
show subtarget assignments
)
1
in_crystallization_trials
No
CD1058
126698642
hbd
3-hydroxybutyryl-CoA dehydrogenase [Clos...
281
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1F0Y
43.9%
Clostridium difficile
Fatty acid and phospholipid metabolism: Degradation
IDP04314
(
show subtarget assignments
)
1
purified
No
YPCD1.73c
5832493
YPCD1.73c
hypothetical protein YPCD1.73c [Yersinia...
149
virulence factor; conserved gene;
Phase 4: April 2009
1JSC
40.7%
Yersinia pestis
IDP05348
(
show subtarget assignments
)
1
expressed
No
CD2408
126700023
putative multidrug efflux pump, outer me...
439
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Cell envelope: Other
IDP04583
(
show subtarget assignments
)
1
cloned
No
BAS0111
49183145
50S ribosomal protein L4 [Bacillus anthr...
207
Proposed to be essential proteins
Phase 4: April 2009
1DMG
47.1%
Bacillus anthracis
IDP04309
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0050
49183085
peptidyl-tRNA hydrolase [Bacillus anthra...
186
Proposed to be essential proteins
Phase 4: April 2009
3KJZ
40.9%
Bacillus anthracis
IDP04586
(
show subtarget assignments
)
1
cloned
No
BAS0117
49183151
50S ribosomal protein L16 [Bacillus anth...
144
Proposed to be essential proteins
Phase 4: April 2009
1VSA
60.4%
Bacillus anthracis
IDP04617
(
show subtarget assignments
)
1
expressed
No
BAS4342
49187337
50S ribosomal protein L21 [Bacillus anth...
102
Proposed to be essential proteins
Phase 4: April 2009
1VSA
54.9%
Bacillus anthracis
IDP04585
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0116
49183150
30S ribosomal protein S3 [Bacillus anthr...
219
Proposed to be essential proteins
Phase 4: April 2009
1VS5
54.3%
Bacillus anthracis
IDP05038
(
show subtarget assignments
)
1
expressed
No
BA_1902
30256562
multicopper oxidase family protein [Baci...
551
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3T6V
25.8%
Bacillus anthracis
Unknown function: Enzymes of unknown specificity
IDP04584
(
show subtarget assignments
)
1
purified
No
BAS0112
49183146
50S ribosomal protein L23 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1N88
43.8%
Bacillus anthracis
IDP05284
(
show subtarget assignments
)
1
expressed
No
CD0369
126697939
hypothetical protein CD0369 [Clostridium...
74
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP05130
(
show subtarget assignments
)
1
cloned
No
CD0119
126697691
phosphoglucomutase/phosphomannomutase mu...
454
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3PDK
50.2%
Clostridium difficile
Central intermediary metabolism: Amino sugars
IDP05231
(
show subtarget assignments
)
1
purified
No
lmo1388
16803428
tcsA
CD4+ T cell-stimulating antigen, lipopro...
346
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2FQW
39.9%
Listeria monocytogenes
Unclassified: Role category not yet assigned
IDP04311
(
show subtarget assignments
)
1
purified
No
BAS4340
49187335
50S ribosomal protein L27 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1VSA
55.2%
Bacillus anthracis
IDP05037
(
show subtarget assignments
)
1
soluble
No
BA_1836
30256106
putative polysaccharide deacetylase [Bac...
234
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2C71
27.4%
Bacillus anthracis
Energy metabolism: Biosynthesis and degradation of polysaccharides
IDP04310
(
show subtarget assignments
)
1
cloned
No
BAS0231
49183264
D-alanine--D-alanine ligase, C-terminus ...
91
Proposed to be essential proteins
Phase 4: April 2009
2I80
54.9%
Bacillus anthracis
IDP05093
(
show subtarget assignments
)
1
cloned
No
lmo0193
16802239
-
hypothetical protein lmo0193 [Listeria m...
225
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
4DK0
24.6%
Listeria monocytogenes
Hypothetical proteins: Conserved
IDP05042
(
show subtarget assignments
)
1
soluble
No
BA_2921
30257513
putative sulfonate ABC transporter, sulf...
328
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2X26
28%
Bacillus anthracis
Transport and binding proteins: Anions
IDP05148
(
show subtarget assignments
)
1
purified
No
BA_0177
30253685
putative lipoprotein [Bacillus anthracis...
254
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP05013
(
show subtarget assignments
)
1
expressed
No
CD0238
126697809
hypothetical protein CD0238 [Clostridium...
111
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP05182
(
show subtarget assignments
)
1
soluble
No
BA_4984
30259476
gerHA
spore germination protein GerHA [Bacillu...
747
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3FBY
7.5%
Bacillus anthracis
Cellular processes: Sporulation and germination
IDP05041
(
show subtarget assignments
)
1
purified
No
BA_2335
30256973
hypothetical protein BA_2335 [Bacillus a...
64
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04590
(
show subtarget assignments
)
1
expressed
No
BAS0136
49183170
30S ribosomal protein S11 [Bacillus anth...
129
Proposed to be essential proteins
Phase 4: April 2009
1VS5
65.9%
Bacillus anthracis
IDP05149
(
show subtarget assignments
)
1
purified
No
BA_0194
30253701
putative oligopeptide ABC transporter, o...
546
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1B05
30.2%
Bacillus anthracis
Transport and binding proteins: Amino acids, peptides and amines
IDP04526
(
show subtarget assignments
)
1
expressed
No
STM1637_1_516
16764981
putative inner membrane protein [Salmone...
516
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP05179
(
show subtarget assignments
)
1
soluble
No
BA_3367
30257910
LPXTG-motif cell wall anchor domain prot...
595
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP04523
(
show subtarget assignments
)
1
cloned
No
STM0884_1_447
16764245
ulaA
ascorbate-specific PTS system enzyme IIC...
447
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04626
(
show subtarget assignments
)
1
cloned
No
BAS5178
49188164
peptide chain release factor 1 [Bacillus...
358
Proposed to be essential proteins
Phase 4: April 2009
1ZBT
59.2%
Bacillus anthracis
IDP05097
(
show subtarget assignments
)
1
cloned
No
CD0226
126697797
putative transglycosylase [Clostridium d...
222
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05098
(
show subtarget assignments
)
1
purified
No
CD0569
126698147
putative outer membrane lipoprotein [Clo...
334
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2FQW
21.3%
Clostridium difficile
Cell envelope: Other
IDP04654
(
show subtarget assignments
)
1
purified
No
FTT1526c
56708560
idh
isocitrate dehydrogenase [Francisella tu...
747
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1ITW
62.7%
Francisella tularensis
IDP04588
(
show subtarget assignments
)
1
cloned
No
BAS0130
49183164
preprotein translocase subunit SecY [Bac...
433
Proposed to be essential proteins
Phase 4: April 2009
3DIN
43.8%
Bacillus anthracis
IDP04589
(
show subtarget assignments
)
1
expressed
No
BAS0135
49183169
30S ribosomal protein S13 [Bacillus anth...
121
Proposed to be essential proteins
Phase 4: April 2009
1FJG
63.9%
Bacillus anthracis
IDP05177
(
show subtarget assignments
)
1
cloned
No
BA_2974
30257564
mqo
malate:quinone-oxidoreductase [Bacillus ...
500
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Energy metabolism: TCA cycle
IDP05096
(
show subtarget assignments
)
1
cloned
No
CD0015
126697581
putative cytosine/adenosine deaminase [C...
155
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1WWR
48.1%
Clostridium difficile
Transport and binding proteins: Unknown substrate
IDP05364
(
show subtarget assignments
)
1
soluble
No
BA_2881
30257478
bacterial extracellular solute-binding p...
578
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3M8U
19.2%
Bacillus anthracis
Transport and binding proteins: Unknown substrate
IDP05181
(
show subtarget assignments
)
1
soluble
No
BA_4729
30259221
bacterial extracellular solute-binding p...
521
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1UQW
30.3%
Bacillus anthracis
Transport and binding proteins: Unknown substrate
IDP04591
(
show subtarget assignments
)
1
cloned
No
BAS0138
49183172
50S ribosomal protein L17 [Bacillus anth...
120
Proposed to be essential proteins
Phase 4: April 2009
1NKW
50.8%
Bacillus anthracis
IDP05367
(
show subtarget assignments
)
1
soluble
No
BA_3326
30257871
conserved hypothetical protein [Bacillus...
355
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP04524
(
show subtarget assignments
)
1
in_pdb
3Q58
Yes
STM1129_1_226
16764486
N-acetylmannosamine-6-phosphate 2-epimer...
226
Salmonella essential protein
Phase 4: April 2009
3Q58
100%
Salmonella enterica
IDP05210
(
show subtarget assignments
)
1
cloned
No
CD2464
126700081
hemN
oxygen-independent coproporphyrinogen II...
380
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1OLT
20.8%
Clostridium difficile
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
IDP05040
(
show subtarget assignments
)
1
expressed
No
BA_2262
30256905
heat shock protein, Hsp20 family [Bacill...
145
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1GME
30.3%
Bacillus anthracis
Cellular processes: Adaptations to atypical conditions
IDP05256
(
show subtarget assignments
)
1
cloned
No
BA_1805
30256080
hypothetical protein BA_1805 [Bacillus a...
44
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05180
(
show subtarget assignments
)
1
soluble
No
BA_3644
30258169
putative oligopeptide ABC transporter, o...
568
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3TCF
29.6%
Bacillus anthracis
Transport and binding proteins: Amino acids, peptides and amines
IDP04592
(
show subtarget assignments
)
1
expressed
No
BAS0143
49183177
50S ribosomal protein L13 [Bacillus anth...
145
Proposed to be essential proteins
Phase 4: April 2009
1P85
56.6%
Bacillus anthracis
IDP05099
(
show subtarget assignments
)
1
cloned
No
CD0754
126698334
thiI
thiamine biosynthesis protein ThiI [Clos...
391
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2C5S
42.2%
Clostridium difficile
Protein synthesis: tRNA and rRNA base modification
IDP05473
(
show subtarget assignments
)
1
expressed
No
BA_2626
30257243
hypothetical protein BA_2626 [Bacillus a...
134
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04525
(
show subtarget assignments
)
1
cloned
No
STM1556_1_483
16764900
putative Na+/H+ antiporter [Salmonella t...
483
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP05132
(
show subtarget assignments
)
1
cloned
No
CD0262
126697834
flhB
bifunctional flagellar biosynthesis prot...
604
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2JLH
7.9%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP04658
(
show subtarget assignments
)
1
purified
No
FTT1736c
56708739
kdpD
two component sensor protein kdpD [Franc...
893
conserved gene;
Phase 4: April 2009
2R8R
11.4%
Francisella tularensis
IDP05229
(
show subtarget assignments
)
1
cloned
No
lmo1286
16803326
parE
DNA topoisomerase IV subunit B [Listeria...
655
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1EI1
29.8%
Listeria monocytogenes
DNA metabolism: DNA replication, recombination, and repair
IDP04080
(
show subtarget assignments
)
1
cloned
No
BAS0123
49183157
30S ribosomal protein S14 [Bacillus anth...
61
Proposed to be essential proteins
Phase 4: April 2009
1FJG
73.8%
Bacillus anthracis
IDP04623
(
show subtarget assignments
)
1
expressed
No
BAS4760
49187751
glucose-1-phosphate adenylyltransferase ...
376
Proposed to be essential proteins
Phase 4: April 2009
3BRK
40%
Bacillus anthracis
IDP04339
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0115
49183149
50S ribosomal protein L22 [Bacillus anth...
113
Proposed to be essential proteins
Phase 4: April 2009
1BXE
59.3%
Bacillus anthracis
IDP05105
(
show subtarget assignments
)
1
cloned
No
CD1374
126698975
hypothetical protein CD1374 [Clostridium...
1743
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
4D9S
5.9%
Clostridium difficile
Regulatory functions: Other
IDP05263
(
show subtarget assignments
)
1
cloned
No
CD2793
126700409
slpA
cell surface protein (S-layer precursor ...
719
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3CVZ
36.4%
Clostridium difficile
Cell envelope: Other
IDP04633
(
show subtarget assignments
)
1
in_pdb
4EEI
No
FTT0015
56707195
purB
adenylosuccinate lyase [Francisella tula...
432
conserved gene; putative drug target function;
Phase 4: April 2009
4EEI
100%
Francisella tularensis
IDP04046
(
show subtarget assignments
)
1
cloned
No
YPCD1.78c
16082765
tap
repA translation protein [Yersinia pesti...
24
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04606
(
show subtarget assignments
)
1
cloned
No
BAS3692
49186691
tRNA (guanine-N(1)-)-methyltransferase [...
244
Proposed to be essential proteins
Phase 4: April 2009
3KY7
62.3%
Bacillus anthracis
IDP05045
(
show subtarget assignments
)
1
soluble
No
BA_3418
30257959
putative lipoprotein [Bacillus anthracis...
131
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP04637
(
show subtarget assignments
)
1
cloned
No
FTT0371c
56707522
folC
FolC bifunctional protein [Francisella t...
393
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1W78
29.8%
Francisella tularensis
IDP04079
(
show subtarget assignments
)
1
purified
No
BAS0100
49183134
50S ribosomal protein L7/L12 [Bacillus a...
119
Proposed to be essential proteins
Phase 4: April 2009
1DD3
63.3%
Bacillus anthracis
IDP04602
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS3667
49186666
transcription elongation factor NusA [Ba...
368
Proposed to be essential proteins
Phase 4: April 2009
1HH2
44%
Bacillus anthracis
IDP05047
(
show subtarget assignments
)
1
soluble
No
BA_4154
30258660
ctaC
cytochrome c oxidase, subunit II [Bacill...
349
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1FFT
19.2%
Bacillus anthracis
Energy metabolism: Electron transport
IDP04223
(
show subtarget assignments
)
8
selected
No
CAC05808
12329077
ipgD
IpgD, secreted by the Mxi-Spa machinery,...
538
Shigella effector protein
Community Requests
Shigella flexneri
IDP04210
(
show subtarget assignments
)
1
expressed
No
ZZZ_0017
243
Effector protein
Phase 4: April 2009
2KXC
18.5%
Escherichia coli
IDP05289
(
show subtarget assignments
)
1
soluble
No
CD0784
126698364
putative N-acetylmuramoyl-L-alanine amid...
281
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05160
(
show subtarget assignments
)
1
purified
No
BA_1349
30255287
conserved hypothetical protein [Bacillus...
256
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2NLY
35.9%
Bacillus anthracis
Hypothetical proteins: Conserved
IDP04534
(
show subtarget assignments
)
8
selected
No
CAC05815
12329084
mxiK
MxiK, putative component of the Mxi-Spa ...
175
Shigella effector protein
Community Requests
Shigella flexneri
IDP05303
(
show subtarget assignments
)
1
cloned
No
SACOL1685
57650511
aspS
aspartyl-tRNA synthetase [Staphylococcus...
588
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1C0A
54.7%
Staphylococcus aureus
Protein synthesis: tRNA aminoacylation
IDP05155
(
show subtarget assignments
)
1
expressed
No
BA_0885
30254634
sap
S-layer protein Sap [Bacillus anthracis ...
814
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3PYW
22.4%
Bacillus anthracis
Cell envelope: Surface structures
IDP05051
(
show subtarget assignments
)
1
cloned
No
CD0127
126697699
mreB1
rod shape-determining protein Mbl [Clost...
339
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1JCE
52.2%
Clostridium difficile
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05109
(
show subtarget assignments
)
1
cloned
No
CD1987
126699595
cell surface protein [Clostridium diffic...
478
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Cell envelope: Other
IDP04081
(
show subtarget assignments
)
1
purified
No
BAS0361
49183389
DNA topoisomerase III [Bacillus anthraci...
729
Proposed to be essential proteins
Phase 4: April 2009
1D6M
27.7%
Bacillus anthracis
IDP04635
(
show subtarget assignments
)
1
soluble
No
FTT0101
56603768
conserved membrane hypothetical protein ...
337
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
4E94
25.5%
Francisella tularensis
IDP04620
(
show subtarget assignments
)
1
cloned
No
BAS4482
49187477
DNA polymerase I [Bacillus anthracis str...
891
Proposed to be essential proteins
Phase 4: April 2009
3TAN
45%
Bacillus anthracis
IDP04416
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS4049
49187047
ribonuclease Z [Bacillus anthracis str. ...
307
Proposed to be essential proteins
Phase 4: April 2009
1Y44
61.2%
Bacillus anthracis
IDP04417
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0033
56707213
nuoC
NADH dehydrogenase I [Francisella tulare...
216
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2FUG
21.8%
Francisella tularensis
IDP05234
(
show subtarget assignments
)
1
cloned
No
lmo1519
16803559
aspS
aspartyl-tRNA synthetase [Listeria monoc...
591
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1EQR
52.2%
Listeria monocytogenes
Protein synthesis: tRNA aminoacylation
IDP05215
(
show subtarget assignments
)
1
cloned
No
CD3091
126700708
treA
trehalose-6-phosphate hydrolase [Clostri...
555
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1UOK
50.2%
Clostridium difficile
Energy metabolism: Biosynthesis and degradation of polysaccharides
IDP05372
(
show subtarget assignments
)
1
cloned
No
BA_0397
30253932
LPXTG-motif cell wall anchor domain prot...
257
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3GHG
24.9%
Bacillus anthracis
Cell envelope: Other
IDP05104
(
show subtarget assignments
)
1
cloned
No
CD1233
126698829
cell surface protein [Clostridium diffic...
475
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Cell envelope: Other
IDP05052
(
show subtarget assignments
)
1
expressed
No
CD0239
126697810
fliC
flagellin subunit [Clostridium difficile...
290
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3K8W
34.8%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP05599
(
show subtarget assignments
)
1
purified
No
BA_3642
30258168
putative oligopeptide ABC transporter, o...
568
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1B05
28.9%
Bacillus anthracis
Transport and binding proteins: Amino acids, peptides and amines
IDP05598
(
show subtarget assignments
)
1
cloned
No
BA_3635
30258161
gerSC
spore germination protein [Bacillus anth...
378
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cellular processes: Sporulation and germination
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