Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00091 (show subtarget assignments)	0	work_stopped	No	NTL01SF0342	30040153	ribD	bifunctional pyrimidine deaminase/reduct...	367	Essential	Phase 1: October 2007	2G6V	97.8%	Shigella flexneri	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP90898 (show subtarget assignments)	8	soluble	No	STM0416	16763796	ribD	bifunctional diaminohydroxyphosphoribosy...	367	Predicted Essential	Community Requests	2G6V	89.4%	Salmonella enterica

IDP90906 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3183	16123345	ribD	bifunctional diaminohydroxyphosphoribosy...	369	Predicted Essential	Community Requests	2G6V	71.8%	Yersinia pestis

IDP05514 (show subtarget assignments)	1	purified	No	CD1315	126698913	ribC	riboflavin biosynthesis protein [Clostri...	309	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1MRZ	32.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP04105 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2391	115348093	ribC	riboflavin synthase alpha chain [Yersini...	218	conserved gene; putative drug target function;	Phase 4: April 2009	1I8D	74.8%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00017 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4333	81581445	ribBA	Riboflavin biosynthesis protein ribBA [I...	397	Drug Target Homolog	Phase 1: October 2007	2BZ0	27%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02186 (show subtarget assignments)	1	soluble	No	FTT1672	56708682	ribB	riboflavin synthase subunit alpha [Franc...	201	Conserved; Drug target functions	Phase 3: June 2008	1KZL	35.8%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP05517 (show subtarget assignments)	1	soluble	No	CD1699	126699305	ribB	riboflavin synthase subunit alpha [Clost...	221	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1KZL	38.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP00479 (show subtarget assignments)	1	in_pdb 3H07	No	YPO0658	16120983	ribB	3,4-dihydroxy-2-butanone 4-phosphate syn...	217	Conserved Gene / Pathway	Phase 2: March 2008	3H07	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP05201 (show subtarget assignments)	1	cloned	No	CD1698	126699304	ribA	riboflavin biosynthesis protein [Clostri...	408	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3MGZ	25.2%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91259 (show subtarget assignments)	8	soluble	No	NT02SA1746	14247541	ribA	riboflavin biosynthesis protein [Staphyl...	393	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3MGZ	24.2%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP90533 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0996	15792323	ribA	GTP cyclohydrolase II [Campylobacter jej...	186	Predicted Essential	Community Requests	2BZ0	47.2%	Campylobacter jejuni

IDP90729 (show subtarget assignments)	8	crystallized	No	Cj0572	15791932	ribA	bifunctional 3,4-dihydroxy-2-butanone 4-...	339	Predicted Essential	Community Requests	3MGZ	29.5%	Campylobacter jejuni

IDP91299 (show subtarget assignments)	8	cloned	No	STM1711	16765055	ribA	GTP cyclohydrolase II protein	196	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2BZ0	95.4%	Salmonella enterica

IDP91289 (show subtarget assignments)	8	soluble	No	SPA1165	56413363	ribA	GTP cyclohydrolase II [Salmonella enteri...	196	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2BZ0	95.4%	Salmonella enterica

IDP00400 (show subtarget assignments)	0	work_stopped	No	YPO2222	16122451	ribA	GTP cyclohydrolase II	196	Virulence Associated Factor	Phase 2: March 2008	2BZ0	88.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP91231 (show subtarget assignments)	8	soluble	No	NT04EC1793	26108012	ribA	GTP cyclohydrolase II [Escherichia coli ...	196	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2BZ0	99.5%	Escherichia coli	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP00332 (show subtarget assignments)	1	purified	No	FTT1673	56708683	ribA	riboflavin biosynthesis protein ribA/GTP...	403	Drug Target Function	Phase 2: March 2008	1G57	27%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP90684 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1218c	15792542	ribA	riboflavin synthase subunit alpha [Campy...	203	Predicted Essential	Community Requests	1KZL	29.6%	Campylobacter jejuni

IDP00313 (show subtarget assignments)	1	expressed	No	CBU_0647	29653985	ribA	riboflavin biosynthesis protein RibA	406	Drug Target Function	Phase 2: March 2008	2BZ0	27.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP91850 (show subtarget assignments)	8	cloned	No	SMU.1509	24379899	rgg	putative transcriptional regulator [Stre...	285	virulence/pathogenesis / Rgg proteins are peptide-ligand-responsive transcription factors that control vi...	Community Requests			Streptococcus mutans

IDP90675 (show subtarget assignments)	8	cloned	No	YPO3861	16123996	rffH	glucose-1-phosphate thymidylyltransferas...	293	Predicted Essential	Community Requests	1MC3	86.7%	Yersinia pestis

IDP90851 (show subtarget assignments)	8	purified	No	YPO3862	16123997	rffG	dTDP-D-glucose-4,6-dehydratase [Yersinia...	355	Predicted Essential	Community Requests	1BXK	82%	Yersinia pestis

IDP01604 (show subtarget assignments)	1	crystallized	No	CBU_0704	29541308	rfbI	lipopolysaccharide/O-antigen ABC transpo...	258	Conserved; Drug target functions	Phase 3: June 2008	3QF4	25.6%	Coxiella burnetii	Transport and binding proteins	Other

IDP90837 (show subtarget assignments)	8	selected	No	S2226	30063491	rfbD	dTDP-4-dehydrorhamnose reductase [Shigel...	299	Predicted Essential	Community Requests	1KBZ	85.6%	Shigella flexneri

IDP01195 (show subtarget assignments)	1	in_pdb 3SC6	No	BA_1231	30255180	rfbD	dTDP-4-dehydrorhamnose reductase	284	Drug Target Function	Phase 2: March 2008	3SC6	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01110 (show subtarget assignments)	1	in_pdb 3RYK	Yes	BA_1229	30255178	rfbC	dTDP-4-dehydrorhamnose 3,5-epimerase	181	Conserved Gene / Pathway	Phase 2: March 2008	3RYK	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90841 (show subtarget assignments)	8	soluble	No	S2223	30063489	rfbC	dTDP-6-deoxy-L-mannose-dehydrogenase [Sh...	181	Predicted Essential	Community Requests	1DZR	70.2%	Shigella flexneri

IDP01194 (show subtarget assignments)	1	in_pdb 4EGB	No	BA_1230	30255179	rfbB	dTDP-glucose 4,6-dehydratase	322	Conserved Gene / Pathway	Phase 2: March 2008	4EGB	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04380 (show subtarget assignments)	1	cloned	No	STM3713_1_404	16766998	rfaL	O-antigen ligase [Salmonella typhimurium...	404	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP90929 (show subtarget assignments)	8	cloned	No	STM3714	16766999	rfaK	putative hexose transferase [Salmonella ...	381	Predicted Essential	Community Requests	2BIS	21.5%	Salmonella enterica

IDP01065 (show subtarget assignments)	1	expressed	No	STM3722	16767007	rfaG	glucosyltransferase I	374	Drug Target Function	Phase 2: March 2008	2IV7	86.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90918 (show subtarget assignments)	8	in_crystallization_trials	No	YPO0057	16120410	rfaF	ADP-heptose:LPS heptosyltransferase II [...	354	Predicted Essential	Community Requests	1PSW	72.3%	Yersinia pestis

IDP00078 (show subtarget assignments)	0	work_stopped	No	NTL01ST3606	16422278	rfaF	ADP-heptose; LPS heptosyltransferase 1	348		Phase 1: October 2007	1PSW	91.7%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00558 (show subtarget assignments)	1	purified	No	YPO0654	16120979	rfaE	bifunctional heptose 7-phosphate kinase/...	476	Conserved Gene / Pathway	Phase 2: March 2008	2FV7	16.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90559 (show subtarget assignments)	8	cloned	No	VC0240	15640270	rfaD	ADP-L-glycero-D-mannoheptose-6-epimerase...	314	Predicted Essential	Community Requests	1EQ2	73.9%	Vibrio cholerae

IDP90552 (show subtarget assignments)	8	soluble	No	YPO0058	16120411	rfaD	ADP-L-glycero-D-mannoheptose-6-epimerase...	310	Predicted Essential	Community Requests	1EQ2	82.3%	Yersinia pestis

IDP00123 (show subtarget assignments)	1	expressed	No	NT01ST4633	16766997	rfaC	ADP-heptose:LPS heptosyl transferase I	317	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2GT1	83.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90822 (show subtarget assignments)	8	purified	No	YPO0056	16120409	rfaC	ADP-heptose:LPS heptosyl transferase I [...	321	Predicted Essential	Community Requests	2GT1	67.9%	Yersinia pestis

IDP01064 (show subtarget assignments)	1	cloned	No	STM3719	16767004	rfaB	UDP-D-galactose:(glucosyl)lipopolysaccha...	359	Essential Gene	Phase 2: March 2008	2JJM	13.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04673 (show subtarget assignments)	1	purified	No	GBAA1498	47777938	resE	sensor histidine kinase ResE [Bacillus a...	591	putative drug target function;	Phase 4: April 2009	3A0R	15.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02519 (show subtarget assignments)	1	cloned	No	GBAA1494	47526768	resA	thiol-disulfide oxidoreductase [Bacillus...	173	Conserved; Drug target functions	Phase 3: June 2008	1ST9	41.6%	Bacillus anthracis	Energy metabolism	Electron transport

IDP90710 (show subtarget assignments)	8	crystallized	No	Cj0451	15791815	rep	ribulose-phosphate 3-epimerase [Campylob...	215	Predicted Essential	Community Requests	1RPX	48.4%	Campylobacter jejuni

IDP91720 (show subtarget assignments)	8	selected	No	NP_068810	223468676	RELA	transcription factor p65 isoform 1 [Homo...	551	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1NFI	54.4%	Homo sapiens

IDP04269 (show subtarget assignments)	1	cloned	No	CPF_2193	110798612	relA	GTP pyrophosphokinase [Clostridium perfr...	726	conserved gene; putative drug target function;	Phase 4: April 2009	1VJ7	28.1%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP02040 (show subtarget assignments)	1	expressed	No	GBAA4637	47529935	relA	GTP pyrophosphokinase [Bacillus anthraci...	727	CONSERVED. Additional information: It is responsible for a down-regulation of RN...	Phase 3: June 2008	1VJ7	31.2%	Bacillus anthracis	Cellular processes: Adaptations to atypical conditions	N/A

IDP05744 (show subtarget assignments)	1	cloned	No	CD2744	126700359	relA	putative GTP pyrophosphokinase [Clostrid...	735	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1VJ7	26.4%	Clostridium difficile	Cellular processes: Adaptations to atypical conditions

IDP02827 (show subtarget assignments)	1	cloned	No	FTT1508c	56708546	relA	GTP pyrophosphokinase [Francisella tular...	647	Drug Target	Phase 3: June 2008	1VJ7	20.1%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP05649 (show subtarget assignments)	1	expressed	No	Cj0464	6967934	recG	zinc protease-like protein [Campylobacte...	607	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GM5	28.8%	Campylobacter jejuni	DNA metabolism: DNA replication, recombination, and repair

IDP00109 (show subtarget assignments)	1	in_crystallization_trials	No	NT01SF4517	30043269	recF	Rec protein	357	Essential	Phase 1: October 2007	2O5V	27.2%	Shigella flexneri	DNA metabolism	DNA replication, recombination, and repair

IDP04218 (show subtarget assignments)	1	expressed	No	STM2996_1_1123	16766298	recC	exonuclease V subunit gamma [Salmonella ...	1123	Salmonella essential protein	Phase 4: April 2009	1W36	88.4%	Salmonella enterica

IDP90986 (show subtarget assignments)	8	cloned	No	y0974	22124881	rdgC	recombination associated protein [Yersin...	303	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests	2OWL	83.2%	Yersinia pestis

IDP91817 (show subtarget assignments)	8	cloned	No	b2217	1788546	rcsB	DNA-binding response regulator in two-co...	216	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1P4W	36.6%	Escherichia coli

IDP02000 (show subtarget assignments)	1	cloned	No	YPO0008	16120361	rbsK	ribokinase [Yersinia pestis CO92]	308	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	1GQT	70.5%	Yersinia pestis	Energy metabolism	Pentose phosphate pathway

IDP00892 (show subtarget assignments)	0	work_stopped	No	STM3881	16767165	rbsD	high-affinity D-ribose transport protein...	139	Conserved Gene / Pathway	Phase 2: March 2008	3DSA	100%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00079 (show subtarget assignments)	1	in_pdb 3DSA 3E7N	No	NT01ST4845	16422456	rbsD	D-ribose high-affinity transport system ...	139	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DSA	100%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP05406 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0669	30254269	rbsB	ribose ABC transporter, ribose-binding p...	308	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2IOY	51.9%	Bacillus anthracis	Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP91714 (show subtarget assignments)	8	selected	No	NP_006734	5803137	RBM3	putative RNA-binding protein 3 [Homo sap...	157	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1X5S	41.4%	Homo sapiens

IDP01807 (show subtarget assignments)	1	cloned	No	FTT0873c	56707977	radA	DNA repair protein RadA [Francisella tul...	456	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3K1J	15.1%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP00018 (show subtarget assignments)	0	work_stopped	No	BA_4717	30259210	racE-2	glutamate racemase	269	Drug Target Homolog	Phase 1: October 2007	2GZM	99.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00007 (show subtarget assignments)	0	work_stopped	No	BA_0847	30254435	racE-1	glutamate racemase	276	Drug Target Homolog	Phase 1: October 2007	2DWU	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00347 (show subtarget assignments)	1	in_pdb 3HFR 3ISV 3IST	Yes	lmo1237	16803277	racE	hypothetical protein lmo1237	266	Drug Target Function	Phase 2: March 2008	3HFR	100%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01680 (show subtarget assignments)	0	work_stopped	No	VC0902	161582018	queF	7-cyano-7-deazaguanine reductase [Vibrio...	281	Conserved; Drug target homolg; Drug target functions	Phase 3: June 2008	3BP1	100%	Vibrio cholerae	N/A	N/A

IDP04629 (show subtarget assignments)	1	soluble	No	CBU_0151	29653509	queF	7-cyano-7-deazaguanine reductase [Coxiel...	278	drug target; conserved gene;	Phase 4: April 2009	3BP1	51.4%	Coxiella burnetii	Hypothetical proteins	Conserved

IDP90007 (show subtarget assignments)	8	cloned	No	Z4378	12517596	qseC	quorum sensing Escherichia coli regulato...	449	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3JZ3	47%	Escherichia coli

IDP90001 (show subtarget assignments)	8	cloned	No	FTT0094c	56603762	qseC	sensor histidine kinase	475	Drug Target (Community Request)	Community Requests	3A0R	15.8%	Francisella tularensis

IDP04630 (show subtarget assignments)	1	cloned	No	CBU_1228	29654531	qseC	sensor protein qseC [Coxiella burnetii R...	478	conserved gene; putative drug target function;	Phase 4: April 2009	3JZ3	19%	Coxiella burnetii	Regulatory functions	Other

IDP90005 (show subtarget assignments)	8	soluble	No	Z4377	12517595	qseB	quorum sensing Escherichia coli regulato...	219	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3Q9S	41.1%	Escherichia coli

IDP02304 (show subtarget assignments)	1	cloned	No	GBAA0703	47525984	qoxA	quinol oxidase, subunit II [Bacillus ant...	291	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FFT	33.7%	Bacillus anthracis	Energy metabolism	Electron transport

IDP04424 (show subtarget assignments)	1	purified	No	GBAA4024	47529317	pyrK	dihydroorotate dehydrogenase electron tr...	259	putative drug target function;	Phase 4: April 2009	1EP3	48.6%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04411 (show subtarget assignments)	1	soluble	No	YPO3589	218930599	pyrI	aspartate carbamoyltransferase regulator...	154	conserved gene; putative drug target function;	Phase 4: April 2009	1D09	77.3%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00561 (show subtarget assignments)	0	work_stopped	No	YPO1046	16121346	pyrH	uridylate kinase	241	Conserved Gene / Pathway	Phase 2: March 2008	2BNE	90.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP05296 (show subtarget assignments)	1	purified	No	CD2138	126699755	pyrH	uridylate kinase [Clostridium difficile ...	234	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1Z9D	59.1%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP00068 (show subtarget assignments)	0	work_stopped	No	NT01ST0271	16418722	pyrH	uridylate kinase	241	Essential	Phase 1: October 2007	2BNE	97.9%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP00154 (show subtarget assignments)	1	crystallized	No	VC2448	15642444	pyrG	CTP synthase	545	Essential	Phase 1: October 2007	1S1M	79.5%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00074 (show subtarget assignments)	0	work_stopped	No	NT01ST3685	16421504	pyrG	CTP synthetase	545	Essential	Phase 1: October 2007	1S1M	95%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP90546 (show subtarget assignments)	8	in_pdb 3RU6	No	Cj0381c	15791748	pyrF	orotidine 5'-phosphate decarboxylase [Ca...	279	Predicted Essential	Community Requests	3RU6	100%	Campylobacter jejuni

IDP01028 (show subtarget assignments)	1	in_crystallization_trials	No	STM1707	16765051	pyrF	orotidine 5'-phosphate decarboxylase	245	Essential Gene	Phase 2: March 2008	1EIX	88.2%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04102 (show subtarget assignments)	1	cloned	No	YPO2227	218929324	pyrF	orotidine 5'-phosphate decarboxylase [Ye...	245	conserved gene; putative drug target function;	Phase 4: April 2009	1EIX	72.2%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04421 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4022	47529315	pyrF	orotidine 5'-phosphate decarboxylase [Ba...	238	putative drug target function;	Phase 4: April 2009	1DBT	61.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90785 (show subtarget assignments)	8	in_pdb 3N2L	Yes	VC0211	15640241	pyrE	orotate phosphoribosyltransferase [Vibri...	214	Predicted Essential	Community Requests	3N2L	100%	Vibrio cholerae

IDP90707 (show subtarget assignments)	8	purified	No	Cj0233c	15791605	pyrE	orotate phosphoribosyltransferase [Campy...	202	Predicted Essential	Community Requests	2YZK	22.3%	Campylobacter jejuni

IDP02311 (show subtarget assignments)	1	in_pdb 3MJD	Yes	FTT0437c	56707581	pyrE	orotate phosphoribosyltransferase [Franc...	208	Drug Target	Phase 3: June 2008	3MJD	100%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04423 (show subtarget assignments)	1	in_pdb 3M3H 3OSC	Yes	GBAA4021	47529314	pyrE	orotate phosphoribosyltransferase [Bacil...	210	conserved gene; putative drug target function;	Phase 4: April 2009	3M3H	100%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04700 (show subtarget assignments)	1	cloned	No	YPO0045	218927266	pyrE	orotate phosphoribosyltransferase [Yersi...	215	conserved gene; putative drug target function;	Phase 4: April 2009	1LH0	85.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP01686 (show subtarget assignments)	1	cloned	No	Cj0804	15792142	pyrD	dihydroorotate dehydrogenase 2 [Campylob...	352	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1UUM	40.3%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP04422 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4023	47529316	pyrD	dihydroorotate dehydrogenase 1B [Bacillu...	309	putative drug target function;	Phase 4: April 2009	1EP1	68%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04724 (show subtarget assignments)	1	cloned	No	YPO1415	115347174	pyrD	dihydroorotate dehydrogenase [Yersinia p...	336	conserved gene; putative drug target function;	Phase 4: April 2009	1F76	83.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00873 (show subtarget assignments)	1	in_pdb 3JZE	No	STM1163	16764519	pyrC	dihydroorotase	348	Conserved Gene / Pathway	Phase 2: March 2008	3IHN	100%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00795 (show subtarget assignments)	1	in_pdb 3GRI	No	SACOL1213	57285956	pyrC	dihydroorotase	424	Drug Target Function	Phase 2: March 2008	3GRI	100%	Staphylococcus aureus	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02818 (show subtarget assignments)	1	selected	No	GBAA4027	47529320	pyrC	dihydroorotase [Bacillus anthracis str. ...	428	Conserved; Drug target functions	Phase 3: June 2008	3MPG	100%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04461 (show subtarget assignments)	1	crystallized	No	YPO1587	218928723	pyrC	dihydroorotase [Yersinia pestis CO92]	348	conserved gene; putative drug target function;	Phase 4: April 2009	3IHN	72.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90750 (show subtarget assignments)	8	in_pdb 3PNU	Yes	Cj0259	15791630	pyrC	dihydroorotase [Campylobacter jejuni sub...	335	Predicted Essential	Community Requests	3PNU	99.7%	Campylobacter jejuni

IDP91385 (show subtarget assignments)	8	soluble	No	VV1_1465	27364849	pyrB	aspartate carbamoyltransferase catalytic...	309	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2BE7	76.4%	Vibrio vulnificus

IDP90752 (show subtarget assignments)	8	soluble	No	Cj1098	15792423	pyrB	aspartate carbamoyltransferase catalytic...	295	Predicted Essential	Community Requests	2AT2	38.5%	Campylobacter jejuni

IDP00670 (show subtarget assignments)	1	purified	No	SACOL1212	57285955	pyrB	aspartate carbamoyltransferase catalytic...	293	Drug Target Function	Phase 2: March 2008	2AT2	55.6%	Staphylococcus aureus	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90587 (show subtarget assignments)	8	in_pdb 3LXM	Yes	YPO3588	16123730	pyrB	aspartate carbamoyltransferase catalytic...	311	Predicted Essential	Community Requests	3LXM	100%	Yersinia pestis

IDP02775 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4028	47529321	pyrB	aspartate carbamoyltransferase catalytic...	304	Conserved; Drug target functions	Phase 3: June 2008	3R7D	61.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP91824 (show subtarget assignments)	8	cloned	No	b1676	1787965	pykF	pyruvate kinase I [Escherichia coli str....	470	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1PKY	99.8%	Escherichia coli

IDP00019 (show subtarget assignments)	1	cloned	No	BA_4843	30259344	pykA-2	pyruvate kinase	585	Drug Target Homolog	Phase 1: October 2007	2E28	69.6%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00091
(show subtarget assignments)

0

work_stopped

No

NTL01SF0342

30040153

ribD

bifunctional pyrimidine deaminase/reduct...

367

Essential

Phase 1: October 2007

2G6V

97.8%

Shigella flexneri

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP90898
(show subtarget assignments)

8

soluble

No

STM0416

16763796

ribD

bifunctional diaminohydroxyphosphoribosy...

367

Predicted Essential

Community Requests

2G6V

89.4%

Salmonella enterica

IDP90906
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3183

16123345

ribD

bifunctional diaminohydroxyphosphoribosy...

369

Predicted Essential

Community Requests

2G6V

71.8%

Yersinia pestis

IDP05514
(show subtarget assignments)

1

purified

No

CD1315

126698913

ribC

riboflavin biosynthesis protein [Clostri...

309

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1MRZ

32.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP04105
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2391

115348093

ribC

riboflavin synthase alpha chain [Yersini...

218

conserved gene; putative drug target function;

Phase 4: April 2009

1I8D

74.8%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00017
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4333

81581445

ribBA

Riboflavin biosynthesis protein ribBA [I...

397

Drug Target Homolog

Phase 1: October 2007

2BZ0

27%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02186
(show subtarget assignments)

1

soluble

No

FTT1672

56708682

ribB

riboflavin synthase subunit alpha [Franc...

201

Conserved; Drug target functions

Phase 3: June 2008

1KZL

35.8%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP05517
(show subtarget assignments)

1

soluble

No

CD1699

126699305

ribB

riboflavin synthase subunit alpha [Clost...

221

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1KZL

38.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP00479
(show subtarget assignments)

1

in_pdb
3H07

No

YPO0658

16120983

ribB

3,4-dihydroxy-2-butanone 4-phosphate syn...

217

Conserved Gene / Pathway

Phase 2: March 2008

3H07

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP05201
(show subtarget assignments)

1

cloned

No

CD1698

126699304

ribA

riboflavin biosynthesis protein [Clostri...

408

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3MGZ

25.2%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91259
(show subtarget assignments)

8

soluble

No

NT02SA1746

14247541

ribA

riboflavin biosynthesis protein [Staphyl...

393

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3MGZ

24.2%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP90533
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0996

15792323

ribA

GTP cyclohydrolase II [Campylobacter jej...

186

Predicted Essential

Community Requests

2BZ0

47.2%

Campylobacter jejuni

IDP90729
(show subtarget assignments)

8

crystallized

No

Cj0572

15791932

ribA

bifunctional 3,4-dihydroxy-2-butanone 4-...

339

Predicted Essential

Community Requests

3MGZ

29.5%

Campylobacter jejuni

IDP91299
(show subtarget assignments)

8

cloned

No

STM1711

16765055

ribA

GTP cyclohydrolase II protein

196

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2BZ0

95.4%

Salmonella enterica

IDP91289
(show subtarget assignments)

8

soluble

No

SPA1165

56413363

ribA

GTP cyclohydrolase II [Salmonella enteri...

196

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2BZ0

95.4%

Salmonella enterica

IDP00400
(show subtarget assignments)

0

work_stopped

No

YPO2222

16122451

ribA

GTP cyclohydrolase II

196

Virulence Associated Factor

Phase 2: March 2008

2BZ0

88.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP91231
(show subtarget assignments)

8

soluble

No

NT04EC1793

26108012

ribA

GTP cyclohydrolase II [Escherichia coli ...

196

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2BZ0

99.5%

Escherichia coli

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP00332
(show subtarget assignments)

1

purified

No

FTT1673

56708683

ribA

riboflavin biosynthesis protein ribA/GTP...

403

Drug Target Function

Phase 2: March 2008

1G57

27%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP90684
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1218c

15792542

ribA

riboflavin synthase subunit alpha [Campy...

203

Predicted Essential

Community Requests

1KZL

29.6%

Campylobacter jejuni

IDP00313
(show subtarget assignments)

1

expressed

No

CBU_0647

29653985

ribA

riboflavin biosynthesis protein RibA

406

Drug Target Function

Phase 2: March 2008

2BZ0

27.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP91850
(show subtarget assignments)

8

cloned

No

SMU.1509

24379899

rgg

putative transcriptional regulator [Stre...

285

virulence/pathogenesis / Rgg proteins are peptide-ligand-responsive transcription factors that control vi...

Community Requests

Streptococcus mutans

IDP90675
(show subtarget assignments)

8

cloned

No

YPO3861

16123996

rffH

glucose-1-phosphate thymidylyltransferas...

293

Predicted Essential

Community Requests

1MC3

86.7%

Yersinia pestis

IDP90851
(show subtarget assignments)

8

purified

No

YPO3862

16123997

rffG

dTDP-D-glucose-4,6-dehydratase [Yersinia...

355

Predicted Essential

Community Requests

1BXK

82%

Yersinia pestis

IDP01604
(show subtarget assignments)

1

crystallized

No

CBU_0704

29541308

rfbI

lipopolysaccharide/O-antigen ABC transpo...

258

Conserved; Drug target functions

Phase 3: June 2008

3QF4

25.6%

Coxiella burnetii

Transport and binding proteins

Other

IDP90837
(show subtarget assignments)

8

selected

No

S2226

30063491

rfbD

dTDP-4-dehydrorhamnose reductase [Shigel...

299

Predicted Essential

Community Requests

1KBZ

85.6%

Shigella flexneri

IDP01195
(show subtarget assignments)

1

in_pdb
3SC6

No

BA_1231

30255180

rfbD

dTDP-4-dehydrorhamnose reductase

284

Drug Target Function

Phase 2: March 2008

3SC6

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01110
(show subtarget assignments)

1

in_pdb
3RYK

Yes

BA_1229

30255178

rfbC

dTDP-4-dehydrorhamnose 3,5-epimerase

181

Conserved Gene / Pathway

Phase 2: March 2008

3RYK

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90841
(show subtarget assignments)

8

soluble

No

S2223

30063489

rfbC

dTDP-6-deoxy-L-mannose-dehydrogenase [Sh...

181

Predicted Essential

Community Requests

1DZR

70.2%

Shigella flexneri

IDP01194
(show subtarget assignments)

1

in_pdb
4EGB

No

BA_1230

30255179

rfbB

dTDP-glucose 4,6-dehydratase

322

Conserved Gene / Pathway

Phase 2: March 2008

4EGB

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04380
(show subtarget assignments)

1

cloned

No

STM3713_1_404

16766998

rfaL

O-antigen ligase [Salmonella typhimurium...

404

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP90929
(show subtarget assignments)

8

cloned

No

STM3714

16766999

rfaK

putative hexose transferase [Salmonella ...

381

Predicted Essential

Community Requests

2BIS

21.5%

Salmonella enterica

IDP01065
(show subtarget assignments)

1

expressed

No

STM3722

16767007

rfaG

glucosyltransferase I

374

Drug Target Function

Phase 2: March 2008

2IV7

86.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90918
(show subtarget assignments)

8

in_crystallization_trials

No

YPO0057

16120410

rfaF

ADP-heptose:LPS heptosyltransferase II [...

354

Predicted Essential

Community Requests

1PSW

72.3%

Yersinia pestis

IDP00078
(show subtarget assignments)

0

work_stopped

No

NTL01ST3606

16422278

rfaF

ADP-heptose; LPS heptosyltransferase 1

348

Phase 1: October 2007

1PSW

91.7%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00558
(show subtarget assignments)

1

purified

No

YPO0654

16120979

rfaE

bifunctional heptose 7-phosphate kinase/...

476

Conserved Gene / Pathway

Phase 2: March 2008

2FV7

16.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90559
(show subtarget assignments)

8

cloned

No

VC0240

15640270

rfaD

ADP-L-glycero-D-mannoheptose-6-epimerase...

314

Predicted Essential

Community Requests

1EQ2

73.9%

Vibrio cholerae

IDP90552
(show subtarget assignments)

8

soluble

No

YPO0058

16120411

rfaD

ADP-L-glycero-D-mannoheptose-6-epimerase...

310

Predicted Essential

Community Requests

1EQ2

82.3%

Yersinia pestis

IDP00123
(show subtarget assignments)

1

expressed

No

NT01ST4633

16766997

rfaC

ADP-heptose:LPS heptosyl transferase I

317

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2GT1

83.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90822
(show subtarget assignments)

8

purified

No

YPO0056

16120409

rfaC

ADP-heptose:LPS heptosyl transferase I [...

321

Predicted Essential

Community Requests

2GT1

67.9%

Yersinia pestis

IDP01064
(show subtarget assignments)

1

cloned

No

STM3719

16767004

rfaB

UDP-D-galactose:(glucosyl)lipopolysaccha...

359

Essential Gene

Phase 2: March 2008

2JJM

13.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04673
(show subtarget assignments)

1

purified

No

GBAA1498

47777938

resE

sensor histidine kinase ResE [Bacillus a...

591

putative drug target function;

Phase 4: April 2009

3A0R

15.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02519
(show subtarget assignments)

1

cloned

No

GBAA1494

47526768

resA

thiol-disulfide oxidoreductase [Bacillus...

173

Conserved; Drug target functions

Phase 3: June 2008

1ST9

41.6%

Bacillus anthracis

Energy metabolism

Electron transport

IDP90710
(show subtarget assignments)

8

crystallized

No

Cj0451

15791815

rep

ribulose-phosphate 3-epimerase [Campylob...

215

Predicted Essential

Community Requests

1RPX

48.4%

Campylobacter jejuni

IDP91720
(show subtarget assignments)

8

selected

No

NP_068810

223468676

RELA

transcription factor p65 isoform 1 [Homo...

551

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1NFI

54.4%

Homo sapiens

IDP04269
(show subtarget assignments)

1

cloned

No

CPF_2193

110798612

relA

GTP pyrophosphokinase [Clostridium perfr...

726

conserved gene; putative drug target function;

Phase 4: April 2009

1VJ7

28.1%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP02040
(show subtarget assignments)

1

expressed

No

GBAA4637

47529935

relA

GTP pyrophosphokinase [Bacillus anthraci...

727

CONSERVED. Additional information: It is responsible for a down-regulation of RN...

Phase 3: June 2008

1VJ7

31.2%

Bacillus anthracis

Cellular processes: Adaptations to atypical conditions

N/A

IDP05744
(show subtarget assignments)

1

cloned

No

CD2744

126700359

relA

putative GTP pyrophosphokinase [Clostrid...

735

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1VJ7

26.4%

Clostridium difficile

Cellular processes: Adaptations to atypical conditions

IDP02827
(show subtarget assignments)

1

cloned

No

FTT1508c

56708546

relA

GTP pyrophosphokinase [Francisella tular...

647

Drug Target

Phase 3: June 2008

1VJ7

20.1%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP05649
(show subtarget assignments)

1

expressed

No

Cj0464

6967934

recG

zinc protease-like protein [Campylobacte...

607

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GM5

28.8%

Campylobacter jejuni

DNA metabolism: DNA replication, recombination, and repair

IDP00109
(show subtarget assignments)

1

in_crystallization_trials

No

NT01SF4517

30043269

recF

Rec protein

357

Essential

Phase 1: October 2007

2O5V

27.2%

Shigella flexneri

DNA metabolism

DNA replication, recombination, and repair

IDP04218
(show subtarget assignments)

1

expressed

No

STM2996_1_1123

16766298

recC

exonuclease V subunit gamma [Salmonella ...

1123

Salmonella essential protein

Phase 4: April 2009

1W36

88.4%

Salmonella enterica

IDP90986
(show subtarget assignments)

8

cloned

No

y0974

22124881

rdgC

recombination associated protein [Yersin...

303

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

2OWL

83.2%

Yersinia pestis

IDP91817
(show subtarget assignments)

8

cloned

No

b2217

1788546

rcsB

DNA-binding response regulator in two-co...

216

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1P4W

36.6%

Escherichia coli

IDP02000
(show subtarget assignments)

1

cloned

No

YPO0008

16120361

rbsK

ribokinase [Yersinia pestis CO92]

308

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

1GQT

70.5%

Yersinia pestis

Energy metabolism

Pentose phosphate pathway

IDP00892
(show subtarget assignments)

0

work_stopped

No

STM3881

16767165

rbsD

high-affinity D-ribose transport protein...

139

Conserved Gene / Pathway

Phase 2: March 2008

3DSA

100%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00079
(show subtarget assignments)

1

in_pdb
3DSA
3E7N

No

NT01ST4845

16422456

rbsD

D-ribose high-affinity transport system ...

139

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DSA

100%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP05406
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0669

30254269

rbsB

ribose ABC transporter, ribose-binding p...

308

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2IOY

51.9%

Bacillus anthracis

Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP91714
(show subtarget assignments)

8

selected

No

NP_006734

5803137

RBM3

putative RNA-binding protein 3 [Homo sap...

157

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1X5S

41.4%

Homo sapiens

IDP01807
(show subtarget assignments)

1

cloned

No

FTT0873c

56707977

radA

DNA repair protein RadA [Francisella tul...

456

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3K1J

15.1%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP00018
(show subtarget assignments)

0

work_stopped

No

BA_4717

30259210

racE-2

glutamate racemase

269

Drug Target Homolog

Phase 1: October 2007

2GZM

99.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00007
(show subtarget assignments)

0

work_stopped

No

BA_0847

30254435

racE-1

glutamate racemase

276

Drug Target Homolog

Phase 1: October 2007

2DWU

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00347
(show subtarget assignments)

1

in_pdb
3HFR
3ISV
3IST

Yes

lmo1237

16803277

racE

hypothetical protein lmo1237

266

Drug Target Function

Phase 2: March 2008

3HFR

100%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01680
(show subtarget assignments)

0

work_stopped

No

VC0902

161582018

queF

7-cyano-7-deazaguanine reductase [Vibrio...

281

Conserved; Drug target homolg; Drug target functions

Phase 3: June 2008

3BP1

100%

Vibrio cholerae

N/A

IDP04629
(show subtarget assignments)

1

soluble

No

CBU_0151

29653509

queF

7-cyano-7-deazaguanine reductase [Coxiel...

278

drug target; conserved gene;

Phase 4: April 2009

3BP1

51.4%

Coxiella burnetii

Hypothetical proteins

Conserved

IDP90007
(show subtarget assignments)

8

cloned

No

Z4378

12517596

qseC

quorum sensing Escherichia coli regulato...

449

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3JZ3

47%

Escherichia coli

IDP90001
(show subtarget assignments)

8

cloned

No

FTT0094c

56603762

qseC

sensor histidine kinase

475

Drug Target (Community Request)

Community Requests

3A0R

15.8%

Francisella tularensis

IDP04630
(show subtarget assignments)

1

cloned

No

CBU_1228

29654531

qseC

sensor protein qseC [Coxiella burnetii R...

478

conserved gene; putative drug target function;

Phase 4: April 2009

3JZ3

19%

Coxiella burnetii

Regulatory functions

Other

IDP90005
(show subtarget assignments)

8

soluble

No

Z4377

12517595

qseB

quorum sensing Escherichia coli regulato...

219

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3Q9S

41.1%

Escherichia coli

IDP02304
(show subtarget assignments)

1

cloned

No

GBAA0703

47525984

qoxA

quinol oxidase, subunit II [Bacillus ant...

291

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FFT

33.7%

Bacillus anthracis

Energy metabolism

Electron transport

IDP04424
(show subtarget assignments)

1

purified

No

GBAA4024

47529317

pyrK

dihydroorotate dehydrogenase electron tr...

259

putative drug target function;

Phase 4: April 2009

1EP3

48.6%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04411
(show subtarget assignments)

1

soluble

No

YPO3589

218930599

pyrI

aspartate carbamoyltransferase regulator...

154

conserved gene; putative drug target function;

Phase 4: April 2009

1D09

77.3%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00561
(show subtarget assignments)

0

work_stopped

No

YPO1046

16121346

pyrH

uridylate kinase

241

Conserved Gene / Pathway

Phase 2: March 2008

2BNE

90.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP05296
(show subtarget assignments)

1

purified

No

CD2138

126699755

pyrH

uridylate kinase [Clostridium difficile ...

234

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1Z9D

59.1%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP00068
(show subtarget assignments)

0

work_stopped

No

NT01ST0271

16418722

pyrH

uridylate kinase

241

Essential

Phase 1: October 2007

2BNE

97.9%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP00154
(show subtarget assignments)

1

crystallized

No

VC2448

15642444

pyrG

CTP synthase

545

Essential

Phase 1: October 2007

1S1M

79.5%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00074
(show subtarget assignments)

0

work_stopped

No

NT01ST3685

16421504

pyrG

CTP synthetase

545

Essential

Phase 1: October 2007

1S1M

95%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP90546
(show subtarget assignments)

8

in_pdb
3RU6

No

Cj0381c

15791748

pyrF

orotidine 5'-phosphate decarboxylase [Ca...

279

Predicted Essential

Community Requests

3RU6

100%

Campylobacter jejuni

IDP01028
(show subtarget assignments)

1

in_crystallization_trials

No

STM1707

16765051

pyrF

orotidine 5'-phosphate decarboxylase

245

Essential Gene

Phase 2: March 2008

1EIX

88.2%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04102
(show subtarget assignments)

1

cloned

No

YPO2227

218929324

pyrF

orotidine 5'-phosphate decarboxylase [Ye...

245

conserved gene; putative drug target function;

Phase 4: April 2009

1EIX

72.2%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04421
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4022

47529315

pyrF

orotidine 5'-phosphate decarboxylase [Ba...

238

putative drug target function;

Phase 4: April 2009

1DBT

61.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90785
(show subtarget assignments)

8

in_pdb
3N2L

Yes

VC0211

15640241

pyrE

orotate phosphoribosyltransferase [Vibri...

214

Predicted Essential

Community Requests

3N2L

100%

Vibrio cholerae

IDP90707
(show subtarget assignments)

8

purified

No

Cj0233c

15791605

pyrE

orotate phosphoribosyltransferase [Campy...

202

Predicted Essential

Community Requests

2YZK

22.3%

Campylobacter jejuni

IDP02311
(show subtarget assignments)

1

in_pdb
3MJD

Yes

FTT0437c

56707581

pyrE

orotate phosphoribosyltransferase [Franc...

208

Drug Target

Phase 3: June 2008

3MJD

100%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04423
(show subtarget assignments)

1

in_pdb
3M3H
3OSC

Yes

GBAA4021

47529314

pyrE

orotate phosphoribosyltransferase [Bacil...

210

conserved gene; putative drug target function;

Phase 4: April 2009

3M3H

100%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04700
(show subtarget assignments)

1

cloned

No

YPO0045

218927266

pyrE

orotate phosphoribosyltransferase [Yersi...

215

conserved gene; putative drug target function;

Phase 4: April 2009

1LH0

85.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP01686
(show subtarget assignments)

1

cloned

No

Cj0804

15792142

pyrD

dihydroorotate dehydrogenase 2 [Campylob...

352

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1UUM

40.3%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP04422
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4023

47529316

pyrD

dihydroorotate dehydrogenase 1B [Bacillu...

309

putative drug target function;

Phase 4: April 2009

1EP1

68%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04724
(show subtarget assignments)

1

cloned

No

YPO1415

115347174

pyrD

dihydroorotate dehydrogenase [Yersinia p...

336

conserved gene; putative drug target function;

Phase 4: April 2009

1F76

83.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00873
(show subtarget assignments)

1

in_pdb
3JZE

No

STM1163

16764519

pyrC

dihydroorotase

348

Conserved Gene / Pathway

Phase 2: March 2008

3IHN

100%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00795
(show subtarget assignments)

1

in_pdb
3GRI

No

SACOL1213

57285956

pyrC

dihydroorotase

424

Drug Target Function

Phase 2: March 2008

3GRI

100%

Staphylococcus aureus

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02818
(show subtarget assignments)

1

selected

No

GBAA4027

47529320

pyrC

dihydroorotase [Bacillus anthracis str. ...

428

Conserved; Drug target functions

Phase 3: June 2008

3MPG

100%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04461
(show subtarget assignments)

1

crystallized

No

YPO1587

218928723

pyrC

dihydroorotase [Yersinia pestis CO92]

348

conserved gene; putative drug target function;

Phase 4: April 2009

3IHN

72.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90750
(show subtarget assignments)

8

in_pdb
3PNU

Yes

Cj0259

15791630

pyrC

dihydroorotase [Campylobacter jejuni sub...

335

Predicted Essential

Community Requests

3PNU

99.7%

Campylobacter jejuni

IDP91385
(show subtarget assignments)

8

soluble

No

VV1_1465

27364849

pyrB

aspartate carbamoyltransferase catalytic...

309

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2BE7

76.4%

Vibrio vulnificus

IDP90752
(show subtarget assignments)

8

soluble

No

Cj1098

15792423

pyrB

aspartate carbamoyltransferase catalytic...

295

Predicted Essential

Community Requests

2AT2

38.5%

Campylobacter jejuni

IDP00670
(show subtarget assignments)

1

purified

No

SACOL1212

57285955

pyrB

aspartate carbamoyltransferase catalytic...

293

Drug Target Function

Phase 2: March 2008

2AT2

55.6%

Staphylococcus aureus

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90587
(show subtarget assignments)

8

in_pdb
3LXM

Yes

YPO3588

16123730

pyrB

aspartate carbamoyltransferase catalytic...

311

Predicted Essential

Community Requests

3LXM

100%

Yersinia pestis

IDP02775
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4028

47529321

pyrB

aspartate carbamoyltransferase catalytic...

304

Conserved; Drug target functions

Phase 3: June 2008

3R7D

61.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP91824
(show subtarget assignments)

8

cloned

No

b1676

1787965

pykF

pyruvate kinase I [Escherichia coli str....

470

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1PKY

99.8%

Escherichia coli

IDP00019
(show subtarget assignments)

1

cloned

No

BA_4843

30259344

pykA-2

pyruvate kinase

585

Drug Target Homolog

Phase 1: October 2007

2E28

69.6%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis