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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 8 of 60, showing 100 records out of 5973 total, starting on record 701
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP90244
(
show subtarget assignments
)
8
expressed
No
YPO3053
218930098
dapE
succinyl-diaminopimelate desuccinylase [...
375
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3IC1
63.2%
Yersinia pestis
IDP00138
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_4159
30258665
conserved hypothetical protein
95
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2ODM
56.8%
Bacillus anthracis
Purines, pyrimidines, nucleosides, and nucleotides
Nucleotide and nucleoside interconversions
IDP90247
(
show subtarget assignments
)
8
purified
No
YPO3928
115349537
argE
acetylornithine deacetylase [Yersinia pe...
389
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3PFO
26%
Yersinia pestis
IDP91277
(
show subtarget assignments
)
8
soluble
No
NT05BA4403
49181145
conserved hypothetical protein [Bacillus...
336
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1JQJ
17.3%
Bacillus anthracis
DNA metabolism: DNA replication, recombination, and repair
IDP91545
(
show subtarget assignments
)
8
expressed
No
AAC78336
3892237
ereA2
erythromycin esterase [Providencia stuar...
408
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Providencia stuartii
IDP91263
(
show subtarget assignments
)
8
soluble
No
NT05BA0394
49177292
pyridine nucleotide-disulfide oxidoreduc...
349
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3LZW
36.4%
Bacillus anthracis
Unknown function: Enzymes of unknown specificity
IDP00096
(
show subtarget assignments
)
1
in_crystallization_trials
No
NTL02SF1070
30040886
ycfO
hypothetical protein S1191
341
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
1TR9
55.7%
Shigella flexneri
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP90436
(
show subtarget assignments
)
8
cloned
No
CT_872
3329347
pmpH
Putative Outer Membrane Protein H [Chlam...
1016
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90334
(
show subtarget assignments
)
8
cloned
No
CT_421.2
3522896
hypothetical protein [Chlamydia trachoma...
53
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90325
(
show subtarget assignments
)
8
cloned
No
CT089
15604808
lcrE
low calcium response E [Chlamydia tracho...
421
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2VJ4
13.3%
Chlamydia trachomatis
IDP00067
(
show subtarget assignments
)
1
in_pdb
3PFI
No
NT01CJ1369
6968796
ruvB
holliday junction DNA helicase [Campylob...
335
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3PFI
100%
Campylobacter jejuni
Biosynthesis of cofactors, prosthetic groups, and carriers
Riboflavin, FMN, and FAD
IDP91252
(
show subtarget assignments
)
8
soluble
No
NT01LM1948
16411261
fabG
fabG [Listeria monocytogenes]
247
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2UVD
66.4%
Listeria monocytogenes
Fatty acid and phospholipid metabolism: Biosynthesis
IDP00134
(
show subtarget assignments
)
1
purified
No
VC_2250
9656811
VC2250
Vibrio cholerae O1 biovar eltor str. N16...
351
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3EH0
63%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP91154
(
show subtarget assignments
)
8
in_pdb
3QFG
Yes
SAOUHSC_00808
88194568
hypothetical protein SAOUHSC_00808 [Stap...
242
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3QFG
93.4%
Staphylococcus aureus
IDP90398
(
show subtarget assignments
)
8
soluble
No
CT_577
3329019
hypothetical protein [Chlamydia trachoma...
119
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90399
(
show subtarget assignments
)
8
expressed
No
CT_569
3329010
gspG
predicted OMP [Chlamydia trachomatis D/U...
109
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91593
(
show subtarget assignments
)
8
expressed
No
BSU08430
16077910
yfiX
hypothetical protein BSU08430 [Bacillus ...
606
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Bacillus subtilis
IDP91305
(
show subtarget assignments
)
8
soluble
No
STM3477
16766765
cysG
siroheme synthase
457
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1PJQ
99.8%
Salmonella enterica
IDP90414
(
show subtarget assignments
)
8
expressed
No
CT_429
3328859
hypothetical protein [Chlamydia trachoma...
329
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00133
(
show subtarget assignments
)
1
purified
No
VC_2095
9656644
VC2095
Vibrio cholerae O1 biovar eltor str. N16...
548
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2FUV
70.3%
Vibrio cholerae
Energy metabolism
Sugars
IDP91268
(
show subtarget assignments
)
8
soluble
No
NT05BA2906
49179679
histidinol-phosphate aminotransferase [B...
366
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3FFH
40.2%
Bacillus anthracis
IDP91303
(
show subtarget assignments
)
8
soluble
No
STM2384
16765711
aroC
chorismate synthase
361
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1SQ1
45.7%
Salmonella enterica
IDP00132
(
show subtarget assignments
)
1
purified
No
VC_0288
9654699
VC0288
Vibrio cholerae O1 biovar eltor str. N16...
618
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2GP4
53.9%
Vibrio cholerae
Energy metabolism
Entner-Doudoroff
IDP90320
(
show subtarget assignments
)
8
cloned
No
CT_779
3329243
hypothetical protein [Chlamydia trachoma...
229
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90321
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_795
3329261
hypothetical protein [Chlamydia trachoma...
163
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00066
(
show subtarget assignments
)
1
expressed
No
NTL01CJ00766
6968259
kdsB
3-deoxy-manno-octulosonate cytidylyltran...
239
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2Y6P
40.2%
Campylobacter jejuni
Protein synthesis
tRNA aminoacylation
IDP91187
(
show subtarget assignments
)
1
in_pdb
3UZR
4DCA
Yes
AF207840_1
10130002
aph(2')-Ib
aminoglycoside phosphotransferase [Enter...
299
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3HAM
100%
Enterococcus faecium
IDP91304
(
show subtarget assignments
)
8
soluble
No
STM2667
16765982
pheA
chorismate mutase P/prephenate dehydrata...
386
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1ECM
25.1%
Salmonella enterica
IDP00090
(
show subtarget assignments
)
1
crystallized
No
NT01SF0319
30040101
crl
transcriptional regulator of cryptic csg...
133
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3RPJ
45.9%
Shigella flexneri
Cell envelope
Surface structures
IDP91254
(
show subtarget assignments
)
8
soluble
No
NT02SA0910
14246689
probable 2-nitropropane dioxygenase [Sta...
355
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3BW2
34.9%
Staphylococcus aureus
Cellular processes: Detoxification
IDP91188
(
show subtarget assignments
)
1
crystallized
No
CAA24743
40923
unnamed protein product [Escherichia col...
341
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3OVC
100%
Escherichia coli
IDP91231
(
show subtarget assignments
)
8
soluble
No
NT04EC1793
26108012
ribA
GTP cyclohydrolase II [Escherichia coli ...
196
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2BZ0
99.5%
Escherichia coli
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
IDP90389
(
show subtarget assignments
)
8
cloned
No
CT_384
3328809
hypothetical protein [Chlamydia trachoma...
539
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00301
(
show subtarget assignments
)
1
expressed
No
CBU_0983
291
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 2: March 2008
3NVT
10.7%
Coxiella burnetii
IDP91296
(
show subtarget assignments
)
8
cloned
No
STM1193
16764548
fabH
3-oxoacyl-(acyl carrier protein) synthas...
317
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1HN9
94.6%
Salmonella enterica
IDP00300
(
show subtarget assignments
)
1
cloned
No
CBU_1153
548
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 2: March 2008
1GXB
10.4%
Coxiella burnetii
IDP90431
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_845
3329317
hypothetical protein [Chlamydia trachoma...
92
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91301
(
show subtarget assignments
)
8
expressed
No
STM1724
16765068
trpD
anthranilate phosphoribosyltransferase
531
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1KGZ
47.1%
Salmonella enterica
IDP90308
(
show subtarget assignments
)
8
cloned
No
CT_700
3329154
hypothetical protein [Chlamydia trachoma...
441
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1NA0
6.3%
Chlamydia trachomatis
IDP91257
(
show subtarget assignments
)
8
soluble
No
NT02SA1359
14247140
trpD
anthranilate phosphoribosyltransferase [...
332
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1VQU
33.8%
Staphylococcus aureus
Amino acid biosynthesis: Aromatic amino acid family
IDP90373
(
show subtarget assignments
)
8
expressed
No
CT_191
3328596
hypothetical protein [Chlamydia trachoma...
116
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91293
(
show subtarget assignments
)
8
soluble
No
SPA3343
56415395
cysG
siroheme synthase [Salmonella enterica s...
457
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1PJQ
99.6%
Salmonella enterica
IDP91302
(
show subtarget assignments
)
8
soluble
No
STM2378
16765705
fabB
3-oxoacyl-(acyl carrier protein) synthas...
404
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1FJ4
96.8%
Salmonella enterica
IDP91546
(
show subtarget assignments
)
8
in_pdb
4E8L
No
AAA26683
398085
vat
acetyltransferase [Staphylococcus aureus...
219
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
4E8L
100%
Staphylococcus aureus
IDP91261
(
show subtarget assignments
)
8
soluble
No
NT05BA0041
49176992
DNA polymerase III, delta prime subunit ...
327
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1A5T
20.2%
Bacillus anthracis
DNA metabolism: DNA replication, recombination, and repair
IDP90326
(
show subtarget assignments
)
8
expressed
No
CT_351
3328772
hypothetical protein [Chlamydia trachoma...
697
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90242
(
show subtarget assignments
)
8
expressed
No
SA1814
15927582
succinyl-diaminopimelate desuccinylase [...
407
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3TX8
25.5%
Staphylococcus aureus
IDP90411
(
show subtarget assignments
)
8
expressed
No
CT_647
3329096
hypothetical protein [Chlamydia trachoma...
192
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90403
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_620
3329066
hypothetical protein [Chlamydia trachoma...
838
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90402
(
show subtarget assignments
)
8
in_crystallization_trials
No
CT_635
3329083
hypothetical protein [Chlamydia trachoma...
144
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91280
(
show subtarget assignments
)
8
soluble
No
NT05BA5064
49181767
conserved hypothetical protein [Bacillus...
430
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
4DN7
19.3%
Bacillus anthracis
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
IDP91285
(
show subtarget assignments
)
8
soluble
No
SPA0480
56412719
aroC
chorismate synthase [Salmonella enterica...
361
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1R52
45.7%
Salmonella enterica
IDP90429
(
show subtarget assignments
)
8
cloned
No
CT_860
3329334
hypothetical protein [Chlamydia trachoma...
493
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91233
(
show subtarget assignments
)
8
expressed
No
NT04EC1775
26107994
trpD
Anthranilate synthase component II [Esch...
531
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1KGZ
47.3%
Escherichia coli
Amino acid biosynthesis: Aromatic amino acid family
IDP91290
(
show subtarget assignments
)
8
soluble
No
SPA1656
56413819
fabG
3-ketoacyl-(acyl-carrier-protein) reduct...
244
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1I01
95.9%
Salmonella enterica
IDP90328
(
show subtarget assignments
)
8
cloned
No
CT_413
3328841
pmpB
Putative outer membrane protein B [Chlam...
1751
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91189
(
show subtarget assignments
)
1
in_pdb
4DE4
4DFB
4DFU
Yes
AAW59417
57918602
aph(2'')-Id
APH(2'')-Id [Enterococcus faecium]
301
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3LZH
100%
Enterococcus faecium
IDP91615
(
show subtarget assignments
)
8
in_crystallization_trials
No
BAB36137
13362182
ECs2714
hypothetical protein [Escherichia coli O...
217
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP90330
(
show subtarget assignments
)
8
expressed
No
CT_602
3329047
hypothetical protein [Chlamydia trachoma...
130
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00095
(
show subtarget assignments
)
1
purified
No
NT01SF1278
30040854
flgN
flagella synthesis protein FlgN
138
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
Shigella flexneri
Cell envelope
Surface structures
IDP90084
(
show subtarget assignments
)
8
soluble
No
ZP_01795673
145640079
hypothetical protein CGSHiII_00674 [Haem...
148
The protein we would like structure analyzed is from Haemophilus influenzae. Pri...
Community Requests
2XM6
28.4%
Haemophilus influenzae
IDP90083
(
show subtarget assignments
)
8
cloned
No
ZP_01795671
145640077
hypothetical protein CGSHiII_00664 [Haem...
219
The protein we would like structure analyzed is from Haemophilus influenzae. Pri...
Community Requests
2XM6
35.6%
Haemophilus influenzae
IDP91529
(
show subtarget assignments
)
8
soluble
No
VC_1312
9655801
alanine racemase, putative [Vibrio chole...
428
other biological interest /
The protein we are submitting is a broad spectrum amino acid racemase (Lam et al...
Community Requests
4ECL
24.8%
Vibrio cholerae
IDP91878
(
show subtarget assignments
)
8
selected
No
pVEF1_014
121633839
vanB
VanA protein [Enterococcus faecium]
343
drug resistance /
The proteins play important roles in vancomycin resistance of Entercocci.
Community Requests
1E4E
98.8%
Enterococcus faecium
IDP91879
(
show subtarget assignments
)
8
selected
No
AAQ16273
33355853
vanG
D-Ala:D-Ser ligase [Enterococcus faecali...
349
drug resistance /
The proteins play important roles in vancomycin resistance of Entercocci.
Community Requests
3SE7
46.4%
Enterococcus faecalis
IDP91071
(
show subtarget assignments
)
8
cloned
No
NGO2165
59719354
putative ABC transporter, ATP-binding pr...
622
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3B5Y
34.2%
Neisseria gonorrhoeae
IDP91073
(
show subtarget assignments
)
8
cloned
No
YPO1395
16121675
msbA
probable transport ATP-binding protein
582
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3B5W
85.2%
Yersinia pestis
IDP91072
(
show subtarget assignments
)
8
cloned
No
YPO2588
16122801
-
putative ABC transport protein
631
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
2HYD
32.2%
Yersinia pestis
IDP91076
(
show subtarget assignments
)
8
cloned
No
CGSHiII_09046
145639651
fused lipid transporter subunits of ABC ...
587
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3B5W
65.9%
Haemophilus influenzae
IDP91074
(
show subtarget assignments
)
8
cloned
No
MSMEG_5659
118469658
ABC transporter, ATP-binding protein [My...
610
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3QF4
32.1%
Mycobacterium smegmatis
IDP91075
(
show subtarget assignments
)
8
cloned
No
jhp0343
15611411
msbA
multi-drug resistance protein [Helicobac...
551
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3B5W
31.4%
Helicobacter pylori
IDP91084
(
show subtarget assignments
)
8
cloned
No
BA_2444
30262443
ABC transporter, ATP-binding/permease pr...
598
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3QF4
44.5%
Bacillus anthracis
IDP91069
(
show subtarget assignments
)
8
cloned
No
SP_1357
15901211
ABC transporter, ATP-binding/permease pr...
596
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3QF4
37.1%
Streptococcus pneumoniae
IDP91083
(
show subtarget assignments
)
8
cloned
No
BA_0528
30260686
ABC transporter, ATP-binding/permease pr...
586
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
2HYD
58.2%
Bacillus anthracis
IDP91081
(
show subtarget assignments
)
8
cloned
No
CD2817
126700433
ABC transporter, ATP-binding/permease pr...
596
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3QF4
39.4%
Clostridium difficile
IDP91078
(
show subtarget assignments
)
8
cloned
No
CBU_0856
29541449
ABC transporter, ATP-binding/permease pr...
596
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3B5X
42.3%
Coxiella burnetii
IDP91077
(
show subtarget assignments
)
8
cloned
No
FTT_0109
56707283
msbA
Lipid A transport protein, ABC transport...
609
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3B5W
41.2%
Francisella tularensis
IDP91079
(
show subtarget assignments
)
8
cloned
No
BMA0204
53725011
ABC transporter, ATP-binding/permease pr...
623
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
4AA3
32.8%
Burkholderia mallei
IDP91080
(
show subtarget assignments
)
8
cloned
No
Cj0803
6968244
msbA
lipid export ABC transport protein
580
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
2HYD
31.6%
Campylobacter jejuni
IDP91082
(
show subtarget assignments
)
8
cloned
No
CPF_1776
110800219
ABC transporter, permease/ATP-binding pr...
589
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3QF4
39.2%
Clostridium perfringens
IDP91070
(
show subtarget assignments
)
8
cloned
No
RP205
15604078
multidrug resistance transporter ATM1 [R...
609
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
2HYD
32%
Rickettsia prowazekii
IDP91068
(
show subtarget assignments
)
8
cloned
No
VF_A0424
59713607
msbA
lipid transporter ATP-binding/permease p...
582
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3B5X
75.1%
Vibrio fischeri
IDP91801
(
show subtarget assignments
)
8
purified
No
AAQ16565
33356632
DAHP synthetase [Toxoplasma gondii]
615
potential drug target /
The presence of the shikimate pathway in a large number of pathogenic organisms,...
Community Requests
2B7O
28.6%
Toxoplasma gondii
IDP90277
(
show subtarget assignments
)
8
soluble
No
TGME49_059690
211962827
orotidine-monophosphate-decarboxylase, p...
320
The orotidine monophosphate decarboxylase (TgODCase) is the last step in de novo...
Community Requests
3QW3
39.1%
Toxoplasma gondii
IDP90291
(
show subtarget assignments
)
8
soluble
No
TGME49_081900
211969063
high mobility group (HMG) box domain-con...
880
The newly described histone lysine methyl-transferase KMTox targets histones H4 ...
Community Requests
Toxoplasma gondii
IDP90948
(
show subtarget assignments
)
8
cloned
No
M5005_Spy_1720
71911533
mga
trans-acting positive regulator [Strepto...
529
The multiple gene regulator of the Group A Streptococcus (Mga) is an established...
Community Requests
Streptococcus pyogenes
IDP91526
(
show subtarget assignments
)
8
in_crystallization_trials
No
lpg1815
52842042
oxyR
hydrogen peroxide-inducible genes activa...
296
other biological interest /
The Legionella pneumophila OxyR is a member of the LysR family that is no longer...
Community Requests
1I6A
28.4%
Legionella pneumophila
IDP91200
(
show subtarget assignments
)
8
cloned
No
CD1911
115250958
two-component sensor histidine kinase [C...
469
virulence/pathogenesis /
The important histidine kinase for ethanolamine utilization in anaerobic bacteri...
Community Requests
Clostridium difficile
IDP90285
(
show subtarget assignments
)
8
soluble
No
TGME49_083850
211966798
peptidyl-prolyl isomerase, putative [Tox...
521
The immunophilin TgFBCP57 uniquely contains domains for both immunosuppressant d...
Community Requests
1KT0
23.2%
Toxoplasma gondii
IDP90290
(
show subtarget assignments
)
8
purified
No
TGME49_019520
211968370
arginine N-methyltransferase 1 [Toxoplas...
392
The histone arginine methyl-transferase TgPRMT1 methylates histone 4 (R3). Whe...
Community Requests
1OR8
44.9%
Toxoplasma gondii
IDP90292
(
show subtarget assignments
)
8
cloned
No
TGGT1_004130
221483205
histone acetyltransferase GCN5, putative...
1169
The histone acetyltransferase TgGCN-5A acetylates prerentially Histone 3 [K18], ...
Community Requests
1Z4R
8.5%
Toxoplasma gondii
IDP91817
(
show subtarget assignments
)
8
cloned
No
b2217
1788546
rcsB
DNA-binding response regulator in two-co...
216
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
1P4W
36.6%
Escherichia coli
IDP91818
(
show subtarget assignments
)
8
cloned
No
b2584
1788938
yfiQ
inhibiting acetyltransferase for acetyl-...
886
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
2CSU
17.3%
Escherichia coli
IDP91815
(
show subtarget assignments
)
8
soluble
No
b3956
1790393
ppc
phosphoenolpyruvate carboxylase [Escheri...
883
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
1FIY
100%
Escherichia coli
IDP91819
(
show subtarget assignments
)
8
expressed
No
b4307
1790761
yjhQ
KpLE2 phage-like element; predicted acet...
181
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
Escherichia coli
IDP91816
(
show subtarget assignments
)
8
cloned
No
b2463
1788806
maeB
fused malic enzyme predicted oxidoreduct...
759
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
1WW8
26.5%
Escherichia coli
IDP91820
(
show subtarget assignments
)
8
soluble
No
b0474
1786680
adk
adenylate kinase [Escherichia coli str. ...
214
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
1AKE
100%
Escherichia coli
IDP91812
(
show subtarget assignments
)
8
soluble
No
b0823
1787044
ybiW
predicted pyruvate formate lyase [Escher...
810
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
1R8W
37.1%
Escherichia coli
IDP91811
(
show subtarget assignments
)
8
soluble
No
b3916
1790350
pfkA
6-phosphofructokinase I [Escherichia col...
320
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
1PFK
100%
Escherichia coli
IDP91810
(
show subtarget assignments
)
8
soluble
No
b3357
1789756
crp
DNA-binding transcriptional dual regulat...
210
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
1G6N
100%
Escherichia coli
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