Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01401 (show subtarget assignments)	1	purified	No	VC0773	15640792		vibriobactin-specific isochorismate synt...	395	Drug Target Function	Phase 2: March 2008	3OS6	44.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00144 (show subtarget assignments)	1	soluble	No	VC0776	15640795	viuP	vibriobactin and enterobactin ABC transp...	325	Virulence	Phase 1: October 2007	3R5S	91.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00145 (show subtarget assignments)	1	expressed	No	VC0777	15640796	viuD	vibriobactin and enterobactin ABC transp...	350	Virulence	Phase 1: October 2007	2NQ2	30.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00146 (show subtarget assignments)	1	soluble	No	VC0778	15640797	viuG	vibriobactin and enterobactin ABC transp...	358	Virulence	Phase 1: October 2007	2QI9	28.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00143 (show subtarget assignments)	1	soluble	No	VC0779	15640798	viuC	vibriobactin and enterobactin ABC transp...	279	Virulence	Phase 1: October 2007	1B0U	29%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00147 (show subtarget assignments)	1	expressed	No	VC0780	15640799	vibD	vibriobactin synthase component D	261	Virulence	Phase 1: October 2007			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP04498 (show subtarget assignments)	1	purified	No	VC0791	15640810		sensor kinase citA [Vibrio cholerae O1 b...	565	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2J80	9.7%	Vibrio cholerae	Regulatory functions	Other

IDP01511 (show subtarget assignments)	1	expressed	No	VC0794	15640812		hypothetical protein VC0794	139	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01345 (show subtarget assignments)	1	soluble	No	VC0824	15640841	tpx	tagD protein	164	Conserved Gene / Pathway	Phase 2: March 2008	1QXH	50%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00157 (show subtarget assignments)	1	soluble	No	VC0829	15640846	tcpB	toxin co-regulated pilus biosynthesis pr...	430	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00158 (show subtarget assignments)	1	soluble	No	VC0830	15640847	tcpQ	toxin co-regulated pilus biosynthesis pr...	150	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00159 (show subtarget assignments)	1	purified	No	VC0831	15640848	tcpC	toxin co-regulated pilus biosynthesis ou...	489	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00160 (show subtarget assignments)	1	soluble	No	VC0834	15640851	tcpS	toxin co-regulated pilus biosynthesis pr...	152	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00161 (show subtarget assignments)	1	soluble	No	VC0835	15640852	tcpT	toxin co-regulated pilus biosynthesis pr...	503	Virulence	Phase 1: October 2007	1P9R	23.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00162 (show subtarget assignments)	1	soluble	No	VC0837	15640854	tcpF	toxin co-regulated pilus biosynthesis pr...	338	Virulence	Phase 1: October 2007	3OC5	93.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00163 (show subtarget assignments)	0	work_stopped	No	VC0838	15640855	tcpN/toxT	TCP pilus virulence regulatory protein	276	Virulence	Phase 1: October 2007	3GBG	100%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00164 (show subtarget assignments)	1	soluble	No	VC0841	15640858	acfC	accessory colonization factor AcfC	256	Virulence	Phase 1: October 2007	3FIR	50%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01402 (show subtarget assignments)	1	cloned	No	VC0843	15640860		tagE protein	302	Drug Target Function	Phase 2: March 2008	3SLU	18.9%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00165 (show subtarget assignments)	1	cloned	No	VC0844	15640861	acfA	accessory colonization factor AcfA	215	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01403 (show subtarget assignments)	1	in_crystallization_trials	No	VC0854	15640870		heat shock protein GrpE	200	Conserved Gene / Pathway	Phase 2: March 2008	1DKG	39.5%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01404 (show subtarget assignments)	1	purified	No	VC0856	15640872		dnaJ protein	381	Conserved Gene / Pathway	Phase 2: March 2008	3LZ8	31.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP04499 (show subtarget assignments)	1	cloned	No	VC0869	15640885		phosphoribosylformylglycinamidine syntha...	1297	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	73.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90551 (show subtarget assignments)	8	diffraction	No	VC0875	15640891		prolyl-tRNA synthetase [Vibrio cholerae ...	571	Predicted Essential	Community Requests	2J3L	45.5%	Vibrio cholerae

IDP00152 (show subtarget assignments)	1	in_pdb 3DZC	Yes	VC0917	15640933	wecB	UDP-N-acetylglucosamine 2-epimerase	372	Virulence	Phase 1: October 2007	3DZC	100%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01406 (show subtarget assignments)	1	crystallized	No	VC0918	15640934	wecC	UDP-N-acetyl-D-mannosamine dehydrogenase...	413	Conserved Gene / Pathway	Phase 2: March 2008	3OJL	45.4%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01315 (show subtarget assignments)	1	cloned	No	VC0942	15640958		hypothetical protein VC0942	117	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Other

IDP01407 (show subtarget assignments)	1	cloned	No	VC0947	15640963		D-alanyl-D-alanine carboxypeptidase	391	Drug Target Function	Phase 2: March 2008	1NZO	52.2%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90848 (show subtarget assignments)	8	cloned	No	VC0953	15640969	holA	DNA polymerase III subunit delta [Vibrio...	342	Predicted Essential	Community Requests	1JQJ	49.1%	Vibrio cholerae

IDP90897 (show subtarget assignments)	8	expressed	No	VC0956	15640972	leuS	leucyl-tRNA synthetase [Vibrio cholerae ...	894	Predicted Essential	Community Requests	1H3N	46.3%	Vibrio cholerae

IDP01408 (show subtarget assignments)	1	purified	No	VC0965	15640981		phosphoenolpyruvate-protein phosphotrans...	573	Conserved Gene / Pathway	Phase 2: March 2008	2KX9	74.7%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01317 (show subtarget assignments)	1	soluble	No	VC0966	15640982		phosphocarrier protein HPr	85	Conserved Gene / Pathway	Phase 2: March 2008	1GGR	75.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP90762 (show subtarget assignments)	8	in_crystallization_trials	No	VC0968	15640984		cysteine synthase A [Vibrio cholerae O1 ...	322	Predicted Essential	Community Requests	1FCJ	79.2%	Vibrio cholerae

IDP90769 (show subtarget assignments)	8	purified	No	VC0971	15640987	ligA	NAD-dependent DNA ligase LigA [Vibrio ch...	669	Predicted Essential	Community Requests	2OWO	65.8%	Vibrio cholerae

IDP01409 (show subtarget assignments)	1	purified	No	VC0972	15640988		porin, putative	349	Conserved Gene / Pathway	Phase 2: March 2008	1PHO	20.9%	Vibrio cholerae	Transport and binding proteins	Porins

IDP04500 (show subtarget assignments)	1	crystallized	No	VC0986	15641001	adk	adenylate kinase [Vibrio cholerae O1 bio...	214	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1AKE	73.4%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP01334 (show subtarget assignments)	1	in_pdb 3IV8 3EGJ	Yes	VC0994	15641009	nagA	N-acetylglucosamine-6-phosphate deacetyl...	378	Drug Target Function	Phase 2: March 2008	3EGJ	100%	Vibrio cholerae	Central intermediary metabolism	Amino sugars

IDP04322 (show subtarget assignments)	1	cloned	No	VC1001	15641016		folylpolyglutamate synthase/dihydrofolat...	421	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3N2A	53.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP04344 (show subtarget assignments)	1	in_crystallization_trials	No	VC1004	15641019		amidophosphoribosyltransferase [Vibrio c...	504	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1ECB	76.1%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04345 (show subtarget assignments)	1	in_pdb 3O6V 3PNS	Yes	VC1034	15641047		uridine phosphorylase [Vibrio cholerae O...	258	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3O6V	100%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP90861 (show subtarget assignments)	8	selected	No	VC1036	15641049		methionyl-tRNA synthetase [Vibrio choler...	731	Predicted Essential	Community Requests	1F4L	57.7%	Vibrio cholerae

IDP90638 (show subtarget assignments)	8	soluble	No	VC1040	15641053		cob(I)yrinic acid a,c-diamide adenosyltr...	201	Predicted Essential	Community Requests	1G5R	64.2%	Vibrio cholerae

IDP04406 (show subtarget assignments)	1	in_crystallization_trials	No	VC1053	15641066		adenine phosphoribosyltransferase [Vibri...	181	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2DY0	73.5%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP90616 (show subtarget assignments)	8	selected	No	VC1054	15641067		DNA polymerase III subunits gamma and ta...	692	Predicted Essential	Community Requests	1JR3	34.5%	Vibrio cholerae

IDP01305 (show subtarget assignments)	1	soluble	No	VC1064	15641077		lipoprotein-related protein	143	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Other

IDP04157 (show subtarget assignments)	1	soluble	No	VC1085	15641098		sensor histidine kinase [Vibrio cholerae...	434	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.1%	Vibrio cholerae	Regulatory functions	Other

IDP04158 (show subtarget assignments)	1	expressed	No	VC1088	15641101		sensor histidine kinase [Vibrio cholerae...	534	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3D36	13.5%	Vibrio cholerae	Regulatory functions	Other

IDP01410 (show subtarget assignments)	1	in_crystallization_trials	No	VC1091	15641104		oligopeptide ABC transporter, periplasmi...	543	Conserved Gene / Pathway	Phase 2: March 2008	2Z23	53.2%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01411 (show subtarget assignments)	1	purified	No	VC1095	15641108		oligopeptide ABC transporter, ATP-bindin...	336	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	28%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP90871 (show subtarget assignments)	8	in_crystallization_trials	No	VC1110	15641123		seryl-tRNA synthetase [Vibrio cholerae O...	435	Predicted Essential	Community Requests	2DQ3	50.3%	Vibrio cholerae

IDP04048 (show subtarget assignments)	1	in_crystallization_trials	No	VC1112	15641125		biotin synthase [Vibrio cholerae O1 biov...	350	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1R30	69.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01412 (show subtarget assignments)	1	purified	No	VC1122	15641135		cyclopropane-fatty-acyl-phospholipid syn...	432	Drug Target Function	Phase 2: March 2008	1KPI	18.7%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04049 (show subtarget assignments)	1	soluble	No	VC1132	15641145	hisG	ATP phosphoribosyltransferase [Vibrio ch...	304	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1H3D	65.8%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP04159 (show subtarget assignments)	1	cloned	No	VC1134	15641147		histidinol-phosphate aminotransferase [V...	346	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1FG3	59.8%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP01335 (show subtarget assignments)	1	soluble	No	VC1144	15641157	clpA	ATP-dependent Clp protease ATP-binding s...	756	Drug Target Function	Phase 2: March 2008	1KSF	77.9%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90758 (show subtarget assignments)	8	cloned	No	VC1149	15641162		glutamate decarboxylase, putative [Vibri...	548	Predicted Essential	Community Requests	2OKJ	26.1%	Vibrio cholerae

IDP04346 (show subtarget assignments)	1	expressed	No	VC1159	15641172		phosphoserine aminotransferase [Vibrio c...	379	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BJN	63.3%	Vibrio cholerae	Amino acid biosynthesis	Serine family

IDP90878 (show subtarget assignments)	8	in_crystallization_trials	No	VC1166	15641179	aspS	aspartyl-tRNA synthetase [Vibrio cholera...	591	Predicted Essential	Community Requests	1C0A	74.8%	Vibrio cholerae

IDP01512 (show subtarget assignments)	1	soluble	No	VC1173	15641186		anthranilate synthase component II	203	Drug Target Function	Phase 2: March 2008	1I1Q	57.1%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP01413 (show subtarget assignments)	1	purified	No	VC1174	15641187		anthranilate synthase component I	523	Drug Target Function	Phase 2: March 2008	1I1Q	59.3%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP90913 (show subtarget assignments)	8	soluble	No	VC1182	15641195		thioredoxin reductase [Vibrio cholerae O...	318	Predicted Essential	Community Requests	1CL0	81.4%	Vibrio cholerae

IDP04162 (show subtarget assignments)	1	expressed	No	VC1190	15641203	hemH	phosphoribosylaminoimidazole-succinocarb...	405	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3R9R	25.4%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90648 (show subtarget assignments)	8	purified	No	VC1219	15641232	pheS	phenylalanyl-tRNA synthetase subunit alp...	327	Predicted Essential	Community Requests	3PCO	76.5%	Vibrio cholerae

IDP90870 (show subtarget assignments)	8	purified	No	VC1220	15641233	pheT	phenylalanyl-tRNA synthetase subunit bet...	795	Predicted Essential	Community Requests	3PCO	64.4%	Vibrio cholerae

IDP04297 (show subtarget assignments)	1	in_pdb 4EG2	No	VC1231	15641244		cytidine deaminase [Vibrio cholerae O1 b...	295	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	4EG2	100%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP90627 (show subtarget assignments)	8	selected	No	VC1239	15641252	cobU	adenosylcobinamide kinase/adenosylcobina...	179	Predicted Essential	Community Requests	1C9K	41.3%	Vibrio cholerae

IDP01517 (show subtarget assignments)	1	expressed	No	VC1254	15641267		iron-sulfur cluster-binding protein, put...	92	Conserved Gene / Pathway	Phase 2: March 2008	1AWD	26.1%	Vibrio cholerae	Energy metabolism	Electron transport

IDP90834 (show subtarget assignments)	8	crystallized	No	VC1258	15641271		DNA gyrase, subunit A [Vibrio cholerae O...	894	Predicted Essential	Community Requests	3NUH	48.3%	Vibrio cholerae

IDP91530 (show subtarget assignments)	8	purified	No	VC1268	15641281		hypothetical protein VC1268 [Vibrio chol...	524	other biological interest / We have recently established that D-amino acids are important signal molecules t...	Community Requests			Vibrio cholerae

IDP01306 (show subtarget assignments)	1	purified	No	VC1281	15641294		PTS system, cellobiose-specific IIB comp...	101	Conserved Gene / Pathway	Phase 2: March 2008	2L2Q	40.6%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01307 (show subtarget assignments)	1	soluble	No	VC1283	15641296		PTS system, cellobiose-specific IIA comp...	111	Conserved Gene / Pathway	Phase 2: March 2008	1WCR	45.9%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP90884 (show subtarget assignments)	8	in_crystallization_trials	No	VC1296	15641309		phosphomethylpyrimidine kinase [Vibrio c...	282	Predicted Essential	Community Requests	1JXH	43.6%	Vibrio cholerae

IDP04007 (show subtarget assignments)	1	expressed	No	VC1319	15641331		sensor histidine kinase [Vibrio cholerae...	440	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Vibrio cholerae	Regulatory functions	Other

IDP04163 (show subtarget assignments)	1	expressed	No	VC1349	15641361		sensory box sensor histidine kinase/resp...	1331	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	6.5%	Vibrio cholerae	Regulatory functions	Other

IDP01414 (show subtarget assignments)	1	purified	No	VC1359	15641371		amino acid ABC transporter, ATP-binding ...	251	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	55.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01415 (show subtarget assignments)	1	in_crystallization_trials	No	VC1363	15641375		siroheme synthase component enzyme	312	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	29.6%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01416 (show subtarget assignments)	1	soluble	No	VC1410	15641421		multidrug resistance protein VceA	406	Conserved Gene / Pathway	Phase 2: March 2008	4DK1	15.3%	Vibrio cholerae	Transport and binding proteins	Other

IDP01417 (show subtarget assignments)	1	soluble	No	VC1414	15641425		thermostable carboxypeptidase 1	524	Drug Target Function	Phase 2: March 2008	3DWC	44.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01418 (show subtarget assignments)	1	purified	No	VC1424	15641435		spermidine/putrescine ABC transporter, p...	345	Conserved Gene / Pathway	Phase 2: March 2008	1POT	61.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01419 (show subtarget assignments)	1	in_crystallization_trials	No	VC1425	15641436		spermidine/putrescine ABC transporter, p...	366	Conserved Gene / Pathway	Phase 2: March 2008	1POT	52.7%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01336 (show subtarget assignments)	1	purified	No	VC1428	15641439	potA	putrescine/spermidine ABC transporter AT...	377	Conserved Gene / Pathway	Phase 2: March 2008	2D62	41.7%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP04164 (show subtarget assignments)	1	cloned	No	VC1445	15641456		sensor histidine kinase/response regulat...	572	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	14.5%	Vibrio cholerae	Regulatory functions	Other

IDP00166 (show subtarget assignments)	1	expressed	No	VC1450	15641461	rtxC	RTX toxin activating protein	153	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00142 (show subtarget assignments)	1	cloned	No	VC1456	15641467	ctxB	cholera enterotoxin, B subunit	124	Virulence	Phase 1: October 2007	1EEI	81.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP90635 (show subtarget assignments)	8	crystallized	No	VC1483	15641492		3-hydroxydecanoyl-(acyl carrier protein)...	172	Predicted Essential	Community Requests	1MKA	77.9%	Vibrio cholerae

IDP90882 (show subtarget assignments)	8	cloned	No	VC1491	15641500		dihydroorotate dehydrogenase 2 [Vibrio c...	336	Predicted Essential	Community Requests	1F76	67.9%	Vibrio cholerae

IDP01420 (show subtarget assignments)	1	cloned	No	VC1496	15641505		carboxy-terminal protease	665	Drug Target Function	Phase 2: March 2008	1FC6	16.1%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91163 (show subtarget assignments)	8	cloned	No	VC1507	15641516		phospho-2-dehydro-3-deoxyheptonate aldol...	395	potential drug target / Shikimate pathway enzyme	Community Requests	1GG1	48.9%	Vibrio cholerae

IDP01518 (show subtarget assignments)	1	purified	No	VC1512	15641521		formate dehydrogenase, iron-sulfur subun...	202	Conserved Gene / Pathway	Phase 2: March 2008	1KQF	29%	Vibrio cholerae	Energy metabolism	Anaerobic

IDP01308 (show subtarget assignments)	1	expressed	No	VC1516	15641524		iron-sulfur cluster-binding protein	553	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Energy metabolism	Electron transport

IDP04165 (show subtarget assignments)	1	expressed	No	VC1521	15641529		sensor histidine kinase [Vibrio cholerae...	677	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	11.7%	Vibrio cholerae	Regulatory functions	Other

IDP01421 (show subtarget assignments)	1	soluble	No	VC1544	15641552		tonB2 protein	206	Conserved Gene / Pathway	Phase 2: March 2008	2K9K	34%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01422 (show subtarget assignments)	1	expressed	No	VC1549	15641557		glycerol-3-phosphate ABC transporter, pe...	434	Conserved Gene / Pathway	Phase 2: March 2008	2HEU	20%	Vibrio cholerae	Transport and binding proteins	Other

IDP01423 (show subtarget assignments)	1	purified	No	VC1552	15641560	ugpC	glycerol-3-phosphate ABC transporter, AT...	393	Conserved Gene / Pathway	Phase 2: March 2008	2D62	45.5%	Vibrio cholerae	Transport and binding proteins	Other

IDP01424 (show subtarget assignments)	1	purified	No	VC1568	15641576		ABC transporter, ATP-binding protein	233	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	49.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01316 (show subtarget assignments)	1	in_crystallization_trials	No	VC1616	15641624		glutaredoxin, putative	77	Conserved Gene / Pathway	Phase 2: March 2008	2KLX	32.5%	Vibrio cholerae	Energy metabolism	Electron transport

IDP01346 (show subtarget assignments)	1	cloned	No	VC1621	15641628		agglutination protein	445	Conserved Gene / Pathway	Phase 2: March 2008	2VDD	24.9%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01425 (show subtarget assignments)	1	expressed	No	VC1630	15641635		ABC transporter, ATP-binding protein	227	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	37%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP04166 (show subtarget assignments)	1	cloned	No	VC1653	15641658		sensory box sensor histidine kinase/resp...	1146	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	6.6%	Vibrio cholerae	Regulatory functions	Other

IDP01426 (show subtarget assignments)	1	expressed	No	VC1680	15641684		peptide ABC transporter, periplasmic pep...	540	Conserved Gene / Pathway	Phase 2: March 2008	1DPP	35%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01427 (show subtarget assignments)	1	purified	No	VC1684	15641688		peptide ABC transporter, ATP-binding pro...	262	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	33.6%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01401
(show subtarget assignments)

1

purified

No

VC0773

15640792

vibriobactin-specific isochorismate synt...

395

Drug Target Function

Phase 2: March 2008

3OS6

44.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00144
(show subtarget assignments)

1

soluble

No

VC0776

15640795

viuP

vibriobactin and enterobactin ABC transp...

325

Virulence

Phase 1: October 2007

3R5S

91.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00145
(show subtarget assignments)

1

expressed

No

VC0777

15640796

viuD

vibriobactin and enterobactin ABC transp...

350

Virulence

Phase 1: October 2007

2NQ2

30.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00146
(show subtarget assignments)

1

soluble

No

VC0778

15640797

viuG

vibriobactin and enterobactin ABC transp...

358

Virulence

Phase 1: October 2007

2QI9

28.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00143
(show subtarget assignments)

1

soluble

No

VC0779

15640798

viuC

vibriobactin and enterobactin ABC transp...

279

Virulence

Phase 1: October 2007

1B0U

29%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00147
(show subtarget assignments)

1

expressed

No

VC0780

15640799

vibD

vibriobactin synthase component D

261

Virulence

Phase 1: October 2007

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP04498
(show subtarget assignments)

1

purified

No

VC0791

15640810

sensor kinase citA [Vibrio cholerae O1 b...

565

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2J80

9.7%

Vibrio cholerae

Regulatory functions

Other

IDP01511
(show subtarget assignments)

1

expressed

No

VC0794

15640812

hypothetical protein VC0794

139

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01345
(show subtarget assignments)

1

soluble

No

VC0824

15640841

tpx

tagD protein

164

Conserved Gene / Pathway

Phase 2: March 2008

1QXH

50%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00157
(show subtarget assignments)

1

soluble

No

VC0829

15640846

tcpB

toxin co-regulated pilus biosynthesis pr...

430

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00158
(show subtarget assignments)

1

soluble

No

VC0830

15640847

tcpQ

toxin co-regulated pilus biosynthesis pr...

150

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00159
(show subtarget assignments)

1

purified

No

VC0831

15640848

tcpC

toxin co-regulated pilus biosynthesis ou...

489

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00160
(show subtarget assignments)

1

soluble

No

VC0834

15640851

tcpS

toxin co-regulated pilus biosynthesis pr...

152

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00161
(show subtarget assignments)

1

soluble

No

VC0835

15640852

tcpT

toxin co-regulated pilus biosynthesis pr...

503

Virulence

Phase 1: October 2007

1P9R

23.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00162
(show subtarget assignments)

1

soluble

No

VC0837

15640854

tcpF

toxin co-regulated pilus biosynthesis pr...

338

Virulence

Phase 1: October 2007

3OC5

93.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00163
(show subtarget assignments)

0

work_stopped

No

VC0838

15640855

tcpN/toxT

TCP pilus virulence regulatory protein

276

Virulence

Phase 1: October 2007

3GBG

100%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00164
(show subtarget assignments)

1

soluble

No

VC0841

15640858

acfC

accessory colonization factor AcfC

256

Virulence

Phase 1: October 2007

3FIR

50%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01402
(show subtarget assignments)

1

cloned

No

VC0843

15640860

tagE protein

302

Drug Target Function

Phase 2: March 2008

3SLU

18.9%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00165
(show subtarget assignments)

1

cloned

No

VC0844

15640861

acfA

accessory colonization factor AcfA

215

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01403
(show subtarget assignments)

1

in_crystallization_trials

No

VC0854

15640870

heat shock protein GrpE

200

Conserved Gene / Pathway

Phase 2: March 2008

1DKG

39.5%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01404
(show subtarget assignments)

1

purified

No

VC0856

15640872

dnaJ protein

381

Conserved Gene / Pathway

Phase 2: March 2008

3LZ8

31.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP04499
(show subtarget assignments)

1

cloned

No

VC0869

15640885

phosphoribosylformylglycinamidine syntha...

1297

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

73.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90551
(show subtarget assignments)

8

diffraction

No

VC0875

15640891

prolyl-tRNA synthetase [Vibrio cholerae ...

571

Predicted Essential

Community Requests

2J3L

45.5%

Vibrio cholerae

IDP00152
(show subtarget assignments)

1

in_pdb
3DZC

Yes

VC0917

15640933

wecB

UDP-N-acetylglucosamine 2-epimerase

372

Virulence

Phase 1: October 2007

3DZC

100%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01406
(show subtarget assignments)

1

crystallized

No

VC0918

15640934

wecC

UDP-N-acetyl-D-mannosamine dehydrogenase...

413

Conserved Gene / Pathway

Phase 2: March 2008

3OJL

45.4%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01315
(show subtarget assignments)

1

cloned

No

VC0942

15640958

hypothetical protein VC0942

117

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Other

IDP01407
(show subtarget assignments)

1

cloned

No

VC0947

15640963

D-alanyl-D-alanine carboxypeptidase

391

Drug Target Function

Phase 2: March 2008

1NZO

52.2%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90848
(show subtarget assignments)

8

cloned

No

VC0953

15640969

holA

DNA polymerase III subunit delta [Vibrio...

342

Predicted Essential

Community Requests

1JQJ

49.1%

Vibrio cholerae

IDP90897
(show subtarget assignments)

8

expressed

No

VC0956

15640972

leuS

leucyl-tRNA synthetase [Vibrio cholerae ...

894

Predicted Essential

Community Requests

1H3N

46.3%

Vibrio cholerae

IDP01408
(show subtarget assignments)

1

purified

No

VC0965

15640981

phosphoenolpyruvate-protein phosphotrans...

573

Conserved Gene / Pathway

Phase 2: March 2008

2KX9

74.7%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01317
(show subtarget assignments)

1

soluble

No

VC0966

15640982

phosphocarrier protein HPr

85

Conserved Gene / Pathway

Phase 2: March 2008

1GGR

75.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP90762
(show subtarget assignments)

8

in_crystallization_trials

No

VC0968

15640984

cysteine synthase A [Vibrio cholerae O1 ...

322

Predicted Essential

Community Requests

1FCJ

79.2%

Vibrio cholerae

IDP90769
(show subtarget assignments)

8

purified

No

VC0971

15640987

ligA

NAD-dependent DNA ligase LigA [Vibrio ch...

669

Predicted Essential

Community Requests

2OWO

65.8%

Vibrio cholerae

IDP01409
(show subtarget assignments)

1

purified

No

VC0972

15640988

porin, putative

349

Conserved Gene / Pathway

Phase 2: March 2008

1PHO

20.9%

Vibrio cholerae

Transport and binding proteins

Porins

IDP04500
(show subtarget assignments)

1

crystallized

No

VC0986

15641001

adk

adenylate kinase [Vibrio cholerae O1 bio...

214

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1AKE

73.4%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP01334
(show subtarget assignments)

1

in_pdb
3IV8
3EGJ

Yes

VC0994

15641009

nagA

N-acetylglucosamine-6-phosphate deacetyl...

378

Drug Target Function

Phase 2: March 2008

3EGJ

100%

Vibrio cholerae

Central intermediary metabolism

Amino sugars

IDP04322
(show subtarget assignments)

1

cloned

No

VC1001

15641016

folylpolyglutamate synthase/dihydrofolat...

421

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3N2A

53.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP04344
(show subtarget assignments)

1

in_crystallization_trials

No

VC1004

15641019

amidophosphoribosyltransferase [Vibrio c...

504

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1ECB

76.1%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04345
(show subtarget assignments)

1

in_pdb
3O6V
3PNS

Yes

VC1034

15641047

uridine phosphorylase [Vibrio cholerae O...

258

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3O6V

100%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP90861
(show subtarget assignments)

8

selected

No

VC1036

15641049

methionyl-tRNA synthetase [Vibrio choler...

731

Predicted Essential

Community Requests

1F4L

57.7%

Vibrio cholerae

IDP90638
(show subtarget assignments)

8

soluble

No

VC1040

15641053

cob(I)yrinic acid a,c-diamide adenosyltr...

201

Predicted Essential

Community Requests

1G5R

64.2%

Vibrio cholerae

IDP04406
(show subtarget assignments)

1

in_crystallization_trials

No

VC1053

15641066

adenine phosphoribosyltransferase [Vibri...

181

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2DY0

73.5%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP90616
(show subtarget assignments)

8

selected

No

VC1054

15641067

DNA polymerase III subunits gamma and ta...

692

Predicted Essential

Community Requests

1JR3

34.5%

Vibrio cholerae

IDP01305
(show subtarget assignments)

1

soluble

No

VC1064

15641077

lipoprotein-related protein

143

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Other

IDP04157
(show subtarget assignments)

1

soluble

No

VC1085

15641098

sensor histidine kinase [Vibrio cholerae...

434

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.1%

Vibrio cholerae

Regulatory functions

Other

IDP04158
(show subtarget assignments)

1

expressed

No

VC1088

15641101

sensor histidine kinase [Vibrio cholerae...

534

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3D36

13.5%

Vibrio cholerae

Regulatory functions

Other

IDP01410
(show subtarget assignments)

1

in_crystallization_trials

No

VC1091

15641104

oligopeptide ABC transporter, periplasmi...

543

Conserved Gene / Pathway

Phase 2: March 2008

2Z23

53.2%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01411
(show subtarget assignments)

1

purified

No

VC1095

15641108

oligopeptide ABC transporter, ATP-bindin...

336

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

28%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP90871
(show subtarget assignments)

8

in_crystallization_trials

No

VC1110

15641123

seryl-tRNA synthetase [Vibrio cholerae O...

435

Predicted Essential

Community Requests

2DQ3

50.3%

Vibrio cholerae

IDP04048
(show subtarget assignments)

1

in_crystallization_trials

No

VC1112

15641125

biotin synthase [Vibrio cholerae O1 biov...

350

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1R30

69.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01412
(show subtarget assignments)

1

purified

No

VC1122

15641135

cyclopropane-fatty-acyl-phospholipid syn...

432

Drug Target Function

Phase 2: March 2008

1KPI

18.7%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04049
(show subtarget assignments)

1

soluble

No

VC1132

15641145

hisG

ATP phosphoribosyltransferase [Vibrio ch...

304

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1H3D

65.8%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP04159
(show subtarget assignments)

1

cloned

No

VC1134

15641147

histidinol-phosphate aminotransferase [V...

346

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1FG3

59.8%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP01335
(show subtarget assignments)

1

soluble

No

VC1144

15641157

clpA

ATP-dependent Clp protease ATP-binding s...

756

Drug Target Function

Phase 2: March 2008

1KSF

77.9%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90758
(show subtarget assignments)

8

cloned

No

VC1149

15641162

glutamate decarboxylase, putative [Vibri...

548

Predicted Essential

Community Requests

2OKJ

26.1%

Vibrio cholerae

IDP04346
(show subtarget assignments)

1

expressed

No

VC1159

15641172

phosphoserine aminotransferase [Vibrio c...

379

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BJN

63.3%

Vibrio cholerae

Amino acid biosynthesis

Serine family

IDP90878
(show subtarget assignments)

8

in_crystallization_trials

No

VC1166

15641179

aspS

aspartyl-tRNA synthetase [Vibrio cholera...

591

Predicted Essential

Community Requests

1C0A

74.8%

Vibrio cholerae

IDP01512
(show subtarget assignments)

1

soluble

No

VC1173

15641186

anthranilate synthase component II

203

Drug Target Function

Phase 2: March 2008

1I1Q

57.1%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP01413
(show subtarget assignments)

1

purified

No

VC1174

15641187

anthranilate synthase component I

523

Drug Target Function

Phase 2: March 2008

1I1Q

59.3%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP90913
(show subtarget assignments)

8

soluble

No

VC1182

15641195

thioredoxin reductase [Vibrio cholerae O...

318

Predicted Essential

Community Requests

1CL0

81.4%

Vibrio cholerae

IDP04162
(show subtarget assignments)

1

expressed

No

VC1190

15641203

hemH

phosphoribosylaminoimidazole-succinocarb...

405

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3R9R

25.4%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90648
(show subtarget assignments)

8

purified

No

VC1219

15641232

pheS

phenylalanyl-tRNA synthetase subunit alp...

327

Predicted Essential

Community Requests

3PCO

76.5%

Vibrio cholerae

IDP90870
(show subtarget assignments)

8

purified

No

VC1220

15641233

pheT

phenylalanyl-tRNA synthetase subunit bet...

795

Predicted Essential

Community Requests

3PCO

64.4%

Vibrio cholerae

IDP04297
(show subtarget assignments)

1

in_pdb
4EG2

No

VC1231

15641244

cytidine deaminase [Vibrio cholerae O1 b...

295

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

4EG2

100%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP90627
(show subtarget assignments)

8

selected

No

VC1239

15641252

cobU

adenosylcobinamide kinase/adenosylcobina...

179

Predicted Essential

Community Requests

1C9K

41.3%

Vibrio cholerae

IDP01517
(show subtarget assignments)

1

expressed

No

VC1254

15641267

iron-sulfur cluster-binding protein, put...

92

Conserved Gene / Pathway

Phase 2: March 2008

1AWD

26.1%

Vibrio cholerae

Energy metabolism

Electron transport

IDP90834
(show subtarget assignments)

8

crystallized

No

VC1258

15641271

DNA gyrase, subunit A [Vibrio cholerae O...

894

Predicted Essential

Community Requests

3NUH

48.3%

Vibrio cholerae

IDP91530
(show subtarget assignments)

8

purified

No

VC1268

15641281

hypothetical protein VC1268 [Vibrio chol...

524

other biological interest / We have recently established that D-amino acids are important signal molecules t...

Community Requests

Vibrio cholerae

IDP01306
(show subtarget assignments)

1

purified

No

VC1281

15641294

PTS system, cellobiose-specific IIB comp...

101

Conserved Gene / Pathway

Phase 2: March 2008

2L2Q

40.6%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01307
(show subtarget assignments)

1

soluble

No

VC1283

15641296

PTS system, cellobiose-specific IIA comp...

111

Conserved Gene / Pathway

Phase 2: March 2008

1WCR

45.9%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP90884
(show subtarget assignments)

8

in_crystallization_trials

No

VC1296

15641309

phosphomethylpyrimidine kinase [Vibrio c...

282

Predicted Essential

Community Requests

1JXH

43.6%

Vibrio cholerae

IDP04007
(show subtarget assignments)

1

expressed

No

VC1319

15641331

sensor histidine kinase [Vibrio cholerae...

440

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Vibrio cholerae

Regulatory functions

Other

IDP04163
(show subtarget assignments)

1

expressed

No

VC1349

15641361

sensory box sensor histidine kinase/resp...

1331

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

6.5%

Vibrio cholerae

Regulatory functions

Other

IDP01414
(show subtarget assignments)

1

purified

No

VC1359

15641371

amino acid ABC transporter, ATP-binding ...

251

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

55.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01415
(show subtarget assignments)

1

in_crystallization_trials

No

VC1363

15641375

siroheme synthase component enzyme

312

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

29.6%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01416
(show subtarget assignments)

1

soluble

No

VC1410

15641421

multidrug resistance protein VceA

406

Conserved Gene / Pathway

Phase 2: March 2008

4DK1

15.3%

Vibrio cholerae

Transport and binding proteins

Other

IDP01417
(show subtarget assignments)

1

soluble

No

VC1414

15641425

thermostable carboxypeptidase 1

524

Drug Target Function

Phase 2: March 2008

3DWC

44.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01418
(show subtarget assignments)

1

purified

No

VC1424

15641435

spermidine/putrescine ABC transporter, p...

345

Conserved Gene / Pathway

Phase 2: March 2008

1POT

61.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01419
(show subtarget assignments)

1

in_crystallization_trials

No

VC1425

15641436

spermidine/putrescine ABC transporter, p...

366

Conserved Gene / Pathway

Phase 2: March 2008

1POT

52.7%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01336
(show subtarget assignments)

1

purified

No

VC1428

15641439

potA

putrescine/spermidine ABC transporter AT...

377

Conserved Gene / Pathway

Phase 2: March 2008

2D62

41.7%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP04164
(show subtarget assignments)

1

cloned

No

VC1445

15641456

sensor histidine kinase/response regulat...

572

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

14.5%

Vibrio cholerae

Regulatory functions

Other

IDP00166
(show subtarget assignments)

1

expressed

No

VC1450

15641461

rtxC

RTX toxin activating protein

153

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00142
(show subtarget assignments)

1

cloned

No

VC1456

15641467

ctxB

cholera enterotoxin, B subunit

124

Virulence

Phase 1: October 2007

1EEI

81.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP90635
(show subtarget assignments)

8

crystallized

No

VC1483

15641492

3-hydroxydecanoyl-(acyl carrier protein)...

172

Predicted Essential

Community Requests

1MKA

77.9%

Vibrio cholerae

IDP90882
(show subtarget assignments)

8

cloned

No

VC1491

15641500

dihydroorotate dehydrogenase 2 [Vibrio c...

336

Predicted Essential

Community Requests

1F76

67.9%

Vibrio cholerae

IDP01420
(show subtarget assignments)

1

cloned

No

VC1496

15641505

carboxy-terminal protease

665

Drug Target Function

Phase 2: March 2008

1FC6

16.1%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91163
(show subtarget assignments)

8

cloned

No

VC1507

15641516

phospho-2-dehydro-3-deoxyheptonate aldol...

395

potential drug target / Shikimate pathway enzyme

Community Requests

1GG1

48.9%

Vibrio cholerae

IDP01518
(show subtarget assignments)

1

purified

No

VC1512

15641521

formate dehydrogenase, iron-sulfur subun...

202

Conserved Gene / Pathway

Phase 2: March 2008

1KQF

29%

Vibrio cholerae

Energy metabolism

Anaerobic

IDP01308
(show subtarget assignments)

1

expressed

No

VC1516

15641524

iron-sulfur cluster-binding protein

553

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Energy metabolism

Electron transport

IDP04165
(show subtarget assignments)

1

expressed

No

VC1521

15641529

sensor histidine kinase [Vibrio cholerae...

677

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

11.7%

Vibrio cholerae

Regulatory functions

Other

IDP01421
(show subtarget assignments)

1

soluble

No

VC1544

15641552

tonB2 protein

206

Conserved Gene / Pathway

Phase 2: March 2008

2K9K

34%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01422
(show subtarget assignments)

1

expressed

No

VC1549

15641557

glycerol-3-phosphate ABC transporter, pe...

434

Conserved Gene / Pathway

Phase 2: March 2008

2HEU

20%

Vibrio cholerae

Transport and binding proteins

Other

IDP01423
(show subtarget assignments)

1

purified

No

VC1552

15641560

ugpC

glycerol-3-phosphate ABC transporter, AT...

393

Conserved Gene / Pathway

Phase 2: March 2008

2D62

45.5%

Vibrio cholerae

Transport and binding proteins

Other

IDP01424
(show subtarget assignments)

1

purified

No

VC1568

15641576

ABC transporter, ATP-binding protein

233

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

49.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01316
(show subtarget assignments)

1

in_crystallization_trials

No

VC1616

15641624

glutaredoxin, putative

77

Conserved Gene / Pathway

Phase 2: March 2008

2KLX

32.5%

Vibrio cholerae

Energy metabolism

Electron transport

IDP01346
(show subtarget assignments)

1

cloned

No

VC1621

15641628

agglutination protein

445

Conserved Gene / Pathway

Phase 2: March 2008

2VDD

24.9%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01425
(show subtarget assignments)

1

expressed

No

VC1630

15641635

ABC transporter, ATP-binding protein

227

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

37%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP04166
(show subtarget assignments)

1

cloned

No

VC1653

15641658

sensory box sensor histidine kinase/resp...

1146

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

6.6%

Vibrio cholerae

Regulatory functions

Other

IDP01426
(show subtarget assignments)

1

expressed

No

VC1680

15641684

peptide ABC transporter, periplasmic pep...

540

Conserved Gene / Pathway

Phase 2: March 2008

1DPP

35%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01427
(show subtarget assignments)

1

purified

No

VC1684

15641688

peptide ABC transporter, ATP-binding pro...

262

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

33.6%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

Targets