Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02695 (show subtarget assignments)	1	soluble	No	Cj0698	15792047	flgG	flagellar basal body rod protein FlgG [C...	263	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	3A69	23.6%	Campylobacter jejuni	Unknown function	Enzymes of unknown specificity

IDP05315 (show subtarget assignments)	1	cloned	No	BAS0383	49183411	-	cell wall anchor domain-containing prote...	267	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	23.6%	Bacillus anthracis	Cell envelope: Other

IDP05607 (show subtarget assignments)	1	soluble	No	BA_4862	30259361		putative lipoprotein [Bacillus anthracis...	123	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2JQO	23.6%	Bacillus anthracis	Cell envelope: Other

IDP00586 (show subtarget assignments)	1	purified	No	YPO3789	16123923	metR	lysR-family transcriptional regulatory p...	317	Virulence Associated Factor	Phase 2: March 2008	1AL3	23.7%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP00207 (show subtarget assignments)	1	soluble	No	YPO1950	16122196	-	putative peptidase	405	Virulence	Phase 1: October 2007	1WN1	23.7%	Yersinia pestis	Hypothetical proteins	Conserved

IDP01811 (show subtarget assignments)	1	expressed	No	FTT0908	56708009	parB	chromosome partition protein B [Francise...	304	Conserved; Drug target functions	Phase 3: June 2008	1VZ0	23.7%	Francisella tularensis	Cellular processes	Cell division

IDP02796 (show subtarget assignments)	1	cloned	No	Cj1127c	15792452	wlaE	general glycosylation pathway protein [C...	365	Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...	Phase 3: June 2008	2JJM	23.7%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00404 (show subtarget assignments)	1	soluble	No	YPCD1.48	16082736	virG	needle complex outer membrane lipoprotei...	131	Virulence Associated Factor	Phase 2: March 2008	2YJL	23.7%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP02269 (show subtarget assignments)	1	cloned	No	Cj0608	15791968		outer membrane efflux protein [Campyloba...	456	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	3PIK	23.7%	Campylobacter jejuni	Protein fate	Protein folding and stabilization

IDP05674 (show subtarget assignments)	1	soluble	No	lmo0859	16802900	-	hypothetical protein lmo0859 [Listeria m...	439	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3QUF	23.7%	Listeria monocytogenes	Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP01502 (show subtarget assignments)	1	expressed	No	VCA0977	15601730		ABC transporter, ATP-binding protein	539	Conserved Gene / Pathway	Phase 2: March 2008	3BK7	23.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01470 (show subtarget assignments)	1	purified	No	VC2608	15642603		ABC transporter, ATP-binding protein	664	Conserved Gene / Pathway	Phase 2: March 2008	2IW3	23.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP91015 (show subtarget assignments)	8	selected	No	y2404	22126288	psn	pesticin/yersiniabactin outer membrane r...	673	TonB-dependent outer membrane receptor (yersiniabactin-binding)	Community Requests	1NQF	23.8%	Yersinia pestis

IDP05548 (show subtarget assignments)	1	cloned	No	lmo0409	16802454	-	hypothetical protein lmo0409 [Listeria m...	821	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1O6S	23.8%	Listeria monocytogenes	Cellular processes: Pathogenesis

IDP91493 (show subtarget assignments)	8	cloned	No	VP1690	28898464		putative type III secretion lipoprotein ...	248	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1YJ7	23.8%	Vibrio parahaemolyticus

IDP00800 (show subtarget assignments)	1	purified	No	SACOL1419	57286070		oligoendopeptidase F, putative	604	Drug Target Function	Phase 2: March 2008	2QR4	23.8%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04115 (show subtarget assignments)	1	expressed	No	STM2352_1_235	16765679	hisM	histidine/lysine/arginine/ornithine tran...	235	Salmonella essential protein	Phase 4: April 2009	3DHW	23.8%	Salmonella enterica

IDP91364 (show subtarget assignments)	8	expressed	No	VV1_2716	27366006		Outer membrane protein [Vibrio vulnificu...	421	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1EK9	23.8%	Vibrio vulnificus

IDP05291 (show subtarget assignments)	1	in_crystallization_trials	No	CD1211	126698807		putative acetyltransferase [Clostridium ...	163	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	1YX0	23.9%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP00579 (show subtarget assignments)	1	cloned	No	YPO1122	16121422	tolR	colicin uptake protein TolR	142	Conserved Gene / Pathway	Phase 2: March 2008	2JWK	23.9%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00791 (show subtarget assignments)	1	selected	No	SACOL1178	57284463		superantigen-like protein	238	Virulence Associated Factor	Phase 2: March 2008	1M4V	23.9%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00176 (show subtarget assignments)	1	cloned	No	YPO4024	16124147	-	putative iron transport permease	335	Virulence	Phase 1: October 2007	2QI9	23.9%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00780 (show subtarget assignments)	1	expressed	No	SACOL0694	57285664		tagH protein, teichoic acid ABC transpor...	264	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	23.9%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01734 (show subtarget assignments)	1	cloned	No	CBU_1094	29541668		efflux transporter, RND family, MFP subu...	380	Conserved; Drug target functions	Phase 3: June 2008	3FPP	23.9%	Coxiella burnetii	Transport and binding proteins	Other

IDP05258 (show subtarget assignments)	1	soluble	No	CD2761	126700377		putative N-acetylmuramoyl-L-alanine amid...	301	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1JWQ	23.9%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP92067 (show subtarget assignments)	8	selected	No	TGME49_069430	237832673		hexaprenyl pyrophosphate synthetase prot...	536	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3APZ	23.9%	Toxoplasma gondii

IDP91448 (show subtarget assignments)	8	expressed	No	VV1_0391	27363859		nucleotidyltransferase/DNA polymerase in...	418	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3QZ7	23.9%	Vibrio vulnificus

IDP00631 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1537	57284636	scpB	segregation and condensation protein B	180	Conserved Gene / Pathway	Phase 2: March 2008	1T6S	23.9%	Staphylococcus aureus	Cellular processes	Cell division

IDP92031 (show subtarget assignments)	8	selected	No	TGME49_019760	237842861		N-terminal acetyltransferase complex sub...	221	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2X7B	24%	Toxoplasma gondii

IDP91872 (show subtarget assignments)	8	selected	No	ACM47285	222159812	vanYD	D,D-carboxypeptidase VanYD [Enterococcus...	363	drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...	Community Requests	1ES4	24%	Enterococcus faecium

IDP02098 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0187	56707352	ftsA	cell division protein FtsA [Francisella ...	420	Conserved; Drug target functions	Phase 3: June 2008	1E4F	24%	Francisella tularensis	Cellular processes	Cell division

IDP00217 (show subtarget assignments)	1	cloned	No	YPO2319	16122543	-	putative pepetidase	278	Virulence	Phase 1: October 2007	1AGJ	24.1%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP01382 (show subtarget assignments)	1	cloned	No	VC0533	15640555		lipoprotein NlpD	311	Drug Target Function	Phase 2: March 2008	1QWY	24.1%	Vibrio cholerae	Cell envelope	Other

IDP02484 (show subtarget assignments)	1	expressed	No	GBAA3922	47529214		zinc protease [Bacillus anthracis str. '...	428	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HDI	24.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90979 (show subtarget assignments)	8	cloned	No	y0636	22124550		hypothetical protein y0636 [Yersinia pes...	158	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests	2Y75	24.1%	Yersinia pestis

IDP02481 (show subtarget assignments)	1	cloned	No	Cj1139c	15792464		putative galactosyltransferase [Campylob...	303	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3BCV	24.1%	Campylobacter jejuni	DNA metabolism	DNA replication, recombination, and repair

IDP00010 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2144	30256791		uroporphyrin-III C-methyltransferase, pu...	474	Drug Target Homolog	Phase 1: October 2007	1PJQ	24.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00727 (show subtarget assignments)	1	cloned	No	SACOL2036	57284905		ABC transporter, ATP-binding protein	642	Conserved Gene / Pathway	Phase 2: March 2008	2IW3	24.1%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP91960 (show subtarget assignments)	8	selected	No	SpneCM_010100008232	298255567		carbamate kinase [Streptococcus pneumoni...	423	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1B7B	24.1%	Streptococcus pneumoniae

IDP04408 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_1426	110798602		iron(III) ABC transporter, iron(III)-bin...	332	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3GFV	24.1%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP00065 (show subtarget assignments)	1	expressed	No	BA_5409	30259882		macrolide efflux pump, putative	544	Virulence	Phase 1: October 2007	1YQT	24.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01495 (show subtarget assignments)	1	cloned	No	VCA0803	15601558		serine protease, putative	330	Drug Target Function	Phase 2: March 2008	1BRU	24.2%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91259 (show subtarget assignments)	8	soluble	No	NT02SA1746	14247541	ribA	riboflavin biosynthesis protein [Staphyl...	393	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3MGZ	24.2%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP01107 (show subtarget assignments)	1	soluble	No	BA_2250	30256894		heat shock protein, Hsp20 family	153	Conserved Gene / Pathway	Phase 2: March 2008	3AAB	24.2%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP05103 (show subtarget assignments)	1	expressed	No	CD1226	126698822		putative exported aminodeoxychorismate l...	359	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2R1F	24.2%	Clostridium difficile	Hypothetical proteins: Conserved

IDP04019 (show subtarget assignments)	1	cloned	No	CPF_2080	110799586	spoIIIAH	stage III sporulation protein AH [Clostr...	165	conserved gene; putative drug target function;	Phase 4: April 2009	3TUF	24.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04660 (show subtarget assignments)	1	expressed	No	GBAA0286	47777799		sensor histidine kinase, putative [Bacil...	314	putative drug target function;	Phase 4: April 2009	2C2A	24.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP05622 (show subtarget assignments)	1	soluble	No	CD0999	126698583		ABC transporter, substrate-binding lipop...	331	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HN0	24.2%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP02702 (show subtarget assignments)	1	cloned	No	GBAA3442	47528726		neutral protease [Bacillus anthracis str...	565	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	1FJ3	24.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90879 (show subtarget assignments)	8	expressed	No	YPO0909	16121214	ubiH	2-octaprenyl-6-methoxyphenyl hydroxylase...	392	Predicted Essential	Community Requests	2X3N	24.2%	Yersinia pestis

IDP02316 (show subtarget assignments)	1	soluble	No	FTT0037	56707217	nuoG	NADH dehydrogenase subunit G [Francisell...	788	Conserved; Drug target functions	Phase 3: June 2008	2FUG	24.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP91769 (show subtarget assignments)	8	soluble	No	YPTB1890	51596222	yjcK	ribosomal-protein-alanine acetyltransfer...	185	drug resistance; innate immunity / Yersinia pseudotuberculosis YjcK (MccE-ctd homolog) - Yersinia pseudotuberculosi...	Community Requests	3R95	24.3%	Yersinia pseudotuberculosis

IDP00443 (show subtarget assignments)	1	soluble	No	YPO0908	16121213	visC	hypothetical protein YPO0908	406	Drug Target Function	Phase 2: March 2008	2R0C	24.3%	Yersinia pestis	Unknown function	General

IDP04089 (show subtarget assignments)	1	expressed	No	STM1952_1_222	16765290	yecS	putative ABC-type amino acid transporter...	222	Salmonella essential protein	Phase 4: April 2009	2R6G	24.3%	Salmonella enterica

IDP02306 (show subtarget assignments)	1	cloned	No	Cj0079c	15791469	cdtA	cytolethal distending toxin [Campylobact...	268	Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...	Phase 3: June 2008	1SR4	24.3%	Campylobacter jejuni	Cellular processes	Pathogenesis

IDP05708 (show subtarget assignments)	1	soluble	No	lmo2839	16804876	-	hypothetical protein lmo2839 [Listeria m...	430	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3QUF	24.4%	Listeria monocytogenes	Transport and binding proteins: Unknown substrate

IDP02482 (show subtarget assignments)	1	expressed	No	CBU_1857	29542411	oppD	peptide ABC transporter, ATP-binding pro...	530	Conserved; Drug target functions	Phase 3: June 2008	3PIH	24.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP05632 (show subtarget assignments)	1	cloned	No	CD1898	126699508		putative phage-related cell wall hydrola...	262	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3QAY	24.4%	Clostridium difficile	Unknown function: Enzymes of unknown specificity

IDP01683 (show subtarget assignments)	1	expressed	No	GBAA0187	47525446		oligopeptide ABC transporter, ATP-bindin...	336	Conserved; Drug target functions	Phase 3: June 2008	2ONK	24.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP05192 (show subtarget assignments)	1	cloned	No	CD0332	126697904	bclA1	putative exosporium glycoprotein [Clostr...	693	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	24.4%	Clostridium difficile	Unclassified: Role category not yet assigned

IDP90779 (show subtarget assignments)	8	cloned	No	YPO3497	16123643	nusA	transcription elongation factor NusA [Ye...	495	Predicted Essential	Community Requests	1K0R	24.4%	Yersinia pestis

IDP05564 (show subtarget assignments)	1	cloned	No	lmo2431	16804469	-	hypothetical protein lmo2431 [Listeria m...	323	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Q8P	24.5%	Listeria monocytogenes	Transport and binding proteins: Unknown substrate

IDP00001 (show subtarget assignments)	1	cloned	No	BA_4599	30259099		aldehyde-alcohol dehydrogenase	867	Drug Target Homolog	Phase 1: October 2007	3MY7	24.5%	Bacillus anthracis	Energy metabolism	Fermentation

IDP02617 (show subtarget assignments)	1	expressed	No	GBAA1286	47526551		D-alanyl-D-alanine carboxypeptidase fami...	428	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3MFD	24.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00464 (show subtarget assignments)	1	purified	No	YPO2522	16122741		hypothetical protein YPO2522	319	Drug Target Function	Phase 2: March 2008	1V8G	24.5%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05551 (show subtarget assignments)	1	cloned	No	CD3049	126700667		putative PTS system, IIB component [Clos...	102	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2L2Q	24.5%	Clostridium difficile	Signal transduction: PTS

IDP02586 (show subtarget assignments)	1	cloned	No	Cj1478c	15792793	cadF	fibronectin-binding protein [Campylobact...	319	Known Predicted virulence-adherence; Predicted virulence-Adhesion of Campylobact...	Phase 3: June 2008	3NB3	24.5%	Campylobacter jejuni	Cell envelope	Other

IDP90289 (show subtarget assignments)	8	purified	No	TGME49_094270	211967870		arginine methyltransferase protein, puta...	660	Epigenetic is an emerging field in Toxoplasma biology that will provide new targ...	Community Requests	2Y1W	24.5%	Toxoplasma gondii

IDP01390 (show subtarget assignments)	1	purified	No	VC0617	15640637		peptide ABC transporter, ATP-binding pro...	327	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	24.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP92063 (show subtarget assignments)	8	selected	No	AAT47116	48857021		putative thioredoxin peroxidase TPX1/1 [...	252	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2P5Q	24.6%	Toxoplasma gondii

IDP02197 (show subtarget assignments)	1	cloned	No	YPO0405	16120739		putative phosphoenolpyruvate-protein pho...	852	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2KX9	24.6%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP05093 (show subtarget assignments)	1	cloned	No	lmo0193	16802239	-	hypothetical protein lmo0193 [Listeria m...	225	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	4DK0	24.6%	Listeria monocytogenes	Hypothetical proteins: Conserved

IDP02207 (show subtarget assignments)	1	expressed	No	YPO0612	16120938		putative sugar binding protein [Yersinia...	414	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3QUF	24.6%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00839 (show subtarget assignments)	1	purified	No	SACOL1328	57284485	glnR	glutamine synthetase repressor	122	Conserved Gene / Pathway	Phase 2: March 2008	3HH0	24.6%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP02455 (show subtarget assignments)	1	expressed	No	GBAA3813	47529098		prophage LambdaBa01, thymidylate synthas...	252	Conserved; Drug target functions	Phase 3: June 2008	3AH5	24.6%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP05165 (show subtarget assignments)	1	soluble	No	BA_1888	30256549		enterotoxin [Bacillus anthracis str. Ame...	402	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2NRJ	24.6%	Bacillus anthracis	Cellular processes: Pathogenesis

IDP01017 (show subtarget assignments)	1	expressed	No	STM2854	16766160	hypA	hydrogenase nickel incorporation protein...	118	Conserved Gene / Pathway	Phase 2: March 2008	3A43	24.6%	Salmonella enterica	Protein fate	Protein modification and repair

IDP02142 (show subtarget assignments)	1	cloned	No	CBU_0754	29541354		efflux transporter, RND family, MFP subu...	348	Conserved; Drug target functions	Phase 3: June 2008	1VF7	24.7%	Coxiella burnetii	Transport and binding proteins	Other

IDP92062 (show subtarget assignments)	8	selected	No	AAK85305	22073900		putative glutathione/thioredoxin peroxid...	251	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2P5Q	24.7%	Toxoplasma gondii

IDP00487 (show subtarget assignments)	1	purified	No	YPO1491	16121764		ABC transporter ATP-binding protein	531	Conserved Gene / Pathway	Phase 2: March 2008	3BK7	24.7%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP05381 (show subtarget assignments)	1	cloned	No	BA_0711	30254309	gerLC	spore germination protein GerLC [Bacillu...	388	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3N54	24.7%	Bacillus anthracis	Cellular processes: Sporulation and germination

IDP02349 (show subtarget assignments)	1	purified	No	GBAA5069	47778360		LPXTG-site transpeptidase family protein...	198	Drug target motif; Drug target functions	Phase 3: June 2008	2XWG	24.7%	Bacillus anthracis	Cell envelope	Other

IDP05324 (show subtarget assignments)	1	cloned	No	CD3431	126701054		putative cobalamin biosynthesis kinase [...	295	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1VIS	24.7%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02602 (show subtarget assignments)	1	cloned	No	Cj1148	15792472	waaF	ADP-heptose--LPS heptosyltransferase II ...	319	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	1PSW	24.7%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91179 (show subtarget assignments)	8	expressed	No	y2283	22126168		hypothetical protein y2283 [Yersinia pes...	291	other biological interest / Other biological interest	Community Requests	2PZ0	24.7%	Yersinia pestis

IDP00673 (show subtarget assignments)	1	expressed	No	SACOL1322	57286057		hydrolase, alpha/beta hydrolase fold fam...	304	Drug Target Function	Phase 2: March 2008	3HJU	24.7%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP91529 (show subtarget assignments)	8	soluble	No	VC_1312	9655801		alanine racemase, putative [Vibrio chole...	428	other biological interest / The protein we are submitting is a broad spectrum amino acid racemase (Lam et al...	Community Requests	4ECL	24.8%	Vibrio cholerae

IDP04394 (show subtarget assignments)	1	cloned	No	CPF_2117	110800208	spoVD	stage V sporulation protein D [Clostridi...	695	conserved gene; putative drug target function;	Phase 4: April 2009	1PYY	24.8%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP02364 (show subtarget assignments)	1	cloned	No	Cj0365c	15791732		putative outer membrane channel protein ...	492	Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...	Phase 3: June 2008	3PIK	24.8%	Campylobacter jejuni	Cellular processes	Toxin production and resistance

IDP01159 (show subtarget assignments)	1	soluble	No	BA_4745	30259235		ABC transporter, ATP-binding protein	294	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	24.8%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP02258 (show subtarget assignments)	1	cloned	No	Cj0178	15791565		putative outer membrane siderophore rece...	755	Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate	Phase 3: June 2008	3CSL	24.9%	Campylobacter jejuni	Cell envelope	Other

IDP91250 (show subtarget assignments)	8	expressed	No	NT01LM1295	16410617	lmo1201	lmo1201 [Listeria monocytogenes]	493	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	24.9%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91919 (show subtarget assignments)	8	selected	No	SpneCM_010100003360	298254637		choline binding protein G [Streptococcus...	197	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1P3C	24.9%	Streptococcus pneumoniae

IDP90571 (show subtarget assignments)	8	expressed	No	YPO0416	16120749		putative lipopolysaccharide core biosynt...	346	Predicted Essential	Community Requests	3TOV	24.9%	Yersinia pestis

IDP91265 (show subtarget assignments)	8	cloned	No	NT05BA1551	49178367		2-heptaprenyl-1,4-naphthoquinone methylt...	237	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1VE3	24.9%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP01972 (show subtarget assignments)	1	cloned	No	CBU_0841	29541435		glycosyl transferase, group 1 family pro...	377	Conserved; Drug target functions	Phase 3: June 2008	2GEJ	24.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01346 (show subtarget assignments)	1	cloned	No	VC1621	15641628		agglutination protein	445	Conserved Gene / Pathway	Phase 2: March 2008	2VDD	24.9%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP05372 (show subtarget assignments)	1	cloned	No	BA_0397	30253932		LPXTG-motif cell wall anchor domain prot...	257	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3GHG	24.9%	Bacillus anthracis	Cell envelope: Other

IDP91292 (show subtarget assignments)	8	soluble	No	SPA2526	56414632	pheA	bifunctional chorismate mutase/prephenat...	386	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1ECM	24.9%	Salmonella enterica

IDP00574 (show subtarget assignments)	1	cloned	No	YPO0531	16120860	leuC	isopropylmalate isomerase large subunit ...	476	Virulence Associated Factor	Phase 2: March 2008	1ACO	25%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP02695
(show subtarget assignments)

1

soluble

No

Cj0698

15792047

flgG

flagellar basal body rod protein FlgG [C...

263

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

3A69

23.6%

Campylobacter jejuni

Unknown function

Enzymes of unknown specificity

IDP05315
(show subtarget assignments)

1

cloned

No

BAS0383

49183411

-

cell wall anchor domain-containing prote...

267

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

23.6%

Bacillus anthracis

Cell envelope: Other

IDP05607
(show subtarget assignments)

1

soluble

No

BA_4862

30259361

putative lipoprotein [Bacillus anthracis...

123

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2JQO

23.6%

Bacillus anthracis

Cell envelope: Other

IDP00586
(show subtarget assignments)

1

purified

No

YPO3789

16123923

metR

lysR-family transcriptional regulatory p...

317

Virulence Associated Factor

Phase 2: March 2008

1AL3

23.7%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP00207
(show subtarget assignments)

1

soluble

No

YPO1950

16122196

-

putative peptidase

405

Virulence

Phase 1: October 2007

1WN1

23.7%

Yersinia pestis

Hypothetical proteins

Conserved

IDP01811
(show subtarget assignments)

1

expressed

No

FTT0908

56708009

parB

chromosome partition protein B [Francise...

304

Conserved; Drug target functions

Phase 3: June 2008

1VZ0

23.7%

Francisella tularensis

Cellular processes

Cell division

IDP02796
(show subtarget assignments)

1

cloned

No

Cj1127c

15792452

wlaE

general glycosylation pathway protein [C...

365

Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...

Phase 3: June 2008

2JJM

23.7%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00404
(show subtarget assignments)

1

soluble

No

YPCD1.48

16082736

virG

needle complex outer membrane lipoprotei...

131

Virulence Associated Factor

Phase 2: March 2008

2YJL

23.7%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP02269
(show subtarget assignments)

1

cloned

No

Cj0608

15791968

outer membrane efflux protein [Campyloba...

456

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

3PIK

23.7%

Campylobacter jejuni

Protein fate

Protein folding and stabilization

IDP05674
(show subtarget assignments)

1

soluble

No

lmo0859

16802900

-

hypothetical protein lmo0859 [Listeria m...

439

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3QUF

23.7%

Listeria monocytogenes

Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP01502
(show subtarget assignments)

1

expressed

No

VCA0977

15601730

ABC transporter, ATP-binding protein

539

Conserved Gene / Pathway

Phase 2: March 2008

3BK7

23.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01470
(show subtarget assignments)

1

purified

No

VC2608

15642603

ABC transporter, ATP-binding protein

664

Conserved Gene / Pathway

Phase 2: March 2008

2IW3

23.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP91015
(show subtarget assignments)

8

selected

No

y2404

22126288

psn

pesticin/yersiniabactin outer membrane r...

673

TonB-dependent outer membrane receptor (yersiniabactin-binding)

Community Requests

1NQF

23.8%

Yersinia pestis

IDP05548
(show subtarget assignments)

1

cloned

No

lmo0409

16802454

-

hypothetical protein lmo0409 [Listeria m...

821

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1O6S

23.8%

Listeria monocytogenes

Cellular processes: Pathogenesis

IDP91493
(show subtarget assignments)

8

cloned

No

VP1690

28898464

putative type III secretion lipoprotein ...

248

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1YJ7

23.8%

Vibrio parahaemolyticus

IDP00800
(show subtarget assignments)

1

purified

No

SACOL1419

57286070

oligoendopeptidase F, putative

604

Drug Target Function

Phase 2: March 2008

2QR4

23.8%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04115
(show subtarget assignments)

1

expressed

No

STM2352_1_235

16765679

hisM

histidine/lysine/arginine/ornithine tran...

235

Salmonella essential protein

Phase 4: April 2009

3DHW

23.8%

Salmonella enterica

IDP91364
(show subtarget assignments)

8

expressed

No

VV1_2716

27366006

Outer membrane protein [Vibrio vulnificu...

421

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1EK9

23.8%

Vibrio vulnificus

IDP05291
(show subtarget assignments)

1

in_crystallization_trials

No

CD1211

126698807

putative acetyltransferase [Clostridium ...

163

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

1YX0

23.9%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP00579
(show subtarget assignments)

1

cloned

No

YPO1122

16121422

tolR

colicin uptake protein TolR

142

Conserved Gene / Pathway

Phase 2: March 2008

2JWK

23.9%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00791
(show subtarget assignments)

1

selected

No

SACOL1178

57284463

superantigen-like protein

238

Virulence Associated Factor

Phase 2: March 2008

1M4V

23.9%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00176
(show subtarget assignments)

1

cloned

No

YPO4024

16124147

-

putative iron transport permease

335

Virulence

Phase 1: October 2007

2QI9

23.9%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00780
(show subtarget assignments)

1

expressed

No

SACOL0694

57285664

tagH protein, teichoic acid ABC transpor...

264

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

23.9%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01734
(show subtarget assignments)

1

cloned

No

CBU_1094

29541668

efflux transporter, RND family, MFP subu...

380

Conserved; Drug target functions

Phase 3: June 2008

3FPP

23.9%

Coxiella burnetii

Transport and binding proteins

Other

IDP05258
(show subtarget assignments)

1

soluble

No

CD2761

126700377

putative N-acetylmuramoyl-L-alanine amid...

301

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1JWQ

23.9%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP92067
(show subtarget assignments)

8

selected

No

TGME49_069430

237832673

hexaprenyl pyrophosphate synthetase prot...

536

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3APZ

23.9%

Toxoplasma gondii

IDP91448
(show subtarget assignments)

8

expressed

No

VV1_0391

27363859

nucleotidyltransferase/DNA polymerase in...

418

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3QZ7

23.9%

Vibrio vulnificus

IDP00631
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1537

57284636

scpB

segregation and condensation protein B

180

Conserved Gene / Pathway

Phase 2: March 2008

1T6S

23.9%

Staphylococcus aureus

Cellular processes

Cell division

IDP92031
(show subtarget assignments)

8

selected

No

TGME49_019760

237842861

N-terminal acetyltransferase complex sub...

221

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2X7B

24%

Toxoplasma gondii

IDP91872
(show subtarget assignments)

8

selected

No

ACM47285

222159812

vanYD

D,D-carboxypeptidase VanYD [Enterococcus...

363

drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...

Community Requests

1ES4

24%

Enterococcus faecium

IDP02098
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0187

56707352

ftsA

cell division protein FtsA [Francisella ...

420

Conserved; Drug target functions

Phase 3: June 2008

1E4F

24%

Francisella tularensis

Cellular processes

Cell division

IDP00217
(show subtarget assignments)

1

cloned

No

YPO2319

16122543

-

putative pepetidase

278

Virulence

Phase 1: October 2007

1AGJ

24.1%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP01382
(show subtarget assignments)

1

cloned

No

VC0533

15640555

lipoprotein NlpD

311

Drug Target Function

Phase 2: March 2008

1QWY

24.1%

Vibrio cholerae

Cell envelope

Other

IDP02484
(show subtarget assignments)

1

expressed

No

GBAA3922

47529214

zinc protease [Bacillus anthracis str. '...

428

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HDI

24.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90979
(show subtarget assignments)

8

cloned

No

y0636

22124550

hypothetical protein y0636 [Yersinia pes...

158

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

2Y75

24.1%

Yersinia pestis

IDP02481
(show subtarget assignments)

1

cloned

No

Cj1139c

15792464

putative galactosyltransferase [Campylob...

303

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3BCV

24.1%

Campylobacter jejuni

DNA metabolism

DNA replication, recombination, and repair

IDP00010
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2144

30256791

uroporphyrin-III C-methyltransferase, pu...

474

Drug Target Homolog

Phase 1: October 2007

1PJQ

24.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00727
(show subtarget assignments)

1

cloned

No

SACOL2036

57284905

ABC transporter, ATP-binding protein

642

Conserved Gene / Pathway

Phase 2: March 2008

2IW3

24.1%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP91960
(show subtarget assignments)

8

selected

No

SpneCM_010100008232

298255567

carbamate kinase [Streptococcus pneumoni...

423

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1B7B

24.1%

Streptococcus pneumoniae

IDP04408
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_1426

110798602

iron(III) ABC transporter, iron(III)-bin...

332

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3GFV

24.1%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP00065
(show subtarget assignments)

1

expressed

No

BA_5409

30259882

macrolide efflux pump, putative

544

Virulence

Phase 1: October 2007

1YQT

24.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01495
(show subtarget assignments)

1

cloned

No

VCA0803

15601558

serine protease, putative

330

Drug Target Function

Phase 2: March 2008

1BRU

24.2%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91259
(show subtarget assignments)

8

soluble

No

NT02SA1746

14247541

ribA

riboflavin biosynthesis protein [Staphyl...

393

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3MGZ

24.2%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP01107
(show subtarget assignments)

1

soluble

No

BA_2250

30256894

heat shock protein, Hsp20 family

153

Conserved Gene / Pathway

Phase 2: March 2008

3AAB

24.2%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP05103
(show subtarget assignments)

1

expressed

No

CD1226

126698822

putative exported aminodeoxychorismate l...

359

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2R1F

24.2%

Clostridium difficile

Hypothetical proteins: Conserved

IDP04019
(show subtarget assignments)

1

cloned

No

CPF_2080

110799586

spoIIIAH

stage III sporulation protein AH [Clostr...

165

conserved gene; putative drug target function;

Phase 4: April 2009

3TUF

24.2%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04660
(show subtarget assignments)

1

expressed

No

GBAA0286

47777799

sensor histidine kinase, putative [Bacil...

314

putative drug target function;

Phase 4: April 2009

2C2A

24.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP05622
(show subtarget assignments)

1

soluble

No

CD0999

126698583

ABC transporter, substrate-binding lipop...

331

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HN0

24.2%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP02702
(show subtarget assignments)

1

cloned

No

GBAA3442

47528726

neutral protease [Bacillus anthracis str...

565

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

1FJ3

24.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90879
(show subtarget assignments)

8

expressed

No

YPO0909

16121214

ubiH

2-octaprenyl-6-methoxyphenyl hydroxylase...

392

Predicted Essential

Community Requests

2X3N

24.2%

Yersinia pestis

IDP02316
(show subtarget assignments)

1

soluble

No

FTT0037

56707217

nuoG

NADH dehydrogenase subunit G [Francisell...

788

Conserved; Drug target functions

Phase 3: June 2008

2FUG

24.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP91769
(show subtarget assignments)

8

soluble

No

YPTB1890

51596222

yjcK

ribosomal-protein-alanine acetyltransfer...

185

drug resistance; innate immunity / Yersinia pseudotuberculosis YjcK (MccE-ctd homolog) - Yersinia pseudotuberculosi...

Community Requests

3R95

24.3%

Yersinia pseudotuberculosis

IDP00443
(show subtarget assignments)

1

soluble

No

YPO0908

16121213

visC

hypothetical protein YPO0908

406

Drug Target Function

Phase 2: March 2008

2R0C

24.3%

Yersinia pestis

Unknown function

General

IDP04089
(show subtarget assignments)

1

expressed

No

STM1952_1_222

16765290

yecS

putative ABC-type amino acid transporter...

222

Salmonella essential protein

Phase 4: April 2009

2R6G

24.3%

Salmonella enterica

IDP02306
(show subtarget assignments)

1

cloned

No

Cj0079c

15791469

cdtA

cytolethal distending toxin [Campylobact...

268

Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...

Phase 3: June 2008

1SR4

24.3%

Campylobacter jejuni

Cellular processes

Pathogenesis

IDP05708
(show subtarget assignments)

1

soluble

No

lmo2839

16804876

-

hypothetical protein lmo2839 [Listeria m...

430

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3QUF

24.4%

Listeria monocytogenes

Transport and binding proteins: Unknown substrate

IDP02482
(show subtarget assignments)

1

expressed

No

CBU_1857

29542411

oppD

peptide ABC transporter, ATP-binding pro...

530

Conserved; Drug target functions

Phase 3: June 2008

3PIH

24.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP05632
(show subtarget assignments)

1

cloned

No

CD1898

126699508

putative phage-related cell wall hydrola...

262

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3QAY

24.4%

Clostridium difficile

Unknown function: Enzymes of unknown specificity

IDP01683
(show subtarget assignments)

1

expressed

No

GBAA0187

47525446

oligopeptide ABC transporter, ATP-bindin...

336

Conserved; Drug target functions

Phase 3: June 2008

2ONK

24.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP05192
(show subtarget assignments)

1

cloned

No

CD0332

126697904

bclA1

putative exosporium glycoprotein [Clostr...

693

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

24.4%

Clostridium difficile

Unclassified: Role category not yet assigned

IDP90779
(show subtarget assignments)

8

cloned

No

YPO3497

16123643

nusA

transcription elongation factor NusA [Ye...

495

Predicted Essential

Community Requests

1K0R

24.4%

Yersinia pestis

IDP05564
(show subtarget assignments)

1

cloned

No

lmo2431

16804469

-

hypothetical protein lmo2431 [Listeria m...

323

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Q8P

24.5%

Listeria monocytogenes

Transport and binding proteins: Unknown substrate

IDP00001
(show subtarget assignments)

1

cloned

No

BA_4599

30259099

aldehyde-alcohol dehydrogenase

867

Drug Target Homolog

Phase 1: October 2007

3MY7

24.5%

Bacillus anthracis

Energy metabolism

Fermentation

IDP02617
(show subtarget assignments)

1

expressed

No

GBAA1286

47526551

D-alanyl-D-alanine carboxypeptidase fami...

428

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3MFD

24.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00464
(show subtarget assignments)

1

purified

No

YPO2522

16122741

hypothetical protein YPO2522

319

Drug Target Function

Phase 2: March 2008

1V8G

24.5%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05551
(show subtarget assignments)

1

cloned

No

CD3049

126700667

putative PTS system, IIB component [Clos...

102

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2L2Q

24.5%

Clostridium difficile

Signal transduction: PTS

IDP02586
(show subtarget assignments)

1

cloned

No

Cj1478c

15792793

cadF

fibronectin-binding protein [Campylobact...

319

Known Predicted virulence-adherence; Predicted virulence-Adhesion of Campylobact...

Phase 3: June 2008

3NB3

24.5%

Campylobacter jejuni

Cell envelope

Other

IDP90289
(show subtarget assignments)

8

purified

No

TGME49_094270

211967870

arginine methyltransferase protein, puta...

660

Epigenetic is an emerging field in Toxoplasma biology that will provide new targ...

Community Requests

2Y1W

24.5%

Toxoplasma gondii

IDP01390
(show subtarget assignments)

1

purified

No

VC0617

15640637

peptide ABC transporter, ATP-binding pro...

327

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

24.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP92063
(show subtarget assignments)

8

selected

No

AAT47116

48857021

putative thioredoxin peroxidase TPX1/1 [...

252

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2P5Q

24.6%

Toxoplasma gondii

IDP02197
(show subtarget assignments)

1

cloned

No

YPO0405

16120739

putative phosphoenolpyruvate-protein pho...

852

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2KX9

24.6%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP05093
(show subtarget assignments)

1

cloned

No

lmo0193

16802239

-

hypothetical protein lmo0193 [Listeria m...

225

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

4DK0

24.6%

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP02207
(show subtarget assignments)

1

expressed

No

YPO0612

16120938

putative sugar binding protein [Yersinia...

414

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3QUF

24.6%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00839
(show subtarget assignments)

1

purified

No

SACOL1328

57284485

glnR

glutamine synthetase repressor

122

Conserved Gene / Pathway

Phase 2: March 2008

3HH0

24.6%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP02455
(show subtarget assignments)

1

expressed

No

GBAA3813

47529098

prophage LambdaBa01, thymidylate synthas...

252

Conserved; Drug target functions

Phase 3: June 2008

3AH5

24.6%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP05165
(show subtarget assignments)

1

soluble

No

BA_1888

30256549

enterotoxin [Bacillus anthracis str. Ame...

402

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2NRJ

24.6%

Bacillus anthracis

Cellular processes: Pathogenesis

IDP01017
(show subtarget assignments)

1

expressed

No

STM2854

16766160

hypA

hydrogenase nickel incorporation protein...

118

Conserved Gene / Pathway

Phase 2: March 2008

3A43

24.6%

Salmonella enterica

Protein fate

Protein modification and repair

IDP02142
(show subtarget assignments)

1

cloned

No

CBU_0754

29541354

efflux transporter, RND family, MFP subu...

348

Conserved; Drug target functions

Phase 3: June 2008

1VF7

24.7%

Coxiella burnetii

Transport and binding proteins

Other

IDP92062
(show subtarget assignments)

8

selected

No

AAK85305

22073900

putative glutathione/thioredoxin peroxid...

251

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2P5Q

24.7%

Toxoplasma gondii

IDP00487
(show subtarget assignments)

1

purified

No

YPO1491

16121764

ABC transporter ATP-binding protein

531

Conserved Gene / Pathway

Phase 2: March 2008

3BK7

24.7%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP05381
(show subtarget assignments)

1

cloned

No

BA_0711

30254309

gerLC

spore germination protein GerLC [Bacillu...

388

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3N54

24.7%

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP02349
(show subtarget assignments)

1

purified

No

GBAA5069

47778360

LPXTG-site transpeptidase family protein...

198

Drug target motif; Drug target functions

Phase 3: June 2008

2XWG

24.7%

Bacillus anthracis

Cell envelope

Other

IDP05324
(show subtarget assignments)

1

cloned

No

CD3431

126701054

putative cobalamin biosynthesis kinase [...

295

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1VIS

24.7%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02602
(show subtarget assignments)

1

cloned

No

Cj1148

15792472

waaF

ADP-heptose--LPS heptosyltransferase II ...

319

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

1PSW

24.7%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91179
(show subtarget assignments)

8

expressed

No

y2283

22126168

hypothetical protein y2283 [Yersinia pes...

291

other biological interest / Other biological interest

Community Requests

2PZ0

24.7%

Yersinia pestis

IDP00673
(show subtarget assignments)

1

expressed

No

SACOL1322

57286057

hydrolase, alpha/beta hydrolase fold fam...

304

Drug Target Function

Phase 2: March 2008

3HJU

24.7%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP91529
(show subtarget assignments)

8

soluble

No

VC_1312

9655801

alanine racemase, putative [Vibrio chole...

428

other biological interest / The protein we are submitting is a broad spectrum amino acid racemase (Lam et al...

Community Requests

4ECL

24.8%

Vibrio cholerae

IDP04394
(show subtarget assignments)

1

cloned

No

CPF_2117

110800208

spoVD

stage V sporulation protein D [Clostridi...

695

conserved gene; putative drug target function;

Phase 4: April 2009

1PYY

24.8%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP02364
(show subtarget assignments)

1

cloned

No

Cj0365c

15791732

putative outer membrane channel protein ...

492

Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...

Phase 3: June 2008

3PIK

24.8%

Campylobacter jejuni

Cellular processes

Toxin production and resistance

IDP01159
(show subtarget assignments)

1

soluble

No

BA_4745

30259235

ABC transporter, ATP-binding protein

294

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

24.8%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP02258
(show subtarget assignments)

1

cloned

No

Cj0178

15791565

putative outer membrane siderophore rece...

755

Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate

Phase 3: June 2008

3CSL

24.9%

Campylobacter jejuni

Cell envelope

Other

IDP91250
(show subtarget assignments)

8

expressed

No

NT01LM1295

16410617

lmo1201

lmo1201 [Listeria monocytogenes]

493

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

24.9%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91919
(show subtarget assignments)

8

selected

No

SpneCM_010100003360

298254637

choline binding protein G [Streptococcus...

197

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1P3C

24.9%

Streptococcus pneumoniae

IDP90571
(show subtarget assignments)

8

expressed

No

YPO0416

16120749

putative lipopolysaccharide core biosynt...

346

Predicted Essential

Community Requests

3TOV

24.9%

Yersinia pestis

IDP91265
(show subtarget assignments)

8

cloned

No

NT05BA1551

49178367

2-heptaprenyl-1,4-naphthoquinone methylt...

237

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1VE3

24.9%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP01972
(show subtarget assignments)

1

cloned

No

CBU_0841

29541435

glycosyl transferase, group 1 family pro...

377

Conserved; Drug target functions

Phase 3: June 2008

2GEJ

24.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01346
(show subtarget assignments)

1

cloned

No

VC1621

15641628

agglutination protein

445

Conserved Gene / Pathway

Phase 2: March 2008

2VDD

24.9%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP05372
(show subtarget assignments)

1

cloned

No

BA_0397

30253932

LPXTG-motif cell wall anchor domain prot...

257

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3GHG

24.9%

Bacillus anthracis

Cell envelope: Other

IDP91292
(show subtarget assignments)

8

soluble

No

SPA2526

56414632

pheA

bifunctional chorismate mutase/prephenat...

386

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1ECM

24.9%

Salmonella enterica

IDP00574
(show subtarget assignments)

1

cloned

No

YPO0531

16120860

leuC

isopropylmalate isomerase large subunit ...

476

Virulence Associated Factor

Phase 2: March 2008

1ACO

25%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family