Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00900 (show subtarget assignments)	0	work_stopped	No	STM4247	16767497	alr	alanine racemase	359	Conserved Gene / Pathway	Phase 2: March 2008	2RJG	91.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00901 (show subtarget assignments)	1	in_crystallization_trials	No	STM0004	16763394	thrC	threonine synthase	428	Conserved Gene / Pathway	Phase 2: March 2008	1VB3	93.5%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP00902 (show subtarget assignments)	1	expressed	No	STM0045	16763435	ribF	bifunctional riboflavin kinase/FMN adeny...	312	Conserved Gene / Pathway	Phase 2: March 2008	1MRZ	33%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00903 (show subtarget assignments)	0	work_stopped	No	STM0123	16763513	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	495	Essential Gene	Phase 2: March 2008	1E8C	91.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00904 (show subtarget assignments)	0	work_stopped	No	STM0124	16763514	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	452	Conserved Gene / Pathway	Phase 2: March 2008	1GG4	87.6%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00905 (show subtarget assignments)	0	work_stopped	No	STM0126	16763516	murD	UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	438	Essential Gene	Phase 2: March 2008	1E0D	92.2%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00906 (show subtarget assignments)	0	work_stopped	No	STM0129	16763519	murC	UDP-N-acetylmuramate--L-alanine ligase	491	Essential Gene	Phase 2: March 2008	2F00	94.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00907 (show subtarget assignments)	1	in_crystallization_trials	No	STM0140	16763530	coaE	dephospho-CoA kinase	206	Conserved Gene / Pathway	Phase 2: March 2008	1N3B	88.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00908 (show subtarget assignments)	1	expressed	No	STM0143	16763533	hofB	hypothetical protein STM0143	461	Conserved Gene / Pathway	Phase 2: March 2008	1P9R	37.3%	Salmonella enterica	Cell envelope	Surface structures

IDP00909 (show subtarget assignments)	0	work_stopped	No	STM0171	16763561	yadF	carbonic anhydrase	220	Conserved Gene / Pathway	Phase 2: March 2008	3QY1	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP00910 (show subtarget assignments)	1	cloned	No	STM0190	16763580	mrcB	penicillin-binding protein 1b	840	Drug Target Function	Phase 2: March 2008	3FWL	84%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00911 (show subtarget assignments)	1	expressed	No	STM0191	16763581	fhuA	ferrichrome outer membrane transporter	729	Conserved Gene / Pathway	Phase 2: March 2008	2FCP	72.3%	Salmonella enterica	Cell envelope	Other

IDP00912 (show subtarget assignments)	1	soluble	No	STM0193	16763583	fhuD	iron-hydroxamate transporter substrate-b...	296	Conserved Gene / Pathway	Phase 2: March 2008	1ESZ	75%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00913 (show subtarget assignments)	0	work_stopped	No	STM0219	16763609	frr	ribosome recycling factor	185	Conserved Gene / Pathway	Phase 2: March 2008	1EK8	94.1%	Salmonella enterica	Protein synthesis	Translation factors

IDP00914 (show subtarget assignments)	1	soluble	No	STM0220	16763610	dxr	1-deoxy-D-xylulose 5-phosphate reductois...	398	Conserved Gene / Pathway	Phase 2: March 2008	1K5H	88.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00915 (show subtarget assignments)	1	in_crystallization_trials	No	STM0236	16763626	tilS	tRNA(Ile)-lysidine synthetase	430	Drug Target Function	Phase 2: March 2008	1NI5	75.3%	Salmonella enterica	Cellular processes	Cell division

IDP00916 (show subtarget assignments)	0	work_stopped	No	STM0247	16763636	metN	DL-methionine transporter ATP-binding su...	343	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	95.3%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP00917 (show subtarget assignments)	1	cloned	No	STM0355	16763735		putative copper chaperone	64	Conserved Gene / Pathway	Phase 2: March 2008	2K2P	39.1%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00918 (show subtarget assignments)	1	soluble	No	STM0372	16763752	hemB	delta-aminolevulinic acid dehydratase	324	Conserved Gene / Pathway	Phase 2: March 2008	1I8J	93.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00919 (show subtarget assignments)	1	in_pdb 3Q1K 3I12	No	STM0380	16763760	ddl	D-alanyl-alanine synthetase A	364	Conserved Gene / Pathway	Phase 2: March 2008	3I12	100%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00920 (show subtarget assignments)	1	in_crystallization_trials	No	STM0417	16763797	ribH	riboflavin synthase subunit beta	156	Conserved Gene / Pathway	Phase 2: March 2008	3MK3	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00921 (show subtarget assignments)	1	purified	No	STM0507	16763887	ybbA	putative ABC transporter ATP-binding pro...	228	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	42.5%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP00922 (show subtarget assignments)	1	soluble	No	STM0533	16763913	purK	phosphoribosylaminoimidazole carboxylase...	355	Conserved Gene / Pathway	Phase 2: March 2008	1B6S	88.2%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00923 (show subtarget assignments)	1	in_pdb 3HZN	No	STM0578	16763955	nfnB	dihydropteridine reductase	217	Conserved Gene / Pathway	Phase 2: March 2008	3HZN	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP00924 (show subtarget assignments)	1	purified	No	STM0590	16763967	fepC	iron-enterobactin transporter ATP-bindin...	264	Conserved Gene / Pathway	Phase 2: March 2008	3GFO	28.4%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00925 (show subtarget assignments)	1	crystallized	No	STM0595	16763972	entC	isochorismate synthase	391	Drug Target Function	Phase 2: March 2008	3HWO	84.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00926 (show subtarget assignments)	1	soluble	No	STM0597	16763974	entB	2,3-dihydro-2,3-dihydroxybenzoate synthe...	285	Conserved Gene / Pathway	Phase 2: March 2008	2FQ1	88.4%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00927 (show subtarget assignments)	1	soluble	No	STM0598	16763975	entA	2,3-dihydroxybenzoate-2,3-dehydrogenase ...	251	Conserved Gene / Pathway	Phase 2: March 2008	2FWM	89.2%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00928 (show subtarget assignments)	1	in_crystallization_trials	No	STM0602	16763979	ybdH	putative glycerol dehydrogenase	362	Conserved Gene / Pathway	Phase 2: March 2008	1KQ3	31.1%	Salmonella enterica	Central intermediary metabolism	Other

IDP00929 (show subtarget assignments)	1	soluble	No	STM0603	16763980	ybdL	putative aminotransferase	386	Conserved Gene / Pathway	Phase 2: March 2008	1U08	85.5%	Salmonella enterica	Central intermediary metabolism	Other

IDP00930 (show subtarget assignments)	1	expressed	No	STM0612	16763989		putative hydrogenase protein	185	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	30.3%	Salmonella enterica	Energy metabolism	Anaerobic

IDP00931 (show subtarget assignments)	1	expressed	No	STM0615	16763992	ybdR	putative dehydrogenase	412	Essential Gene	Phase 2: March 2008	1KOL	32.5%	Salmonella enterica	Central intermediary metabolism	Other

IDP00932 (show subtarget assignments)	1	in_crystallization_trials	No	STM0645	16764022	nadD	nicotinic acid mononucleotide adenyltran...	213	Conserved Gene / Pathway	Phase 2: March 2008	1K4K	85.4%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00933 (show subtarget assignments)	1	purified	No	STM0662	16764039	gltL	glutamate/aspartate transporter	241	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	54.4%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00934 (show subtarget assignments)	0	work_stopped	No	STM0779	16764143	modE	DNA-binding transcriptional dual regulat...	262	Conserved Gene / Pathway	Phase 2: March 2008	1B9M	89.3%	Salmonella enterica	Transport and binding proteins	Anions

IDP00935 (show subtarget assignments)	1	purified	No	STM0783	16764147	modC	molybdate transporter ATP-binding protei...	352	Conserved Gene / Pathway	Phase 2: March 2008	3D31	29.5%	Salmonella enterica	Transport and binding proteins	Anions

IDP00936 (show subtarget assignments)	1	soluble	No	STM0793	16764156	bioA	adenosylmethionine--8-amino-7-oxononanoa...	429	Conserved Gene / Pathway	Phase 2: March 2008	1MLY	86.2%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00937 (show subtarget assignments)	1	cloned	No	STM0795	16764158	bioF	8-amino-7-oxononanoate synthase	385	Conserved Gene / Pathway	Phase 2: March 2008	1BS0	80%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00938 (show subtarget assignments)	1	cloned	No	STM0813	16764176	ybhP	putative cytoplasmic protein	252	Essential Gene	Phase 2: March 2008			Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP00939 (show subtarget assignments)	1	expressed	No	STM0828	16764190	glnQ	glutamine ABC transporter ATP-binding pr...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	55%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00940 (show subtarget assignments)	1	soluble	No	STM0845	16764207	moeB	molybdopterin biosynthesis protein MoeB ...	249	Conserved Gene / Pathway	Phase 2: March 2008	1JW9	88.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP00941 (show subtarget assignments)	1	purified	No	STM0846	16764208	moeA	molybdopterin biosynthesis protein MoeA ...	413	Conserved Gene / Pathway	Phase 2: March 2008	1FC5	87.2%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP00942 (show subtarget assignments)	1	in_crystallization_trials	No	STM0857	16764219		putative acyl-CoA dehydrogenase	387	Essential Gene	Phase 2: March 2008	3MPI	32%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP00943 (show subtarget assignments)	1	crystallized	No	STM0862	16764224	yliJ	putative glutathione S-transferase	208	Conserved Gene / Pathway	Phase 2: March 2008	4ECI	30.8%	Salmonella enterica	Cellular processes	Detoxification

IDP00944 (show subtarget assignments)	1	crystallized	No	STM0891	16764252	artP	arginine transporter ATP-binding subunit...	242	Conserved Gene / Pathway	Phase 2: March 2008	1B0U	43.8%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00945 (show subtarget assignments)	0	work_stopped	No	STM0977	16764337	serC	phosphoserine aminotransferase	362	Conserved Gene / Pathway	Phase 2: March 2008	3QM2	100%	Salmonella enterica	Amino acid biosynthesis	Serine family

IDP00946 (show subtarget assignments)	1	expressed	No	STM0978	16764338	aroA	3-phosphoshikimate 1-carboxyvinyltransfe...	427	Conserved Gene / Pathway	Phase 2: March 2008	1G6S	89.5%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP00947 (show subtarget assignments)	1	purified	No	STM0988	16764348	kdsB	3-deoxy-manno-octulosonate cytidylyltran...	248	Essential Gene	Phase 2: March 2008	1VH1	94%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00948 (show subtarget assignments)	1	expressed	No	STM1060	16764419		putative iron-sulfur protein	369	Conserved Gene / Pathway	Phase 2: March 2008	1ROE	8.4%	Salmonella enterica	Energy metabolism	Electron transport

IDP00949 (show subtarget assignments)	1	purified	No	STM1102	16764460	hpaE	4-hydroxyphenylacetate catabolism	488	Conserved Gene / Pathway	Phase 2: March 2008	2D4E	47.7%	Salmonella enterica	Central intermediary metabolism	Other

IDP00950 (show subtarget assignments)	1	soluble	No	STM1119	16764477	wraB	TrpR binding protein WrbA	198	Conserved Gene / Pathway	Phase 2: March 2008	2R96	94.4%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP00951 (show subtarget assignments)	1	in_pdb 3PP8 3KBO	No	STM1135	16764491	ycdW	putative oxidoreductase	312	Conserved Gene / Pathway	Phase 2: March 2008	3KBO	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP00952 (show subtarget assignments)	1	purified	No	STM1176	16764532	flgD	flagellar basal body rod modification pr...	232	Conserved Gene / Pathway	Phase 2: March 2008	3C12	19.8%	Salmonella enterica	Cell envelope	Surface structures

IDP00953 (show subtarget assignments)	1	in_crystallization_trials	No	STM1183	16764539	flgK	flagellar hook-associated protein FlgK	553	Conserved Gene / Pathway	Phase 2: March 2008	2D4Y	83.5%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00954 (show subtarget assignments)	1	in_crystallization_trials	No	STM1189	16764544	maf	Maf-like protein	194	Essential Gene	Phase 2: March 2008	1EX2	31.4%	Salmonella enterica	Cellular processes	Cell division

IDP00955 (show subtarget assignments)	1	cloned	No	STM1192	16764547	plsX	fatty acid/phospholipid synthesis protei...	359	Conserved Gene / Pathway	Phase 2: March 2008	1U7N	36.5%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00956 (show subtarget assignments)	1	in_pdb 3H0P	No	STM1194	16764549	fabD	acyl carrier protein S-malonyltransferas...	309	potential drug target / Essential Gene	Phase 2: March 2008	3H0P	100%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00957 (show subtarget assignments)	0	work_stopped	No	STM1202	16764557	ycfH	predicted metallodependent hydrolase	265	Conserved Gene / Pathway	Phase 2: March 2008	1YIX	92.8%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP00958 (show subtarget assignments)	1	soluble	No	STM1218	16764573	lolD	lipoprotein transporter ATP-binding subu...	233	Conserved Gene / Pathway	Phase 2: March 2008	2PCJ	43.3%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP00959 (show subtarget assignments)	1	soluble	No	STM1303	16764654	argD	bifunctional succinylornithine transamin...	408	Conserved Gene / Pathway	Phase 2: March 2008	2PB0	60.8%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP00960 (show subtarget assignments)	1	in_pdb 3HMQ	No	STM1310	16764661	nadE	NAD synthetase	275	Drug Target Function	Phase 2: March 2008	3HMQ	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00961 (show subtarget assignments)	1	expressed	No	STM1385	16764735	ttrB	tetrathionate reductase complex subunit ...	250	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	34.4%	Salmonella enterica	Energy metabolism	Electron transport

IDP00962 (show subtarget assignments)	1	cloned	No	STM1427	16764775	cfa	cyclopropane fatty acyl phospholipid syn...	382	Drug Target Function	Phase 2: March 2008	1KP9	26.7%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00963 (show subtarget assignments)	1	in_crystallization_trials	No	STM1436	16764784	nemA	N-ethylmaleimide reductase, FMN-linked	365	Conserved Gene / Pathway	Phase 2: March 2008	3P62	87.4%	Salmonella enterica	Central intermediary metabolism	Other

IDP00964 (show subtarget assignments)	0	work_stopped	No	STM1439	16764787	ydhF	putative aldo/keto reductase	298	Conserved Gene / Pathway	Phase 2: March 2008	1OG6	88.9%	Salmonella enterica	Unknown function	General

IDP00965 (show subtarget assignments)	1	purified	No	STM1463	16764811	add	adenosine deaminase	333	Conserved Gene / Pathway	Phase 2: March 2008	1NDV	33.8%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP00966 (show subtarget assignments)	1	expressed	No	STM1552	16764897		putative cytoplasmic protein	302	Essential Gene	Phase 2: March 2008			Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP00967 (show subtarget assignments)	1	in_crystallization_trials	No	STM1559	16764903		putative glycosyl hydrolase	842	Essential Gene	Phase 2: March 2008	3HJE	31.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00968 (show subtarget assignments)	1	in_pdb 3M07	No	STM1560	16764904		putative alpha amylase	594	Essential Gene	Phase 2: March 2008	3M07	100%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00969 (show subtarget assignments)	1	purified	No	STM1597	161353598	ydcW	putative aldehyde dehydrogenase	474	Conserved Gene / Pathway	Phase 2: March 2008	1WNB	83.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00970 (show subtarget assignments)	1	soluble	No	STM1682	16765025	tpx	thiol peroxidase	168	Conserved Gene / Pathway	Phase 2: March 2008	1QXH	87.5%	Salmonella enterica	Cellular processes	Detoxification

IDP00971 (show subtarget assignments)	1	in_pdb 3IAH	Yes	STM1717	16765061	yciK	short chain dehydrogenase	253	Conserved Gene / Pathway	Phase 2: March 2008	3IAH	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP00972 (show subtarget assignments)	1	expressed	No	STM1743	16765087	oppD	oligopeptide transporter ATP-binding com...	335	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	25.7%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00973 (show subtarget assignments)	1	purified	No	STM1756	16765100	purU	formyltetrahydrofolate deformylase	280	Conserved Gene / Pathway	Phase 2: March 2008	3O1L	42.7%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00974 (show subtarget assignments)	1	in_crystallization_trials	No	STM1775	16765116	hemK	N5-glutamine S-adenosyl-L-methionine-dep...	277	Essential Gene	Phase 2: March 2008	1T43	76.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00975 (show subtarget assignments)	1	cloned	No	STM1815	16765156	minD	cell division inhibitor MinD	270	Conserved Gene / Pathway	Phase 2: March 2008	3Q9L	93.3%	Salmonella enterica	Cellular processes	Cell division

IDP00976 (show subtarget assignments)	1	in_crystallization_trials	No	STM1879	16765221	ptrB	protease 2	683	Drug Target Function	Phase 2: March 2008	2XE4	37.6%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00977 (show subtarget assignments)	1	expressed	No	STM1932	16765273	ftnB	ferritin-like protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1EUM	33.5%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00978 (show subtarget assignments)	1	purified	No	STM1951	16765289	yecC	putative amino-acid ABC transporter ATP-...	250	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	54.8%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00979 (show subtarget assignments)	1	purified	No	STM1953	16765291	yedO	D-cysteine desulfhydrase	328	Conserved Gene / Pathway	Phase 2: March 2008	1J0A	38.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP00980 (show subtarget assignments)	1	in_crystallization_trials	No	STM1970	16765308	fliG	flagellar motor switch protein G	331	Conserved Gene / Pathway	Phase 2: March 2008	3HJL	28.7%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP00981 (show subtarget assignments)	1	in_crystallization_trials	No	STM2052	16765382	pduQ	propanol dehydrogenase	370	Conserved Gene / Pathway	Phase 2: March 2008	3OWO	35.3%	Salmonella enterica	Energy metabolism	Fermentation

IDP00982 (show subtarget assignments)	1	soluble	No	STM2062	16765392	dacD	D-alanyl-D-alanine carboxypeptidase	390	Drug Target Function	Phase 2: March 2008	1NZO	45.1%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00983 (show subtarget assignments)	1	cloned	No	STM2064	16765394	phsB	thiosulfate reductase electron transport...	192	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	37%	Salmonella enterica	Energy metabolism	Electron transport

IDP00984 (show subtarget assignments)	1	in_crystallization_trials	No	STM2073	16765403	hisC	histidinol-phosphate aminotransferase	359	Conserved Gene / Pathway	Phase 2: March 2008	1FG3	88%	Salmonella enterica	Amino acid biosynthesis	Histidine family

IDP00985 (show subtarget assignments)	1	soluble	No	STM2076	16765406	hisA	1-(5-phosphoribosyl)-5-[(5-phosphoribosy...	245	Conserved Gene / Pathway	Phase 2: March 2008	2Y85	35.1%	Salmonella enterica	Amino acid biosynthesis	Histidine family

IDP00986 (show subtarget assignments)	1	cloned	No	STM2106	16765436	wcaI	predicted glycosyl transferase	407	Drug Target Function	Phase 2: March 2008			Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00987 (show subtarget assignments)	1	soluble	No	STM2147	16765476	thiM	hydroxyethylthiazole kinase	265	Conserved Gene / Pathway	Phase 2: March 2008	1C3Q	36.6%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP00988 (show subtarget assignments)	1	expressed	No	STM2163	16765493	yehX	putative ABC-type proline/glycine betain...	315	Conserved Gene / Pathway	Phase 2: March 2008	1V43	32.4%	Salmonella enterica	Transport and binding proteins	Other

IDP00989 (show subtarget assignments)	1	purified	No	STM2183	16765513	cdd	cytidine deaminase	294	Conserved Gene / Pathway	Phase 2: March 2008	1AF2	87.4%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP00990 (show subtarget assignments)	0	work_stopped	No	STM2193	16765523	folE	GTP cyclohydrolase I	222	Conserved Gene / Pathway	Phase 2: March 2008	1FBX	95.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00991 (show subtarget assignments)	1	in_crystallization_trials	No	STM2212	16765541	yeiR	putative cobalamin biosynthetic protein ...	328	Conserved Gene / Pathway	Phase 2: March 2008	1NIJ	18.9%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00992 (show subtarget assignments)	1	soluble	No	STM2227	16765556	yejL	putative cytoplasmic protein	75	Conserved Gene / Pathway	Phase 2: March 2008	2JRX	90.7%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP00993 (show subtarget assignments)	0	work_stopped	No	STM2250	16765578	ccmE	cytochrome c-type biogenesis protein Ccm...	159	Conserved Gene / Pathway	Phase 2: March 2008	1SR3	68.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00994 (show subtarget assignments)	1	in_pdb 3GC2	No	STM2306	16765633	menC	O-succinylbenzoate synthase	320	Conserved Gene / Pathway	Phase 2: March 2008	3GC2	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00995 (show subtarget assignments)	1	in_pdb 3H02	No	STM2307	16765634	menB	naphthoate synthase	285	Conserved Gene / Pathway	Phase 2: March 2008	3H02	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00996 (show subtarget assignments)	1	in_crystallization_trials	No	STM2310	16765637	menF	menaquinone-specific isochorismate synth...	431	Drug Target Function	Phase 2: March 2008	2EUA	78.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP00997 (show subtarget assignments)	1	soluble	No	STM2314	16765641		putative chemotaxis signal transduction ...	333	Conserved Gene / Pathway	Phase 2: March 2008	1K68	12%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP00998 (show subtarget assignments)	1	in_crystallization_trials	No	STM2369	16765696	usg	hypothetical protein STM2369	337	Conserved Gene / Pathway	Phase 2: March 2008	2QZ9	46.6%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP00999 (show subtarget assignments)	1	expressed	No	STM2388	16765715	fadJ	multifunctional fatty acid oxidation com...	715	Conserved Gene / Pathway	Phase 2: March 2008	1WDK	35.8%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP00900
(show subtarget assignments)

0

work_stopped

No

STM4247

16767497

alr

alanine racemase

359

Conserved Gene / Pathway

Phase 2: March 2008

2RJG

91.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00901
(show subtarget assignments)

1

in_crystallization_trials

No

STM0004

16763394

thrC

threonine synthase

428

Conserved Gene / Pathway

Phase 2: March 2008

1VB3

93.5%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP00902
(show subtarget assignments)

1

expressed

No

STM0045

16763435

ribF

bifunctional riboflavin kinase/FMN adeny...

312

Conserved Gene / Pathway

Phase 2: March 2008

1MRZ

33%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00903
(show subtarget assignments)

0

work_stopped

No

STM0123

16763513

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

495

Essential Gene

Phase 2: March 2008

1E8C

91.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00904
(show subtarget assignments)

0

work_stopped

No

STM0124

16763514

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

452

Conserved Gene / Pathway

Phase 2: March 2008

1GG4

87.6%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00905
(show subtarget assignments)

0

work_stopped

No

STM0126

16763516

murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

438

Essential Gene

Phase 2: March 2008

1E0D

92.2%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00906
(show subtarget assignments)

0

work_stopped

No

STM0129

16763519

murC

UDP-N-acetylmuramate--L-alanine ligase

491

Essential Gene

Phase 2: March 2008

2F00

94.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00907
(show subtarget assignments)

1

in_crystallization_trials

No

STM0140

16763530

coaE

dephospho-CoA kinase

206

Conserved Gene / Pathway

Phase 2: March 2008

1N3B

88.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00908
(show subtarget assignments)

1

expressed

No

STM0143

16763533

hofB

hypothetical protein STM0143

461

Conserved Gene / Pathway

Phase 2: March 2008

1P9R

37.3%

Salmonella enterica

Cell envelope

Surface structures

IDP00909
(show subtarget assignments)

0

work_stopped

No

STM0171

16763561

yadF

carbonic anhydrase

220

Conserved Gene / Pathway

Phase 2: March 2008

3QY1

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP00910
(show subtarget assignments)

1

cloned

No

STM0190

16763580

mrcB

penicillin-binding protein 1b

840

Drug Target Function

Phase 2: March 2008

3FWL

84%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00911
(show subtarget assignments)

1

expressed

No

STM0191

16763581

fhuA

ferrichrome outer membrane transporter

729

Conserved Gene / Pathway

Phase 2: March 2008

2FCP

72.3%

Salmonella enterica

Cell envelope

Other

IDP00912
(show subtarget assignments)

1

soluble

No

STM0193

16763583

fhuD

iron-hydroxamate transporter substrate-b...

296

Conserved Gene / Pathway

Phase 2: March 2008

1ESZ

75%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00913
(show subtarget assignments)

0

work_stopped

No

STM0219

16763609

frr

ribosome recycling factor

185

Conserved Gene / Pathway

Phase 2: March 2008

1EK8

94.1%

Salmonella enterica

Protein synthesis

Translation factors

IDP00914
(show subtarget assignments)

1

soluble

No

STM0220

16763610

dxr

1-deoxy-D-xylulose 5-phosphate reductois...

398

Conserved Gene / Pathway

Phase 2: March 2008

1K5H

88.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00915
(show subtarget assignments)

1

in_crystallization_trials

No

STM0236

16763626

tilS

tRNA(Ile)-lysidine synthetase

430

Drug Target Function

Phase 2: March 2008

1NI5

75.3%

Salmonella enterica

Cellular processes

Cell division

IDP00916
(show subtarget assignments)

0

work_stopped

No

STM0247

16763636

metN

DL-methionine transporter ATP-binding su...

343

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

95.3%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP00917
(show subtarget assignments)

1

cloned

No

STM0355

16763735

putative copper chaperone

64

Conserved Gene / Pathway

Phase 2: March 2008

2K2P

39.1%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00918
(show subtarget assignments)

1

soluble

No

STM0372

16763752

hemB

delta-aminolevulinic acid dehydratase

324

Conserved Gene / Pathway

Phase 2: March 2008

1I8J

93.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00919
(show subtarget assignments)

1

in_pdb
3Q1K
3I12

No

STM0380

16763760

ddl

D-alanyl-alanine synthetase A

364

Conserved Gene / Pathway

Phase 2: March 2008

3I12

100%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00920
(show subtarget assignments)

1

in_crystallization_trials

No

STM0417

16763797

ribH

riboflavin synthase subunit beta

156

Conserved Gene / Pathway

Phase 2: March 2008

3MK3

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00921
(show subtarget assignments)

1

purified

No

STM0507

16763887

ybbA

putative ABC transporter ATP-binding pro...

228

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

42.5%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP00922
(show subtarget assignments)

1

soluble

No

STM0533

16763913

purK

phosphoribosylaminoimidazole carboxylase...

355

Conserved Gene / Pathway

Phase 2: March 2008

1B6S

88.2%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00923
(show subtarget assignments)

1

in_pdb
3HZN

No

STM0578

16763955

nfnB

dihydropteridine reductase

217

Conserved Gene / Pathway

Phase 2: March 2008

3HZN

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP00924
(show subtarget assignments)

1

purified

No

STM0590

16763967

fepC

iron-enterobactin transporter ATP-bindin...

264

Conserved Gene / Pathway

Phase 2: March 2008

3GFO

28.4%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00925
(show subtarget assignments)

1

crystallized

No

STM0595

16763972

entC

isochorismate synthase

391

Drug Target Function

Phase 2: March 2008

3HWO

84.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00926
(show subtarget assignments)

1

soluble

No

STM0597

16763974

entB

2,3-dihydro-2,3-dihydroxybenzoate synthe...

285

Conserved Gene / Pathway

Phase 2: March 2008

2FQ1

88.4%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00927
(show subtarget assignments)

1

soluble

No

STM0598

16763975

entA

2,3-dihydroxybenzoate-2,3-dehydrogenase ...

251

Conserved Gene / Pathway

Phase 2: March 2008

2FWM

89.2%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00928
(show subtarget assignments)

1

in_crystallization_trials

No

STM0602

16763979

ybdH

putative glycerol dehydrogenase

362

Conserved Gene / Pathway

Phase 2: March 2008

1KQ3

31.1%

Salmonella enterica

Central intermediary metabolism

Other

IDP00929
(show subtarget assignments)

1

soluble

No

STM0603

16763980

ybdL

putative aminotransferase

386

Conserved Gene / Pathway

Phase 2: March 2008

1U08

85.5%

Salmonella enterica

Central intermediary metabolism

Other

IDP00930
(show subtarget assignments)

1

expressed

No

STM0612

16763989

putative hydrogenase protein

185

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

30.3%

Salmonella enterica

Energy metabolism

Anaerobic

IDP00931
(show subtarget assignments)

1

expressed

No

STM0615

16763992

ybdR

putative dehydrogenase

412

Essential Gene

Phase 2: March 2008

1KOL

32.5%

Salmonella enterica

Central intermediary metabolism

Other

IDP00932
(show subtarget assignments)

1

in_crystallization_trials

No

STM0645

16764022

nadD

nicotinic acid mononucleotide adenyltran...

213

Conserved Gene / Pathway

Phase 2: March 2008

1K4K

85.4%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00933
(show subtarget assignments)

1

purified

No

STM0662

16764039

gltL

glutamate/aspartate transporter

241

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

54.4%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00934
(show subtarget assignments)

0

work_stopped

No

STM0779

16764143

modE

DNA-binding transcriptional dual regulat...

262

Conserved Gene / Pathway

Phase 2: March 2008

1B9M

89.3%

Salmonella enterica

Transport and binding proteins

Anions

IDP00935
(show subtarget assignments)

1

purified

No

STM0783

16764147

modC

molybdate transporter ATP-binding protei...

352

Conserved Gene / Pathway

Phase 2: March 2008

3D31

29.5%

Salmonella enterica

Transport and binding proteins

Anions

IDP00936
(show subtarget assignments)

1

soluble

No

STM0793

16764156

bioA

adenosylmethionine--8-amino-7-oxononanoa...

429

Conserved Gene / Pathway

Phase 2: March 2008

1MLY

86.2%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00937
(show subtarget assignments)

1

cloned

No

STM0795

16764158

bioF

8-amino-7-oxononanoate synthase

385

Conserved Gene / Pathway

Phase 2: March 2008

1BS0

80%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00938
(show subtarget assignments)

1

cloned

No

STM0813

16764176

ybhP

putative cytoplasmic protein

252

Essential Gene

Phase 2: March 2008

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP00939
(show subtarget assignments)

1

expressed

No

STM0828

16764190

glnQ

glutamine ABC transporter ATP-binding pr...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

55%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00940
(show subtarget assignments)

1

soluble

No

STM0845

16764207

moeB

molybdopterin biosynthesis protein MoeB ...

249

Conserved Gene / Pathway

Phase 2: March 2008

1JW9

88.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP00941
(show subtarget assignments)

1

purified

No

STM0846

16764208

moeA

molybdopterin biosynthesis protein MoeA ...

413

Conserved Gene / Pathway

Phase 2: March 2008

1FC5

87.2%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP00942
(show subtarget assignments)

1

in_crystallization_trials

No

STM0857

16764219

putative acyl-CoA dehydrogenase

387

Essential Gene

Phase 2: March 2008

3MPI

32%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP00943
(show subtarget assignments)

1

crystallized

No

STM0862

16764224

yliJ

putative glutathione S-transferase

208

Conserved Gene / Pathway

Phase 2: March 2008

4ECI

30.8%

Salmonella enterica

Cellular processes

Detoxification

IDP00944
(show subtarget assignments)

1

crystallized

No

STM0891

16764252

artP

arginine transporter ATP-binding subunit...

242

Conserved Gene / Pathway

Phase 2: March 2008

1B0U

43.8%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00945
(show subtarget assignments)

0

work_stopped

No

STM0977

16764337

serC

phosphoserine aminotransferase

362

Conserved Gene / Pathway

Phase 2: March 2008

3QM2

100%

Salmonella enterica

Amino acid biosynthesis

Serine family

IDP00946
(show subtarget assignments)

1

expressed

No

STM0978

16764338

aroA

3-phosphoshikimate 1-carboxyvinyltransfe...

427

Conserved Gene / Pathway

Phase 2: March 2008

1G6S

89.5%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP00947
(show subtarget assignments)

1

purified

No

STM0988

16764348

kdsB

3-deoxy-manno-octulosonate cytidylyltran...

248

Essential Gene

Phase 2: March 2008

1VH1

94%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00948
(show subtarget assignments)

1

expressed

No

STM1060

16764419

putative iron-sulfur protein

369

Conserved Gene / Pathway

Phase 2: March 2008

1ROE

8.4%

Salmonella enterica

Energy metabolism

Electron transport

IDP00949
(show subtarget assignments)

1

purified

No

STM1102

16764460

hpaE

4-hydroxyphenylacetate catabolism

488

Conserved Gene / Pathway

Phase 2: March 2008

2D4E

47.7%

Salmonella enterica

Central intermediary metabolism

Other

IDP00950
(show subtarget assignments)

1

soluble

No

STM1119

16764477

wraB

TrpR binding protein WrbA

198

Conserved Gene / Pathway

Phase 2: March 2008

2R96

94.4%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP00951
(show subtarget assignments)

1

in_pdb
3PP8
3KBO

No

STM1135

16764491

ycdW

putative oxidoreductase

312

Conserved Gene / Pathway

Phase 2: March 2008

3KBO

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP00952
(show subtarget assignments)

1

purified

No

STM1176

16764532

flgD

flagellar basal body rod modification pr...

232

Conserved Gene / Pathway

Phase 2: March 2008

3C12

19.8%

Salmonella enterica

Cell envelope

Surface structures

IDP00953
(show subtarget assignments)

1

in_crystallization_trials

No

STM1183

16764539

flgK

flagellar hook-associated protein FlgK

553

Conserved Gene / Pathway

Phase 2: March 2008

2D4Y

83.5%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00954
(show subtarget assignments)

1

in_crystallization_trials

No

STM1189

16764544

maf

Maf-like protein

194

Essential Gene

Phase 2: March 2008

1EX2

31.4%

Salmonella enterica

Cellular processes

Cell division

IDP00955
(show subtarget assignments)

1

cloned

No

STM1192

16764547

plsX

fatty acid/phospholipid synthesis protei...

359

Conserved Gene / Pathway

Phase 2: March 2008

1U7N

36.5%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00956
(show subtarget assignments)

1

in_pdb
3H0P

No

STM1194

16764549

fabD

acyl carrier protein S-malonyltransferas...

309

potential drug target / Essential Gene

Phase 2: March 2008

3H0P

100%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00957
(show subtarget assignments)

0

work_stopped

No

STM1202

16764557

ycfH

predicted metallodependent hydrolase

265

Conserved Gene / Pathway

Phase 2: March 2008

1YIX

92.8%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP00958
(show subtarget assignments)

1

soluble

No

STM1218

16764573

lolD

lipoprotein transporter ATP-binding subu...

233

Conserved Gene / Pathway

Phase 2: March 2008

2PCJ

43.3%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP00959
(show subtarget assignments)

1

soluble

No

STM1303

16764654

argD

bifunctional succinylornithine transamin...

408

Conserved Gene / Pathway

Phase 2: March 2008

2PB0

60.8%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP00960
(show subtarget assignments)

1

in_pdb
3HMQ

No

STM1310

16764661

nadE

NAD synthetase

275

Drug Target Function

Phase 2: March 2008

3HMQ

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00961
(show subtarget assignments)

1

expressed

No

STM1385

16764735

ttrB

tetrathionate reductase complex subunit ...

250

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

34.4%

Salmonella enterica

Energy metabolism

Electron transport

IDP00962
(show subtarget assignments)

1

cloned

No

STM1427

16764775

cfa

cyclopropane fatty acyl phospholipid syn...

382

Drug Target Function

Phase 2: March 2008

1KP9

26.7%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00963
(show subtarget assignments)

1

in_crystallization_trials

No

STM1436

16764784

nemA

N-ethylmaleimide reductase, FMN-linked

365

Conserved Gene / Pathway

Phase 2: March 2008

3P62

87.4%

Salmonella enterica

Central intermediary metabolism

Other

IDP00964
(show subtarget assignments)

0

work_stopped

No

STM1439

16764787

ydhF

putative aldo/keto reductase

298

Conserved Gene / Pathway

Phase 2: March 2008

1OG6

88.9%

Salmonella enterica

Unknown function

General

IDP00965
(show subtarget assignments)

1

purified

No

STM1463

16764811

add

adenosine deaminase

333

Conserved Gene / Pathway

Phase 2: March 2008

1NDV

33.8%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP00966
(show subtarget assignments)

1

expressed

No

STM1552

16764897

putative cytoplasmic protein

302

Essential Gene

Phase 2: March 2008

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP00967
(show subtarget assignments)

1

in_crystallization_trials

No

STM1559

16764903

putative glycosyl hydrolase

842

Essential Gene

Phase 2: March 2008

3HJE

31.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00968
(show subtarget assignments)

1

in_pdb
3M07

No

STM1560

16764904

putative alpha amylase

594

Essential Gene

Phase 2: March 2008

3M07

100%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00969
(show subtarget assignments)

1

purified

No

STM1597

161353598

ydcW

putative aldehyde dehydrogenase

474

Conserved Gene / Pathway

Phase 2: March 2008

1WNB

83.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00970
(show subtarget assignments)

1

soluble

No

STM1682

16765025

tpx

thiol peroxidase

168

Conserved Gene / Pathway

Phase 2: March 2008

1QXH

87.5%

Salmonella enterica

Cellular processes

Detoxification

IDP00971
(show subtarget assignments)

1

in_pdb
3IAH

Yes

STM1717

16765061

yciK

short chain dehydrogenase

253

Conserved Gene / Pathway

Phase 2: March 2008

3IAH

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP00972
(show subtarget assignments)

1

expressed

No

STM1743

16765087

oppD

oligopeptide transporter ATP-binding com...

335

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

25.7%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00973
(show subtarget assignments)

1

purified

No

STM1756

16765100

purU

formyltetrahydrofolate deformylase

280

Conserved Gene / Pathway

Phase 2: March 2008

3O1L

42.7%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00974
(show subtarget assignments)

1

in_crystallization_trials

No

STM1775

16765116

hemK

N5-glutamine S-adenosyl-L-methionine-dep...

277

Essential Gene

Phase 2: March 2008

1T43

76.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00975
(show subtarget assignments)

1

cloned

No

STM1815

16765156

minD

cell division inhibitor MinD

270

Conserved Gene / Pathway

Phase 2: March 2008

3Q9L

93.3%

Salmonella enterica

Cellular processes

Cell division

IDP00976
(show subtarget assignments)

1

in_crystallization_trials

No

STM1879

16765221

ptrB

protease 2

683

Drug Target Function

Phase 2: March 2008

2XE4

37.6%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00977
(show subtarget assignments)

1

expressed

No

STM1932

16765273

ftnB

ferritin-like protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1EUM

33.5%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00978
(show subtarget assignments)

1

purified

No

STM1951

16765289

yecC

putative amino-acid ABC transporter ATP-...

250

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

54.8%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00979
(show subtarget assignments)

1

purified

No

STM1953

16765291

yedO

D-cysteine desulfhydrase

328

Conserved Gene / Pathway

Phase 2: March 2008

1J0A

38.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP00980
(show subtarget assignments)

1

in_crystallization_trials

No

STM1970

16765308

fliG

flagellar motor switch protein G

331

Conserved Gene / Pathway

Phase 2: March 2008

3HJL

28.7%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP00981
(show subtarget assignments)

1

in_crystallization_trials

No

STM2052

16765382

pduQ

propanol dehydrogenase

370

Conserved Gene / Pathway

Phase 2: March 2008

3OWO

35.3%

Salmonella enterica

Energy metabolism

Fermentation

IDP00982
(show subtarget assignments)

1

soluble

No

STM2062

16765392

dacD

D-alanyl-D-alanine carboxypeptidase

390

Drug Target Function

Phase 2: March 2008

1NZO

45.1%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00983
(show subtarget assignments)

1

cloned

No

STM2064

16765394

phsB

thiosulfate reductase electron transport...

192

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

37%

Salmonella enterica

Energy metabolism

Electron transport

IDP00984
(show subtarget assignments)

1

in_crystallization_trials

No

STM2073

16765403

hisC

histidinol-phosphate aminotransferase

359

Conserved Gene / Pathway

Phase 2: March 2008

1FG3

88%

Salmonella enterica

Amino acid biosynthesis

Histidine family

IDP00985
(show subtarget assignments)

1

soluble

No

STM2076

16765406

hisA

1-(5-phosphoribosyl)-5-[(5-phosphoribosy...

245

Conserved Gene / Pathway

Phase 2: March 2008

2Y85

35.1%

Salmonella enterica

Amino acid biosynthesis

Histidine family

IDP00986
(show subtarget assignments)

1

cloned

No

STM2106

16765436

wcaI

predicted glycosyl transferase

407

Drug Target Function

Phase 2: March 2008

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00987
(show subtarget assignments)

1

soluble

No

STM2147

16765476

thiM

hydroxyethylthiazole kinase

265

Conserved Gene / Pathway

Phase 2: March 2008

1C3Q

36.6%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP00988
(show subtarget assignments)

1

expressed

No

STM2163

16765493

yehX

putative ABC-type proline/glycine betain...

315

Conserved Gene / Pathway

Phase 2: March 2008

1V43

32.4%

Salmonella enterica

Transport and binding proteins

Other

IDP00989
(show subtarget assignments)

1

purified

No

STM2183

16765513

cdd

cytidine deaminase

294

Conserved Gene / Pathway

Phase 2: March 2008

1AF2

87.4%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP00990
(show subtarget assignments)

0

work_stopped

No

STM2193

16765523

folE

GTP cyclohydrolase I

222

Conserved Gene / Pathway

Phase 2: March 2008

1FBX

95.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00991
(show subtarget assignments)

1

in_crystallization_trials

No

STM2212

16765541

yeiR

putative cobalamin biosynthetic protein ...

328

Conserved Gene / Pathway

Phase 2: March 2008

1NIJ

18.9%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00992
(show subtarget assignments)

1

soluble

No

STM2227

16765556

yejL

putative cytoplasmic protein

75

Conserved Gene / Pathway

Phase 2: March 2008

2JRX

90.7%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP00993
(show subtarget assignments)

0

work_stopped

No

STM2250

16765578

ccmE

cytochrome c-type biogenesis protein Ccm...

159

Conserved Gene / Pathway

Phase 2: March 2008

1SR3

68.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00994
(show subtarget assignments)

1

in_pdb
3GC2

No

STM2306

16765633

menC

O-succinylbenzoate synthase

320

Conserved Gene / Pathway

Phase 2: March 2008

3GC2

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00995
(show subtarget assignments)

1

in_pdb
3H02

No

STM2307

16765634

menB

naphthoate synthase

285

Conserved Gene / Pathway

Phase 2: March 2008

3H02

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00996
(show subtarget assignments)

1

in_crystallization_trials

No

STM2310

16765637

menF

menaquinone-specific isochorismate synth...

431

Drug Target Function

Phase 2: March 2008

2EUA

78.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP00997
(show subtarget assignments)

1

soluble

No

STM2314

16765641

putative chemotaxis signal transduction ...

333

Conserved Gene / Pathway

Phase 2: March 2008

1K68

12%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP00998
(show subtarget assignments)

1

in_crystallization_trials

No

STM2369

16765696

usg

hypothetical protein STM2369

337

Conserved Gene / Pathway

Phase 2: March 2008

2QZ9

46.6%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP00999
(show subtarget assignments)

1

expressed

No

STM2388

16765715

fadJ

multifunctional fatty acid oxidation com...

715

Conserved Gene / Pathway

Phase 2: March 2008

1WDK

35.8%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

Targets