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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 9 of 60, showing 100 records out of 5973 total, starting on record 801
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP04520
(
show subtarget assignments
)
1
purified
No
Z0985
15800520
hypothetical protein Z0985 [Escherichia ...
326
Effector protein
Phase 4: April 2009
Escherichia coli
IDP05424
(
show subtarget assignments
)
1
cloned
No
lmo0438
16802482
-
hypothetical protein lmo0438 [Listeria m...
192
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2XL4
89.1%
Listeria monocytogenes
IDP91090
(
show subtarget assignments
)
8
cloned
No
aq_1546
15606685
kpsF
polysialic acid capsule expression prote...
322
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
2XHZ
25.5%
Aquifex aeolicus
IDP91092
(
show subtarget assignments
)
8
soluble
No
A1S_1236
193076931
D-arabinose 5-phosphate isomerase [Acine...
325
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
2XHZ
32.9%
Acinetobacter baumannii
IDP91091
(
show subtarget assignments
)
8
cloned
No
APL_0387
126096663
kpsF
arabinose-5-phosphate isomerase [Actinob...
311
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
2XHZ
27%
Actinobacillus pleuropneumoniae
IDP91093
(
show subtarget assignments
)
0
work_stopped
No
BPSL0538
52208591
conserved hypothetical protein [Burkhold...
327
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
2XHZ
30.9%
Burkholderia pseudomallei
IDP91106
(
show subtarget assignments
)
8
in_pdb
3QFK
Yes
SAOUHSC_00107
88193920
hypothetical protein SAOUHSC_00107 [Stap...
511
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3QFK
99.8%
Staphylococcus aureus
IDP91454
(
show subtarget assignments
)
8
cloned
No
VV1_0254
27363735
hemA
glutamyl-tRNA reductase [Vibrio vulnific...
419
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1GPJ
36.3%
Vibrio vulnificus
IDP91094
(
show subtarget assignments
)
8
cloned
No
APL_0085
126096365
kdsB
3-deoxy-manno-octulosonate cytidylyltran...
250
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
1VH3
70.6%
Actinobacillus pleuropneumoniae
IDP91095
(
show subtarget assignments
)
8
in_pdb
3POL
No
A1S_1557
193077192
3-deoxy-manno-octulosonate cytidylyltran...
253
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
3POL
100%
Acinetobacter baumannii
IDP91096
(
show subtarget assignments
)
8
soluble
No
BPSL0876
52208929
kdsB
putative 3-deoxy-manno-octulosonate cyti...
278
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
3K8D
49.6%
Burkholderia pseudomallei
IDP04277
(
show subtarget assignments
)
1
cloned
No
BAS3960
49186958
PTS system, glucose-specific IIABC compo...
687
Proposed to be essential proteins
Phase 4: April 2009
1AX3
14.7%
Bacillus anthracis
IDP04275
(
show subtarget assignments
)
1
cloned
No
BAS3684
49186683
DNA topoisomerase I [Bacillus anthracis ...
692
Proposed to be essential proteins
Phase 4: April 2009
2GAI
38.2%
Bacillus anthracis
IDP04276
(
show subtarget assignments
)
1
soluble
No
FTT0312c
56707465
folA
dihydrofolate reductase type I [Francise...
166
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3JW3
41.6%
Francisella tularensis
IDP04635
(
show subtarget assignments
)
1
soluble
No
FTT0101
56603768
conserved membrane hypothetical protein ...
337
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
4E94
25.5%
Francisella tularensis
IDP91154
(
show subtarget assignments
)
8
in_pdb
3QFG
Yes
SAOUHSC_00808
88194568
hypothetical protein SAOUHSC_00808 [Stap...
242
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3QFG
93.4%
Staphylococcus aureus
IDP91163
(
show subtarget assignments
)
8
cloned
No
VC1507
15641516
phospho-2-dehydro-3-deoxyheptonate aldol...
395
potential drug target /
Shikimate pathway enzyme
Community Requests
1GG1
48.9%
Vibrio cholerae
IDP91164
(
show subtarget assignments
)
8
purified
No
VC0695
15640714
phospho-2-dehydro-3-deoxyheptonate aldol...
357
potential drug target /
Shikimate pathway enzyme
Community Requests
1GG1
50.7%
Vibrio cholerae
IDP04288
(
show subtarget assignments
)
1
expressed
No
YPCD1.08c
5832431
YPCD1.08c
hypothetical protein YPCD1.08c [Yersinia...
99
virulence factor; conserved gene;
Phase 4: April 2009
3KXE
28.3%
Yersinia pestis
IDP91168
(
show subtarget assignments
)
8
purified
No
lmo1490
16803530
-
similar to shikimate 5-dehydrogenase (Ar...
273
potential drug target /
Shikimate pathway enzyme
Community Requests
3DON
45.6%
Listeria monocytogenes
IDP04633
(
show subtarget assignments
)
1
in_pdb
4EEI
No
FTT0015
56707195
purB
adenylosuccinate lyase [Francisella tula...
432
conserved gene; putative drug target function;
Phase 4: April 2009
4EEI
100%
Francisella tularensis
IDP04634
(
show subtarget assignments
)
1
in_pdb
3MSU
No
FTT0071c
56707250
gltA
citrate synthase [Francisella tularensis...
424
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3MSU
100%
Francisella tularensis
IDP04636
(
show subtarget assignments
)
1
soluble
No
FTT0238
56707395
aroE1
shikimate 5-dehydrogenase [Francisella t...
257
drug target; conserved gene;
Phase 4: April 2009
3O8Q
36.8%
Francisella tularensis
IDP04640
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0559c
56707689
cmk
cytidylate kinase [Francisella tularensi...
221
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1CKE
47.1%
Francisella tularensis
IDP04292
(
show subtarget assignments
)
1
cloned
No
YPO0812
218927992
general secretion pathway protein H [Yer...
180
conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP91170
(
show subtarget assignments
)
8
cloned
No
lmo2236
16804275
-
similar to oxidoreductase
289
potential drug target /
Shikimate pathway enzyme
Community Requests
3TNL
52.6%
Listeria monocytogenes
IDP91457
(
show subtarget assignments
)
8
in_crystallization_trials
No
VV1_0163
27363646
hypothetical protein VV1_0163 [Vibrio vu...
252
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1NMO
57.9%
Vibrio vulnificus
IDP04638
(
show subtarget assignments
)
1
expressed
No
FTT0372c
56707523
accD
Acetyl-CoA carboxylase beta subunit [Fra...
302
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2F9Y
60.3%
Francisella tularensis
IDP04637
(
show subtarget assignments
)
1
cloned
No
FTT0371c
56707522
folC
FolC bifunctional protein [Francisella t...
393
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1W78
29.8%
Francisella tularensis
IDP91172
(
show subtarget assignments
)
8
purified
No
PA1706
15596903
pcrV
type III secretion protein PcrV [Pseudom...
294
potential drug target /
P. aeruginosa is an important clinical pathogen. PcrV is a critical component (t...
Community Requests
1R6F
35.4%
Pseudomonas aeruginosa
IDP04307
(
show subtarget assignments
)
1
cloned
No
CPF_1812
110799901
putative lipoprotein [Clostridium perfri...
44
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
IDP04524
(
show subtarget assignments
)
1
in_pdb
3Q58
Yes
STM1129_1_226
16764486
N-acetylmannosamine-6-phosphate 2-epimer...
226
Salmonella essential protein
Phase 4: April 2009
3Q58
100%
Salmonella enterica
IDP05432
(
show subtarget assignments
)
1
cloned
No
BA_2714
30257323
hypothetical protein BA_2714 [Bacillus a...
31
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05221
(
show subtarget assignments
)
1
expressed
No
BA_4349
30258849
hypothetical protein BA_4349 [Bacillus a...
62
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP91183
(
show subtarget assignments
)
8
in_pdb
3T7Y
No
CT091
15604810
yscU
type III secretion system protein [Chlam...
360
virulence/pathogenesis /
Targets that are in a network of interactions with CT670 and CT671. These protei...
Community Requests
3T7Y
26.7%
Chlamydia trachomatis
IDP91185
(
show subtarget assignments
)
8
cloned
No
AAC46367
2352978
477
virulence/pathogenesis /
FlrC regulates flagellar synthesis in Vibrio cholerae, and my lab has determined...
Community Requests
1NY5
31.9%
Vibrio cholerae
IDP91188
(
show subtarget assignments
)
1
crystallized
No
CAA24743
40923
unnamed protein product [Escherichia col...
341
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3OVC
100%
Escherichia coli
IDP91187
(
show subtarget assignments
)
1
in_pdb
3UZR
4DCA
Yes
AF207840_1
10130002
aph(2')-Ib
aminoglycoside phosphotransferase [Enter...
299
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3HAM
100%
Enterococcus faecium
IDP91192
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAD95814
62857277
neoU
aminoglycoside 3'-phosphotransferase [St...
268
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3R78
38.1%
Streptomyces fradiae
IDP04350
(
show subtarget assignments
)
1
cloned
No
STM1338_1_795
16764689
pheT
phenylalanyl-tRNA synthetase subunit bet...
795
Salmonella essential protein
Phase 4: April 2009
3PCO
92.6%
Salmonella enterica
IDP91191
(
show subtarget assignments
)
1
in_pdb
4EJ7
3R78
No
CAJ77079
90265397
aphA1
Aminoglycoside phosphotransferase [Acine...
271
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3R78
100%
Acinetobacter baumannii
IDP91197
(
show subtarget assignments
)
8
soluble
No
BAS4345
49187340
-
stage IV sporulation protein FA
248
essential/virulence/pathogenesis /
Essential proteins
Community Requests
3TUF
10.9%
Bacillus anthracis
IDP91193
(
show subtarget assignments
)
8
cloned
No
BAS4092
49187090
-
Stage III sporulation protein AF
210
essential/virulence/pathogenesis /
Essential proteins
Community Requests
Bacillus anthracis
IDP04306
(
show subtarget assignments
)
8
selected
No
CAC05809
12329078
ipgE
IpgE, cytoplasmic chaperone for IpgD [Sh...
120
Shigella effector protein
Community Requests
1K3S
27.5%
Shigella flexneri
IDP91195
(
show subtarget assignments
)
8
cloned
No
BAS4091
49187089
-
Stage III sporulation protein AG
220
essential/virulence/pathogenesis /
Essential proteins
Community Requests
Bacillus anthracis
IDP91194
(
show subtarget assignments
)
8
cloned
No
BAS4090
49187088
-
Stage III sporulation protein AH
223
essential/virulence/pathogenesis /
Essential proteins
Community Requests
3TUF
32.7%
Bacillus anthracis
IDP04310
(
show subtarget assignments
)
1
cloned
No
BAS0231
49183264
D-alanine--D-alanine ligase, C-terminus ...
91
Proposed to be essential proteins
Phase 4: April 2009
2I80
54.9%
Bacillus anthracis
IDP04308
(
show subtarget assignments
)
1
cloned
No
YPCD1.14n
40548797
hypothetical protein YPCD1.14n [Yersinia...
65
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP91463
(
show subtarget assignments
)
8
expressed
No
VV1_0079
27363564
bacteriophage phi gp55-like protein [Vib...
159
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP91199
(
show subtarget assignments
)
1
cloned
No
BSU40540
16081106
yybR
putative transcriptional regulator [Baci...
125
other biological interest /
YybR belongs to the MarR/DUF24 family of transcriptional regulators that are hig...
Community Requests
4A5M
100%
Bacillus subtilis
IDP91202
(
show subtarget assignments
)
8
in_pdb
3U80
No
BLD_0610
189439473
aroQ
3-dehydroquinate dehydratase [Bifidobact...
148
potential drug target /
Shikimate pathway enzyme
Community Requests
3U80
100%
Bifidobacterium longum
IDP04309
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0050
49183085
peptidyl-tRNA hydrolase [Bacillus anthra...
186
Proposed to be essential proteins
Phase 4: April 2009
3KJZ
40.9%
Bacillus anthracis
IDP91200
(
show subtarget assignments
)
8
cloned
No
CD1911
115250958
two-component sensor histidine kinase [C...
469
virulence/pathogenesis /
The important histidine kinase for ethanolamine utilization in anaerobic bacteri...
Community Requests
Clostridium difficile
IDP04530
(
show subtarget assignments
)
1
soluble
No
STM2519_1_490
16765839
engA
GTP-binding protein EngA [Salmonella typ...
490
Salmonella essential protein
Phase 4: April 2009
2HJG
36.1%
Salmonella enterica
IDP04647
(
show subtarget assignments
)
1
purified
No
FTT1127
56604696
Rhodanese-like family protein [Francisel...
252
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1YT8
18.3%
Francisella tularensis
IDP04650
(
show subtarget assignments
)
1
expressed
No
FTT1302
56708360
hypothetical protein FTT_1302 [Francisel...
276
drug target; conserved gene;
Phase 4: April 2009
3GBP
88.3%
Francisella tularensis
IDP91205
(
show subtarget assignments
)
8
soluble
No
BT_3975
29349383
3-dehydroquinate synthase [Bacteroides t...
353
potential drug target /
Shikimate pathway enzyme
Community Requests
3CLH
34.3%
Bacteroides thetaiotaomicron
IDP91204
(
show subtarget assignments
)
8
cloned
No
BT_4215
29349623
shikimate 5-dehydrogenase [Bacteroides t...
248
potential drug target /
Shikimate pathway enzyme
Community Requests
2HK7
38%
Bacteroides thetaiotaomicron
IDP04311
(
show subtarget assignments
)
1
purified
No
BAS4340
49187335
50S ribosomal protein L27 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1VSA
55.2%
Bacillus anthracis
IDP91209
(
show subtarget assignments
)
8
expressed
No
BT_2084
29347494
chorismate synthase [Bacteroides thetaio...
358
potential drug target /
Shikimate pathway enzyme
Community Requests
1R52
47.9%
Bacteroides thetaiotaomicron
IDP91208
(
show subtarget assignments
)
8
purified
No
BT_2186
29347596
3-phosphoshikimate 1-carboxyvinyltransfe...
410
potential drug target /
Shikimate pathway enzyme
Community Requests
1EPS
36.2%
Bacteroides thetaiotaomicron
IDP91207
(
show subtarget assignments
)
8
soluble
No
BT_2842
29348251
3-dehydroquinate dehydratase [Bacteroide...
140
potential drug target /
Shikimate pathway enzyme
Community Requests
2C4W
49%
Bacteroides thetaiotaomicron
IDP04349
(
show subtarget assignments
)
1
expressed
No
STM0557_1_550
16763935
putative inner membrane protein [Salmone...
550
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP91216
(
show subtarget assignments
)
1
crystallized
No
FTT_1275
56708335
mglA
macrophage growth locus, subunit A [Fran...
205
potential drug target; virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3MDK
25.4%
Francisella tularensis
IDP04326
(
show subtarget assignments
)
8
purified
No
CAC05800
12329069
ipaA
IpaA, secreted by the Mxi-Spa machinery,...
633
Shigella effector protein
Community Requests
2FM8
10.7%
Shigella flexneri
IDP04335
(
show subtarget assignments
)
1
cloned
No
STM1543_1_428
16764888
putative transport protein [Salmonella t...
428
Salmonella essential protein
Phase 4: April 2009
1PW4
23.4%
Salmonella enterica
IDP91214
(
show subtarget assignments
)
8
expressed
No
Blon_1597
189439474
aroB
bifunctional shikimate kinase/3-dehydroq...
540
potential drug target /
Shikimate pathway enzyme
Community Requests
3QBD
32.6%
Bifidobacterium longum
IDP04658
(
show subtarget assignments
)
1
purified
No
FTT1736c
56708739
kdpD
two component sensor protein kdpD [Franc...
893
conserved gene;
Phase 4: April 2009
2R8R
11.4%
Francisella tularensis
IDP04339
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0115
49183149
50S ribosomal protein L22 [Bacillus anth...
113
Proposed to be essential proteins
Phase 4: April 2009
1BXE
59.3%
Bacillus anthracis
IDP04526
(
show subtarget assignments
)
1
expressed
No
STM1637_1_516
16764981
putative inner membrane protein [Salmone...
516
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04525
(
show subtarget assignments
)
1
cloned
No
STM1556_1_483
16764900
putative Na+/H+ antiporter [Salmonella t...
483
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04654
(
show subtarget assignments
)
1
purified
No
FTT1526c
56708560
idh
isocitrate dehydrogenase [Francisella tu...
747
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1ITW
62.7%
Francisella tularensis
IDP91219
(
show subtarget assignments
)
1
cloned
No
SAOUHSC_01359
110810462
RecName: Full=Phosphatidylglycerol lysyl...
840
virulence/pathogenesis /
Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound...
Community Requests
Staphylococcus aureus
IDP91221
(
show subtarget assignments
)
8
soluble
No
SAV1231
15924221
fabG
3-oxoacyl-(acyl-carrier protein) reducta...
246
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3OSU
100%
Staphylococcus aureus
IDP04529
(
show subtarget assignments
)
1
crystallized
No
STM2481_1_1037
16765801
acrD
aminoglycoside/multidrug efflux system [...
1037
Salmonella essential protein
Phase 4: April 2009
1IWG
66.2%
Salmonella enterica
IDP91222
(
show subtarget assignments
)
8
soluble
No
SF3387
24114633
cysG
siroheme synthase [Shigella flexneri 2a ...
457
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1PJQ
90.2%
Shigella flexneri
IDP04336
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAC05790
12329059
ospC1
OspC1, secreted by the Mxi-Spa secretion...
470
Shigella effector protein
Community Requests
Shigella flexneri
IDP91223
(
show subtarget assignments
)
8
purified
No
SF1267
24112663
trpE
anthranilate synthase component I [Shige...
520
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1I1Q
89.2%
Shigella flexneri
IDP91279
(
show subtarget assignments
)
8
soluble
No
NT05BA4913
49181643
DNA-binding response regulator [Bacillus...
231
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2OQR
32%
Bacillus anthracis
IDP05383
(
show subtarget assignments
)
1
purified
No
BA_1433
30255366
hypothetical protein BA_1433 [Bacillus a...
55
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP91272
(
show subtarget assignments
)
8
cloned
No
NT05BA3926
49180681
RNA polymerase sigma-29 factor [Bacillus...
239
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1L0O
31.4%
Bacillus anthracis
IDP91268
(
show subtarget assignments
)
8
soluble
No
NT05BA2906
49179679
histidinol-phosphate aminotransferase [B...
366
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3FFH
40.2%
Bacillus anthracis
IDP04663
(
show subtarget assignments
)
1
cloned
No
BAS5325
49188309
30S ribosomal protein S18 [Bacillus anth...
77
Proposed to be essential proteins
Phase 4: April 2009
1P6G
50.6%
Bacillus anthracis
IDP91370
(
show subtarget assignments
)
8
expressed
No
VV1_2349
27365668
lactonizing lipase [Vibrio vulnificus CM...
302
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1EX9
55%
Vibrio vulnificus
IDP91273
(
show subtarget assignments
)
8
soluble
No
NT05BA4146
49180892
conserved hypothetical protein TIGR00281...
190
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2Z99
32.1%
Bacillus anthracis
IDP04340
(
show subtarget assignments
)
1
cloned
No
BAS0122
49183156
50S ribosomal protein L5 [Bacillus anthr...
179
Proposed to be essential proteins
Phase 4: April 2009
1IQ4
85.5%
Bacillus anthracis
IDP91285
(
show subtarget assignments
)
8
soluble
No
SPA0480
56412719
aroC
chorismate synthase [Salmonella enterica...
361
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1R52
45.7%
Salmonella enterica
IDP04528
(
show subtarget assignments
)
1
expressed
No
STM2257_1_289
16765585
napH
quinol dehydrogenase membrane component ...
289
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04527
(
show subtarget assignments
)
1
cloned
No
STM1824_1_454
16765165
pabB
para-aminobenzoate synthase component I ...
454
Salmonella essential protein
Phase 4: April 2009
1K0E
76.2%
Salmonella enterica
IDP91284
(
show subtarget assignments
)
8
cloned
No
SF2405
56480091
aroC
chorismate synthase [Shigella flexneri 2...
361
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1SQ1
46.3%
Shigella flexneri
IDP05237
(
show subtarget assignments
)
1
soluble
No
lmo1653
16803693
-
putative cellsurface protein [Listeria m...
201
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP91288
(
show subtarget assignments
)
8
soluble
No
SPA1153
56413351
trpD
bifunctional glutamine amidotransferase/...
531
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1KGZ
47.3%
Salmonella enterica
IDP05242
(
show subtarget assignments
)
1
cloned
No
lmo2079
16804118
-
hypothetical protein lmo2079 [Listeria m...
380
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP91286
(
show subtarget assignments
)
8
expressed
No
SPA1154
56413352
trpE
anthranilate synthase component I [Salmo...
520
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1I1Q
99%
Salmonella enterica
IDP91314
(
show subtarget assignments
)
8
cloned
No
VP1662
28898436
low calcium response protein [Vibrio par...
708
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2X49
16.2%
Vibrio parahaemolyticus
IDP05480
(
show subtarget assignments
)
1
cloned
No
BA_3532
30258067
putative lipoprotein [Bacillus anthracis...
44
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05479
(
show subtarget assignments
)
1
soluble
No
BA_3874
30258390
hypothetical protein BA_3874 [Bacillus a...
105
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05458
(
show subtarget assignments
)
1
cloned
No
BA_0431
30253964
hypothetical protein BA_0431 [Bacillus p...
44
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP91739
(
show subtarget assignments
)
8
selected
No
Q6V4K9_STRPY
0
310
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2XNX
17.1%
Streptococcus pyogenes
IDP91738
(
show subtarget assignments
)
8
selected
No
Q5YB85_STRSG
0
598
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1I84
15.1%
Streptococcus sp.
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