Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP90191 (show subtarget assignments)	8	expressed	No	AAM13632.1	20153171	CPXV193 CDS	CPXV193 protein	563	kelch-like protein	Community Requests	3II7	13%	Cowpox virus	conserved hypothetical proteins	0

IDP90190 (show subtarget assignments)	8	cloned	No	AAM13631.1	20153170	CrmC	CrmC or CPXV191 protein	186	soluble vTNF receptor CrmC	Community Requests	3ALQ	30.6%	Cowpox virus	host defense modulator	0

IDP00810 (show subtarget assignments)	1	cloned	No	SACOL1870	57284791		hypothetical protein SACOL1870	188	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	0	0

IDP90192 (show subtarget assignments)	8	cloned	No	AAM13635.1	20153174	CPXV196 CDS	CPXV196 protein	299	serine-threonine kinase	Community Requests	2KTY	40.7%	Cowpox virus	Unknown function	0

IDP90204 (show subtarget assignments)	8	cloned	No	AAM13452.1	20152991	CPXV006 CDS	CPXV006 protein	619	ankyrin repeat protein	Community Requests			Cowpox virus	conserved hypothetical proteins	0

IDP90188 (show subtarget assignments)	8	cloned	No	AAM13496.1	20153035	CPXV050 CDS	CPXV050 protein	480	kelch-like protein	Community Requests	3II7	12.3%	Cowpox virus	conserved hypothetical proteins	0

IDP90184 (show subtarget assignments)	8	expressed	No	AAM13486.1	20153025	CPXV039 CDS	CPXV039 protein	473	ankyrin repeat protein	Community Requests	1N11	14.4%	Cowpox virus	conserved hypothetical proteins	0

IDP90185 (show subtarget assignments)	0	work_stopped	No	AAM13488.1	20153027	CPXV041 CDS	CPXV041 protein	284	K1L like Host range protein	Community Requests	3KEA	95.1%	Cowpox virus	host defense modulator	0

IDP90186 (show subtarget assignments)	8	cloned	No	AAM13489.1	20153028	SPI3	SPI3 or CPXV042 protein	373	serine protease inhibitor 3	Community Requests	3LW2	28.7%	Cowpox virus	host defense modulator	0

IDP90189 (show subtarget assignments)	8	cloned	No	AAM13616.1	20153155	CPXV175 CDS	CPXV175 protein	277	CD47-like putative membrane protein	Community Requests	2JJS	13%	Cowpox virus	host defense modulator	0

IDP90187 (show subtarget assignments)	8	cloned	No	AAM13490.1	20153029	CPXV043 CDS	CPXV043 protein	88	IFN resistance, K3L like	Community Requests	1LUZ	90.9%	Cowpox virus	host defense modulator	0

IDP90179 (show subtarget assignments)	8	cloned	No	AAM13473.1	20153012	CPXV025 CDS	CPXV026 protein	63	ankyrin-like protein	Community Requests			Cowpox virus	conserved hypothetical proteins	0

IDP90180 (show subtarget assignments)	8	cloned	No	AAM13474.1	20153013	CPXV027 CDS	CPXV027 protein	632	ankyrin-like protein	Community Requests	3NOC	5.4%	Cowpox virus	conserved hypothetical proteins	0

IDP90177 (show subtarget assignments)	8	expressed	No	AAM13471.1	20153010	CPXV024 CDS	CPXV024 protein	126	Orthopoxvirus interleukin 18 binding protein; plays a key role in the activation...	Community Requests	3F62	80.2%	Cowpox virus	host defense modulator	0

IDP90178 (show subtarget assignments)	8	purified	No	AAM13472.1	20153011	VHR1	VHR1 or CPXV025 protein	668	ankyrin-like protein, CP77	Community Requests	1N11	10%	Cowpox virus	host range protein	0

IDP90181 (show subtarget assignments)	8	cloned	No	AAM13478.1	20153017	CPXV031 CDS	CPXV031 protein	69	kelch-like protein	Community Requests			Cowpox virus	conserved hypothetical proteins	0

IDP90176 (show subtarget assignments)	8	expressed	No	AAM13470.1	20153009	CPXV023 CDS	CPXV023 protein	242	zinc-finger-like protein	Community Requests	2ECW	8.3%	Cowpox virus	host defense modulator	0

IDP90182 (show subtarget assignments)	8	soluble	No	AAM13479.1	20153018	CPXV032	CPXV032 protein	125	kelch-like protein	Community Requests			Cowpox virus	conserved hypothetical proteins	0

IDP00616 (show subtarget assignments)	1	cloned	No	SACOL1586	57286108		hypothetical protein SACOL1586	94	Drug Target Function	Phase 2: March 2008			Staphylococcus aureus	0	0

IDP90175 (show subtarget assignments)	8	expressed	No	AAM13468.1	20153007	VGF	CPXV021 protein or CPXV VGF protein	139	similar to viral growth factor C11R vaccinia virus	Community Requests	1K36	15.8%	Cowpox virus	host range protein	0

IDP00600 (show subtarget assignments)	1	cloned	No	SACOL0532	57285557		hypothetical protein SACOL0532	51	Drug Target Function	Phase 2: March 2008			Staphylococcus aureus	0	0

IDP90183 (show subtarget assignments)	8	cloned	No	AAM13482.1	20153021	CPXV035 CDS	CPXV035 protein	512	kelch-like protein	Community Requests	2XN4	12.7%	Cowpox virus	conserved hypothetical proteins	0

IDP90205 (show subtarget assignments)	8	expressed	No	AAM13465.1	20153004	CPXV018 CDS	CPXV018 protein, VO18	171	similar to MPV-Z-N3R	Community Requests			Cowpox virus	host defense modulator	0

IDP00225 (show subtarget assignments)	1	cloned	No	YPO3069	16123246	-	putative exported protein	486	Virulence	Phase 1: October 2007	3C37	15%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP02455 (show subtarget assignments)	1	expressed	No	GBAA3813	47529098		prophage LambdaBa01, thymidylate synthas...	252	Conserved; Drug target functions	Phase 3: June 2008	3AH5	24.6%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP04496 (show subtarget assignments)	1	expressed	No	VC0675	15640694	thyA	thymidylate synthase [Vibrio cholerae O1...	283	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3V8H	35.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP02391 (show subtarget assignments)	1	cloned	No	FTT0534c	56707667	nrdA	ribonucleotide-diphosphate reductase sub...	590	Drug Target	Phase 3: June 2008	2WGH	31.2%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP02400 (show subtarget assignments)	1	purified	No	YPO3454	16123600	nrdD	anaerobic ribonucleoside triphosphate re...	712	Conserved; CD; Drug target functions	Phase 3: June 2008	1H78	48.2%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP02619 (show subtarget assignments)	1	cloned	No	GBAA1372	47526645	nrdF	ribonucleotide-diphosphate reductase sub...	322	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	4DR0	58.4%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP01318 (show subtarget assignments)	1	in_pdb 3IQ1	No	VC0139	15640170		DPS family protein	156	Conserved Gene / Pathway	Phase 2: March 2008	3IQ1	100%	Vibrio cholerae	Cellular processes	Adaptations to atypical conditions

IDP00576 (show subtarget assignments)	1	cloned	No	YPO1398	16121678	cspB	cold shock-like protein	69	Virulence Associated Factor	Phase 2: March 2008	3I2Z	50.7%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP00557 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3382	16123531	gsrA	serine endoprotease	481	Virulence Associated Factor	Phase 2: March 2008	2ZLE	71.9%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP01061 (show subtarget assignments)	1	in_crystallization_trials	No	STM3591	16766877	uspA	universal stress protein A	144	Conserved Gene / Pathway	Phase 2: March 2008	1JMV	66.7%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP00524 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0490	16120820	apaH	diadenosine tetraphosphatase	289	Conserved Gene / Pathway	Phase 2: March 2008	2DFJ	73.7%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP04269 (show subtarget assignments)	1	cloned	No	CPF_2193	110798612	relA	GTP pyrophosphokinase [Clostridium perfr...	726	conserved gene; putative drug target function;	Phase 4: April 2009	1VJ7	28.1%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP01613 (show subtarget assignments)	1	in_crystallization_trials	No	STM1927	16765269	yecG	universal stress protein UspC [Salmonell...	142	Conserved; Drug target functions	Phase 3: June 2008	1JMV	35.2%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP04697 (show subtarget assignments)	1	soluble	No	YPCD1.29c	16082717	yopB	secreted effector protein [Yersinia pest...	401	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP04018 (show subtarget assignments)	1	cloned	No	CPF_1860	110799668	msrB	methionine sulfoxide reductase B [Clostr...	147	conserved gene; putative drug target function;	Phase 4: April 2009	1XM0	64.6%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04552 (show subtarget assignments)	1	cloned	No	CPF_2913	110799629	msrA	methionine sulfoxide reductase A [Clostr...	157	conserved gene; putative drug target function;	Phase 4: April 2009	3BQE	52.2%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP01516 (show subtarget assignments)	1	crystallized	No	VC0576	15640598	sspA	stringent starvation protein A	211	Conserved Gene / Pathway	Phase 2: March 2008	1YY7	73.9%	Vibrio cholerae	Cellular processes	Adaptations to atypical conditions

IDP01037 (show subtarget assignments)	0	work_stopped	No	STM2927	16766233	surE	stationary phase survival protein SurE	253	potential drug target / Conserved Gene / Pathway	Phase 2: March 2008	2V4N	100%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP02827 (show subtarget assignments)	1	cloned	No	FTT1508c	56708546	relA	GTP pyrophosphokinase [Francisella tular...	647	Drug Target	Phase 3: June 2008	1VJ7	20.1%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP01255 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5132	30259616	yugI	general stress protein 13	114	Conserved Gene / Pathway	Phase 2: March 2008	2K4K	53.3%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP00848 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1753	57286190		universal stress protein family	137	Conserved Gene / Pathway	Phase 2: March 2008	1MJH	33.5%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP00833 (show subtarget assignments)	1	cloned	No	SACOL2627	57286532	betA	choline dehydrogenase	569	Conserved Gene / Pathway	Phase 2: March 2008	3LJP	32.7%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP00436 (show subtarget assignments)	1	cloned	No	YPO3358	16123508	surE	stationary phase survival protein SurE	254	Conserved Gene / Pathway	Phase 2: March 2008	2V4N	79.9%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP00803 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1759	57286194		universal stress protein family	166	Conserved Gene / Pathway	Phase 2: March 2008	1TQ8	30.7%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP01111 (show subtarget assignments)	1	cloned	No	BA_1135	49035527		Major cold shock protein cspA	67	Conserved Gene / Pathway	Phase 2: March 2008	1CSP	73.1%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP01102 (show subtarget assignments)	1	soluble	No	BA_5424	49040749		Cold shock-like protein cspC	65	Essential Gene	Phase 2: March 2008	1C9O	74.2%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP00404 (show subtarget assignments)	1	soluble	No	YPCD1.48	16082736	virG	needle complex outer membrane lipoprotei...	131	Virulence Associated Factor	Phase 2: March 2008	2YJL	23.7%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP00699 (show subtarget assignments)	1	in_pdb 3ED6 3FG0	Yes	SACOL2628	57286533	betB	betaine aldehyde dehydrogenase	496	Conserved Gene / Pathway	Phase 2: March 2008	3ED6	100%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP02334 (show subtarget assignments)	1	soluble	No	FTT0391c	56707540	cspC	cold shock protein [Francisella tularens...	67	Drug Target	Phase 3: June 2008	3I2Z	61.8%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP00630 (show subtarget assignments)	1	cloned	No	SACOL0861	57284322		cold shock protein, CSD family	66	Conserved Gene / Pathway	Phase 2: March 2008	2I5M	71.2%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP00627 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0552	57285570		hypothetical protein SACOL0552	133	Conserved Gene / Pathway	Phase 2: March 2008	2K4K	40.6%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP00623 (show subtarget assignments)	1	cloned	No	SACOL2731	57285285		cold shock protein, CSD family	66	Conserved Gene / Pathway	Phase 2: March 2008	2I5M	68.2%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP04328 (show subtarget assignments)	1	cloned	No	CPF_1452	110798743		cold shock protein [Clostridium perfring...	69	conserved gene; putative drug target function;	Phase 4: April 2009	2L15	56.3%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP00610 (show subtarget assignments)	1	cloned	No	SACOL1437	57286088		cold shock protein, CSD family	66	Conserved Gene / Pathway	Phase 2: March 2008	1CSP	75.8%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP02020 (show subtarget assignments)	1	crystallized	No	FTT0245	56707402	usp	universal stress protein [Francisella tu...	278	Drug Target	Phase 3: June 2008	2PFS	20.5%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP02706 (show subtarget assignments)	1	cloned	No	FTT0470	56707612	apaH	diadenosine tetraphosphatase [Francisell...	275	Drug Target	Phase 3: June 2008	2DFJ	37.8%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP02351 (show subtarget assignments)	1	cloned	No	FTT1112c	56708190	rpoH	RNA polymerase factor sigma-32 [Francise...	292	Drug Target	Phase 3: June 2008	1IW7	25%	Francisella tularensis	Cellular processesTranscription	Adaptations to atypical conditionsTranscription factors

IDP01967 (show subtarget assignments)	1	soluble	No	STM1789	16765130		hydrogenase 1 maturation protease [Salmo...	198	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1CFZ	30.8%	Salmonella enterica	Energy metabolism	Aerobic

IDP01909 (show subtarget assignments)	1	soluble	No	STM1536	16764881		putative hydrogenase maturation protease...	202	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1CFZ	30.7%	Salmonella enterica	Energy metabolism	Aerobic

IDP02111 (show subtarget assignments)	1	in_crystallization_trials	No	STM3694	16766979	lldD	L-lactate dehydrogenase [Salmonella typh...	396	Conserved; Drug target functions	Phase 3: June 2008	1AL7	32.6%	Salmonella enterica	Energy metabolism	Aerobic

IDP02007 (show subtarget assignments)	1	in_crystallization_trials	No	STM2330	16765657	lrhA	NADH dehydrogenase transcriptional repre...	312	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3ONM	38.8%	Salmonella enterica	Energy metabolism	Aerobic

IDP01730 (show subtarget assignments)	1	expressed	No	FTT0871	56707975	gpsA	glycerol-3-phosphate dehydrogenase (NAD(...	332	Conserved; Drug target functions	Phase 3: June 2008	3K96	43.1%	Francisella tularensis	Energy metabolismFatty acid and phospholipid metabolism	AerobicAnaerobic,Biosynthesis

IDP04146 (show subtarget assignments)	1	expressed	No	YPO2147	218929248	dadA	D-amino acid dehydrogenase small subunit...	434	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1PJ5	19.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP00569 (show subtarget assignments)	1	purified	No	YPO4016	16124139	hutH	histidine ammonia-lyase	510	Drug Target Function	Phase 2: March 2008	1GK2	77.5%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04154 (show subtarget assignments)	1	cloned	No	YPO4017	218931008	hutU	urocanate hydratase [Yersinia pestis CO9...	563	conserved gene; putative drug target function;	Phase 4: April 2009	1UWL	86.3%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02561 (show subtarget assignments)	1	purified	No	FTT0714c	56707833	kbl	2-amino-3-ketobutyrate coenzyme A ligase...	398	Conserved; Drug target functions	Phase 3: June 2008	1FC4	62.1%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP02643 (show subtarget assignments)	1	in_pdb 3RUY	No	GBAA1154	47526421	rocD	ornithine--oxo-acid transaminase [Bacill...	396	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3RUY	98.7%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP04283 (show subtarget assignments)	1	expressed	No	YPO1971	218929083	hutG	putative N-formylglutamate amidohydrolas...	268	conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Energy metabolism	Amino acids and amines

IDP01218 (show subtarget assignments)	1	expressed	No	BA_3712	73919984		Histidine ammonia-lyase (Histidase)	505	Drug Target Function	Phase 2: March 2008	1GK2	42%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP04050 (show subtarget assignments)	1	purified	No	YPO1765	218928887	hpaF	5-carboxymethyl-2-hydroxymuconate delta-...	132	conserved gene; putative drug target function;	Phase 4: April 2009	1OTG	67.4%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP01041 (show subtarget assignments)	1	purified	No	STM2971	16766276	sdaB	L-serine dehydratase/L-threonine deamina...	455	Conserved Gene / Pathway	Phase 2: March 2008	2IQQ	16%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP02094 (show subtarget assignments)	1	cloned	No	STM3598	16766884		putative L-asparaginase [Salmonella typh...	347	Conserved; Drug target functions	Phase 3: June 2008	1ZCF	68.9%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP04721 (show subtarget assignments)	1	expressed	No	YPO1289	115347051		conserved hypothetical protein [Yersinia...	380	conserved gene; putative drug target function;	Phase 4: April 2009	2Q18	16.8%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02251 (show subtarget assignments)	1	cloned	No	YPO1201	16121494		putative amino acid decarboxylase [Yersi...	768	Involved in virulence; Drug target functions	Phase 3: June 2008	2VYC	51.6%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04037 (show subtarget assignments)	1	in_pdb 3S52	No	YPO2082	115347800		putative fumarylacetoacetate hydrolase f...	218	putative drug target function;	Phase 4: April 2009	3S52	100%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04722 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1357	115347116	ltaA	L-allo-threonine aldolase [Yersinia pest...	339	conserved gene; putative drug target function;	Phase 4: April 2009	1LW4	46.5%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02640 (show subtarget assignments)	1	purified	No	GBAA0609	47525887	aspA	aspartate ammonia-lyase [Bacillus anthra...	477	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1J3U	70.6%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP04008 (show subtarget assignments)	1	cloned	No	YPO0906	218928079	gcsH	glycine cleavage system protein H [Yersi...	128	conserved gene; putative drug target function;	Phase 4: April 2009	3A7A	75%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP01830 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0407	56707556	gcvT	glycine cleavage system aminomethyltrans...	358	Drug Target	Phase 3: June 2008	1VLO	47.9%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP02829 (show subtarget assignments)	1	cloned	No	GBAA4382	47529677	bfmbB	branched-chain alpha-keto acid dehydroge...	439	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	38.4%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02647 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0537	16802580		allantoate amidohydrolase [Listeria mono...	423	Presence of Protease Motifs; DNA binding Motifs	Phase 3: June 2008	3N5F	38.1%	Listeria monocytogenes	Energy metabolism	Amino acids and amines

IDP02466 (show subtarget assignments)	1	crystallized	No	YPO1771	16122025		L-serine dehydratase [Yersinia pestis CO...	454	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	2IQQ	17%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04493 (show subtarget assignments)	1	cloned	No	YPO4089	115349677		pyridoxal-phosphate dependent enzyme [Ye...	320	putative drug target function;	Phase 4: April 2009	3HMK	36.6%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04470 (show subtarget assignments)	1	cloned	No	YPO2306	218929398		putative amino acid antiporter [Yersinia...	463	putative drug target function;	Phase 4: April 2009	3HQK	26.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP00831 (show subtarget assignments)	0	work_stopped	No	SACOL2545	57285227	sdaAB	L-serine dehydratase, iron-sulfur-depend...	226	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Energy metabolism	Amino acids and amines

IDP00830 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2544	57285226	sdaAA	L-serine dehydratase, iron-sulfur-depend...	299	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Energy metabolism	Amino acids and amines

IDP02417 (show subtarget assignments)	1	cloned	No	FTT0812	56707923	gcvH1	glycine cleavage system protein H [Franc...	126	Conserved; Drug target functions	Phase 3: June 2008	1ZKO	40.5%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP04466 (show subtarget assignments)	1	in_pdb 3NTX	No	YPO2161	115347872	ansA	L-asparaginase I [Yersinia pestis CO92]	338	putative drug target function;	Phase 4: April 2009	3NTX	99.7%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02743 (show subtarget assignments)	1	cloned	No	GBAA4383	47529678	bfmbAb	3-methyl-2-oxobutanoate dehydrogenase, b...	327	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1UM9	52.9%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02745 (show subtarget assignments)	1	cloned	No	GBAA4384	47529679	bfmbAa	3-methyl-2-oxobutanoate dehydrogenase, a...	333	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1UM9	41.7%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02210 (show subtarget assignments)	1	cloned	No	FTT0980	56708072		hypothetical protein FTT0980 [Francisell...	413	Conserved; Drug target functions	Phase 3: June 2008	1FC4	26.4%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP00744 (show subtarget assignments)	1	soluble	No	SACOL1563	57284661	lpdA	2-oxoisovalerate dehydrogenase, E3 compo...	473	Drug Target Function	Phase 2: March 2008	3URH	37%	Staphylococcus aureus	Energy metabolism	Amino acids and amines

IDP04462 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1939	115347664		putative glutaminase [Yersinia pestis CO...	340	putative drug target function;	Phase 4: April 2009	1U60	38.2%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04464 (show subtarget assignments)	1	purified	No	YPO1972	218929084	hutI	imidazolonepropionase [Yersinia pestis C...	406	conserved gene; putative drug target function;	Phase 4: April 2009	2OOF	54.9%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP01980 (show subtarget assignments)	0	work_stopped	No	STM3054	16766355	gcvH	glycine cleavage system protein H [Salmo...	129	Conserved; Drug target functions	Phase 3: June 2008	3A8I	98.5%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP00700 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2656	57286560	arcB2	ornithine carbamoyltransferase	336	Drug Target Function	Phase 2: March 2008	2W37	63.3%	Staphylococcus aureus	Energy metabolism	Amino acids and amines

IDP02192 (show subtarget assignments)	1	soluble	No	YPO0348	16120683	aspA	aspartate ammonia-lyase [Yersinia pestis...	478	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	1JSW	89.3%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP90191
(show subtarget assignments)

8

expressed

No

AAM13632.1

20153171

CPXV193 CDS

CPXV193 protein

563

kelch-like protein

Community Requests

3II7

13%

Cowpox virus

conserved hypothetical proteins

0

IDP90190
(show subtarget assignments)

8

cloned

No

AAM13631.1

20153170

CrmC

CrmC or CPXV191 protein

186

soluble vTNF receptor CrmC

Community Requests

3ALQ

30.6%

Cowpox virus

host defense modulator

0

IDP00810
(show subtarget assignments)

1

cloned

No

SACOL1870

57284791

hypothetical protein SACOL1870

188

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

0

IDP90192
(show subtarget assignments)

8

cloned

No

AAM13635.1

20153174

CPXV196 CDS

CPXV196 protein

299

serine-threonine kinase

Community Requests

2KTY

40.7%

Cowpox virus

Unknown function

0

IDP90204
(show subtarget assignments)

8

cloned

No

AAM13452.1

20152991

CPXV006 CDS

CPXV006 protein

619

ankyrin repeat protein

Community Requests

Cowpox virus

conserved hypothetical proteins

0

IDP90188
(show subtarget assignments)

8

cloned

No

AAM13496.1

20153035

CPXV050 CDS

CPXV050 protein

480

kelch-like protein

Community Requests

3II7

12.3%

Cowpox virus

conserved hypothetical proteins

0

IDP90184
(show subtarget assignments)

8

expressed

No

AAM13486.1

20153025

CPXV039 CDS

CPXV039 protein

473

ankyrin repeat protein

Community Requests

1N11

14.4%

Cowpox virus

conserved hypothetical proteins

0

IDP90185
(show subtarget assignments)

0

work_stopped

No

AAM13488.1

20153027

CPXV041 CDS

CPXV041 protein

284

K1L like Host range protein

Community Requests

3KEA

95.1%

Cowpox virus

host defense modulator

0

IDP90186
(show subtarget assignments)

8

cloned

No

AAM13489.1

20153028

SPI3

SPI3 or CPXV042 protein

373

serine protease inhibitor 3

Community Requests

3LW2

28.7%

Cowpox virus

host defense modulator

0

IDP90189
(show subtarget assignments)

8

cloned

No

AAM13616.1

20153155

CPXV175 CDS

CPXV175 protein

277

CD47-like putative membrane protein

Community Requests

2JJS

13%

Cowpox virus

host defense modulator

0

IDP90187
(show subtarget assignments)

8

cloned

No

AAM13490.1

20153029

CPXV043 CDS

CPXV043 protein

88

IFN resistance, K3L like

Community Requests

1LUZ

90.9%

Cowpox virus

host defense modulator

0

IDP90179
(show subtarget assignments)

8

cloned

No

AAM13473.1

20153012

CPXV025 CDS

CPXV026 protein

63

ankyrin-like protein

Community Requests

Cowpox virus

conserved hypothetical proteins

0

IDP90180
(show subtarget assignments)

8

cloned

No

AAM13474.1

20153013

CPXV027 CDS

CPXV027 protein

632

ankyrin-like protein

Community Requests

3NOC

5.4%

Cowpox virus

conserved hypothetical proteins

0

IDP90177
(show subtarget assignments)

8

expressed

No

AAM13471.1

20153010

CPXV024 CDS

CPXV024 protein

126

Orthopoxvirus interleukin 18 binding protein; plays a key role in the activation...

Community Requests

3F62

80.2%

Cowpox virus

host defense modulator

0

IDP90178
(show subtarget assignments)

8

purified

No

AAM13472.1

20153011

VHR1

VHR1 or CPXV025 protein

668

ankyrin-like protein, CP77

Community Requests

1N11

10%

Cowpox virus

host range protein

0

IDP90181
(show subtarget assignments)

8

cloned

No

AAM13478.1

20153017

CPXV031 CDS

CPXV031 protein

69

kelch-like protein

Community Requests

Cowpox virus

conserved hypothetical proteins

0

IDP90176
(show subtarget assignments)

8

expressed

No

AAM13470.1

20153009

CPXV023 CDS

CPXV023 protein

242

zinc-finger-like protein

Community Requests

2ECW

8.3%

Cowpox virus

host defense modulator

0

IDP90182
(show subtarget assignments)

8

soluble

No

AAM13479.1

20153018

CPXV032

CPXV032 protein

125

kelch-like protein

Community Requests

Cowpox virus

conserved hypothetical proteins

0

IDP00616
(show subtarget assignments)

1

cloned

No

SACOL1586

57286108

hypothetical protein SACOL1586

94

Drug Target Function

Phase 2: March 2008

Staphylococcus aureus

0

IDP90175
(show subtarget assignments)

8

expressed

No

AAM13468.1

20153007

VGF

CPXV021 protein or CPXV VGF protein

139

Community Requests

1K36

15.8%

Cowpox virus

host range protein

0

IDP00600
(show subtarget assignments)

1

cloned

No

SACOL0532

57285557

hypothetical protein SACOL0532

51

Drug Target Function

Phase 2: March 2008

Staphylococcus aureus

0

IDP90183
(show subtarget assignments)

8

cloned

No

AAM13482.1

20153021

CPXV035 CDS

CPXV035 protein

512

kelch-like protein

Community Requests

2XN4

12.7%

Cowpox virus

conserved hypothetical proteins

0

IDP90205
(show subtarget assignments)

8

expressed

No

AAM13465.1

20153004

CPXV018 CDS

CPXV018 protein, VO18

171

similar to MPV-Z-N3R

Community Requests

Cowpox virus

host defense modulator

0

IDP00225
(show subtarget assignments)

1

cloned

No

YPO3069

16123246

-

putative exported protein

486

Virulence

Phase 1: October 2007

3C37

15%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP02455
(show subtarget assignments)

1

expressed

No

GBAA3813

47529098

prophage LambdaBa01, thymidylate synthas...

252

Conserved; Drug target functions

Phase 3: June 2008

3AH5

24.6%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP04496
(show subtarget assignments)

1

expressed

No

VC0675

15640694

thyA

thymidylate synthase [Vibrio cholerae O1...

283

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3V8H

35.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP02391
(show subtarget assignments)

1

cloned

No

FTT0534c

56707667

nrdA

ribonucleotide-diphosphate reductase sub...

590

Drug Target

Phase 3: June 2008

2WGH

31.2%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP02400
(show subtarget assignments)

1

purified

No

YPO3454

16123600

nrdD

anaerobic ribonucleoside triphosphate re...

712

Conserved; CD; Drug target functions

Phase 3: June 2008

1H78

48.2%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP02619
(show subtarget assignments)

1

cloned

No

GBAA1372

47526645

nrdF

ribonucleotide-diphosphate reductase sub...

322

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

4DR0

58.4%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP01318
(show subtarget assignments)

1

in_pdb
3IQ1

No

VC0139

15640170

DPS family protein

156

Conserved Gene / Pathway

Phase 2: March 2008

3IQ1

100%

Vibrio cholerae

Cellular processes

Adaptations to atypical conditions

IDP00576
(show subtarget assignments)

1

cloned

No

YPO1398

16121678

cspB

cold shock-like protein

69

Virulence Associated Factor

Phase 2: March 2008

3I2Z

50.7%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP00557
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3382

16123531

gsrA

serine endoprotease

481

Virulence Associated Factor

Phase 2: March 2008

2ZLE

71.9%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP01061
(show subtarget assignments)

1

in_crystallization_trials

No

STM3591

16766877

uspA

universal stress protein A

144

Conserved Gene / Pathway

Phase 2: March 2008

1JMV

66.7%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP00524
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0490

16120820

apaH

diadenosine tetraphosphatase

289

Conserved Gene / Pathway

Phase 2: March 2008

2DFJ

73.7%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP04269
(show subtarget assignments)

1

cloned

No

CPF_2193

110798612

relA

GTP pyrophosphokinase [Clostridium perfr...

726

conserved gene; putative drug target function;

Phase 4: April 2009

1VJ7

28.1%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP01613
(show subtarget assignments)

1

in_crystallization_trials

No

STM1927

16765269

yecG

universal stress protein UspC [Salmonell...

142

Conserved; Drug target functions

Phase 3: June 2008

1JMV

35.2%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP04697
(show subtarget assignments)

1

soluble

No

YPCD1.29c

16082717

yopB

secreted effector protein [Yersinia pest...

401

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP04018
(show subtarget assignments)

1

cloned

No

CPF_1860

110799668

msrB

methionine sulfoxide reductase B [Clostr...

147

conserved gene; putative drug target function;

Phase 4: April 2009

1XM0

64.6%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04552
(show subtarget assignments)

1

cloned

No

CPF_2913

110799629

msrA

methionine sulfoxide reductase A [Clostr...

157

conserved gene; putative drug target function;

Phase 4: April 2009

3BQE

52.2%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP01516
(show subtarget assignments)

1

crystallized

No

VC0576

15640598

sspA

stringent starvation protein A

211

Conserved Gene / Pathway

Phase 2: March 2008

1YY7

73.9%

Vibrio cholerae

Cellular processes

Adaptations to atypical conditions

IDP01037
(show subtarget assignments)

0

work_stopped

No

STM2927

16766233

surE

stationary phase survival protein SurE

253

potential drug target / Conserved Gene / Pathway

Phase 2: March 2008

2V4N

100%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP02827
(show subtarget assignments)

1

cloned

No

FTT1508c

56708546

relA

GTP pyrophosphokinase [Francisella tular...

647

Drug Target

Phase 3: June 2008

1VJ7

20.1%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP01255
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5132

30259616

yugI

general stress protein 13

114

Conserved Gene / Pathway

Phase 2: March 2008

2K4K

53.3%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP00848
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1753

57286190

universal stress protein family

137

Conserved Gene / Pathway

Phase 2: March 2008

1MJH

33.5%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP00833
(show subtarget assignments)

1

cloned

No

SACOL2627

57286532

betA

choline dehydrogenase

569

Conserved Gene / Pathway

Phase 2: March 2008

3LJP

32.7%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP00436
(show subtarget assignments)

1

cloned

No

YPO3358

16123508

surE

stationary phase survival protein SurE

254

Conserved Gene / Pathway

Phase 2: March 2008

2V4N

79.9%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP00803
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1759

57286194

universal stress protein family

166

Conserved Gene / Pathway

Phase 2: March 2008

1TQ8

30.7%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP01111
(show subtarget assignments)

1

cloned

No

BA_1135

49035527

Major cold shock protein cspA

67

Conserved Gene / Pathway

Phase 2: March 2008

1CSP

73.1%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP01102
(show subtarget assignments)

1

soluble

No

BA_5424

49040749

Cold shock-like protein cspC

65

Essential Gene

Phase 2: March 2008

1C9O

74.2%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP00404
(show subtarget assignments)

1

soluble

No

YPCD1.48

16082736

virG

needle complex outer membrane lipoprotei...

131

Virulence Associated Factor

Phase 2: March 2008

2YJL

23.7%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP00699
(show subtarget assignments)

1

in_pdb
3ED6
3FG0

Yes

SACOL2628

57286533

betB

betaine aldehyde dehydrogenase

496

Conserved Gene / Pathway

Phase 2: March 2008

3ED6

100%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP02334
(show subtarget assignments)

1

soluble

No

FTT0391c

56707540

cspC

cold shock protein [Francisella tularens...

67

Drug Target

Phase 3: June 2008

3I2Z

61.8%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP00630
(show subtarget assignments)

1

cloned

No

SACOL0861

57284322

cold shock protein, CSD family

66

Conserved Gene / Pathway

Phase 2: March 2008

2I5M

71.2%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP00627
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0552

57285570

hypothetical protein SACOL0552

133

Conserved Gene / Pathway

Phase 2: March 2008

2K4K

40.6%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP00623
(show subtarget assignments)

1

cloned

No

SACOL2731

57285285

cold shock protein, CSD family

66

Conserved Gene / Pathway

Phase 2: March 2008

2I5M

68.2%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP04328
(show subtarget assignments)

1

cloned

No

CPF_1452

110798743

cold shock protein [Clostridium perfring...

69

conserved gene; putative drug target function;

Phase 4: April 2009

2L15

56.3%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP00610
(show subtarget assignments)

1

cloned

No

SACOL1437

57286088

cold shock protein, CSD family

66

Conserved Gene / Pathway

Phase 2: March 2008

1CSP

75.8%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP02020
(show subtarget assignments)

1

crystallized

No

FTT0245

56707402

usp

universal stress protein [Francisella tu...

278

Drug Target

Phase 3: June 2008

2PFS

20.5%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP02706
(show subtarget assignments)

1

cloned

No

FTT0470

56707612

apaH

diadenosine tetraphosphatase [Francisell...

275

Drug Target

Phase 3: June 2008

2DFJ

37.8%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP02351
(show subtarget assignments)

1

cloned

No

FTT1112c

56708190

rpoH

RNA polymerase factor sigma-32 [Francise...

292

Drug Target

Phase 3: June 2008

1IW7

25%

Francisella tularensis

Cellular processesTranscription

Adaptations to atypical conditionsTranscription factors

IDP01967
(show subtarget assignments)

1

soluble

No

STM1789

16765130

hydrogenase 1 maturation protease [Salmo...

198

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1CFZ

30.8%

Salmonella enterica

Energy metabolism

Aerobic

IDP01909
(show subtarget assignments)

1

soluble

No

STM1536

16764881

putative hydrogenase maturation protease...

202

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1CFZ

30.7%

Salmonella enterica

Energy metabolism

Aerobic

IDP02111
(show subtarget assignments)

1

in_crystallization_trials

No

STM3694

16766979

lldD

L-lactate dehydrogenase [Salmonella typh...

396

Conserved; Drug target functions

Phase 3: June 2008

1AL7

32.6%

Salmonella enterica

Energy metabolism

Aerobic

IDP02007
(show subtarget assignments)

1

in_crystallization_trials

No

STM2330

16765657

lrhA

NADH dehydrogenase transcriptional repre...

312

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3ONM

38.8%

Salmonella enterica

Energy metabolism

Aerobic

IDP01730
(show subtarget assignments)

1

expressed

No

FTT0871

56707975

gpsA

glycerol-3-phosphate dehydrogenase (NAD(...

332

Conserved; Drug target functions

Phase 3: June 2008

3K96

43.1%

Francisella tularensis

Energy metabolismFatty acid and phospholipid metabolism

AerobicAnaerobic,Biosynthesis

IDP04146
(show subtarget assignments)

1

expressed

No

YPO2147

218929248

dadA

D-amino acid dehydrogenase small subunit...

434

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1PJ5

19.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP00569
(show subtarget assignments)

1

purified

No

YPO4016

16124139

hutH

histidine ammonia-lyase

510

Drug Target Function

Phase 2: March 2008

1GK2

77.5%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04154
(show subtarget assignments)

1

cloned

No

YPO4017

218931008

hutU

urocanate hydratase [Yersinia pestis CO9...

563

conserved gene; putative drug target function;

Phase 4: April 2009

1UWL

86.3%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02561
(show subtarget assignments)

1

purified

No

FTT0714c

56707833

kbl

2-amino-3-ketobutyrate coenzyme A ligase...

398

Conserved; Drug target functions

Phase 3: June 2008

1FC4

62.1%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP02643
(show subtarget assignments)

1

in_pdb
3RUY

No

GBAA1154

47526421

rocD

ornithine--oxo-acid transaminase [Bacill...

396

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3RUY

98.7%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP04283
(show subtarget assignments)

1

expressed

No

YPO1971

218929083

hutG

putative N-formylglutamate amidohydrolas...

268

conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP01218
(show subtarget assignments)

1

expressed

No

BA_3712

73919984

Histidine ammonia-lyase (Histidase)

505

Drug Target Function

Phase 2: March 2008

1GK2

42%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP04050
(show subtarget assignments)

1

purified

No

YPO1765

218928887

hpaF

5-carboxymethyl-2-hydroxymuconate delta-...

132

conserved gene; putative drug target function;

Phase 4: April 2009

1OTG

67.4%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP01041
(show subtarget assignments)

1

purified

No

STM2971

16766276

sdaB

L-serine dehydratase/L-threonine deamina...

455

Conserved Gene / Pathway

Phase 2: March 2008

2IQQ

16%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP02094
(show subtarget assignments)

1

cloned

No

STM3598

16766884

putative L-asparaginase [Salmonella typh...

347

Conserved; Drug target functions

Phase 3: June 2008

1ZCF

68.9%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP04721
(show subtarget assignments)

1

expressed

No

YPO1289

115347051

conserved hypothetical protein [Yersinia...

380

conserved gene; putative drug target function;

Phase 4: April 2009

2Q18

16.8%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02251
(show subtarget assignments)

1

cloned

No

YPO1201

16121494

putative amino acid decarboxylase [Yersi...

768

Involved in virulence; Drug target functions

Phase 3: June 2008

2VYC

51.6%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04037
(show subtarget assignments)

1

in_pdb
3S52

No

YPO2082

115347800

putative fumarylacetoacetate hydrolase f...

218

putative drug target function;

Phase 4: April 2009

3S52

100%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04722
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1357

115347116

ltaA

L-allo-threonine aldolase [Yersinia pest...

339

conserved gene; putative drug target function;

Phase 4: April 2009

1LW4

46.5%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02640
(show subtarget assignments)

1

purified

No

GBAA0609

47525887

aspA

aspartate ammonia-lyase [Bacillus anthra...

477

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1J3U

70.6%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP04008
(show subtarget assignments)

1

cloned

No

YPO0906

218928079

gcsH

glycine cleavage system protein H [Yersi...

128

conserved gene; putative drug target function;

Phase 4: April 2009

3A7A

75%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP01830
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0407

56707556

gcvT

glycine cleavage system aminomethyltrans...

358

Drug Target

Phase 3: June 2008

1VLO

47.9%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP02829
(show subtarget assignments)

1

cloned

No

GBAA4382

47529677

bfmbB

branched-chain alpha-keto acid dehydroge...

439

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

38.4%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02647
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0537

16802580

allantoate amidohydrolase [Listeria mono...

423

Presence of Protease Motifs; DNA binding Motifs

Phase 3: June 2008

3N5F

38.1%

Listeria monocytogenes

Energy metabolism

Amino acids and amines

IDP02466
(show subtarget assignments)

1

crystallized

No

YPO1771

16122025

L-serine dehydratase [Yersinia pestis CO...

454

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

2IQQ

17%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04493
(show subtarget assignments)

1

cloned

No

YPO4089

115349677

pyridoxal-phosphate dependent enzyme [Ye...

320

putative drug target function;

Phase 4: April 2009

3HMK

36.6%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04470
(show subtarget assignments)

1

cloned

No

YPO2306

218929398

putative amino acid antiporter [Yersinia...

463

putative drug target function;

Phase 4: April 2009

3HQK

26.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP00831
(show subtarget assignments)

0

work_stopped

No

SACOL2545

57285227

sdaAB

L-serine dehydratase, iron-sulfur-depend...

226

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Energy metabolism

Amino acids and amines

IDP00830
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2544

57285226

sdaAA

L-serine dehydratase, iron-sulfur-depend...

299

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Energy metabolism

Amino acids and amines

IDP02417
(show subtarget assignments)

1

cloned

No

FTT0812

56707923

gcvH1

glycine cleavage system protein H [Franc...

126

Conserved; Drug target functions

Phase 3: June 2008

1ZKO

40.5%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP04466
(show subtarget assignments)

1

in_pdb
3NTX

No

YPO2161

115347872

ansA

L-asparaginase I [Yersinia pestis CO92]

338

putative drug target function;

Phase 4: April 2009

3NTX

99.7%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02743
(show subtarget assignments)

1

cloned

No

GBAA4383

47529678

bfmbAb

3-methyl-2-oxobutanoate dehydrogenase, b...

327

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1UM9

52.9%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02745
(show subtarget assignments)

1

cloned

No

GBAA4384

47529679

bfmbAa

3-methyl-2-oxobutanoate dehydrogenase, a...

333

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1UM9

41.7%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02210
(show subtarget assignments)

1

cloned

No

FTT0980

56708072

hypothetical protein FTT0980 [Francisell...

413

Conserved; Drug target functions

Phase 3: June 2008

1FC4

26.4%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP00744
(show subtarget assignments)

1

soluble

No

SACOL1563

57284661

lpdA

2-oxoisovalerate dehydrogenase, E3 compo...

473

Drug Target Function

Phase 2: March 2008

3URH

37%

Staphylococcus aureus

Energy metabolism

Amino acids and amines

IDP04462
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1939

115347664

putative glutaminase [Yersinia pestis CO...

340

putative drug target function;

Phase 4: April 2009

1U60

38.2%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04464
(show subtarget assignments)

1

purified

No

YPO1972

218929084

hutI

imidazolonepropionase [Yersinia pestis C...

406

conserved gene; putative drug target function;

Phase 4: April 2009

2OOF

54.9%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP01980
(show subtarget assignments)

0

work_stopped

No

STM3054

16766355

gcvH

glycine cleavage system protein H [Salmo...

129

Conserved; Drug target functions

Phase 3: June 2008

3A8I

98.5%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP00700
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2656

57286560

arcB2

ornithine carbamoyltransferase

336

Drug Target Function

Phase 2: March 2008

2W37

63.3%

Staphylococcus aureus

Energy metabolism

Amino acids and amines

IDP02192
(show subtarget assignments)

1

soluble

No

YPO0348

16120683

aspA

aspartate ammonia-lyase [Yersinia pestis...

478

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

1JSW

89.3%

Yersinia pestis

Energy metabolism

Amino acids and amines

Targets