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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 9 of 60, showing 100 records out of 5973 total, starting on record 801
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP02413
(
show subtarget assignments
)
1
cloned
No
YPO3568
16123712
degS
serine endoprotease [Yersinia pestis CO9...
362
Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...
Phase 3: June 2008
1SOT
63%
Yersinia pestis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP01889
(
show subtarget assignments
)
1
soluble
No
STM0209
16763599
htrA
serine endoprotease [Salmonella typhimur...
475
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
2ZLE
87.6%
Salmonella enterica
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP01919
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM3349
16766644
degS
serine endoprotease [Salmonella typhimur...
356
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
3GCN
84.3%
Salmonella enterica
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP02087
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM3348
16766643
degQ
serine endoprotease [Salmonella typhimur...
455
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
4A8A
84.4%
Salmonella enterica
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP00557
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO3382
16123531
gsrA
serine endoprotease
481
Virulence Associated Factor
Phase 2: March 2008
2ZLE
71.9%
Yersinia pestis
Cellular processes
Adaptations to atypical conditions
IDP90794
(
show subtarget assignments
)
8
purified
No
Cj0763c
15792101
cysE
serine acetyltransferase [Campylobacter ...
212
Predicted Essential
Community Requests
3P1B
34.9%
Campylobacter jejuni
IDP00538
(
show subtarget assignments
)
1
in_pdb
3GVD
No
YPO0070
16120421
cysE
serine acetyltransferase
273
Drug Target Function
Phase 2: March 2008
3GVD
100%
Yersinia pestis
Amino acid biosynthesis
Serine family
IDP01343
(
show subtarget assignments
)
1
cloned
No
VC2649
15642644
cysE
serine acetyltransferase
273
Drug Target Function
Phase 2: March 2008
1T3D
72.2%
Vibrio cholerae
Amino acid biosynthesis
Serine family
IDP91037
(
show subtarget assignments
)
8
cloned
No
SAHV_0560
156978891
sdrD
Ser-Asp rich fibrinogen-binding, bone si...
1385
virulence/pathogenesis /
Sdr family proteins are interesting cell surface proteins in Staphylococcus aure...
Community Requests
3IS1
8.5%
Staphylococcus aureus
IDP04010
(
show subtarget assignments
)
1
cloned
No
CPF_2393
110798628
minD
septum site-determining protein MinD [Cl...
265
conserved gene; putative drug target function;
Phase 4: April 2009
3Q9L
43.4%
Clostridium perfringens
Cellular processes
Cell division
IDP01342
(
show subtarget assignments
)
1
soluble
No
VC1960
15641962
septum site-determining protein MinD
276
Conserved Gene / Pathway
Phase 2: March 2008
3Q9L
73.6%
Vibrio cholerae
Cellular processes
Cell division
IDP91876
(
show subtarget assignments
)
8
purified
No
HMPREF0023_2561
226953731
ftsI
septum formation, penicillin binding pro...
609
Acinetobacter spp. are increasingly problematic pathogens in United States hospi...
Community Requests
3UE3
89.7%
Acinetobacter sp.
IDP04087
(
show subtarget assignments
)
1
cloned
No
CPF_2394
110799648
minC
septum formation inhibitor [Clostridium ...
211
conserved gene; putative drug target function;
Phase 4: April 2009
1HF2
29.7%
Clostridium perfringens
Cellular processes
Cell division
IDP00876
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM1814
16765155
minC
septum formation inhibitor
235
Conserved Gene / Pathway
Phase 2: March 2008
3GHF
46.4%
Salmonella enterica
Cellular processes
Cell division
IDP01114
(
show subtarget assignments
)
1
soluble
No
BA_4901
38502945
Septation ring formation regulator ezrA
570
Conserved Gene / Pathway
Phase 2: March 2008
Bacillus anthracis
Cellular processes
Cell division
IDP04414
(
show subtarget assignments
)
8
selected
No
CAC05786
12329055
sepA
SepA, extracellular serine protease of t...
1364
Shigella effector protein
Community Requests
1WXR
34.9%
Shigella flexneri
IDP90302
(
show subtarget assignments
)
0
work_stopped
No
BB_0420
2688313
sensory transduction histidine kinase, p...
1494
Mutational studies suggest that Hk1 is required for the survival of the Lyme dis...
Community Requests
3A0R
5.6%
Borrelia burgdorferi
IDP04375
(
show subtarget assignments
)
1
expressed
No
VCA0211
15600980
sensory box sensor histidine kinase [Vib...
648
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3D36
9.7%
Vibrio cholerae
Regulatory functions
Other
IDP04166
(
show subtarget assignments
)
1
cloned
No
VC1653
15641658
sensory box sensor histidine kinase/resp...
1146
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
6.6%
Vibrio cholerae
Regulatory functions
Other
IDP04163
(
show subtarget assignments
)
1
expressed
No
VC1349
15641361
sensory box sensor histidine kinase/resp...
1331
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
6.5%
Vibrio cholerae
Regulatory functions
Other
IDP04495
(
show subtarget assignments
)
1
soluble
No
VC0622
15640642
sensory box sensor histidine kinase/resp...
1177
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
6.6%
Vibrio cholerae
Regulatory functions
Other
IDP02415
(
show subtarget assignments
)
1
soluble
No
CBU_1761
29542318
sensory box sensor histidine kinase/resp...
657
Conserved; Drug target functions
Phase 3: June 2008
2C2A
11.6%
Coxiella burnetii
Signal transduction
Two-component systems
IDP01805
(
show subtarget assignments
)
1
soluble
No
CBU_1084
29541658
sensory box sensor histidine kinase/resp...
683
Conserved; Drug target functions
Phase 3: June 2008
2C2A
12.4%
Coxiella burnetii
Signal transduction
Two-component systems
IDP90959
(
show subtarget assignments
)
8
cloned
No
PP2258
81441302
Sensory box protein
562
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
2R6O
20.6%
Pseudomonas putida
IDP04694
(
show subtarget assignments
)
1
soluble
No
GBAA5714
47531051
yycG
sensory box histidine kinase YycG [Bacil...
613
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
15.3%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04428
(
show subtarget assignments
)
1
soluble
No
GBAA4832
47530128
phoR
sensory box histidine kinase PhoR [Bacil...
587
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
15.2%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04258
(
show subtarget assignments
)
1
soluble
No
CPF_2010
110801347
sensory box histidine kinase [Clostridiu...
571
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
17.3%
Clostridium perfringens
Regulatory functions
IDP04227
(
show subtarget assignments
)
1
expressed
No
CPF_0198
110799765
sensory box histidine kinase [Clostridiu...
791
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
11.6%
Clostridium perfringens
Regulatory functions
IDP04327
(
show subtarget assignments
)
1
cloned
No
CPF_1243
110801193
sensory box histidine kinase [Clostridiu...
623
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
11.2%
Clostridium perfringens
Regulatory functions
IDP04365
(
show subtarget assignments
)
1
cloned
No
CPF_1523
110798905
sensory box histidine kinase [Clostridiu...
787
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
11.6%
Clostridium perfringens
Regulatory functions
Protein interactions
IDP04691
(
show subtarget assignments
)
1
soluble
No
GBAA5067
47530367
sensory box histidine kinase [Bacillus a...
617
putative drug target function;
Phase 4: April 2009
3A0R
10.7%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04188
(
show subtarget assignments
)
1
expressed
No
VCA0939
15601692
sensory box/GGDEF family protein [Vibrio...
321
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3BRE
20.6%
Vibrio cholerae
Regulatory functions
Other
IDP90953
(
show subtarget assignments
)
8
expressed
No
VF0985
75354249
Sensory box/GGDEF family protein
827
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3HVB
12.1%
Vibrio fischeri
IDP90965
(
show subtarget assignments
)
8
purified
No
VF0094
75354809
Sensory box/GGDEF family protein
852
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3PJW
11.2%
Vibrio fischeri
IDP90964
(
show subtarget assignments
)
8
purified
No
VC0072
81545617
Sensory box/GGDEF family protein
768
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3PJW
15.4%
Vibrio cholerae
IDP90957
(
show subtarget assignments
)
8
cloned
No
PFL_1902
123656875
Sensory box-containing diguanylate cycla...
572
C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...
Community Requests
3PJW
18.4%
Pseudomonas fluorescens
IDP04185
(
show subtarget assignments
)
1
expressed
No
VCA0683
15601440
sensor protein UhpB [Vibrio cholerae O1 ...
527
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3GIG
12%
Vibrio cholerae
Regulatory functions
Other
IDP04186
(
show subtarget assignments
)
1
cloned
No
VCA0709
9658128
sensor protein TorS [Vibrio cholerae O1 ...
1020
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3I9Y
17.1%
Vibrio cholerae
Regulatory functions
Other
IDP04630
(
show subtarget assignments
)
1
cloned
No
CBU_1228
29654531
qseC
sensor protein qseC [Coxiella burnetii R...
478
conserved gene; putative drug target function;
Phase 4: April 2009
3JZ3
19%
Coxiella burnetii
Regulatory functions
Other
IDP02394
(
show subtarget assignments
)
1
cloned
No
YPO1633
16121901
phoQ
sensor protein PhoQ [Yersinia pestis CO9...
484
Conserved; CD; Drug target functions
Phase 3: June 2008
1ID0
20.9%
Yersinia pestis
Regulatory functions
Other
IDP01908
(
show subtarget assignments
)
1
cloned
No
STM1392
16764742
ssrA
sensor kinase [Salmonella typhimurium LT...
920
Conserved; Drug target functions
Phase 3: June 2008
2C2A
7.1%
Salmonella enterica
Energy metabolism
Anaerobic
IDP04498
(
show subtarget assignments
)
1
purified
No
VC0791
15640810
sensor kinase citA [Vibrio cholerae O1 b...
565
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2J80
9.7%
Vibrio cholerae
Regulatory functions
Other
IDP04251
(
show subtarget assignments
)
1
cloned
No
CPF_1751
110801372
virS
sensor histidine kinase VirS [Clostridiu...
440
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Toxin production and resistance
IDP04043
(
show subtarget assignments
)
1
soluble
No
VCA0565
15601324
sensor histidine kinase [Vibrio cholerae...
499
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1BXD
6%
Vibrio cholerae
Regulatory functions
Other
IDP04165
(
show subtarget assignments
)
1
expressed
No
VC1521
15641529
sensor histidine kinase [Vibrio cholerae...
677
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
11.7%
Vibrio cholerae
Regulatory functions
Other
IDP04182
(
show subtarget assignments
)
1
cloned
No
VCA0238
15601006
sensor histidine kinase [Vibrio cholerae...
549
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
12%
Vibrio cholerae
Regulatory functions
Other
IDP04158
(
show subtarget assignments
)
1
expressed
No
VC1088
15641101
sensor histidine kinase [Vibrio cholerae...
534
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3D36
13.5%
Vibrio cholerae
Regulatory functions
Other
IDP04007
(
show subtarget assignments
)
1
expressed
No
VC1319
15641331
sensor histidine kinase [Vibrio cholerae...
440
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
15.2%
Vibrio cholerae
Regulatory functions
Other
IDP04183
(
show subtarget assignments
)
1
expressed
No
VCA0257
15601025
sensor histidine kinase [Vibrio cholerae...
484
drug target; putative drug target function;
Phase 4: April 2009
Vibrio cholerae
Regulatory functions
Other
IDP04505
(
show subtarget assignments
)
1
soluble
No
VCA0531
15601291
sensor histidine kinase [Vibrio cholerae...
497
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
15.9%
Vibrio cholerae
Regulatory functions
Other
IDP04401
(
show subtarget assignments
)
1
expressed
No
VC1831
15641833
sensor histidine kinase [Vibrio cholerae...
736
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
10.2%
Vibrio cholerae
Regulatory functions
Other
IDP04157
(
show subtarget assignments
)
1
soluble
No
VC1085
15641098
sensor histidine kinase [Vibrio cholerae...
434
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
16.1%
Vibrio cholerae
Regulatory functions
Other
IDP92003
(
show subtarget assignments
)
8
selected
No
SpneCM_010100002775
298254522
sensor histidine kinase [Streptococcus p...
350
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2C2A
22%
Streptococcus pneumoniae
IDP04419
(
show subtarget assignments
)
1
soluble
No
GBAA2861
47528156
sensor histidine kinase SrrB, putative [...
458
putative drug target function;
Phase 4: April 2009
2C2A
18.1%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04543
(
show subtarget assignments
)
1
expressed
No
VC2453
9657030
sensor histidine kinase/response regulat...
927
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
8.1%
Vibrio cholerae
Regulatory functions
Other
IDP04164
(
show subtarget assignments
)
1
cloned
No
VC1445
15641456
sensor histidine kinase/response regulat...
572
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
14.5%
Vibrio cholerae
Regulatory functions
Other
IDP04184
(
show subtarget assignments
)
1
expressed
No
VCA0522
15601282
sensor histidine kinase/response regulat...
686
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
10.9%
Vibrio cholerae
Regulatory functions
Other
IDP04664
(
show subtarget assignments
)
1
purified
No
GBAA0996
47526275
sensor histidine kinase/response regulat...
896
putative drug target function;
Phase 4: April 2009
2C2A
10.3%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04673
(
show subtarget assignments
)
1
purified
No
GBAA1498
47777938
resE
sensor histidine kinase ResE [Bacillus a...
591
putative drug target function;
Phase 4: April 2009
3A0R
15.9%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04369
(
show subtarget assignments
)
1
expressed
No
GBAA1792
47527081
sensor histidine kinase, putative [Bacil...
368
putative drug target function;
Phase 4: April 2009
3GIG
17.1%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04680
(
show subtarget assignments
)
1
expressed
No
GBAA3066
47528358
sensor histidine kinase, putative [Bacil...
333
putative drug target function;
Phase 4: April 2009
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04660
(
show subtarget assignments
)
1
expressed
No
GBAA0286
47777799
sensor histidine kinase, putative [Bacil...
314
putative drug target function;
Phase 4: April 2009
2C2A
24.2%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP01779
(
show subtarget assignments
)
1
soluble
No
CBU_0366
29540977
phoR
sensor histidine kinase PhoR protein, pu...
252
Conserved; Drug target functions
Phase 3: June 2008
2C2A
31.3%
Coxiella burnetii
Signal transduction
Two-component systems
IDP04669
(
show subtarget assignments
)
1
expressed
No
GBAA1351
47526623
sensor histidine kinase KinD [Bacillus a...
498
putative drug target function;
Phase 4: April 2009
3D36
15.5%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04351
(
show subtarget assignments
)
1
cloned
No
CPF_1213
110799898
kdpD
sensor histidine kinase KdpD [Clostridiu...
900
conserved gene; putative drug target function;
Phase 4: April 2009
2R8R
12.7%
Clostridium perfringens
Regulatory functions
Protein interactions
IDP04241
(
show subtarget assignments
)
1
soluble
No
CPF_1112
110801022
sensor histidine kinase [Clostridium per...
574
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Regulatory functions
Protein interactions
IDP04236
(
show subtarget assignments
)
1
expressed
No
CPF_0837
110799475
sensor histidine kinase [Clostridium per...
336
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
19.9%
Clostridium perfringens
Regulatory functions
Protein interactions
IDP04012
(
show subtarget assignments
)
1
cloned
No
CPF_2355
110800506
virJ
sensor histidine kinase [Clostridium per...
482
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
15.4%
Clostridium perfringens
Cellular processes
Pathogenesis
IDP04191
(
show subtarget assignments
)
1
expressed
No
CPF_0554
110800843
sensor histidine kinase [Clostridium per...
583
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Signal transduction
Two-component systems
IDP04331
(
show subtarget assignments
)
1
purified
No
CPF_2181
110799592
sensor histidine kinase [Clostridium per...
507
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
16.4%
Clostridium perfringens
Signal transduction
Two-component systems
IDP04304
(
show subtarget assignments
)
1
cloned
No
CPF_2640
110798722
sensor histidine kinase [Clostridium per...
310
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
23.5%
Clostridium perfringens
Signal transduction
Two-component systems
IDP04302
(
show subtarget assignments
)
1
soluble
No
CPF_2503
110801437
sensor histidine kinase [Clostridium per...
471
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
16.6%
Clostridium perfringens
Signal transduction
Two-component systems
IDP04382
(
show subtarget assignments
)
1
expressed
No
CPF_0116
110801065
sensor histidine kinase [Clostridium per...
337
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
17.8%
Clostridium perfringens
Regulatory functions
Protein interactions
IDP04243
(
show subtarget assignments
)
1
soluble
No
CPF_1140
110799522
sensor histidine kinase [Clostridium per...
418
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
16.7%
Clostridium perfringens
Signal transduction
Two-component systems
IDP04271
(
show subtarget assignments
)
1
expressed
No
CPF_2241
110798635
sensor histidine kinase [Clostridium per...
678
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
12.4%
Clostridium perfringens
Signal transduction
Two-component systems
IDP04347
(
show subtarget assignments
)
1
expressed
No
CPF_2345
110801165
sensor histidine kinase [Clostridium per...
578
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Signal transduction
Two-component systems
IDP04247
(
show subtarget assignments
)
1
expressed
No
CPF_1402
110798994
sensor histidine kinase [Clostridium per...
478
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
16.3%
Clostridium perfringens
Regulatory functions
Protein interactions
IDP04238
(
show subtarget assignments
)
1
cloned
No
CPF_0889
110799788
sensor histidine kinase [Clostridium per...
475
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Signal transduction
Two-component systems
IDP04239
(
show subtarget assignments
)
1
cloned
No
CPF_1057
110799811
sensor histidine kinase [Clostridium per...
418
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
19.4%
Clostridium perfringens
Regulatory functions
Protein interactions
IDP04133
(
show subtarget assignments
)
1
cloned
No
CPF_1195
110798868
hpkA
sensor histidine kinase [Clostridium per...
287
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
25.8%
Clostridium perfringens
Regulatory functions
Other
IDP04540
(
show subtarget assignments
)
1
purified
No
CPF_0511
110801291
sensor histidine kinase [Clostridium per...
516
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
18.2%
Clostridium perfringens
Signal transduction
Two-component systems
IDP04189
(
show subtarget assignments
)
1
expressed
No
CPF_0225
110799110
sensor histidine kinase [Clostridium per...
476
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
13%
Clostridium perfringens
Regulatory functions
Protein interactions
IDP04550
(
show subtarget assignments
)
1
cloned
No
CPF_0460
110798921
sensor histidine kinase [Clostridium per...
743
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
9.6%
Clostridium perfringens
Regulatory functions
Protein interactions
IDP04201
(
show subtarget assignments
)
1
expressed
No
CPF_0499
110800753
sensor histidine kinase [Clostridium per...
431
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Signal transduction
Two-component systems
IDP04569
(
show subtarget assignments
)
1
cloned
No
CPF_2242
110799545
sensor histidine kinase [Clostridium per...
620
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
10%
Clostridium perfringens
Signal transduction
Two-component systems
IDP04244
(
show subtarget assignments
)
1
soluble
No
CPF_1171
110801284
sensor histidine kinase [Clostridium per...
410
conserved gene; putative drug target function;
Phase 4: April 2009
1B3Q
9.5%
Clostridium perfringens
Signal transduction
Two-component systems
IDP04433
(
show subtarget assignments
)
1
cloned
No
GBAA5276
47530584
sensor histidine kinase [Bacillus anthra...
480
putative drug target function;
Phase 4: April 2009
3A0R
13.3%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04661
(
show subtarget assignments
)
1
expressed
No
GBAA0572
47777831
sensor histidine kinase [Bacillus anthra...
416
putative drug target function;
Phase 4: April 2009
2C2A
16.6%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04665
(
show subtarget assignments
)
1
purified
No
GBAA1118
47526389
sensor histidine kinase [Bacillus anthra...
580
putative drug target function;
Phase 4: April 2009
2C2A
11.4%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04692
(
show subtarget assignments
)
1
expressed
No
GBAA5105
47778363
sensor histidine kinase [Bacillus anthra...
368
putative drug target function;
Phase 4: April 2009
2C2A
20.9%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04693
(
show subtarget assignments
)
1
cloned
No
GBAA5598
47530920
sensor histidine kinase [Bacillus anthra...
376
drug target; putative drug target function;
Phase 4: April 2009
3GIG
26.9%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04659
(
show subtarget assignments
)
1
soluble
No
GBAA0272
47525531
sensor histidine kinase [Bacillus anthra...
501
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
15.2%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04430
(
show subtarget assignments
)
1
purified
No
GBAA4921
47530215
sensor histidine kinase [Bacillus anthra...
484
putative drug target function;
Phase 4: April 2009
2C2A
16.9%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04678
(
show subtarget assignments
)
1
cloned
No
GBAA2560
47527849
sensor histidine kinase [Bacillus anthra...
385
putative drug target function;
Phase 4: April 2009
3DGE
20.5%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04371
(
show subtarget assignments
)
1
expressed
No
GBAA4776
47778322
sensor histidine kinase [Bacillus anthra...
311
putative drug target function;
Phase 4: April 2009
2C2A
19.6%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04672
(
show subtarget assignments
)
1
expressed
No
GBAA1482
47526755
sensor histidine kinase [Bacillus anthra...
603
putative drug target function;
Phase 4: April 2009
3A0R
14.1%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP01736
(
show subtarget assignments
)
1
expressed
No
GBAA5503
47530821
sensor histidine kinase [Bacillus anthra...
476
Conserved; Drug target functions
Phase 3: June 2008
2C2A
15.5%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04662
(
show subtarget assignments
)
1
cloned
No
GBAA0650
47525929
sensor histidine kinase [Bacillus anthra...
463
putative drug target function;
Phase 4: April 2009
2C2A
17.9%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04431
(
show subtarget assignments
)
1
cloned
No
GBAA5088
47530387
sensor histidine kinase [Bacillus anthra...
340
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
18.5%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP04674
(
show subtarget assignments
)
1
expressed
No
GBAA1956
47527252
sensor histidine kinase [Bacillus anthra...
351
putative drug target function;
Phase 4: April 2009
3A0R
23.1%
Bacillus anthracis
Regulatory functions
Protein interactions
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