Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP91823 (show subtarget assignments)	8	soluble	No	b1854	1788160	pykA	pyruvate kinase II [Escherichia coli str...	480	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	2E28	40.6%	Escherichia coli

IDP90253 (show subtarget assignments)	0	work_stopped	No	SAR1776	49483939	pyk	pyruvate kinase [Staphylococcus aureus s...	585	(From requester) Potential drug target	Community Requests	3T05	100%	Staphylococcus aureus

IDP02363 (show subtarget assignments)	1	purified	No	FTT1366c	56708419	pyk	pyruvate kinase [Francisella tularensis ...	478	Conserved; Drug target functions	Phase 3: June 2008	1E0U	39.5%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00605 (show subtarget assignments)	0	work_stopped	No	SACOL1745	57284754	pyk	pyruvate kinase	585	Drug Target Function	Phase 2: March 2008	3T05	99.5%	Staphylococcus aureus	Energy metabolism	Glycolysis/gluconeogenesis

IDP00973 (show subtarget assignments)	1	purified	No	STM1756	16765100	purU	formyltetrahydrofolate deformylase	280	Conserved Gene / Pathway	Phase 2: March 2008	3O1L	42.7%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02449 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1775	16122029	purT	phosphoribosylglycinamide formyltransfer...	393	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1EYZ	78.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04418 (show subtarget assignments)	1	purified	No	FTT1767c	56708762	purT	phosphoribosylglycinamide formyltransfer...	386	conserved gene; putative drug target function;	Phase 4: April 2009	1EYZ	53.4%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04516 (show subtarget assignments)	1	cloned	No	CPF_2815	110800431	purR	purine operon repressor [Clostridium per...	267	conserved gene; putative drug target function;	Phase 4: April 2009	1O57	40.8%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90827 (show subtarget assignments)	8	expressed	No	Cj0514	15791876	purQ	phosphoribosylformylglycinamidine syntha...	223	Predicted Essential	Community Requests	3D54	40.4%	Campylobacter jejuni

IDP04644 (show subtarget assignments)	1	cloned	No	FTT0895	56707996	purN	phosphoribosylglycinamide formyltransfer...	191	conserved gene;	Phase 4: April 2009	1C2T	40.3%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04477 (show subtarget assignments)	1	soluble	No	YPO2829	115348505	purN	putative phosphoribosylglycinamide formy...	212	conserved gene; putative drug target function;	Phase 4: April 2009	2GAR	71.7%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90536 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0187c	15791574	purN	phosphoribosylglycinamide formyltransfer...	188	Predicted Essential	Community Requests	1C2T	38.6%	Campylobacter jejuni

IDP04229 (show subtarget assignments)	1	purified	No	CPF_0676	110798651	purN	phosphoribosylglycinamide formyltransfer...	204	conserved gene; putative drug target function;	Phase 4: April 2009	2YWR	42.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04228 (show subtarget assignments)	1	cloned	No	CPF_0675	110800755	purM	phosphoribosylaminoimidazole synthetase ...	333	conserved gene; putative drug target function;	Phase 4: April 2009	2BTU	54.9%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04643 (show subtarget assignments)	1	in_pdb 3M84 3QTY	No	FTT0893	56707994	purM	phosphoribosylaminoimidazole synthetase ...	347	conserved gene;	Phase 4: April 2009	3M84	100%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90875 (show subtarget assignments)	8	purified	No	Cj1529c	15792837	purM	phosphoribosylaminoimidazole synthetase ...	329	Predicted Essential	Community Requests	3P4E	53.8%	Campylobacter jejuni

IDP04656 (show subtarget assignments)	1	cloned	No	FTT1720c	56708726	purL	phosphoribosylformylglycinamidine syntha...	1290	conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	55.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04400 (show subtarget assignments)	1	cloned	No	YPO2921	218929976	purL	phosphoribosylformylglycinamidine syntha...	1296	conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	82.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01906 (show subtarget assignments)	1	soluble	No	GBAA0294	47525557	purL	phosphoribosylformylglycinamidine syntha...	739	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3AC6	46.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90708 (show subtarget assignments)	8	cloned	No	Cj0955c	15792284	purL	phosphoribosylformylglycinamidine syntha...	728	Predicted Essential	Community Requests	3AC6	40.2%	Campylobacter jejuni

IDP04479 (show subtarget assignments)	1	purified	No	YPO3077	115348733	purK	phosphoribosylaminoimidazole carboxylase...	354	conserved gene; putative drug target function;	Phase 4: April 2009	1B6S	76.8%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00922 (show subtarget assignments)	1	soluble	No	STM0533	16763913	purK	phosphoribosylaminoimidazole carboxylase...	355	Conserved Gene / Pathway	Phase 2: March 2008	1B6S	88.2%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04645 (show subtarget assignments)	1	soluble	No	FTT0897	56707998	purK	phosphoribosylaminoimidazole carboxylase...	365	conserved gene; putative drug target function;	Phase 4: April 2009	3AW8	42.7%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04124 (show subtarget assignments)	1	crystallized	No	YPO2828	218929893	purI	phosphoribosylaminoimidazole synthetase ...	347	conserved gene; putative drug target function;	Phase 4: April 2009	1CLI	81.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90570 (show subtarget assignments)	8	in_pdb 4EHI	No	Cj0953c	15792282	purH	bifunctional phosphoribosylaminoimidazol...	510	Predicted Essential	Community Requests	3ZZM	39.2%	Campylobacter jejuni

IDP02302 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0203c	56707367	purH	bifunctional phosphoribosylaminoimidazol...	515	Drug Target	Phase 3: June 2008	3ZZM	47.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04407 (show subtarget assignments)	1	cloned	No	CPF_0677	110799553	purH	bifunctional phosphoribosylaminoimidazol...	501	conserved gene; putative drug target function;	Phase 4: April 2009	3ZZM	41.1%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04489 (show subtarget assignments)	1	cloned	No	YPO3728	115349344	purH	bifunctional purine biosynthesis protein...	529	conserved gene; putative drug target function;	Phase 4: April 2009	3ZZM	44.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04541 (show subtarget assignments)	1	cloned	No	CPF_0674	110800675	purF	amidophosphoribosyltransferase [Clostrid...	473	conserved gene; putative drug target function;	Phase 4: April 2009	1AO0	44.6%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02568 (show subtarget assignments)	1	cloned	No	GBAA0295	47525558	purF	amidophosphoribosyltransferase [Bacillus...	471	Drug target motif; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1AO0	69.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04657 (show subtarget assignments)	1	expressed	No	FTT1721c	56708727	purF	amidophosphoribosyltransferase [Francise...	496	conserved gene; putative drug target function;	Phase 4: April 2009	1ECB	55.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90700 (show subtarget assignments)	8	soluble	No	Cj0196c	15791583	purF	amidophosphoribosyltransferase [Campylob...	445	Predicted Essential	Community Requests	1AO0	46.3%	Campylobacter jejuni

IDP00665 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1079	57285865	purF	amidophosphoribosyltransferase	494	Drug Target Function	Phase 2: March 2008	1AO0	51%	Staphylococcus aureus	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04475 (show subtarget assignments)	1	cloned	No	YPO2772	115348455	purF	amidophosphoribosyltransferase [Yersinia...	505	drug target; virulence factor; conserved gene; putative drug target function;...	Phase 4: April 2009	1ECB	86.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90677 (show subtarget assignments)	8	crystallized	No	Cj0702	15792051	purE	phosphoribosylaminoimidazole carboxylase...	164	Predicted Essential	Community Requests	3TRH	53.7%	Campylobacter jejuni

IDP02536 (show subtarget assignments)	1	in_pdb 3KUU	No	YPO3076	16123253	purE	phosphoribosylaminoimidazole carboxylase...	174	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3KUU	99.4%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04300 (show subtarget assignments)	1	purified	No	CPF_0672	110798984	purE	phosphoribosylaminoimidazole carboxylase...	159	conserved gene; putative drug target function;	Phase 4: April 2009	1O4V	51.6%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00880 (show subtarget assignments)	0	work_stopped	No	STM0534	16763914	purE	phosphoribosylaminoimidazole carboxylase...	169	Conserved Gene / Pathway	Phase 2: March 2008	1QCZ	95.3%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04072 (show subtarget assignments)	1	in_pdb 3OOW 3OPQ	No	FTT0896	56707997	purE	phosphoribosylaminoimidazole carboxylase...	163	conserved gene; putative drug target function;	Phase 4: April 2009	3OOW	100%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04230 (show subtarget assignments)	1	purified	No	CPF_0678	110801134	purD	phosphoribosylamine--glycine ligase [Clo...	416	conserved gene; putative drug target function;	Phase 4: April 2009	2YW2	51.1%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04490 (show subtarget assignments)	1	in_pdb 3MJF	No	YPO3729	218930734	purD	phosphoribosylamine--glycine ligase [Yer...	428	conserved gene; putative drug target function;	Phase 4: April 2009	3MJF	100%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90869 (show subtarget assignments)	8	cloned	No	Cj1250	15792574	purD	phosphoribosylamine--glycine ligase [Cam...	416	Predicted Essential	Community Requests	1VKZ	42.3%	Campylobacter jejuni

IDP02239 (show subtarget assignments)	1	expressed	No	GBAA0299	47525562	purD	phosphoribosylamine--glycine ligase [Bac...	423	Conserved; Drug target functions	Phase 3: June 2008	2YRW	64.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04357 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0894	56707995	purCD	fusion protein PurC/PurD [Francisella tu...	770	conserved gene; putative drug target function;	Phase 4: April 2009	2YRW	20.3%	Francisella tularensis

IDP04362 (show subtarget assignments)	1	soluble	No	YPO3059	218930104	purC	phosphoribosylaminoimidazole-succinocarb...	237	conserved gene; putative drug target function;	Phase 4: April 2009	2GQR	86.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04560 (show subtarget assignments)	1	in_pdb 3NUA	Yes	CPF_0673	110799762	purC	phosphoribosylaminoimidazole-succinocarb...	235	conserved gene; putative drug target function;	Phase 4: April 2009	3NUA	100%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90788 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0512	15791874	purC	phosphoribosylaminoimidazole-succinocarb...	236	Predicted Essential	Community Requests	3NUA	50.8%	Campylobacter jejuni

IDP04633 (show subtarget assignments)	1	in_pdb 4EEI	No	FTT0015	56707195	purB	adenylosuccinate lyase [Francisella tula...	432	conserved gene; putative drug target function;	Phase 4: April 2009	4EEI	100%	Francisella tularensis

IDP04255 (show subtarget assignments)	1	cloned	No	CPF_1922	110799469	purB	adenylosuccinate lyase [Clostridium perf...	476	conserved gene; putative drug target function;	Phase 4: April 2009	2J91	56.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01765 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5716	47531053	purA	adenylosuccinate synthetase [Bacillus an...	429	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GIM	47.1%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04208 (show subtarget assignments)	1	purified	No	CPF_2958	110799195	purA	adenylosuccinate synthetase [Clostridium...	428	conserved gene; putative drug target function;	Phase 4: April 2009	1IWE	47.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04312 (show subtarget assignments)	1	cloned	No	FTT0204	56707368	purA	adenylosuccinate synthetase [Francisella...	428	conserved gene;	Phase 4: April 2009	1ADE	45.9%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00422 (show subtarget assignments)	1	in_pdb 3HID	No	YPO0378	16120713	purA	adenylosuccinate synthetase	432	Virulence Associated Factor	Phase 2: March 2008	3HID	100%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90608 (show subtarget assignments)	8	in_pdb 3R7T	No	Cj1498c	15792813	purA	adenylosuccinate synthetase [Campylobact...	416	Predicted Essential	Community Requests	3R7T	100%	Campylobacter jejuni

IDP02361 (show subtarget assignments)	1	expressed	No	CBU_1550	29542109	ptsP	phosphoenolpyruvate-protein phosphotrans...	759	Conserved; Drug target functions	Phase 3: June 2008	2HRO	28.3%	Coxiella burnetii	Signal transduction	PTS

IDP01052 (show subtarget assignments)	1	expressed	No	STM3324	16766619	ptsO	phosphohistidinoprotein-hexose phosphotr...	90	Conserved Gene / Pathway	Phase 2: March 2008	1JEM	34.4%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP91536 (show subtarget assignments)	0	work_stopped	No	SAR1057	49483247	ptsI	phosphoenolpyruvate-protein phosphotrans...	572	potential drug target / Protein is a proposed to be a S. aureus (MRSA252) drug target and having crystal...	Community Requests	2WQD	99%	Staphylococcus aureus

IDP01123 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4267	30258769	ptsI	phosphoenolpyruvate-protein phosphotrans...	570	Conserved Gene / Pathway	Phase 2: March 2008	2HRO	65.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01131 (show subtarget assignments)	1	in_pdb 3IHS	Yes	BA_5381	30259854	ptsH-2	phosphocarrier protein HPr	82	Conserved Gene / Pathway	Phase 2: March 2008	3IHS	100%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01227 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4268	30258770	ptsH-1	phosphocarrier protein HPr	87	Conserved Gene / Pathway	Phase 2: March 2008	1Y4Y	72.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02552 (show subtarget assignments)	1	expressed	No	CBU_0743	29541343	ptsH	phosphocarrier protein HPr [Coxiella bur...	89	Conserved; Drug target functions	Phase 3: June 2008	3LE1	46.1%	Coxiella burnetii	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP91826 (show subtarget assignments)	8	expressed	No	b2415	1788755	ptsH	phosphohistidinoprotein-hexose phosphotr...	85	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1GGR	100%	Escherichia coli

IDP00976 (show subtarget assignments)	1	in_crystallization_trials	No	STM1879	16765221	ptrB	protease 2	683	Drug Target Function	Phase 2: March 2008	2XE4	37.6%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00423 (show subtarget assignments)	1	soluble	No	YPO1019	16121320	ptrA	protease III precursor	962	Drug Target Function	Phase 2: March 2008	1Q2L	61.5%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01775 (show subtarget assignments)	1	cloned	No	Cj1331	15792654	ptmB	acylneuraminate cytidylyltransferase (fl...	235	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted Essential-...	Phase 3: June 2008	1EYR	28.9%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01741 (show subtarget assignments)	1	cloned	No	Cj1332	15792655	ptmA	flagellin modification protein A [Campyl...	256	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008	3QIV	30.2%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP02515 (show subtarget assignments)	1	cloned	No	YPO2567	16122785	pta	phosphate acetyltransferase [Yersinia pe...	717	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	1TD9	20.6%	Yersinia pestis	Energy metabolism	Fermentation

IDP01848 (show subtarget assignments)	1	cloned	No	FTT1754	56708752	pta	phosphate acetyltransferase [Francisella...	698	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1TD9	19.9%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP04389 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0617	110799796	pstS	phosphate ABC transporter, phosphate-bin...	276	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	32.6%	Clostridium perfringens	Transport and binding proteins	Anions

IDP04390 (show subtarget assignments)	1	cloned	No	CPF_0618	110799563	pstS	phosphate ABC transporter, phosphate-bin...	272	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	36.4%	Clostridium perfringens	Transport and binding proteins	Anions

IDP01067 (show subtarget assignments)	1	expressed	No	STM3854	16767138	pstB	phosphate transporter subunit	257	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	36.2%	Salmonella enterica	Transport and binding proteins	Anions

IDP01823 (show subtarget assignments)	1	in_crystallization_trials	No	YPPCP1.05c	16082684	pst	pesticin [Yersinia pestis CO92]	357	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulen...	Phase 3: June 2008	4AQN	100%	Yersinia pestis	Regulatory functions	Other

IDP90901 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3273	16123430	pssA	phosphatidylserine synthase [Yersinia pe...	452	Predicted Essential	Community Requests	3HSI	50.3%	Yersinia pestis

IDP91015 (show subtarget assignments)	8	selected	No	y2404	22126288	psn	pesticin/yersiniabactin outer membrane r...	673	TonB-dependent outer membrane receptor (yersiniabactin-binding)	Community Requests	1NQF	23.8%	Yersinia pestis

IDP91700 (show subtarget assignments)	8	selected	No	NP_002791	4506205	PSMB9	proteasome subunit beta type-9 proprotei...	219	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	3UNF	82.2%	Homo sapiens

IDP91225 (show subtarget assignments)	8	expressed	No	NT04EC4200	26110357	pshM	Putative general secretion pathway prote...	153	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli	Protein fate: Protein and peptide secretion and trafficking

IDP02229 (show subtarget assignments)	1	cloned	No	YPO1302	16121584	psaF	hypothetical protein YPO1302 [Yersinia p...	162	Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Energy metabolism	Photosynthesis

IDP02145 (show subtarget assignments)	1	cloned	No	YPO1301	16121583	psaE	putative regulatory protein [Yersinia pe...	214	Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Energy metabolism	Photosynthesis

IDP02281 (show subtarget assignments)	1	cloned	No	YPO1305	16121587	psaC	outer membrane usher protein PsaC precur...	837	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	3RFZ	36.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP02265 (show subtarget assignments)	1	cloned	No	YPO1303	16121585	psaA	pH 6 antigen precursor (antigen 4) (adhe...	158	Involved in virulence; Vaccine TargetDrug target functions	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP90686 (show subtarget assignments)	8	crystallized	No	Cj0918c	15792247	prsA	ribose-phosphate pyrophosphokinase [Camp...	309	Predicted Essential	Community Requests	3DAH	57.1%	Campylobacter jejuni

IDP02319 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1169	47526434	prsA	peptidylprolyl isomerase [Bacillus anthr...	285	Drug target motif; Drug target functions	Phase 3: June 2008	3RFW	29.5%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP04206 (show subtarget assignments)	1	cloned	No	CPF_2812	110799133	prsA	ribose-phosphate pyrophosphokinase [Clos...	319	conserved gene; putative drug target function;	Phase 4: April 2009	1DKR	63%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04253 (show subtarget assignments)	1	purified	No	CPF_1800	110800480	prs	phosphoribosylpyrophosphate synthetase [...	364	conserved gene; putative drug target function;	Phase 4: April 2009	2C4K	25.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02381 (show subtarget assignments)	1	expressed	No	GBAA2279	47527580	proV-1	glycine betaine/L-proline ABC transporte...	315	Conserved; Drug target functions	Phase 3: June 2008	1Z47	36.2%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP02339 (show subtarget assignments)	1	expressed	No	YPO2647	16122856	proV	glycine betaine/L-proline transport ATP-...	399	CD; Drug target functions	Phase 3: June 2008	3FVQ	25.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP05650 (show subtarget assignments)	1	soluble	No	Cj0543	6968007	proS	hypothetical protein Cj0539 [Campylobact...	569	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2J3L	42.8%	Campylobacter jejuni	Protein synthesis: tRNA aminoacylation

IDP90581 (show subtarget assignments)	8	soluble	No	Cj0543	15791904	proS	prolyl-tRNA synthetase [Campylobacter je...	569	Predicted Essential	Community Requests	2J3L	42.8%	Campylobacter jejuni

IDP90927 (show subtarget assignments)	8	in_crystallization_trials	No	YPO1068	16121369	proS	prolyl-tRNA synthetase [Yersinia pestis ...	572	Predicted Essential	Community Requests	2J3L	47.2%	Yersinia pestis

IDP05337 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1282	57651833	proS	prolyl-tRNA synthetase [Staphylococcus a...	567	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2J3L	55.7%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP05230 (show subtarget assignments)	1	soluble	No	lmo1319	16803359	proS	prolyl-tRNA synthetase [Listeria monocyt...	568	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2J3L	63%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP02492 (show subtarget assignments)	1	crystallized	No	FTT1559c	56708586	proC	pyrroline-5-carboxylate reductase [Franc...	274	Conserved; Drug target functions	Phase 3: June 2008	3TRI	37.6%	Francisella tularensis	Amino acid biosynthesis	Glutamate family

IDP02179 (show subtarget assignments)	1	soluble	No	CBU_2090	29542640	proC	pyrroline-5-carboxylate reductase [Coxie...	274	Conserved; Drug target functions	Phase 3: June 2008	3TRI	100%	Coxiella burnetii	Amino acid biosynthesis	Glutamate family

IDP01891 (show subtarget assignments)	1	purified	No	STM3464	16766752	prkB	putative phosphoribulokinase [Salmonella...	289	Conserved; Drug target functions	Phase 3: June 2008	1A7J	50.5%	Salmonella enterica	Energy metabolism	Sugars

IDP02096 (show subtarget assignments)	1	cloned	No	YPO0178	16120519	prk	phosphoribulokinase 1 [Yersinia pestis C...	289	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1A7J	49.5%	Yersinia pestis	Energy metabolism	Photosynthesis

IDP90937 (show subtarget assignments)	8	cloned	No	YPO0110	16120456	priA	primosome assembly protein PriA	732	Predicted Essential	Community Requests	2EYQ	9.4%	Yersinia pestis

IDP91925 (show subtarget assignments)	8	selected	No	SpneCM_010100003175	298254600	prfC	peptide chain release factor 3 [Streptoc...	514	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3TR5	48.1%	Streptococcus pneumoniae

IDP02659 (show subtarget assignments)	1	cloned	No	lmo0988	16803028	prfC	peptide chain release factor 3 [Listeria...	522	Predicted virulence-Regulation	Phase 3: June 2008	3TR5	48.5%	Listeria monocytogenes	Protein synthesis	Translation factors

IDP01645 (show subtarget assignments)	1	soluble	No	lmo2509	16804547	prfB	peptide chain release factor 2 [Listeria...	327	Predicted virulence-Regulation; Possible Vaccine Candidate	Phase 3: June 2008	2B9M	49.2%	Listeria monocytogenes	Protein synthesis	Translation factors

IDP02047 (show subtarget assignments)	0	work_stopped	No	STM3041c	39546356	prfB	peptide chain release factor 2 [Salmonel...	358	Essential; Drug target functions	Phase 3: June 2008	1GQE	91.9%	Salmonella enterica	N/A	N/A

IDP91823
(show subtarget assignments)

8

soluble

No

b1854

1788160

pykA

pyruvate kinase II [Escherichia coli str...

480

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

2E28

40.6%

Escherichia coli

IDP90253
(show subtarget assignments)

0

work_stopped

No

SAR1776

49483939

pyk

pyruvate kinase [Staphylococcus aureus s...

585

(From requester) Potential drug target

Community Requests

3T05

100%

Staphylococcus aureus

IDP02363
(show subtarget assignments)

1

purified

No

FTT1366c

56708419

pyk

pyruvate kinase [Francisella tularensis ...

478

Conserved; Drug target functions

Phase 3: June 2008

1E0U

39.5%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP00605
(show subtarget assignments)

0

work_stopped

No

SACOL1745

57284754

pyk

pyruvate kinase

585

Drug Target Function

Phase 2: March 2008

3T05

99.5%

Staphylococcus aureus

Energy metabolism

Glycolysis/gluconeogenesis

IDP00973
(show subtarget assignments)

1

purified

No

STM1756

16765100

purU

formyltetrahydrofolate deformylase

280

Conserved Gene / Pathway

Phase 2: March 2008

3O1L

42.7%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02449
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1775

16122029

purT

phosphoribosylglycinamide formyltransfer...

393

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1EYZ

78.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04418
(show subtarget assignments)

1

purified

No

FTT1767c

56708762

purT

phosphoribosylglycinamide formyltransfer...

386

conserved gene; putative drug target function;

Phase 4: April 2009

1EYZ

53.4%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04516
(show subtarget assignments)

1

cloned

No

CPF_2815

110800431

purR

purine operon repressor [Clostridium per...

267

conserved gene; putative drug target function;

Phase 4: April 2009

1O57

40.8%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90827
(show subtarget assignments)

8

expressed

No

Cj0514

15791876

purQ

phosphoribosylformylglycinamidine syntha...

223

Predicted Essential

Community Requests

3D54

40.4%

Campylobacter jejuni

IDP04644
(show subtarget assignments)

1

cloned

No

FTT0895

56707996

purN

phosphoribosylglycinamide formyltransfer...

191

conserved gene;

Phase 4: April 2009

1C2T

40.3%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04477
(show subtarget assignments)

1

soluble

No

YPO2829

115348505

purN

putative phosphoribosylglycinamide formy...

212

conserved gene; putative drug target function;

Phase 4: April 2009

2GAR

71.7%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90536
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0187c

15791574

purN

phosphoribosylglycinamide formyltransfer...

188

Predicted Essential

Community Requests

1C2T

38.6%

Campylobacter jejuni

IDP04229
(show subtarget assignments)

1

purified

No

CPF_0676

110798651

purN

phosphoribosylglycinamide formyltransfer...

204

conserved gene; putative drug target function;

Phase 4: April 2009

2YWR

42.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04228
(show subtarget assignments)

1

cloned

No

CPF_0675

110800755

purM

phosphoribosylaminoimidazole synthetase ...

333

conserved gene; putative drug target function;

Phase 4: April 2009

2BTU

54.9%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04643
(show subtarget assignments)

1

in_pdb
3M84
3QTY

No

FTT0893

56707994

purM

phosphoribosylaminoimidazole synthetase ...

347

conserved gene;

Phase 4: April 2009

3M84

100%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90875
(show subtarget assignments)

8

purified

No

Cj1529c

15792837

purM

phosphoribosylaminoimidazole synthetase ...

329

Predicted Essential

Community Requests

3P4E

53.8%

Campylobacter jejuni

IDP04656
(show subtarget assignments)

1

cloned

No

FTT1720c

56708726

purL

phosphoribosylformylglycinamidine syntha...

1290

conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

55.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04400
(show subtarget assignments)

1

cloned

No

YPO2921

218929976

purL

phosphoribosylformylglycinamidine syntha...

1296

conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

82.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01906
(show subtarget assignments)

1

soluble

No

GBAA0294

47525557

purL

phosphoribosylformylglycinamidine syntha...

739

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3AC6

46.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90708
(show subtarget assignments)

8

cloned

No

Cj0955c

15792284

purL

phosphoribosylformylglycinamidine syntha...

728

Predicted Essential

Community Requests

3AC6

40.2%

Campylobacter jejuni

IDP04479
(show subtarget assignments)

1

purified

No

YPO3077

115348733

purK

phosphoribosylaminoimidazole carboxylase...

354

conserved gene; putative drug target function;

Phase 4: April 2009

1B6S

76.8%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00922
(show subtarget assignments)

1

soluble

No

STM0533

16763913

purK

phosphoribosylaminoimidazole carboxylase...

355

Conserved Gene / Pathway

Phase 2: March 2008

1B6S

88.2%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04645
(show subtarget assignments)

1

soluble

No

FTT0897

56707998

purK

phosphoribosylaminoimidazole carboxylase...

365

conserved gene; putative drug target function;

Phase 4: April 2009

3AW8

42.7%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04124
(show subtarget assignments)

1

crystallized

No

YPO2828

218929893

purI

phosphoribosylaminoimidazole synthetase ...

347

conserved gene; putative drug target function;

Phase 4: April 2009

1CLI

81.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90570
(show subtarget assignments)

8

in_pdb
4EHI

No

Cj0953c

15792282

purH

bifunctional phosphoribosylaminoimidazol...

510

Predicted Essential

Community Requests

3ZZM

39.2%

Campylobacter jejuni

IDP02302
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0203c

56707367

purH

bifunctional phosphoribosylaminoimidazol...

515

Drug Target

Phase 3: June 2008

3ZZM

47.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04407
(show subtarget assignments)

1

cloned

No

CPF_0677

110799553

purH

bifunctional phosphoribosylaminoimidazol...

501

conserved gene; putative drug target function;

Phase 4: April 2009

3ZZM

41.1%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04489
(show subtarget assignments)

1

cloned

No

YPO3728

115349344

purH

bifunctional purine biosynthesis protein...

529

conserved gene; putative drug target function;

Phase 4: April 2009

3ZZM

44.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04541
(show subtarget assignments)

1

cloned

No

CPF_0674

110800675

purF

amidophosphoribosyltransferase [Clostrid...

473

conserved gene; putative drug target function;

Phase 4: April 2009

1AO0

44.6%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02568
(show subtarget assignments)

1

cloned

No

GBAA0295

47525558

purF

amidophosphoribosyltransferase [Bacillus...

471

Drug target motif; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1AO0

69.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04657
(show subtarget assignments)

1

expressed

No

FTT1721c

56708727

purF

amidophosphoribosyltransferase [Francise...

496

conserved gene; putative drug target function;

Phase 4: April 2009

1ECB

55.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90700
(show subtarget assignments)

8

soluble

No

Cj0196c

15791583

purF

amidophosphoribosyltransferase [Campylob...

445

Predicted Essential

Community Requests

1AO0

46.3%

Campylobacter jejuni

IDP00665
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1079

57285865

purF

amidophosphoribosyltransferase

494

Drug Target Function

Phase 2: March 2008

1AO0

51%

Staphylococcus aureus

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04475
(show subtarget assignments)

1

cloned

No

YPO2772

115348455

purF

amidophosphoribosyltransferase [Yersinia...

505

drug target; virulence factor; conserved gene; putative drug target function;...

Phase 4: April 2009

1ECB

86.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90677
(show subtarget assignments)

8

crystallized

No

Cj0702

15792051

purE

phosphoribosylaminoimidazole carboxylase...

164

Predicted Essential

Community Requests

3TRH

53.7%

Campylobacter jejuni

IDP02536
(show subtarget assignments)

1

in_pdb
3KUU

No

YPO3076

16123253

purE

phosphoribosylaminoimidazole carboxylase...

174

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3KUU

99.4%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04300
(show subtarget assignments)

1

purified

No

CPF_0672

110798984

purE

phosphoribosylaminoimidazole carboxylase...

159

conserved gene; putative drug target function;

Phase 4: April 2009

1O4V

51.6%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00880
(show subtarget assignments)

0

work_stopped

No

STM0534

16763914

purE

phosphoribosylaminoimidazole carboxylase...

169

Conserved Gene / Pathway

Phase 2: March 2008

1QCZ

95.3%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04072
(show subtarget assignments)

1

in_pdb
3OOW
3OPQ

No

FTT0896

56707997

purE

phosphoribosylaminoimidazole carboxylase...

163

conserved gene; putative drug target function;

Phase 4: April 2009

3OOW

100%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04230
(show subtarget assignments)

1

purified

No

CPF_0678

110801134

purD

phosphoribosylamine--glycine ligase [Clo...

416

conserved gene; putative drug target function;

Phase 4: April 2009

2YW2

51.1%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04490
(show subtarget assignments)

1

in_pdb
3MJF

No

YPO3729

218930734

purD

phosphoribosylamine--glycine ligase [Yer...

428

conserved gene; putative drug target function;

Phase 4: April 2009

3MJF

100%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90869
(show subtarget assignments)

8

cloned

No

Cj1250

15792574

purD

phosphoribosylamine--glycine ligase [Cam...

416

Predicted Essential

Community Requests

1VKZ

42.3%

Campylobacter jejuni

IDP02239
(show subtarget assignments)

1

expressed

No

GBAA0299

47525562

purD

phosphoribosylamine--glycine ligase [Bac...

423

Conserved; Drug target functions

Phase 3: June 2008

2YRW

64.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04357
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0894

56707995

purCD

fusion protein PurC/PurD [Francisella tu...

770

conserved gene; putative drug target function;

Phase 4: April 2009

2YRW

20.3%

Francisella tularensis

IDP04362
(show subtarget assignments)

1

soluble

No

YPO3059

218930104

purC

phosphoribosylaminoimidazole-succinocarb...

237

conserved gene; putative drug target function;

Phase 4: April 2009

2GQR

86.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04560
(show subtarget assignments)

1

in_pdb
3NUA

Yes

CPF_0673

110799762

purC

phosphoribosylaminoimidazole-succinocarb...

235

conserved gene; putative drug target function;

Phase 4: April 2009

3NUA

100%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90788
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0512

15791874

purC

phosphoribosylaminoimidazole-succinocarb...

236

Predicted Essential

Community Requests

3NUA

50.8%

Campylobacter jejuni

IDP04633
(show subtarget assignments)

1

in_pdb
4EEI

No

FTT0015

56707195

purB

adenylosuccinate lyase [Francisella tula...

432

conserved gene; putative drug target function;

Phase 4: April 2009

4EEI

100%

Francisella tularensis

IDP04255
(show subtarget assignments)

1

cloned

No

CPF_1922

110799469

purB

adenylosuccinate lyase [Clostridium perf...

476

conserved gene; putative drug target function;

Phase 4: April 2009

2J91

56.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01765
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5716

47531053

purA

adenylosuccinate synthetase [Bacillus an...

429

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GIM

47.1%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04208
(show subtarget assignments)

1

purified

No

CPF_2958

110799195

purA

adenylosuccinate synthetase [Clostridium...

428

conserved gene; putative drug target function;

Phase 4: April 2009

1IWE

47.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04312
(show subtarget assignments)

1

cloned

No

FTT0204

56707368

purA

adenylosuccinate synthetase [Francisella...

428

conserved gene;

Phase 4: April 2009

1ADE

45.9%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00422
(show subtarget assignments)

1

in_pdb
3HID

No

YPO0378

16120713

purA

adenylosuccinate synthetase

432

Virulence Associated Factor

Phase 2: March 2008

3HID

100%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90608
(show subtarget assignments)

8

in_pdb
3R7T

No

Cj1498c

15792813

purA

adenylosuccinate synthetase [Campylobact...

416

Predicted Essential

Community Requests

3R7T

100%

Campylobacter jejuni

IDP02361
(show subtarget assignments)

1

expressed

No

CBU_1550

29542109

ptsP

phosphoenolpyruvate-protein phosphotrans...

759

Conserved; Drug target functions

Phase 3: June 2008

2HRO

28.3%

Coxiella burnetii

Signal transduction

PTS

IDP01052
(show subtarget assignments)

1

expressed

No

STM3324

16766619

ptsO

phosphohistidinoprotein-hexose phosphotr...

90

Conserved Gene / Pathway

Phase 2: March 2008

1JEM

34.4%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP91536
(show subtarget assignments)

0

work_stopped

No

SAR1057

49483247

ptsI

phosphoenolpyruvate-protein phosphotrans...

572

potential drug target / Protein is a proposed to be a S. aureus (MRSA252) drug target and having crystal...

Community Requests

2WQD

99%

Staphylococcus aureus

IDP01123
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4267

30258769

ptsI

phosphoenolpyruvate-protein phosphotrans...

570

Conserved Gene / Pathway

Phase 2: March 2008

2HRO

65.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01131
(show subtarget assignments)

1

in_pdb
3IHS

Yes

BA_5381

30259854

ptsH-2

phosphocarrier protein HPr

82

Conserved Gene / Pathway

Phase 2: March 2008

3IHS

100%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01227
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4268

30258770

ptsH-1

phosphocarrier protein HPr

87

Conserved Gene / Pathway

Phase 2: March 2008

1Y4Y

72.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02552
(show subtarget assignments)

1

expressed

No

CBU_0743

29541343

ptsH

phosphocarrier protein HPr [Coxiella bur...

89

Conserved; Drug target functions

Phase 3: June 2008

3LE1

46.1%

Coxiella burnetii

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP91826
(show subtarget assignments)

8

expressed

No

b2415

1788755

ptsH

phosphohistidinoprotein-hexose phosphotr...

85

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1GGR

100%

Escherichia coli

IDP00976
(show subtarget assignments)

1

in_crystallization_trials

No

STM1879

16765221

ptrB

protease 2

683

Drug Target Function

Phase 2: March 2008

2XE4

37.6%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00423
(show subtarget assignments)

1

soluble

No

YPO1019

16121320

ptrA

protease III precursor

962

Drug Target Function

Phase 2: March 2008

1Q2L

61.5%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01775
(show subtarget assignments)

1

cloned

No

Cj1331

15792654

ptmB

acylneuraminate cytidylyltransferase (fl...

235

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted Essential-...

Phase 3: June 2008

1EYR

28.9%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01741
(show subtarget assignments)

1

cloned

No

Cj1332

15792655

ptmA

flagellin modification protein A [Campyl...

256

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

3QIV

30.2%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP02515
(show subtarget assignments)

1

cloned

No

YPO2567

16122785

pta

phosphate acetyltransferase [Yersinia pe...

717

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

1TD9

20.6%

Yersinia pestis

Energy metabolism

Fermentation

IDP01848
(show subtarget assignments)

1

cloned

No

FTT1754

56708752

pta

phosphate acetyltransferase [Francisella...

698

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1TD9

19.9%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP04389
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0617

110799796

pstS

phosphate ABC transporter, phosphate-bin...

276

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

32.6%

Clostridium perfringens

Transport and binding proteins

Anions

IDP04390
(show subtarget assignments)

1

cloned

No

CPF_0618

110799563

pstS

phosphate ABC transporter, phosphate-bin...

272

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

36.4%

Clostridium perfringens

Transport and binding proteins

Anions

IDP01067
(show subtarget assignments)

1

expressed

No

STM3854

16767138

pstB

phosphate transporter subunit

257

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

36.2%

Salmonella enterica

Transport and binding proteins

Anions

IDP01823
(show subtarget assignments)

1

in_crystallization_trials

No

YPPCP1.05c

16082684

pst

pesticin [Yersinia pestis CO92]

357

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulen...

Phase 3: June 2008

4AQN

100%

Yersinia pestis

Regulatory functions

Other

IDP90901
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3273

16123430

pssA

phosphatidylserine synthase [Yersinia pe...

452

Predicted Essential

Community Requests

3HSI

50.3%

Yersinia pestis

IDP91015
(show subtarget assignments)

8

selected

No

y2404

22126288

psn

pesticin/yersiniabactin outer membrane r...

673

TonB-dependent outer membrane receptor (yersiniabactin-binding)

Community Requests

1NQF

23.8%

Yersinia pestis

IDP91700
(show subtarget assignments)

8

selected

No

NP_002791

4506205

PSMB9

proteasome subunit beta type-9 proprotei...

219

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

3UNF

82.2%

Homo sapiens

IDP91225
(show subtarget assignments)

8

expressed

No

NT04EC4200

26110357

pshM

Putative general secretion pathway prote...

153

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

Protein fate: Protein and peptide secretion and trafficking

IDP02229
(show subtarget assignments)

1

cloned

No

YPO1302

16121584

psaF

hypothetical protein YPO1302 [Yersinia p...

162

Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Energy metabolism

Photosynthesis

IDP02145
(show subtarget assignments)

1

cloned

No

YPO1301

16121583

psaE

putative regulatory protein [Yersinia pe...

214

Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Energy metabolism

Photosynthesis

IDP02281
(show subtarget assignments)

1

cloned

No

YPO1305

16121587

psaC

outer membrane usher protein PsaC precur...

837

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

3RFZ

36.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02265
(show subtarget assignments)

1

cloned

No

YPO1303

16121585

psaA

pH 6 antigen precursor (antigen 4) (adhe...

158

Involved in virulence; Vaccine TargetDrug target functions

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP90686
(show subtarget assignments)

8

crystallized

No

Cj0918c

15792247

prsA

ribose-phosphate pyrophosphokinase [Camp...

309

Predicted Essential

Community Requests

3DAH

57.1%

Campylobacter jejuni

IDP02319
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1169

47526434

prsA

peptidylprolyl isomerase [Bacillus anthr...

285

Drug target motif; Drug target functions

Phase 3: June 2008

3RFW

29.5%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP04206
(show subtarget assignments)

1

cloned

No

CPF_2812

110799133

prsA

ribose-phosphate pyrophosphokinase [Clos...

319

conserved gene; putative drug target function;

Phase 4: April 2009

1DKR

63%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04253
(show subtarget assignments)

1

purified

No

CPF_1800

110800480

prs

phosphoribosylpyrophosphate synthetase [...

364

conserved gene; putative drug target function;

Phase 4: April 2009

2C4K

25.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02381
(show subtarget assignments)

1

expressed

No

GBAA2279

47527580

proV-1

glycine betaine/L-proline ABC transporte...

315

Conserved; Drug target functions

Phase 3: June 2008

1Z47

36.2%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP02339
(show subtarget assignments)

1

expressed

No

YPO2647

16122856

proV

glycine betaine/L-proline transport ATP-...

399

CD; Drug target functions

Phase 3: June 2008

3FVQ

25.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP05650
(show subtarget assignments)

1

soluble

No

Cj0543

6968007

proS

hypothetical protein Cj0539 [Campylobact...

569

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2J3L

42.8%

Campylobacter jejuni

Protein synthesis: tRNA aminoacylation

IDP90581
(show subtarget assignments)

8

soluble

No

Cj0543

15791904

proS

prolyl-tRNA synthetase [Campylobacter je...

569

Predicted Essential

Community Requests

2J3L

42.8%

Campylobacter jejuni

IDP90927
(show subtarget assignments)

8

in_crystallization_trials

No

YPO1068

16121369

proS

prolyl-tRNA synthetase [Yersinia pestis ...

572

Predicted Essential

Community Requests

2J3L

47.2%

Yersinia pestis

IDP05337
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1282

57651833

proS

prolyl-tRNA synthetase [Staphylococcus a...

567

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2J3L

55.7%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP05230
(show subtarget assignments)

1

soluble

No

lmo1319

16803359

proS

prolyl-tRNA synthetase [Listeria monocyt...

568

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2J3L

63%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP02492
(show subtarget assignments)

1

crystallized

No

FTT1559c

56708586

proC

pyrroline-5-carboxylate reductase [Franc...

274

Conserved; Drug target functions

Phase 3: June 2008

3TRI

37.6%

Francisella tularensis

Amino acid biosynthesis

Glutamate family

IDP02179
(show subtarget assignments)

1

soluble

No

CBU_2090

29542640

proC

pyrroline-5-carboxylate reductase [Coxie...

274

Conserved; Drug target functions

Phase 3: June 2008

3TRI

100%

Coxiella burnetii

Amino acid biosynthesis

Glutamate family

IDP01891
(show subtarget assignments)

1

purified

No

STM3464

16766752

prkB

putative phosphoribulokinase [Salmonella...

289

Conserved; Drug target functions

Phase 3: June 2008

1A7J

50.5%

Salmonella enterica

Energy metabolism

Sugars

IDP02096
(show subtarget assignments)

1

cloned

No

YPO0178

16120519

prk

phosphoribulokinase 1 [Yersinia pestis C...

289

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1A7J

49.5%

Yersinia pestis

Energy metabolism

Photosynthesis

IDP90937
(show subtarget assignments)

8

cloned

No

YPO0110

16120456

priA

primosome assembly protein PriA

732

Predicted Essential

Community Requests

2EYQ

9.4%

Yersinia pestis

IDP91925
(show subtarget assignments)

8

selected

No

SpneCM_010100003175

298254600

prfC

peptide chain release factor 3 [Streptoc...

514

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3TR5

48.1%

Streptococcus pneumoniae

IDP02659
(show subtarget assignments)

1

cloned

No

lmo0988

16803028

prfC

peptide chain release factor 3 [Listeria...

522

Predicted virulence-Regulation

Phase 3: June 2008

3TR5

48.5%

Listeria monocytogenes

Protein synthesis

Translation factors

IDP01645
(show subtarget assignments)

1

soluble

No

lmo2509

16804547

prfB

peptide chain release factor 2 [Listeria...

327

Predicted virulence-Regulation; Possible Vaccine Candidate

Phase 3: June 2008

2B9M

49.2%

Listeria monocytogenes

Protein synthesis

Translation factors

IDP02047
(show subtarget assignments)

0

work_stopped

No

STM3041c

39546356

prfB

peptide chain release factor 2 [Salmonel...

358

Essential; Drug target functions

Phase 3: June 2008

1GQE

91.9%

Salmonella enterica

N/A

Targets