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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP91196
(
show subtarget assignments
)
8
soluble
No
BAS4097
49187095
-
Stage III sporulation protein AA
308
essential/virulence/pathogenesis /
Essential proteins
Community Requests
Bacillus anthracis
IDP04614
(
show subtarget assignments
)
1
purified
No
BAS4131
49187128
glycine cleavage system aminomethyltrans...
366
Proposed to be essential proteins
Phase 4: April 2009
1YX2
66.1%
Bacillus anthracis
IDP90222
(
show subtarget assignments
)
1
in_pdb
3H2Y
No
BAS4233
49187229
YqeH
GTP-binding protein YqeH, possibly invol...
368
YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess in...
January 2009
3H2Y
100%
Bacillus anthracis
IDP04730
(
show subtarget assignments
)
1
cloned
No
BAS4284
49187280
alanyl-tRNA synthetase [Bacillus anthrac...
880
Proposed to be essential proteins
Phase 4: April 2009
1RIQ
26.3%
Bacillus anthracis
IDP04615
(
show subtarget assignments
)
1
cloned
No
BAS4297
49187293
aspartyl-tRNA synthetase [Bacillus anthr...
591
Proposed to be essential proteins
Phase 4: April 2009
1EQR
52.7%
Bacillus anthracis
IDP04616
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS4313
49187308
S-adenosylmethionine:tRNA ribosyltransfe...
350
Proposed to be essential proteins
Phase 4: April 2009
1YY3
71.4%
Bacillus anthracis
IDP04311
(
show subtarget assignments
)
1
purified
No
BAS4340
49187335
50S ribosomal protein L27 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1VSA
55.2%
Bacillus anthracis
IDP04617
(
show subtarget assignments
)
1
expressed
No
BAS4342
49187337
50S ribosomal protein L21 [Bacillus anth...
102
Proposed to be essential proteins
Phase 4: April 2009
1VSA
54.9%
Bacillus anthracis
IDP91197
(
show subtarget assignments
)
8
soluble
No
BAS4345
49187340
-
stage IV sporulation protein FA
248
essential/virulence/pathogenesis /
Essential proteins
Community Requests
3TUF
10.9%
Bacillus anthracis
IDP04005
(
show subtarget assignments
)
1
purified
No
BAS4355
49187350
valyl-tRNA synthetase [Bacillus anthraci...
881
Proposed to be essential proteins
Phase 4: April 2009
1GAX
42.6%
Bacillus anthracis
IDP04067
(
show subtarget assignments
)
1
purified
No
BAS4417
49187412
thioredoxin [Bacillus anthracis str. Ste...
104
Proposed to be essential proteins
Phase 4: April 2009
2GZY
75%
Bacillus anthracis
IDP05143
(
show subtarget assignments
)
1
cloned
No
BAS4423
49187418
-
triple helix repeat-containing collagen ...
312
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1WCK
27.6%
Bacillus anthracis
Unknown function: General
IDP05569
(
show subtarget assignments
)
1
soluble
No
BAS4454
49187449
-
asparaginyl-tRNA synthetase [Bacillus an...
463
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1X54
35.9%
Bacillus anthracis
Protein synthesis: tRNA aminoacylation
IDP04383
(
show subtarget assignments
)
1
purified
No
BAS4455
49187450
phenylalanyl-tRNA synthetase subunit bet...
806
Proposed to be essential proteins
Phase 4: April 2009
2RHS
49.8%
Bacillus anthracis
IDP04618
(
show subtarget assignments
)
1
cloned
No
BAS4456
49187451
phenylalanyl-tRNA synthetase subunit alp...
344
Proposed to be essential proteins
Phase 4: April 2009
2RHQ
57.6%
Bacillus anthracis
IDP04074
(
show subtarget assignments
)
1
cloned
No
BAS4469
49187464
50S ribosomal protein L20 [Bacillus anth...
118
Proposed to be essential proteins
Phase 4: April 2009
1VS6
55.1%
Bacillus anthracis
IDP04135
(
show subtarget assignments
)
1
cloned
No
BAS4470
49187465
50S ribosomal protein L35 [Bacillus anth...
66
Proposed to be essential proteins
Phase 4: April 2009
1VS6
48.5%
Bacillus anthracis
IDP05712
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS4472
49187467
-
threonyl-tRNA synthetase [Bacillus anthr...
645
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1NYQ
69.5%
Bacillus anthracis
Protein synthesis: tRNA aminoacylation
IDP04619
(
show subtarget assignments
)
1
in_pdb
4DIB
No
BAS4478
49187473
glyceraldehyde-3-phosphate dehydrogenase...
342
Proposed to be essential proteins
Phase 4: April 2009
4DIB
100%
Bacillus anthracis
IDP04620
(
show subtarget assignments
)
1
cloned
No
BAS4482
49187477
DNA polymerase I [Bacillus anthracis str...
891
Proposed to be essential proteins
Phase 4: April 2009
3TAN
45%
Bacillus anthracis
IDP04621
(
show subtarget assignments
)
1
cloned
No
BAS4494
49187489
acetyl-CoA carboxylase carboxyltransfera...
324
Proposed to be essential proteins
Phase 4: April 2009
2F9I
60.2%
Bacillus anthracis
IDP05144
(
show subtarget assignments
)
1
soluble
No
BAS4556
49187550
-
tyrosyl-tRNA synthetase [Bacillus anthra...
418
Known drug target or ortholog of known drug target
Phase 5: 2010
2TS1
70.6%
Bacillus anthracis
Protein synthesis: tRNA aminoacylation
IDP04622
(
show subtarget assignments
)
1
soluble
No
BAS4556
49187550
tyrosyl-tRNA synthetase [Bacillus anthra...
418
potential drug target /
Proposed to be essential proteins
Phase 4: April 2009
2TS1
70.6%
Bacillus anthracis
IDP04027
(
show subtarget assignments
)
1
cloned
No
BAS4637
49187628
leucyl-tRNA synthetase [Bacillus anthrac...
802
Proposed to be essential proteins
Phase 4: April 2009
1H3N
45.9%
Bacillus anthracis
IDP05024
(
show subtarget assignments
)
1
soluble
No
BAS4675
49187666
-
ABC transporter, substrate-binding prote...
325
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3IX1
20.6%
Bacillus anthracis
Unclassified: Role category not yet assigned
IDP05145
(
show subtarget assignments
)
1
soluble
No
BAS4679
49187670
-
hypothetical protein BAS4679 [Bacillus a...
357
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP90228
(
show subtarget assignments
)
1
in_pdb
3T5P
3S40
No
BAS4713
49187704
-
Transcription regulator [contains diacyl...
300
Transcription regulator [contains diacylglycerol kinase catalytic domain]; Predi...
January 2009
3S40
100%
Bacillus anthracis
IDP05025
(
show subtarget assignments
)
1
cloned
No
BAS4742
49187733
-
hypothetical protein BAS4742 [Bacillus a...
200
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP04623
(
show subtarget assignments
)
1
expressed
No
BAS4760
49187751
glucose-1-phosphate adenylyltransferase ...
376
Proposed to be essential proteins
Phase 4: April 2009
3BRK
40%
Bacillus anthracis
IDP05146
(
show subtarget assignments
)
1
cloned
No
BAS4784
49187774
-
glycyl-tRNA synthetase [Bacillus anthrac...
458
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1ATI
43.2%
Bacillus anthracis
Protein synthesis: tRNA aminoacylation
IDP04396
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS4797
49187787
pyridine nucleotide-disulphide oxidoredu...
331
Proposed to be essential proteins
Phase 4: April 2009
3LZW
76.7%
Bacillus anthracis
IDP05573
(
show subtarget assignments
)
1
selected
No
BAS4798
49187788
-
cell surface protein, anchor [Bacillus a...
2025
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
DNA metabolism: DNA replication, recombination, and repair
IDP05147
(
show subtarget assignments
)
1
cloned
No
BAS4903
49187891
-
methionyl-tRNA synthetase [Bacillus anth...
544
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1RQG
38.7%
Bacillus anthracis
Protein synthesis: tRNA aminoacylation
IDP04624
(
show subtarget assignments
)
1
in_pdb
3B2B
3UWD
No
BAS4988
49187974
phosphoglycerate kinase [Bacillus anthra...
394
Proposed to be essential proteins
Phase 4: April 2009
3B2B
99.7%
Bacillus anthracis
IDP04625
(
show subtarget assignments
)
1
cloned
No
BAS5050
49188036
glycosyl transferase, group 4 family pro...
357
Proposed to be essential proteins
Phase 4: April 2009
Bacillus anthracis
IDP05570
(
show subtarget assignments
)
1
expressed
No
BAS5100
49188086
-
hypothetical protein BAS5100 [Bacillus a...
132
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP91198
(
show subtarget assignments
)
8
cloned
No
BAS5131
49188117
-
stage II sporulation protein
301
essential/virulence/pathogenesis /
Essential proteins
Community Requests
3TUF
33.6%
Bacillus anthracis
IDP04626
(
show subtarget assignments
)
1
cloned
No
BAS5178
49188164
peptide chain release factor 1 [Bacillus...
358
Proposed to be essential proteins
Phase 4: April 2009
1ZBT
59.2%
Bacillus anthracis
IDP05452
(
show subtarget assignments
)
1
cloned
No
BAS5207
49188193
-
collagen adhesion protein, C-terminal [B...
882
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3KPT
12.6%
Bacillus anthracis
Protein fate: Degradation of proteins, peptides, and glycopeptides
IDP05453
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS5213
49188199
-
arginyl-tRNA synthetase [Bacillus anthra...
556
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
3FNR
31.8%
Bacillus anthracis
Protein synthesis: tRNA aminoacylation
IDP04035
(
show subtarget assignments
)
1
in_pdb
3P0R
Yes
BAS5262
49188247
azoreductase [Bacillus anthracis str. St...
208
Proposed to be essential proteins
Phase 4: April 2009
3P0R
100%
Bacillus anthracis
IDP04024
(
show subtarget assignments
)
1
cloned
No
BAS5319
49188303
DNA-binding response regulator YycF [Bac...
235
Proposed to be essential proteins
Phase 4: April 2009
2OQR
47.7%
Bacillus anthracis
IDP04627
(
show subtarget assignments
)
8
cloned
No
BAS5321
49188305
replicative DNA helicase [Bacillus anthr...
453
Proposed to be essential proteins
Community Requests
2VYE
75.3%
Bacillus anthracis
IDP04628
(
show subtarget assignments
)
1
soluble
No
BAS5322
49188306
50S ribosomal protein L9 [Bacillus anthr...
148
Proposed to be essential proteins
Phase 4: April 2009
1DIV
75%
Bacillus anthracis
IDP04663
(
show subtarget assignments
)
1
cloned
No
BAS5325
49188309
30S ribosomal protein S18 [Bacillus anth...
77
Proposed to be essential proteins
Phase 4: April 2009
1P6G
50.6%
Bacillus anthracis
IDP04069
(
show subtarget assignments
)
1
in_pdb
3R3T
Yes
BAS5327
49188311
30S ribosomal protein S6 [Bacillus anthr...
96
Proposed to be essential proteins
Phase 4: April 2009
3R3T
100%
Bacillus anthracis
IDP04732
(
show subtarget assignments
)
1
cloned
No
BAS5341
49188325
50S ribosomal protein L34 [Bacillus anth...
44
Proposed to be essential proteins
Phase 4: April 2009
1NKW
65.9%
Bacillus anthracis
IDP90302
(
show subtarget assignments
)
0
work_stopped
No
BB_0420
2688313
sensory transduction histidine kinase, p...
1494
Mutational studies suggest that Hk1 is required for the survival of the Lyme dis...
Community Requests
3A0R
5.6%
Borrelia burgdorferi
IDP91203
(
show subtarget assignments
)
8
cloned
No
BLD_0429
189439292
aroE
Shikimate 5-dehydrogenase [Bifidobacteri...
323
potential drug target /
Shikimate pathway enzyme
Community Requests
1WXD
26%
Bifidobacterium longum
IDP91202
(
show subtarget assignments
)
8
in_pdb
3U80
No
BLD_0610
189439473
aroQ
3-dehydroquinate dehydratase [Bifidobact...
148
potential drug target /
Shikimate pathway enzyme
Community Requests
3U80
100%
Bifidobacterium longum
IDP91210
(
show subtarget assignments
)
8
expressed
No
BLIJ_0364
189439941
aroG2
phospho-2-dehydro-3-deoxyheptonate aldol...
377
potential drug target /
Shikimate pathway enzyme
Community Requests
1GG1
47.7%
Bifidobacterium longum
IDP91211
(
show subtarget assignments
)
8
purified
No
BLIJ_0365
189439940
aroG1
phospho-2-dehydro-3-deoxyheptonate aldol...
410
potential drug target /
Shikimate pathway enzyme
Community Requests
1HFB
44.1%
Bifidobacterium longum
IDP91212
(
show subtarget assignments
)
8
cloned
No
BLIJ_1793
189439586
aroA
3-phosphoshikimate 1-carboxyvinyltransfe...
445
potential drug target /
Shikimate pathway enzyme
Community Requests
2BJB
44.9%
Bifidobacterium longum
IDP91214
(
show subtarget assignments
)
8
expressed
No
Blon_1597
189439474
aroB
bifunctional shikimate kinase/3-dehydroq...
540
potential drug target /
Shikimate pathway enzyme
Community Requests
3QBD
32.6%
Bifidobacterium longum
IDP91213
(
show subtarget assignments
)
8
in_pdb
4ECD
No
Blon_1598
189439475
aroC
chorismate synthase [Bifidobacterium lon...
395
potential drug target /
Shikimate pathway enzyme
Community Requests
4ECD
100%
Bifidobacterium longum
IDP91079
(
show subtarget assignments
)
8
cloned
No
BMA0204
53725011
ABC transporter, ATP-binding/permease pr...
623
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
4AA3
32.8%
Burkholderia mallei
IDP91088
(
show subtarget assignments
)
8
cloned
No
BMA_2275
52429282
kdsB
3-deoxy-D-manno-octulosonate cytidylyltr...
263
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
3K8D
52.1%
Burkholderia mallei
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP91087
(
show subtarget assignments
)
8
expressed
No
BMA_3102
52427493
carbohydrate isomerase, KpsF/GutQ family...
327
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
2XHZ
30.9%
Burkholderia mallei
Energy metabolism: Sugars
IDP90946
(
show subtarget assignments
)
8
cloned
No
BP1878
33592926
bvgA
virulence factors transcription regulato...
209
BvgA is the transcriptional activator for all known virulence genes in the human...
Community Requests
3C3W
31.6%
Bordetella pertussis
IDP91093
(
show subtarget assignments
)
0
work_stopped
No
BPSL0538
52208591
conserved hypothetical protein [Burkhold...
327
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
2XHZ
30.9%
Burkholderia pseudomallei
IDP91096
(
show subtarget assignments
)
8
soluble
No
BPSL0876
52208929
kdsB
putative 3-deoxy-manno-octulosonate cyti...
278
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
3K8D
49.6%
Burkholderia pseudomallei
IDP91593
(
show subtarget assignments
)
8
expressed
No
BSU08430
16077910
yfiX
hypothetical protein BSU08430 [Bacillus ...
606
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Bacillus subtilis
IDP91199
(
show subtarget assignments
)
1
cloned
No
BSU40540
16081106
yybR
putative transcriptional regulator [Baci...
125
other biological interest /
YybR belongs to the MarR/DUF24 family of transcriptional regulators that are hig...
Community Requests
4A5M
100%
Bacillus subtilis
IDP91209
(
show subtarget assignments
)
8
expressed
No
BT_2084
29347494
chorismate synthase [Bacteroides thetaio...
358
potential drug target /
Shikimate pathway enzyme
Community Requests
1R52
47.9%
Bacteroides thetaiotaomicron
IDP91208
(
show subtarget assignments
)
8
purified
No
BT_2186
29347596
3-phosphoshikimate 1-carboxyvinyltransfe...
410
potential drug target /
Shikimate pathway enzyme
Community Requests
1EPS
36.2%
Bacteroides thetaiotaomicron
IDP91207
(
show subtarget assignments
)
8
soluble
No
BT_2842
29348251
3-dehydroquinate dehydratase [Bacteroide...
140
potential drug target /
Shikimate pathway enzyme
Community Requests
2C4W
49%
Bacteroides thetaiotaomicron
IDP91206
(
show subtarget assignments
)
8
in_pdb
3VAA
No
BT_3393
29348802
shikimate kinase [Bacteroides thetaiotao...
175
potential drug target /
Shikimate pathway enzyme
Community Requests
3VAA
100%
Bacteroides thetaiotaomicron
IDP91205
(
show subtarget assignments
)
8
soluble
No
BT_3975
29349383
3-dehydroquinate synthase [Bacteroides t...
353
potential drug target /
Shikimate pathway enzyme
Community Requests
3CLH
34.3%
Bacteroides thetaiotaomicron
IDP91204
(
show subtarget assignments
)
8
cloned
No
BT_4215
29349623
shikimate 5-dehydrogenase [Bacteroides t...
248
potential drug target /
Shikimate pathway enzyme
Community Requests
2HK7
38%
Bacteroides thetaiotaomicron
IDP91797
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAA23892
43749
neomycin phosphotransferase [Escherichia...
264
other biological interest /
Kinase
Community Requests
1ND4
100%
Escherichia coli
IDP91188
(
show subtarget assignments
)
1
crystallized
No
CAA24743
40923
unnamed protein product [Escherichia col...
341
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3OVC
100%
Escherichia coli
IDP91795
(
show subtarget assignments
)
8
purified
No
CAA24789
47034
unnamed protein product [Enterococcus fa...
264
other biological interest /
Kinase
Community Requests
1J7I
100%
Enterococcus faecalis
IDP91780
(
show subtarget assignments
)
8
cloned
No
CAA27977
48190
unnamed protein product [Enterococcus fa...
639
drug resistance /
Tetracycline resistance
Community Requests
1DAR
28.4%
Enterococcus faecalis
IDP91870
(
show subtarget assignments
)
8
selected
No
CAA30578
38663
unnamed protein product [Acinetobacter b...
259
drug resistance /
confers resistance to aminoglycoside antibiotics by phosphorylation
Community Requests
2BKK
34.4%
Acinetobacter baumannii
IDP91534
(
show subtarget assignments
)
8
selected
No
CAA36299
40706
major outer membrane protein precursor [...
395
vaccine candidate /
Vaccine formulation
Community Requests
Chlamydia trachomatis
IDP91186
(
show subtarget assignments
)
1
in_crystallization_trials
No
CAA37605
47078
unnamed protein product [Streptomyces gr...
272
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1ND4
39.8%
Streptomyces griseus
IDP91782
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAA38136
46982
fosB
fosB [Staphylococcus epidermidis]
139
drug resistance /
Fosfomycin resistance
Community Requests
3UH9
59.7%
Staphylococcus epidermidis
IDP92558
(
show subtarget assignments
)
8
selected
No
CAA87463
1065719
aadB
aminoglycoside adenylyltransferase [Esch...
177
drug resistance /
This enzyme is one of the most clinically widespread aminogylcoside-deactivating...
Community Requests
Escherichia coli
IDP91877
(
show subtarget assignments
)
8
selected
No
CAB89086
7649401
fox-4
beta-lactamase class C [Escherichia coli...
382
potential drug target /
Dissemination of plasmid-mediated class C ?-lactamases is currently a critical c...
Community Requests
1ZKJ
71.7%
Escherichia coli
IDP04538
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAC05770
12329039
ospB
OspB, protein secreted by the Mxi-Spa se...
288
Shigella effector protein
Community Requests
Shigella flexneri
IDP04539
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAC05775
12329044
ospD1
OspD1, secreted by the Mxi-Spa secretion...
225
Shigella effector protein
Community Requests
Shigella flexneri
IDP04537
(
show subtarget assignments
)
8
selected
No
CAC05780
12329049
virF
VirF, member of the AraC family of trans...
262
Shigella effector protein
Community Requests
3GBG
26.3%
Shigella flexneri
IDP04414
(
show subtarget assignments
)
8
selected
No
CAC05786
12329055
sepA
SepA, extracellular serine protease of t...
1364
Shigella effector protein
Community Requests
1WXR
34.9%
Shigella flexneri
IDP04336
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAC05790
12329059
ospC1
OspC1, secreted by the Mxi-Spa secretion...
470
Shigella effector protein
Community Requests
Shigella flexneri
IDP04381
(
show subtarget assignments
)
8
selected
No
CAC05791
12329060
unnamed protein product [Shigella flexne...
296
Shigella effector protein
Community Requests
3MKL
8.4%
Shigella flexneri
IDP04326
(
show subtarget assignments
)
8
purified
No
CAC05800
12329069
ipaA
IpaA, secreted by the Mxi-Spa machinery,...
633
Shigella effector protein
Community Requests
2FM8
10.7%
Shigella flexneri
IDP04224
(
show subtarget assignments
)
8
selected
No
CAC05802
12329071
ipaC
IpaC, secreted by the Mxi-Spa secretion ...
363
Shigella effector protein
Community Requests
Shigella flexneri
IDP04225
(
show subtarget assignments
)
8
cloned
No
CAC05803
12329072
ipaB
IpaB, secreted by the Mxi-Spa secretion ...
580
Shigella effector protein
Community Requests
3U0C
34.3%
Shigella flexneri
IDP04002
(
show subtarget assignments
)
8
selected
No
CAC05806
12329075
ipgA
IpgA, similarities to IpgE, putative cha...
129
Shigella effector protein
Community Requests
Shigella flexneri
IDP04075
(
show subtarget assignments
)
8
selected
No
CAC05807
12329076
icsB
IcsB, function unknown [Shigella flexner...
494
Shigella effector protein
Community Requests
Shigella flexneri
IDP04223
(
show subtarget assignments
)
8
selected
No
CAC05808
12329077
ipgD
IpgD, secreted by the Mxi-Spa machinery,...
538
Shigella effector protein
Community Requests
Shigella flexneri
IDP04306
(
show subtarget assignments
)
8
selected
No
CAC05809
12329078
ipgE
IpgE, cytoplasmic chaperone for IpgD [Sh...
120
Shigella effector protein
Community Requests
1K3S
27.5%
Shigella flexneri
IDP04558
(
show subtarget assignments
)
8
selected
No
CAC05811
12329080
mxiG
MxiG, component of the Mxi-Spa secretion...
371
Shigella effector protein
Community Requests
4A4Y
34%
Shigella flexneri
IDP04060
(
show subtarget assignments
)
8
selected
No
CAC05813
12329082
mxiI
MxiI, component of the Mxi-Spa secretion...
97
Shigella effector protein
Community Requests
Shigella flexneri
IDP04534
(
show subtarget assignments
)
8
selected
No
CAC05815
12329084
mxiK
MxiK, putative component of the Mxi-Spa ...
175
Shigella effector protein
Community Requests
Shigella flexneri
IDP04535
(
show subtarget assignments
)
8
selected
No
CAC05816
12329085
mxiN
MxiN, putative component of the Mxi-Spa ...
231
Shigella effector protein
Community Requests
Shigella flexneri
IDP04066
(
show subtarget assignments
)
8
selected
No
CAC05819
12329088
mxiE
MxiE, similarities to transcriptional ac...
210
Shigella effector protein
Community Requests
Shigella flexneri
IDP04117
(
show subtarget assignments
)
8
selected
No
CAC05825
12329094
spa13
spa13, component of the Mxi-Spa secretio...
112
Shigella effector protein
Community Requests
Shigella flexneri
IDP04536
(
show subtarget assignments
)
8
selected
No
CAC05826
12329095
spa32
Spa32, secreted by and component of the ...
292
Shigella effector protein
Community Requests
Shigella flexneri
IDP04222
(
show subtarget assignments
)
8
selected
No
CAC05827
12329096
spa33
Spa33, component of the Mxi-Spa secretio...
293
Shigella effector protein
Community Requests
Shigella flexneri
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