Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01428 (show subtarget assignments)	1	purified	No	VC1709	15641713		zinc protease, insulinase family	922	Drug Target Function	Phase 2: March 2008	3CWW	19%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90524 (show subtarget assignments)	8	purified	No	VC1730	15641734		DNA topoisomerase I [Vibrio cholerae O1 ...	876	Predicted Essential	Community Requests	1CY0	48.3%	Vibrio cholerae

IDP90626 (show subtarget assignments)	8	in_pdb 3TI2 3NVS	No	VC1732	15641736		3-phosphoshikimate 1-carboxyvinyltransfe...	426	Predicted Essential	Community Requests	3NVS	100%	Vibrio cholerae

IDP04401 (show subtarget assignments)	1	expressed	No	VC1831	15641833		sensor histidine kinase [Vibrio cholerae...	736	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10.2%	Vibrio cholerae	Regulatory functions	Other

IDP90673 (show subtarget assignments)	8	expressed	No	VC1833	15641835		quinolinate synthetase [Vibrio cholerae ...	353	Predicted Essential	Community Requests	1WZU	30.6%	Vibrio cholerae

IDP90577 (show subtarget assignments)	8	soluble	No	VC1848	15641850	cysS	cysteinyl-tRNA synthetase [Vibrio choler...	459	Predicted Essential	Community Requests	1LI5	75.1%	Vibrio cholerae

IDP01429 (show subtarget assignments)	1	in_crystallization_trials	No	VC1849	15641851		peptidyl-prolyl cis-trans isomerase B	164	Conserved Gene / Pathway	Phase 2: March 2008	1LOP	64%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01430 (show subtarget assignments)	1	in_crystallization_trials	No	VC1863	15641865		amino acid ABC transporter, periplasmic ...	260	Conserved Gene / Pathway	Phase 2: March 2008	1LAF	39.2%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01431 (show subtarget assignments)	1	purified	No	VC1864	15641866		amino acid ABC transporter, ATP-binding ...	256	Conserved Gene / Pathway	Phase 2: March 2008	1B0U	62.9%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP90521 (show subtarget assignments)	8	in_pdb 3OAM	No	VC1875	15641877		3-deoxy-manno-octulosonate cytidylyltran...	252	Predicted Essential	Community Requests	3OAM	100%	Vibrio cholerae

IDP01320 (show subtarget assignments)	1	purified	No	VC1883	15641885		ABC transporter, ATP-binding protein	228	Conserved Gene / Pathway	Phase 2: March 2008	2PCJ	45.6%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP91531 (show subtarget assignments)	8	soluble	No	VC1887	15641889		hypothetical protein VC1887 [Vibrio chol...	266	potential drug target / Vc1887 was found in a knockout screen for determinants of cell shape by action o...	Community Requests			Vibrio cholerae

IDP90525 (show subtarget assignments)	8	in_pdb 3UWQ 3LDV	No	VC1911	15641913		orotidine 5'-phosphate decarboxylase [Vi...	231	Predicted Essential	Community Requests	3LDV	100%	Vibrio cholerae

IDP01432 (show subtarget assignments)	1	cloned	No	VC1918	15641920		peptidyl-prolyl cis-trans isomerse D	619	Drug Target Function	Phase 2: March 2008	1M5Y	16%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01433 (show subtarget assignments)	1	purified	No	VC1922	15641924	clpP	ATP-dependent Clp protease proteolytic s...	200	Drug Target Function	Phase 2: March 2008	1TYF	76%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01434 (show subtarget assignments)	1	purified	No	VC1944	15641946		PvcB protein	287	Conserved Gene / Pathway	Phase 2: March 2008	3EAT	46%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP04033 (show subtarget assignments)	1	soluble	No	VC1950	15641952		biotin sulfoxide reductase [Vibrio chole...	815	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1E18	48.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01435 (show subtarget assignments)	1	purified	No	VC1956	15641958		lytic murein transglycosylase, putative ...	323	Drug Target Function	Phase 2: March 2008	4ANR	32.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01342 (show subtarget assignments)	1	soluble	No	VC1960	15641962		septum site-determining protein MinD	276	Conserved Gene / Pathway	Phase 2: March 2008	3Q9L	73.6%	Vibrio cholerae	Cellular processes	Cell division

IDP90633 (show subtarget assignments)	8	cloned	No	VC1971	15641973		O-succinylbenzoic acid--CoA ligase [Vibr...	476	Predicted Essential	Community Requests	2QVX	27.9%	Vibrio cholerae

IDP90609 (show subtarget assignments)	8	in_crystallization_trials	No	VC1972	15641974		O-succinylbenzoate synthase [Vibrio chol...	332	Predicted Essential	Community Requests	1FHU	54.2%	Vibrio cholerae

IDP01436 (show subtarget assignments)	1	crystallized	No	VC1976	15641978		menaquinone-specific isochorismate synth...	435	Drug Target Function	Phase 2: March 2008	3GSE	42.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01437 (show subtarget assignments)	1	purified	No	VC1983	15641985		peptidase, putative	615	Drug Target Function	Phase 2: March 2008			Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01438 (show subtarget assignments)	1	expressed	No	VC1993	15641995		2,4-dienoyl-CoA reductase	666	Drug Target Function	Phase 2: March 2008	1PS9	56.6%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Degradation

IDP90607 (show subtarget assignments)	8	purified	No	VC2015	15642017		DNA polymerase III subunit delta' [Vibri...	324	Predicted Essential	Community Requests	1A5T	33%	Vibrio cholerae

IDP90611 (show subtarget assignments)	8	in_pdb 3N2I 3LV8	Yes	VC2016	15642018	tmk	thymidylate kinase [Vibrio cholerae O1 b...	212	Predicted Essential	Community Requests	3LV8	100%	Vibrio cholerae

IDP90852 (show subtarget assignments)	8	expressed	No	VC2018	15642020		4-amino-4-deoxychorismate lyase [Vibrio ...	277	Predicted Essential	Community Requests	1ET0	34.3%	Vibrio cholerae

IDP01439 (show subtarget assignments)	1	crystallized	No	VC2019	15642021		3-oxoacyl-(acyl carrier protein) synthas...	414	Drug Target Function	Phase 2: March 2008	1B3N	74.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP90557 (show subtarget assignments)	8	in_pdb 3U09 3TZK 3TZH 3TZC 3RSH 3OP4 3RRO	No	VC2021	15642023	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	248	Predicted Essential	Community Requests	3OP4	100%	Vibrio cholerae

IDP01440 (show subtarget assignments)	1	in_pdb 3HJV	No	VC2022	15642024		acyl carrier protein S-malonyltransferas...	312	Drug Target Function	Phase 2: March 2008	3HJV	100%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01441 (show subtarget assignments)	1	in_crystallization_trials	No	VC2023	15642025		3-oxoacyl-(acyl carrier protein) synthas...	316	Drug Target Function	Phase 2: March 2008	1EBL	72.6%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01507 (show subtarget assignments)	1	in_crystallization_trials	No	VC2045	15642047		superoxide dismutase, Fe	194	Conserved Gene / Pathway	Phase 2: March 2008	2W7W	86.6%	Vibrio cholerae	Cellular processes	Detoxification

IDP01442 (show subtarget assignments)	1	expressed	No	VC2048	15642050		vacJ lipoprotein	254	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Other

IDP01443 (show subtarget assignments)	1	soluble	No	VC2061	15642061		ParA family protein	258	Conserved Gene / Pathway	Phase 2: March 2008	1WCV	34.1%	Vibrio cholerae	Cellular processes	Cell division

IDP01309 (show subtarget assignments)	1	purified	No	VC2078	15642078		ferrous iron transport protein A	76	Drug Target Function	Phase 2: March 2008	2K5I	34.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01444 (show subtarget assignments)	1	soluble	No	VC2081	15642081		zinc ABC transporter, periplasmic zinc-b...	297	Conserved Gene / Pathway	Phase 2: March 2008	2OGW	44.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01321 (show subtarget assignments)	1	purified	No	VC2082	15642082		zinc ABC transporter, ATP-binding protei...	262	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	28.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01445 (show subtarget assignments)	1	soluble	No	VC2088	15642088	sdhB	succinate dehydrogenase iron-sulfur subu...	236	Conserved Gene / Pathway	Phase 2: March 2008	1NEK	77.2%	Vibrio cholerae	Energy metabolism	TCA cycle

IDP01446 (show subtarget assignments)	1	in_crystallization_trials	No	VC2099	15642099		flavodoxin FldA	175	Conserved Gene / Pathway	Phase 2: March 2008	1AG9	75.4%	Vibrio cholerae	Energy metabolism	Electron transport

IDP90773 (show subtarget assignments)	8	selected	No	VC2108	15642108		erythronate-4-phosphate dehydrogenase [V...	387	Predicted Essential	Community Requests	3OET	48.3%	Vibrio cholerae

IDP04168 (show subtarget assignments)	1	purified	No	VC2142	15642141		flagellin [Vibrio cholerae O1 biovar elt...	376	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3K8V	37.5%	Vibrio cholerae	Cellular processes	Chemotaxis and motility

IDP01519 (show subtarget assignments)	1	purified	No	VC2149	15642148		hypothetical protein VC2149	95	Drug Target Function	Phase 2: March 2008	3KE2	43.2%	Vibrio cholerae

IDP90246 (show subtarget assignments)	8	in_pdb 3T68 3T6M	Yes	VC2152	15642151		succinyl-diaminopimelate desuccinylase [...	377	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3T68	70%	Vibrio cholerae

IDP90663 (show subtarget assignments)	8	soluble	No	VC2157	15642156	dapA	dihydrodipicolinate synthase [Vibrio cho...	292	Predicted Essential	Community Requests	3G0S	59.6%	Vibrio cholerae

IDP01300 (show subtarget assignments)	1	in_pdb 3F0I	Yes	VC2165	15642164		arsenate reductase	116	Conserved Gene / Pathway	Phase 2: March 2008	3F0I	100%	Vibrio cholerae	Cellular processes	Detoxification

IDP01337 (show subtarget assignments)	1	in_pdb 3E9A	No	VC2175	15642174		2-dehydro-3-deoxyphosphooctonate aldolas...	283	Conserved Gene / Pathway	Phase 2: March 2008	3E9A	100%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04169 (show subtarget assignments)	1	in_crystallization_trials	No	VC2180	15642179	hemA	glutamyl-tRNA reductase [Vibrio cholerae...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GPJ	35.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01447 (show subtarget assignments)	1	in_crystallization_trials	No	VC2181	15642180	lolB	outer membrane lipoprotein LolB	211	Conserved Gene / Pathway	Phase 2: March 2008	1IWM	30.3%	Vibrio cholerae	Cell envelope	Other

IDP90543 (show subtarget assignments)	8	cloned	No	VC2182	15642181	ipk	4-diphosphocytidyl-2-C-methyl-D-erythrit...	295	Predicted Essential	Community Requests	1OJ4	58%	Vibrio cholerae

IDP04170 (show subtarget assignments)	1	cloned	No	VC2183	15642182		ribose-phosphate pyrophosphokinase [Vibr...	314	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3DAH	63.7%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01448 (show subtarget assignments)	1	cloned	No	VC2213	15642211		outer membrane protein OmpA	321	Conserved Gene / Pathway	Phase 2: March 2008	3NB3	34.7%	Vibrio cholerae	Cell envelope	Other

IDP90905 (show subtarget assignments)	8	in_pdb 3P4E	Yes	VC2226	15642224		phosphoribosylaminoimidazole synthetase ...	346	Predicted Essential	Community Requests	3P4E	100%	Vibrio cholerae

IDP90666 (show subtarget assignments)	8	purified	No	VC2242	15642240		mesJ protein [Vibrio cholerae O1 biovar ...	440	Predicted Essential	Community Requests	1NI5	44.1%	Vibrio cholerae

IDP04171 (show subtarget assignments)	1	cloned	No	VC2244	15642242		acetyl-CoA carboxylase carboxyltransfera...	319	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	74.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP90928 (show subtarget assignments)	8	soluble	No	VC2245	15642243	dnaE	DNA polymerase III subunit alpha [Vibrio...	1164	Predicted Essential	Community Requests	2HQA	62.5%	Vibrio cholerae

IDP01449 (show subtarget assignments)	1	purified	No	VC2248	15642246		UDP-N-acetylglucosamine acyltransferase ...	262	Drug Target Function	Phase 2: March 2008	1LXA	68.3%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01310 (show subtarget assignments)	1	purified	No	VC2251	15642249		outer membrane protein OmpH	169	Conserved Gene / Pathway	Phase 2: March 2008	1SG2	30.2%	Vibrio cholerae	Cell envelope	Other

IDP04402 (show subtarget assignments)	1	cloned	No	VC2254	15642252		1-deoxy-D-xylulose 5-phosphate reductois...	402	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1K5H	60.9%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04086 (show subtarget assignments)	1	expressed	No	VC2256	15642254		undecaprenyl diphosphate synthase [Vibri...	256	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1JP3	54.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01338 (show subtarget assignments)	1	in_crystallization_trials	No	VC2261	15642259		methionine aminopeptidase	280	Drug Target Function	Community Interest	1MAT	57.5%	Vibrio cholerae	Protein fate	Protein modification and repair

IDP01450 (show subtarget assignments)	1	in_crystallization_trials	No	VC2269	15642267		3,4-dihydroxy-2-butanone 4-phosphate syn...	369	Drug Target Function	Phase 2: March 2008	1G57	30.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP90507 (show subtarget assignments)	8	soluble	No	VC2270	15642268		riboflavin synthase subunit alpha [Vibri...	217	Predicted Essential	Community Requests	1KZL	35.5%	Vibrio cholerae

IDP04009 (show subtarget assignments)	1	cloned	No	VC2277	15642275		xanthine-guanine phosphoribosyltransfera...	154	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1A95	68.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP04503 (show subtarget assignments)	1	cloned	No	VC2289	15642287		thiamin biosynthesis lipoprotein ApbE [V...	367	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3PND	39.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP01322 (show subtarget assignments)	1	purified	No	VC2296	15642294		bolA protein	106	Conserved Gene / Pathway	Phase 2: March 2008	2DHM	50.9%	Vibrio cholerae	Cellular processes	Other

IDP01451 (show subtarget assignments)	1	purified	No	VC2305	15642303		outer membrane protein OmpK	296	Conserved Gene / Pathway	Phase 2: March 2008	1TLW	26%	Vibrio cholerae	Transport and binding proteins	Nucleosides, purines and pyrimidines

IDP04504 (show subtarget assignments)	1	cloned	No	VC2307	15642305		2-dehydropantoate 2-reductase [Vibrio ch...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KS9	43.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04323 (show subtarget assignments)	1	in_pdb 3OT1	No	VC2308	15642306		4-methyl-5(B-hydroxyethyl)-thiazole mono...	205	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3OT1	100%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP04413 (show subtarget assignments)	1	cloned	No	VC2373	15642370		glutamate synthase, large subunit [Vibri...	1530	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1LLW	44.6%	Vibrio cholerae	Amino acid biosynthesis	Glutamate family

IDP90592 (show subtarget assignments)	8	in_crystallization_trials	No	VC2389	15642386	carB	carbamoyl phosphate synthase large subun...	1076	Predicted Essential	Community Requests	1BXR	85.6%	Vibrio cholerae

IDP90910 (show subtarget assignments)	8	soluble	No	VC2390	15642387		carbamoyl phosphate synthase small subun...	379	Predicted Essential	Community Requests	1CS0	82.3%	Vibrio cholerae

IDP90532 (show subtarget assignments)	8	soluble	No	VC2391	15642388		dihydrodipicolinate reductase [Vibrio ch...	269	Predicted Essential	Community Requests	1ARZ	63.9%	Vibrio cholerae

IDP01339 (show subtarget assignments)	1	purified	No	VC2397	15642394		cell division protein FtsZ	398	Conserved Gene / Pathway	Phase 2: March 2008	2VAW	58.6%	Vibrio cholerae	Cellular processes	Cell division

IDP01452 (show subtarget assignments)	1	soluble	No	VC2400	15642397	murC	UDP-N-acetylmuramate--L-alanine ligase	506	Conserved Gene / Pathway	Phase 2: March 2008	2F00	69.4%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01453 (show subtarget assignments)	1	cloned	No	VC2401	15642398	murG	N-acetylglucosaminyl transferase	354	Conserved Gene / Pathway	Phase 2: March 2008	1F0K	63.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01455 (show subtarget assignments)	1	purified	No	VC2405	15642402		UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	453	Conserved Gene / Pathway	Phase 2: March 2008	1GG4	52.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01456 (show subtarget assignments)	1	purified	No	VC2406	15642403	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	512	Conserved Gene / Pathway	Phase 2: March 2008	1E8C	50.6%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01457 (show subtarget assignments)	1	cloned	No	VC2407	15642404		penicillin-binding protein 3	580	Drug Target Function	Phase 2: March 2008	3OC2	41.6%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01458 (show subtarget assignments)	1	soluble	No	VC2418	15642415		thiol:disulfide interchange protein DsbC...	250	Drug Target Function	Phase 2: March 2008	1JZD	38.4%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01347 (show subtarget assignments)	1	purified	No	VC2421	15642418		N-acetyl-anhydromuranmyl-L-alanine amida...	181	Conserved Gene / Pathway	Phase 2: March 2008	1J3G	63%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP90669 (show subtarget assignments)	8	in_pdb 3PAJ	Yes	VC2422	15642419		quinolinate phosphoribosyltransferase [V...	296	Predicted Essential	Community Requests	3PAJ	100%	Vibrio cholerae

IDP01460 (show subtarget assignments)	1	cloned	No	VC2423	15642420		fimbrial protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1OQW	37.1%	Vibrio cholerae	Cell envelope	Surface structures

IDP90865 (show subtarget assignments)	8	purified	No	VC2430	15642427		DNA topoisomerase IV subunit A [Vibrio c...	761	Predicted Essential	Community Requests	1ZVU	66.9%	Vibrio cholerae

IDP90817 (show subtarget assignments)	8	cloned	No	VC2431	15642428		DNA topoisomerase IV subunit B [Vibrio c...	626	Predicted Essential	Community Requests	1S16	49.8%	Vibrio cholerae

IDP00154 (show subtarget assignments)	1	crystallized	No	VC2448	15642444	pyrG	CTP synthase	545	Essential	Phase 1: October 2007	1S1M	79.5%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP01461 (show subtarget assignments)	1	in_pdb 3H88	No	VC2457	15642453	acpS	4'-phosphopantetheinyl transferase	126	Drug Target Function	Phase 2: March 2008	3H88	100%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP90553 (show subtarget assignments)	8	soluble	No	VC2458	15642454		pyridoxal phosphate biosynthetic protein...	243	Predicted Essential	Community Requests	1M5W	70.8%	Vibrio cholerae

IDP90855 (show subtarget assignments)	8	cloned	No	VC2461	15642457	rnc	ribonuclease III [Vibrio cholerae O1 bio...	225	Predicted Essential	Community Requests	2A11	43.3%	Vibrio cholerae

IDP01462 (show subtarget assignments)	1	soluble	No	VC2462	15642458		signal peptidase I	298	Drug Target Function	Phase 2: March 2008	1B12	46.6%	Vibrio cholerae	Protein fate	Protein and peptide secretion and trafficking

IDP04173 (show subtarget assignments)	1	expressed	No	VC2490	15642486		2-isopropylmalate synthase [Vibrio chole...	516	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3RMJ	39%	Vibrio cholerae	Amino acid biosynthesis	Pyruvate family

IDP90658 (show subtarget assignments)	8	cloned	No	VC2503	15642499	valS	valyl-tRNA synthetase [Vibrio cholerae O...	953	Predicted Essential	Community Requests	1GAX	38.8%	Vibrio cholerae

IDP04174 (show subtarget assignments)	1	diffraction	No	VC2508	15642504		ornithine carbamoyltransferase [Vibrio c...	334	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3UPD	82.6%	Vibrio cholerae	Amino acid biosynthesis	Glutamate family

IDP01463 (show subtarget assignments)	1	in_crystallization_trials	No	VC2514	15642510		UDP-N-acetylglucosamine 1-carboxyvinyltr...	419	Drug Target Function	Phase 2: March 2008	3VCY	85.9%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01464 (show subtarget assignments)	1	soluble	No	VC2520	15642516		ABC transporter, ATP-binding protein	267	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	34.5%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP90653 (show subtarget assignments)	8	soluble	No	VC2524	15642520		3-deoxy-D-manno-octulosonate 8-phosphate...	185	Predicted Essential	Community Requests	3N07	99.5%	Vibrio cholerae

IDP01465 (show subtarget assignments)	1	purified	No	VC2528	15642523		ABC transporter, ATP-binding protein	241	Conserved Gene / Pathway	Phase 2: March 2008	1JI0	33.6%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01466 (show subtarget assignments)	1	in_crystallization_trials	No	VC2542	15642537		UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...	451	Conserved Gene / Pathway	Phase 2: March 2008	3HN7	51%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01467 (show subtarget assignments)	1	purified	No	VC2549	15642544		methionine sulfoxide reductase A	212	Conserved Gene / Pathway	Phase 2: March 2008	2GT3	56.1%	Vibrio cholerae	Protein fate	Protein modification and repair

IDP01468 (show subtarget assignments)	1	purified	No	VC2553	15642548		ABC transporter, ATP-binding protein, au...	238	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	32.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP04084 (show subtarget assignments)	1	cloned	No	VC2561	15642556		uroporphyrin-III C-methyltransferase [Vi...	299	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1PJQ	50.8%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01428
(show subtarget assignments)

1

purified

No

VC1709

15641713

zinc protease, insulinase family

922

Drug Target Function

Phase 2: March 2008

3CWW

19%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90524
(show subtarget assignments)

8

purified

No

VC1730

15641734

DNA topoisomerase I [Vibrio cholerae O1 ...

876

Predicted Essential

Community Requests

1CY0

48.3%

Vibrio cholerae

IDP90626
(show subtarget assignments)

8

in_pdb
3TI2
3NVS

No

VC1732

15641736

3-phosphoshikimate 1-carboxyvinyltransfe...

426

Predicted Essential

Community Requests

3NVS

100%

Vibrio cholerae

IDP04401
(show subtarget assignments)

1

expressed

No

VC1831

15641833

sensor histidine kinase [Vibrio cholerae...

736

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10.2%

Vibrio cholerae

Regulatory functions

Other

IDP90673
(show subtarget assignments)

8

expressed

No

VC1833

15641835

quinolinate synthetase [Vibrio cholerae ...

353

Predicted Essential

Community Requests

1WZU

30.6%

Vibrio cholerae

IDP90577
(show subtarget assignments)

8

soluble

No

VC1848

15641850

cysS

cysteinyl-tRNA synthetase [Vibrio choler...

459

Predicted Essential

Community Requests

1LI5

75.1%

Vibrio cholerae

IDP01429
(show subtarget assignments)

1

in_crystallization_trials

No

VC1849

15641851

peptidyl-prolyl cis-trans isomerase B

164

Conserved Gene / Pathway

Phase 2: March 2008

1LOP

64%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01430
(show subtarget assignments)

1

in_crystallization_trials

No

VC1863

15641865

amino acid ABC transporter, periplasmic ...

260

Conserved Gene / Pathway

Phase 2: March 2008

1LAF

39.2%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01431
(show subtarget assignments)

1

purified

No

VC1864

15641866

amino acid ABC transporter, ATP-binding ...

256

Conserved Gene / Pathway

Phase 2: March 2008

1B0U

62.9%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP90521
(show subtarget assignments)

8

in_pdb
3OAM

No

VC1875

15641877

3-deoxy-manno-octulosonate cytidylyltran...

252

Predicted Essential

Community Requests

3OAM

100%

Vibrio cholerae

IDP01320
(show subtarget assignments)

1

purified

No

VC1883

15641885

ABC transporter, ATP-binding protein

228

Conserved Gene / Pathway

Phase 2: March 2008

2PCJ

45.6%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP91531
(show subtarget assignments)

8

soluble

No

VC1887

15641889

hypothetical protein VC1887 [Vibrio chol...

266

potential drug target / Vc1887 was found in a knockout screen for determinants of cell shape by action o...

Community Requests

Vibrio cholerae

IDP90525
(show subtarget assignments)

8

in_pdb
3UWQ
3LDV

No

VC1911

15641913

orotidine 5'-phosphate decarboxylase [Vi...

231

Predicted Essential

Community Requests

3LDV

100%

Vibrio cholerae

IDP01432
(show subtarget assignments)

1

cloned

No

VC1918

15641920

peptidyl-prolyl cis-trans isomerse D

619

Drug Target Function

Phase 2: March 2008

1M5Y

16%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01433
(show subtarget assignments)

1

purified

No

VC1922

15641924

clpP

ATP-dependent Clp protease proteolytic s...

200

Drug Target Function

Phase 2: March 2008

1TYF

76%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01434
(show subtarget assignments)

1

purified

No

VC1944

15641946

PvcB protein

287

Conserved Gene / Pathway

Phase 2: March 2008

3EAT

46%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP04033
(show subtarget assignments)

1

soluble

No

VC1950

15641952

biotin sulfoxide reductase [Vibrio chole...

815

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1E18

48.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01435
(show subtarget assignments)

1

purified

No

VC1956

15641958

lytic murein transglycosylase, putative ...

323

Drug Target Function

Phase 2: March 2008

4ANR

32.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01342
(show subtarget assignments)

1

soluble

No

VC1960

15641962

septum site-determining protein MinD

276

Conserved Gene / Pathway

Phase 2: March 2008

3Q9L

73.6%

Vibrio cholerae

Cellular processes

Cell division

IDP90633
(show subtarget assignments)

8

cloned

No

VC1971

15641973

O-succinylbenzoic acid--CoA ligase [Vibr...

476

Predicted Essential

Community Requests

2QVX

27.9%

Vibrio cholerae

IDP90609
(show subtarget assignments)

8

in_crystallization_trials

No

VC1972

15641974

O-succinylbenzoate synthase [Vibrio chol...

332

Predicted Essential

Community Requests

1FHU

54.2%

Vibrio cholerae

IDP01436
(show subtarget assignments)

1

crystallized

No

VC1976

15641978

menaquinone-specific isochorismate synth...

435

Drug Target Function

Phase 2: March 2008

3GSE

42.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01437
(show subtarget assignments)

1

purified

No

VC1983

15641985

peptidase, putative

615

Drug Target Function

Phase 2: March 2008

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01438
(show subtarget assignments)

1

expressed

No

VC1993

15641995

2,4-dienoyl-CoA reductase

666

Drug Target Function

Phase 2: March 2008

1PS9

56.6%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Degradation

IDP90607
(show subtarget assignments)

8

purified

No

VC2015

15642017

DNA polymerase III subunit delta' [Vibri...

324

Predicted Essential

Community Requests

1A5T

33%

Vibrio cholerae

IDP90611
(show subtarget assignments)

8

in_pdb
3N2I
3LV8

Yes

VC2016

15642018

tmk

thymidylate kinase [Vibrio cholerae O1 b...

212

Predicted Essential

Community Requests

3LV8

100%

Vibrio cholerae

IDP90852
(show subtarget assignments)

8

expressed

No

VC2018

15642020

4-amino-4-deoxychorismate lyase [Vibrio ...

277

Predicted Essential

Community Requests

1ET0

34.3%

Vibrio cholerae

IDP01439
(show subtarget assignments)

1

crystallized

No

VC2019

15642021

3-oxoacyl-(acyl carrier protein) synthas...

414

Drug Target Function

Phase 2: March 2008

1B3N

74.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP90557
(show subtarget assignments)

8

in_pdb
3U09
3TZK
3TZH
3TZC
3RSH
3OP4
3RRO

No

VC2021

15642023

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

248

Predicted Essential

Community Requests

3OP4

100%

Vibrio cholerae

IDP01440
(show subtarget assignments)

1

in_pdb
3HJV

No

VC2022

15642024

acyl carrier protein S-malonyltransferas...

312

Drug Target Function

Phase 2: March 2008

3HJV

100%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01441
(show subtarget assignments)

1

in_crystallization_trials

No

VC2023

15642025

3-oxoacyl-(acyl carrier protein) synthas...

316

Drug Target Function

Phase 2: March 2008

1EBL

72.6%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01507
(show subtarget assignments)

1

in_crystallization_trials

No

VC2045

15642047

superoxide dismutase, Fe

194

Conserved Gene / Pathway

Phase 2: March 2008

2W7W

86.6%

Vibrio cholerae

Cellular processes

Detoxification

IDP01442
(show subtarget assignments)

1

expressed

No

VC2048

15642050

vacJ lipoprotein

254

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Other

IDP01443
(show subtarget assignments)

1

soluble

No

VC2061

15642061

ParA family protein

258

Conserved Gene / Pathway

Phase 2: March 2008

1WCV

34.1%

Vibrio cholerae

Cellular processes

Cell division

IDP01309
(show subtarget assignments)

1

purified

No

VC2078

15642078

ferrous iron transport protein A

76

Drug Target Function

Phase 2: March 2008

2K5I

34.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01444
(show subtarget assignments)

1

soluble

No

VC2081

15642081

zinc ABC transporter, periplasmic zinc-b...

297

Conserved Gene / Pathway

Phase 2: March 2008

2OGW

44.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01321
(show subtarget assignments)

1

purified

No

VC2082

15642082

zinc ABC transporter, ATP-binding protei...

262

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

28.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01445
(show subtarget assignments)

1

soluble

No

VC2088

15642088

sdhB

succinate dehydrogenase iron-sulfur subu...

236

Conserved Gene / Pathway

Phase 2: March 2008

1NEK

77.2%

Vibrio cholerae

Energy metabolism

TCA cycle

IDP01446
(show subtarget assignments)

1

in_crystallization_trials

No

VC2099

15642099

flavodoxin FldA

175

Conserved Gene / Pathway

Phase 2: March 2008

1AG9

75.4%

Vibrio cholerae

Energy metabolism

Electron transport

IDP90773
(show subtarget assignments)

8

selected

No

VC2108

15642108

erythronate-4-phosphate dehydrogenase [V...

387

Predicted Essential

Community Requests

3OET

48.3%

Vibrio cholerae

IDP04168
(show subtarget assignments)

1

purified

No

VC2142

15642141

flagellin [Vibrio cholerae O1 biovar elt...

376

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3K8V

37.5%

Vibrio cholerae

Cellular processes

Chemotaxis and motility

IDP01519
(show subtarget assignments)

1

purified

No

VC2149

15642148

hypothetical protein VC2149

95

Drug Target Function

Phase 2: March 2008

3KE2

43.2%

Vibrio cholerae

IDP90246
(show subtarget assignments)

8

in_pdb
3T68
3T6M

Yes

VC2152

15642151

succinyl-diaminopimelate desuccinylase [...

377

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3T68

70%

Vibrio cholerae

IDP90663
(show subtarget assignments)

8

soluble

No

VC2157

15642156

dapA

dihydrodipicolinate synthase [Vibrio cho...

292

Predicted Essential

Community Requests

3G0S

59.6%

Vibrio cholerae

IDP01300
(show subtarget assignments)

1

in_pdb
3F0I

Yes

VC2165

15642164

arsenate reductase

116

Conserved Gene / Pathway

Phase 2: March 2008

3F0I

100%

Vibrio cholerae

Cellular processes

Detoxification

IDP01337
(show subtarget assignments)

1

in_pdb
3E9A

No

VC2175

15642174

2-dehydro-3-deoxyphosphooctonate aldolas...

283

Conserved Gene / Pathway

Phase 2: March 2008

3E9A

100%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04169
(show subtarget assignments)

1

in_crystallization_trials

No

VC2180

15642179

hemA

glutamyl-tRNA reductase [Vibrio cholerae...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GPJ

35.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01447
(show subtarget assignments)

1

in_crystallization_trials

No

VC2181

15642180

lolB

outer membrane lipoprotein LolB

211

Conserved Gene / Pathway

Phase 2: March 2008

1IWM

30.3%

Vibrio cholerae

Cell envelope

Other

IDP90543
(show subtarget assignments)

8

cloned

No

VC2182

15642181

ipk

4-diphosphocytidyl-2-C-methyl-D-erythrit...

295

Predicted Essential

Community Requests

1OJ4

58%

Vibrio cholerae

IDP04170
(show subtarget assignments)

1

cloned

No

VC2183

15642182

ribose-phosphate pyrophosphokinase [Vibr...

314

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3DAH

63.7%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01448
(show subtarget assignments)

1

cloned

No

VC2213

15642211

outer membrane protein OmpA

321

Conserved Gene / Pathway

Phase 2: March 2008

3NB3

34.7%

Vibrio cholerae

Cell envelope

Other

IDP90905
(show subtarget assignments)

8

in_pdb
3P4E

Yes

VC2226

15642224

phosphoribosylaminoimidazole synthetase ...

346

Predicted Essential

Community Requests

3P4E

100%

Vibrio cholerae

IDP90666
(show subtarget assignments)

8

purified

No

VC2242

15642240

mesJ protein [Vibrio cholerae O1 biovar ...

440

Predicted Essential

Community Requests

1NI5

44.1%

Vibrio cholerae

IDP04171
(show subtarget assignments)

1

cloned

No

VC2244

15642242

acetyl-CoA carboxylase carboxyltransfera...

319

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

74.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP90928
(show subtarget assignments)

8

soluble

No

VC2245

15642243

dnaE

DNA polymerase III subunit alpha [Vibrio...

1164

Predicted Essential

Community Requests

2HQA

62.5%

Vibrio cholerae

IDP01449
(show subtarget assignments)

1

purified

No

VC2248

15642246

UDP-N-acetylglucosamine acyltransferase ...

262

Drug Target Function

Phase 2: March 2008

1LXA

68.3%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01310
(show subtarget assignments)

1

purified

No

VC2251

15642249

outer membrane protein OmpH

169

Conserved Gene / Pathway

Phase 2: March 2008

1SG2

30.2%

Vibrio cholerae

Cell envelope

Other

IDP04402
(show subtarget assignments)

1

cloned

No

VC2254

15642252

1-deoxy-D-xylulose 5-phosphate reductois...

402

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1K5H

60.9%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04086
(show subtarget assignments)

1

expressed

No

VC2256

15642254

undecaprenyl diphosphate synthase [Vibri...

256

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1JP3

54.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01338
(show subtarget assignments)

1

in_crystallization_trials

No

VC2261

15642259

methionine aminopeptidase

280

Drug Target Function

Community Interest

1MAT

57.5%

Vibrio cholerae

Protein fate

Protein modification and repair

IDP01450
(show subtarget assignments)

1

in_crystallization_trials

No

VC2269

15642267

3,4-dihydroxy-2-butanone 4-phosphate syn...

369

Drug Target Function

Phase 2: March 2008

1G57

30.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP90507
(show subtarget assignments)

8

soluble

No

VC2270

15642268

riboflavin synthase subunit alpha [Vibri...

217

Predicted Essential

Community Requests

1KZL

35.5%

Vibrio cholerae

IDP04009
(show subtarget assignments)

1

cloned

No

VC2277

15642275

xanthine-guanine phosphoribosyltransfera...

154

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1A95

68.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP04503
(show subtarget assignments)

1

cloned

No

VC2289

15642287

thiamin biosynthesis lipoprotein ApbE [V...

367

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3PND

39.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP01322
(show subtarget assignments)

1

purified

No

VC2296

15642294

bolA protein

106

Conserved Gene / Pathway

Phase 2: March 2008

2DHM

50.9%

Vibrio cholerae

Cellular processes

Other

IDP01451
(show subtarget assignments)

1

purified

No

VC2305

15642303

outer membrane protein OmpK

296

Conserved Gene / Pathway

Phase 2: March 2008

1TLW

26%

Vibrio cholerae

Transport and binding proteins

Nucleosides, purines and pyrimidines

IDP04504
(show subtarget assignments)

1

cloned

No

VC2307

15642305

2-dehydropantoate 2-reductase [Vibrio ch...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KS9

43.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04323
(show subtarget assignments)

1

in_pdb
3OT1

No

VC2308

15642306

4-methyl-5(B-hydroxyethyl)-thiazole mono...

205

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3OT1

100%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP04413
(show subtarget assignments)

1

cloned

No

VC2373

15642370

glutamate synthase, large subunit [Vibri...

1530

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1LLW

44.6%

Vibrio cholerae

Amino acid biosynthesis

Glutamate family

IDP90592
(show subtarget assignments)

8

in_crystallization_trials

No

VC2389

15642386

carB

carbamoyl phosphate synthase large subun...

1076

Predicted Essential

Community Requests

1BXR

85.6%

Vibrio cholerae

IDP90910
(show subtarget assignments)

8

soluble

No

VC2390

15642387

carbamoyl phosphate synthase small subun...

379

Predicted Essential

Community Requests

1CS0

82.3%

Vibrio cholerae

IDP90532
(show subtarget assignments)

8

soluble

No

VC2391

15642388

dihydrodipicolinate reductase [Vibrio ch...

269

Predicted Essential

Community Requests

1ARZ

63.9%

Vibrio cholerae

IDP01339
(show subtarget assignments)

1

purified

No

VC2397

15642394

cell division protein FtsZ

398

Conserved Gene / Pathway

Phase 2: March 2008

2VAW

58.6%

Vibrio cholerae

Cellular processes

Cell division

IDP01452
(show subtarget assignments)

1

soluble

No

VC2400

15642397

murC

UDP-N-acetylmuramate--L-alanine ligase

506

Conserved Gene / Pathway

Phase 2: March 2008

2F00

69.4%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01453
(show subtarget assignments)

1

cloned

No

VC2401

15642398

murG

N-acetylglucosaminyl transferase

354

Conserved Gene / Pathway

Phase 2: March 2008

1F0K

63.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01455
(show subtarget assignments)

1

purified

No

VC2405

15642402

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

453

Conserved Gene / Pathway

Phase 2: March 2008

1GG4

52.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01456
(show subtarget assignments)

1

purified

No

VC2406

15642403

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

512

Conserved Gene / Pathway

Phase 2: March 2008

1E8C

50.6%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01457
(show subtarget assignments)

1

cloned

No

VC2407

15642404

penicillin-binding protein 3

580

Drug Target Function

Phase 2: March 2008

3OC2

41.6%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01458
(show subtarget assignments)

1

soluble

No

VC2418

15642415

thiol:disulfide interchange protein DsbC...

250

Drug Target Function

Phase 2: March 2008

1JZD

38.4%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01347
(show subtarget assignments)

1

purified

No

VC2421

15642418

N-acetyl-anhydromuranmyl-L-alanine amida...

181

Conserved Gene / Pathway

Phase 2: March 2008

1J3G

63%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP90669
(show subtarget assignments)

8

in_pdb
3PAJ

Yes

VC2422

15642419

quinolinate phosphoribosyltransferase [V...

296

Predicted Essential

Community Requests

3PAJ

100%

Vibrio cholerae

IDP01460
(show subtarget assignments)

1

cloned

No

VC2423

15642420

fimbrial protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1OQW

37.1%

Vibrio cholerae

Cell envelope

Surface structures

IDP90865
(show subtarget assignments)

8

purified

No

VC2430

15642427

DNA topoisomerase IV subunit A [Vibrio c...

761

Predicted Essential

Community Requests

1ZVU

66.9%

Vibrio cholerae

IDP90817
(show subtarget assignments)

8

cloned

No

VC2431

15642428

DNA topoisomerase IV subunit B [Vibrio c...

626

Predicted Essential

Community Requests

1S16

49.8%

Vibrio cholerae

IDP00154
(show subtarget assignments)

1

crystallized

No

VC2448

15642444

pyrG

CTP synthase

545

Essential

Phase 1: October 2007

1S1M

79.5%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP01461
(show subtarget assignments)

1

in_pdb
3H88

No

VC2457

15642453

acpS

4'-phosphopantetheinyl transferase

126

Drug Target Function

Phase 2: March 2008

3H88

100%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP90553
(show subtarget assignments)

8

soluble

No

VC2458

15642454

pyridoxal phosphate biosynthetic protein...

243

Predicted Essential

Community Requests

1M5W

70.8%

Vibrio cholerae

IDP90855
(show subtarget assignments)

8

cloned

No

VC2461

15642457

rnc

ribonuclease III [Vibrio cholerae O1 bio...

225

Predicted Essential

Community Requests

2A11

43.3%

Vibrio cholerae

IDP01462
(show subtarget assignments)

1

soluble

No

VC2462

15642458

signal peptidase I

298

Drug Target Function

Phase 2: March 2008

1B12

46.6%

Vibrio cholerae

Protein fate

Protein and peptide secretion and trafficking

IDP04173
(show subtarget assignments)

1

expressed

No

VC2490

15642486

2-isopropylmalate synthase [Vibrio chole...

516

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3RMJ

39%

Vibrio cholerae

Amino acid biosynthesis

Pyruvate family

IDP90658
(show subtarget assignments)

8

cloned

No

VC2503

15642499

valS

valyl-tRNA synthetase [Vibrio cholerae O...

953

Predicted Essential

Community Requests

1GAX

38.8%

Vibrio cholerae

IDP04174
(show subtarget assignments)

1

diffraction

No

VC2508

15642504

ornithine carbamoyltransferase [Vibrio c...

334

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3UPD

82.6%

Vibrio cholerae

Amino acid biosynthesis

Glutamate family

IDP01463
(show subtarget assignments)

1

in_crystallization_trials

No

VC2514

15642510

UDP-N-acetylglucosamine 1-carboxyvinyltr...

419

Drug Target Function

Phase 2: March 2008

3VCY

85.9%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01464
(show subtarget assignments)

1

soluble

No

VC2520

15642516

ABC transporter, ATP-binding protein

267

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

34.5%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP90653
(show subtarget assignments)

8

soluble

No

VC2524

15642520

3-deoxy-D-manno-octulosonate 8-phosphate...

185

Predicted Essential

Community Requests

3N07

99.5%

Vibrio cholerae

IDP01465
(show subtarget assignments)

1

purified

No

VC2528

15642523

ABC transporter, ATP-binding protein

241

Conserved Gene / Pathway

Phase 2: March 2008

1JI0

33.6%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01466
(show subtarget assignments)

1

in_crystallization_trials

No

VC2542

15642537

UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...

451

Conserved Gene / Pathway

Phase 2: March 2008

3HN7

51%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01467
(show subtarget assignments)

1

purified

No

VC2549

15642544

methionine sulfoxide reductase A

212

Conserved Gene / Pathway

Phase 2: March 2008

2GT3

56.1%

Vibrio cholerae

Protein fate

Protein modification and repair

IDP01468
(show subtarget assignments)

1

purified

No

VC2553

15642548

ABC transporter, ATP-binding protein, au...

238

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

32.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP04084
(show subtarget assignments)

1

cloned

No

VC2561

15642556

uroporphyrin-III C-methyltransferase [Vi...

299

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1PJQ

50.8%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

Targets