Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04233 (show subtarget assignments)	1	cloned	No	CPF_0722	110798767		putative lipoprotein [Clostridium perfri...	384	drug target; putative drug target function;	Phase 4: April 2009	2UVK	16.1%	Clostridium perfringens	Cell envelope	Other

IDP04234 (show subtarget assignments)	1	cloned	No	CPF_0807	110799166		iron compound ABC transporter, iron comp...	314	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HXP	29.3%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04235 (show subtarget assignments)	1	cloned	No	CPF_0823	110800089		polysaccharide deacetylase family protei...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W3Z	32.1%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP04238 (show subtarget assignments)	1	cloned	No	CPF_0889	110799788		sensor histidine kinase [Clostridium per...	475	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Signal transduction	Two-component systems

IDP04239 (show subtarget assignments)	1	cloned	No	CPF_1057	110799811		sensor histidine kinase [Clostridium per...	418	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	19.4%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04240 (show subtarget assignments)	1	cloned	No	CPF_1077	110800997		extracellular solute-binding protein [Cl...	477	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W7Y	15.3%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04242 (show subtarget assignments)	1	cloned	No	CPF_1113	110798641		sugar ABC transporter, sugar-binding pro...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3QUF	22.9%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04245 (show subtarget assignments)	1	cloned	No	CPF_1193	110801261		bacitracin ABC transporter, ATP-binding ...	306	conserved gene; putative drug target function;	Phase 4: April 2009	1VPL	27.5%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04246 (show subtarget assignments)	1	cloned	No	CPF_1362	110799745		aluminum resistance protein [Clostridium...	426	conserved gene; putative drug target function;	Phase 4: April 2009	3GWP	71.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP04250 (show subtarget assignments)	1	cloned	No	BAS2213	49185222		DNA-binding protein HU [Bacillus anthrac...	90	Proposed to be essential proteins	Phase 4: April 2009	3RHI	78.9%	Bacillus anthracis

IDP04251 (show subtarget assignments)	1	cloned	No	CPF_1751	110801372	virS	sensor histidine kinase VirS [Clostridiu...	440	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04252 (show subtarget assignments)	1	cloned	No	CPF_1780	110799805		putative lipoprotein [Clostridium perfri...	445	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04254 (show subtarget assignments)	1	cloned	No	CPF_1823	110798846		putative lipoprotein [Clostridium perfri...	233	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04255 (show subtarget assignments)	1	cloned	No	CPF_1922	110799469	purB	adenylosuccinate lyase [Clostridium perf...	476	conserved gene; putative drug target function;	Phase 4: April 2009	2J91	56.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04257 (show subtarget assignments)	1	cloned	No	CPF_2008	110798819	engA	GTP-binding protein EngA [Clostridium pe...	438	conserved gene; putative drug target function;	Phase 4: April 2009	2HJG	54.3%	Clostridium perfringens	Cellular processes	Cell division

IDP04259 (show subtarget assignments)	1	cloned	No	CPF_2018	110799691	ftsZ	cell division protein FtsZ [Clostridium ...	381	conserved gene; putative drug target function;	Phase 4: April 2009	2VAM	58%	Clostridium perfringens	Cellular processes	Cell division

IDP04260 (show subtarget assignments)	1	cloned	No	CPF_2020	110798885	pilT	twitching motility protein PilT [Clostri...	350	conserved gene; putative drug target function;	Phase 4: April 2009	2EWV	49.1%	Clostridium perfringens	Cellular processes	Chemotaxis and motility

IDP04261 (show subtarget assignments)	1	cloned	No	CPF_2059	110798854	scpB	segregation and condensation protein B [...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1T6S	28.2%	Clostridium perfringens	Cellular processes	Cell division

IDP04262 (show subtarget assignments)	1	cloned	No	CPF_2067	110799430	spo0A	Spo0A protein [Clostridium perfringens A...	276	conserved gene; putative drug target function;	Phase 4: April 2009	1LQ1	31.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04263 (show subtarget assignments)	1	cloned	No	CPF_2068	110800995		stage IV sporulation protein B [Clostrid...	386	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04264 (show subtarget assignments)	1	cloned	No	CPF_2101	110800507		fibronectin-binding protein [Clostridium...	575	conserved gene; putative drug target function;	Phase 4: April 2009	3DOA	17.7%	Clostridium perfringens	Cellular processes

IDP04266 (show subtarget assignments)	1	cloned	No	CPF_2122	110798774	pdaA	delta-lactam-biosynthetic de-N-acetylase...	265	conserved gene; putative drug target function;	Phase 4: April 2009	2J13	41.5%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04267 (show subtarget assignments)	1	cloned	No	CPF_2134	110799922	spoVD	stage V sporulation protein D [Clostridi...	727	conserved gene; putative drug target function;	Phase 4: April 2009	1RP5	26.1%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04269 (show subtarget assignments)	1	cloned	No	CPF_2193	110798612	relA	GTP pyrophosphokinase [Clostridium perfr...	726	conserved gene; putative drug target function;	Phase 4: April 2009	1VJ7	28.1%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04270 (show subtarget assignments)	1	cloned	No	CPF_2226	110799081	potD	spermidine/putrescine ABC transporter, s...	360	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	4EQB	40.3%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP04273 (show subtarget assignments)	1	cloned	No	YPCD1.23	5832444	YPCD1.23	hypothetical protein YPCD1.23 [Yersinia ...	139	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04274 (show subtarget assignments)	1	cloned	No	YPCD1.49	16082737	virF	transcriptional regulator [Yersinia pest...	271	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	3OIO	11.8%	Yersinia pestis	Regulatory functions	Other

IDP04275 (show subtarget assignments)	1	cloned	No	BAS3684	49186683		DNA topoisomerase I [Bacillus anthracis ...	692	Proposed to be essential proteins	Phase 4: April 2009	2GAI	38.2%	Bacillus anthracis

IDP04277 (show subtarget assignments)	1	cloned	No	BAS3960	49186958		PTS system, glucose-specific IIABC compo...	687	Proposed to be essential proteins	Phase 4: April 2009	1AX3	14.7%	Bacillus anthracis

IDP04281 (show subtarget assignments)	1	cloned	No	YPO1150	115346925	bioA	adenosylmethionine-8-amino-7-oxononanoat...	422	conserved gene; putative drug target function;	Phase 4: April 2009	1MLY	73.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04284 (show subtarget assignments)	1	cloned	No	YPO0808	218927988		general secretion pathway protein L [Yer...	389	putative drug target function;	Phase 4: April 2009	1W97	13.1%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04287 (show subtarget assignments)	1	cloned	No	YPO2703	115348386	pcp	putative pyrrolidone-carboxylate peptida...	215	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3LAC	54%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04290 (show subtarget assignments)	1	cloned	No	YPO3099	218930141	manC	mannose-1-phosphate guanylyltransferase ...	470	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2CU2	28.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides

IDP04292 (show subtarget assignments)	1	cloned	No	YPO0812	218927992		general secretion pathway protein H [Yer...	180	conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04294 (show subtarget assignments)	1	cloned	No	YPO3477	115349102		putative lipid carrier protein [Yersinia...	173	conserved gene; putative drug target function;	Phase 4: April 2009	1C44	13.3%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04295 (show subtarget assignments)	1	cloned	No	FTT0031	56707211	nuoA	NADH dehydrogenase I, A subunit [Francis...	132	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3RKO	33.3%	Francisella tularensis	Energy metabolism	Electron transport

IDP04303 (show subtarget assignments)	1	cloned	No	CPF_0251	110800905	lacA	galactoside O-acetyltransferase [Clostri...	204	conserved gene; putative drug target function;	Phase 4: April 2009	1KQA	51%	Clostridium perfringens	Cellular processes	Detoxification

IDP04304 (show subtarget assignments)	1	cloned	No	CPF_2640	110798722		sensor histidine kinase [Clostridium per...	310	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	23.5%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04305 (show subtarget assignments)	1	cloned	No	CPF_2386	110798631		ribonuclease [Clostridium perfringens AT...	480	conserved gene; putative drug target function;	Phase 4: April 2009	2BX2	27.7%	Clostridium perfringens	Cellular processes	Cell division

IDP04307 (show subtarget assignments)	1	cloned	No	CPF_1812	110799901		putative lipoprotein [Clostridium perfri...	44	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens

IDP04308 (show subtarget assignments)	1	cloned	No	YPCD1.14n	40548797		hypothetical protein YPCD1.14n [Yersinia...	65	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04310 (show subtarget assignments)	1	cloned	No	BAS0231	49183264		D-alanine--D-alanine ligase, C-terminus ...	91	Proposed to be essential proteins	Phase 4: April 2009	2I80	54.9%	Bacillus anthracis

IDP04312 (show subtarget assignments)	1	cloned	No	FTT0204	56707368	purA	adenylosuccinate synthetase [Francisella...	428	conserved gene;	Phase 4: April 2009	1ADE	45.9%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04317 (show subtarget assignments)	1	cloned	No	YPO0512	218927711		putative lipoprotein [Yersinia pestis CO...	163	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cell envelope	Other

IDP04321 (show subtarget assignments)	1	cloned	No	VC0756	15640775	ndk	nucleoside diphosphate kinase [Vibrio ch...	142	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2HUR	64.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP04322 (show subtarget assignments)	1	cloned	No	VC1001	15641016		folylpolyglutamate synthase/dihydrofolat...	421	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3N2A	53.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP04327 (show subtarget assignments)	1	cloned	No	CPF_1243	110801193		sensory box histidine kinase [Clostridiu...	623	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	11.2%	Clostridium perfringens	Regulatory functions

IDP04328 (show subtarget assignments)	1	cloned	No	CPF_1452	110798743		cold shock protein [Clostridium perfring...	69	conserved gene; putative drug target function;	Phase 4: April 2009	2L15	56.3%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04332 (show subtarget assignments)	1	cloned	No	YPO2723	218929795		putative OmpA family protein [Yersinia p...	261	virulence factor; putative drug target function;	Phase 4: April 2009	2ZOV	18%	Yersinia pestis	Cell envelope	Other

IDP04333 (show subtarget assignments)	1	cloned	No	VC2483	9657062		acetolactate synthase III, large subunit...	573	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1JSC	42.8%	Vibrio cholerae	Amino acid biosynthesis	Pyruvate family

IDP04335 (show subtarget assignments)	1	cloned	No	STM1543_1_428	16764888		putative transport protein [Salmonella t...	428	Salmonella essential protein	Phase 4: April 2009	1PW4	23.4%	Salmonella enterica

IDP04337 (show subtarget assignments)	1	cloned	No	CPF_0720	110801161	splB	spore photoproduct lyase [Clostridium pe...	340	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04338 (show subtarget assignments)	1	cloned	No	CPF_1446	110801179	sodF	Mn/Fe superoxide dismutase [Clostridium ...	227	conserved gene; putative drug target function;	Phase 4: April 2009	1JR9	44.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP04340 (show subtarget assignments)	1	cloned	No	BAS0122	49183156		50S ribosomal protein L5 [Bacillus anthr...	179	Proposed to be essential proteins	Phase 4: April 2009	1IQ4	85.5%	Bacillus anthracis

IDP04342 (show subtarget assignments)	1	cloned	No	GBAA1564	47526837	panD	aspartate alpha-decarboxylase [Bacillus ...	127	conserved gene; putative drug target function;	Phase 4: April 2009	2C45	52.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04348 (show subtarget assignments)	1	cloned	No	CPF_2547	110801206		two component regulator [Clostridium per...	686	viruelnce factor;	Phase 4: April 2009			Clostridium perfringens	Unknown function	General

IDP04350 (show subtarget assignments)	1	cloned	No	STM1338_1_795	16764689	pheT	phenylalanyl-tRNA synthetase subunit bet...	795	Salmonella essential protein	Phase 4: April 2009	3PCO	92.6%	Salmonella enterica

IDP04351 (show subtarget assignments)	1	cloned	No	CPF_1213	110799898	kdpD	sensor histidine kinase KdpD [Clostridiu...	900	conserved gene; putative drug target function;	Phase 4: April 2009	2R8R	12.7%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04356 (show subtarget assignments)	1	cloned	No	YPO0509	115346318		hypothetical protein [Yersinia pestis CO...	540	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2XT4	9.3%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04358 (show subtarget assignments)	1	cloned	No	YPO0895	115346679	creC	putative histidine kinase sensor [Yersin...	472	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	14.8%	Yersinia pestis	Regulatory functions	Other

IDP04359 (show subtarget assignments)	1	cloned	No	YPO1414	218928562	pepN	aminopeptidase N [Yersinia pestis CO92]	871	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2DQ6	77.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04365 (show subtarget assignments)	1	cloned	No	CPF_1523	110798905		sensory box histidine kinase [Clostridiu...	787	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	11.6%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04367 (show subtarget assignments)	1	cloned	No	BAS3563	49186564		PTS system, fructose-specific IIABC comp...	622	Proposed to be essential proteins	Phase 4: April 2009	2R4Q	11.4%	Bacillus anthracis

IDP04370 (show subtarget assignments)	1	cloned	No	GBAA4766	47530065		iron compound ABC transporter, iron comp...	324	virulence factor; putative drug target function;	Phase 4: April 2009	3EIW	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP04373 (show subtarget assignments)	1	cloned	No	YPO3097	218930139	manB	phosphomannomutase [Yersinia pestis CO92...	457	drug target; virulence factor; putative drug target function;	Phase 4: April 2009	3UW2	37.8%	Yersinia pestis	Energy metabolism	Sugars

IDP04378 (show subtarget assignments)	1	cloned	No	CPF_2335	110799804		extracellular solute-binding protein [Cl...	482	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04380 (show subtarget assignments)	1	cloned	No	STM3713_1_404	16766998	rfaL	O-antigen ligase [Salmonella typhimurium...	404	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04386 (show subtarget assignments)	1	cloned	No	YPO3230	218930257	pepD	aminoacyl-histidine dipeptidase [Yersini...	486	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3MRU	63%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04390 (show subtarget assignments)	1	cloned	No	CPF_0618	110799563	pstS	phosphate ABC transporter, phosphate-bin...	272	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	36.4%	Clostridium perfringens	Transport and binding proteins	Anions

IDP04391 (show subtarget assignments)	1	cloned	No	CPF_1067	110798883	cotJB	spore coat protein CotJB [Clostridium pe...	83	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04392 (show subtarget assignments)	1	cloned	No	CPF_1500	110798925		putative lipoprotein [Clostridium perfri...	202	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04393 (show subtarget assignments)	1	cloned	No	CPF_1645	110798596	lonB	ATP-dependent protease LonB [Clostridium...	570	conserved gene; putative drug target function;	Phase 4: April 2009	3K1J	29.4%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04394 (show subtarget assignments)	1	cloned	No	CPF_2117	110800208	spoVD	stage V sporulation protein D [Clostridi...	695	conserved gene; putative drug target function;	Phase 4: April 2009	1PYY	24.8%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04395 (show subtarget assignments)	1	cloned	No	FTT0076	56707255	sucA	2-oxoglutarate dehydrogenase E1 componen...	941	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2JGD	47.8%	Francisella tularensis

IDP04398 (show subtarget assignments)	1	cloned	No	YPO1376	218928524	ftsK	putative cell division protein [Yersinia...	1305	drug target; putative drug target function;	Phase 4: April 2009	2IUS	33.3%	Yersinia pestis	Cellular processes	Cell division

IDP04399 (show subtarget assignments)	1	cloned	No	YPO3613	218930623		putative Rhs accessory genetic element [...	732	virulence factor; putative drug target function;	Phase 4: April 2009	2P5Z	15.8%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP04400 (show subtarget assignments)	1	cloned	No	YPO2921	218929976	purL	phosphoribosylformylglycinamidine syntha...	1296	conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	82.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04402 (show subtarget assignments)	1	cloned	No	VC2254	15642252		1-deoxy-D-xylulose 5-phosphate reductois...	402	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1K5H	60.9%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04403 (show subtarget assignments)	1	cloned	No	CPF_0630	110801303		spore germination protein [Clostridium p...	374	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3N54	17.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04404 (show subtarget assignments)	1	cloned	No	VC2602	15642597		adenylosuccinate synthetase [Vibrio chol...	432	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KJX	75.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04405 (show subtarget assignments)	1	cloned	No	CPF_2987	110799346		stage 0 sporulation protein J [Clostridi...	286	conserved gene; putative drug target function;	Phase 4: April 2009	1VZ0	33.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04407 (show subtarget assignments)	1	cloned	No	CPF_0677	110799553	purH	bifunctional phosphoribosylaminoimidazol...	501	conserved gene; putative drug target function;	Phase 4: April 2009	3ZZM	41.1%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04409 (show subtarget assignments)	1	cloned	No	YPO3965	115349572		putative hybrid two-component system reg...	851	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	9.3%	Yersinia pestis	Regulatory functions	Other

IDP04410 (show subtarget assignments)	1	cloned	No	VC1047	9655512		fatty oxidation complex, alpha subunit [...	724	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1WDK	36.4%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Degradation

IDP04412 (show subtarget assignments)	1	cloned	No	CPF_0435	110799959		putative lipoprotein [Clostridium perfri...	431	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04413 (show subtarget assignments)	1	cloned	No	VC2373	15642370		glutamate synthase, large subunit [Vibri...	1530	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1LLW	44.6%	Vibrio cholerae	Amino acid biosynthesis	Glutamate family

IDP04420 (show subtarget assignments)	1	cloned	No	GBAA3308	47528594	sdhB-1	l-serine dehydratase, iron-sulfur-depend...	232	virulence factor; putative drug target function;	Phase 4: April 2009	2IQQ	15.5%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP04425 (show subtarget assignments)	1	cloned	No	GBAA4025	47529318	carB	carbamoyl phosphate synthase large subun...	1072	conserved gene; putative drug target function;	Phase 4: April 2009	1BXR	49.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04431 (show subtarget assignments)	1	cloned	No	GBAA5088	47530387		sensor histidine kinase [Bacillus anthra...	340	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	18.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04433 (show subtarget assignments)	1	cloned	No	GBAA5276	47530584		sensor histidine kinase [Bacillus anthra...	480	putative drug target function;	Phase 4: April 2009	3A0R	13.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04434 (show subtarget assignments)	1	cloned	No	YPCD1.52	16082740	yscC	outer membrane secretin precursor [Yersi...	607	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2Y9K	6.9%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP04437 (show subtarget assignments)	1	cloned	No	YPO0023	115345855	glnR	Two component regulatory protein involve...	349	putative drug target function;	Phase 4: April 2009	1R62	38.4%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP04439 (show subtarget assignments)	1	cloned	No	YPO0185	115346005	ssiD	putative taurine dioxygenase [Yersinia p...	282	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GQW	75.9%	Yersinia pestis	Energy metabolism	Other

IDP04440 (show subtarget assignments)	1	cloned	No	YPO0266	115346083		secretion system apparatus protein [Yers...	682	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2X49	15.4%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04443 (show subtarget assignments)	1	cloned	No	YPO0506	218927704	clpB	putative Clp ATPase [Yersinia pestis CO9...	867	virulence factor; putative drug target function;	Phase 4: April 2009	1QVR	36.3%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04445 (show subtarget assignments)	1	cloned	No	YPO0619	115346424		putative HlyD family secretion protein [...	349	conserved gene; putative drug target function;	Phase 4: April 2009	4DK1	17.5%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04446 (show subtarget assignments)	1	cloned	No	YPO0653	115346457	glnE	glutamate-ammonia-ligase adenylyltransfe...	951	conserved gene; putative drug target function;	Phase 4: April 2009	3K7D	38.5%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP04448 (show subtarget assignments)	1	cloned	No	YPO0810	218927990		general secretion pathway protein J [Yer...	198	putative drug target function;	Phase 4: April 2009	2RET	20.2%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04449 (show subtarget assignments)	1	cloned	No	YPO0816	218927995		general secretion pathway protein D [Yer...	640	putative drug target function;	Phase 4: April 2009	3EZJ	15.6%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04450 (show subtarget assignments)	1	cloned	No	YPO0905	218928078	gcvP	glycine dehydrogenase [Yersinia pestis C...	959	conserved gene; putative drug target function;	Phase 4: April 2009	1WYT	19.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04233
(show subtarget assignments)

1

cloned

No

CPF_0722

110798767

putative lipoprotein [Clostridium perfri...

384

drug target; putative drug target function;

Phase 4: April 2009

2UVK

16.1%

Clostridium perfringens

Cell envelope

Other

IDP04234
(show subtarget assignments)

1

cloned

No

CPF_0807

110799166

iron compound ABC transporter, iron comp...

314

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HXP

29.3%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04235
(show subtarget assignments)

1

cloned

No

CPF_0823

110800089

polysaccharide deacetylase family protei...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W3Z

32.1%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP04238
(show subtarget assignments)

1

cloned

No

CPF_0889

110799788

sensor histidine kinase [Clostridium per...

475

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Signal transduction

Two-component systems

IDP04239
(show subtarget assignments)

1

cloned

No

CPF_1057

110799811

sensor histidine kinase [Clostridium per...

418

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

19.4%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04240
(show subtarget assignments)

1

cloned

No

CPF_1077

110800997

extracellular solute-binding protein [Cl...

477

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W7Y

15.3%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04242
(show subtarget assignments)

1

cloned

No

CPF_1113

110798641

sugar ABC transporter, sugar-binding pro...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3QUF

22.9%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04245
(show subtarget assignments)

1

cloned

No

CPF_1193

110801261

bacitracin ABC transporter, ATP-binding ...

306

conserved gene; putative drug target function;

Phase 4: April 2009

1VPL

27.5%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04246
(show subtarget assignments)

1

cloned

No

CPF_1362

110799745

aluminum resistance protein [Clostridium...

426

conserved gene; putative drug target function;

Phase 4: April 2009

3GWP

71.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP04250
(show subtarget assignments)

1

cloned

No

BAS2213

49185222

DNA-binding protein HU [Bacillus anthrac...

90

Proposed to be essential proteins

Phase 4: April 2009

3RHI

78.9%

Bacillus anthracis

IDP04251
(show subtarget assignments)

1

cloned

No

CPF_1751

110801372

virS

sensor histidine kinase VirS [Clostridiu...

440

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04252
(show subtarget assignments)

1

cloned

No

CPF_1780

110799805

putative lipoprotein [Clostridium perfri...

445

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04254
(show subtarget assignments)

1

cloned

No

CPF_1823

110798846

putative lipoprotein [Clostridium perfri...

233

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04255
(show subtarget assignments)

1

cloned

No

CPF_1922

110799469

purB

adenylosuccinate lyase [Clostridium perf...

476

conserved gene; putative drug target function;

Phase 4: April 2009

2J91

56.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04257
(show subtarget assignments)

1

cloned

No

CPF_2008

110798819

engA

GTP-binding protein EngA [Clostridium pe...

438

conserved gene; putative drug target function;

Phase 4: April 2009

2HJG

54.3%

Clostridium perfringens

Cellular processes

Cell division

IDP04259
(show subtarget assignments)

1

cloned

No

CPF_2018

110799691

ftsZ

cell division protein FtsZ [Clostridium ...

381

conserved gene; putative drug target function;

Phase 4: April 2009

2VAM

58%

Clostridium perfringens

Cellular processes

Cell division

IDP04260
(show subtarget assignments)

1

cloned

No

CPF_2020

110798885

pilT

twitching motility protein PilT [Clostri...

350

conserved gene; putative drug target function;

Phase 4: April 2009

2EWV

49.1%

Clostridium perfringens

Cellular processes

Chemotaxis and motility

IDP04261
(show subtarget assignments)

1

cloned

No

CPF_2059

110798854

scpB

segregation and condensation protein B [...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1T6S

28.2%

Clostridium perfringens

Cellular processes

Cell division

IDP04262
(show subtarget assignments)

1

cloned

No

CPF_2067

110799430

spo0A

Spo0A protein [Clostridium perfringens A...

276

conserved gene; putative drug target function;

Phase 4: April 2009

1LQ1

31.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04263
(show subtarget assignments)

1

cloned

No

CPF_2068

110800995

stage IV sporulation protein B [Clostrid...

386

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04264
(show subtarget assignments)

1

cloned

No

CPF_2101

110800507

fibronectin-binding protein [Clostridium...

575

conserved gene; putative drug target function;

Phase 4: April 2009

3DOA

17.7%

Clostridium perfringens

Cellular processes

IDP04266
(show subtarget assignments)

1

cloned

No

CPF_2122

110798774

pdaA

delta-lactam-biosynthetic de-N-acetylase...

265

conserved gene; putative drug target function;

Phase 4: April 2009

2J13

41.5%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04267
(show subtarget assignments)

1

cloned

No

CPF_2134

110799922

spoVD

stage V sporulation protein D [Clostridi...

727

conserved gene; putative drug target function;

Phase 4: April 2009

1RP5

26.1%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04269
(show subtarget assignments)

1

cloned

No

CPF_2193

110798612

relA

GTP pyrophosphokinase [Clostridium perfr...

726

conserved gene; putative drug target function;

Phase 4: April 2009

1VJ7

28.1%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04270
(show subtarget assignments)

1

cloned

No

CPF_2226

110799081

potD

spermidine/putrescine ABC transporter, s...

360

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

4EQB

40.3%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP04273
(show subtarget assignments)

1

cloned

No

YPCD1.23

5832444

YPCD1.23

hypothetical protein YPCD1.23 [Yersinia ...

139

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04274
(show subtarget assignments)

1

cloned

No

YPCD1.49

16082737

virF

transcriptional regulator [Yersinia pest...

271

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

3OIO

11.8%

Yersinia pestis

Regulatory functions

Other

IDP04275
(show subtarget assignments)

1

cloned

No

BAS3684

49186683

DNA topoisomerase I [Bacillus anthracis ...

692

Proposed to be essential proteins

Phase 4: April 2009

2GAI

38.2%

Bacillus anthracis

IDP04277
(show subtarget assignments)

1

cloned

No

BAS3960

49186958

PTS system, glucose-specific IIABC compo...

687

Proposed to be essential proteins

Phase 4: April 2009

1AX3

14.7%

Bacillus anthracis

IDP04281
(show subtarget assignments)

1

cloned

No

YPO1150

115346925

bioA

adenosylmethionine-8-amino-7-oxononanoat...

422

conserved gene; putative drug target function;

Phase 4: April 2009

1MLY

73.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04284
(show subtarget assignments)

1

cloned

No

YPO0808

218927988

general secretion pathway protein L [Yer...

389

putative drug target function;

Phase 4: April 2009

1W97

13.1%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04287
(show subtarget assignments)

1

cloned

No

YPO2703

115348386

pcp

putative pyrrolidone-carboxylate peptida...

215

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3LAC

54%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04290
(show subtarget assignments)

1

cloned

No

YPO3099

218930141

manC

mannose-1-phosphate guanylyltransferase ...

470

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2CU2

28.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

IDP04292
(show subtarget assignments)

1

cloned

No

YPO0812

218927992

general secretion pathway protein H [Yer...

180

conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04294
(show subtarget assignments)

1

cloned

No

YPO3477

115349102

putative lipid carrier protein [Yersinia...

173

conserved gene; putative drug target function;

Phase 4: April 2009

1C44

13.3%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04295
(show subtarget assignments)

1

cloned

No

FTT0031

56707211

nuoA

NADH dehydrogenase I, A subunit [Francis...

132

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3RKO

33.3%

Francisella tularensis

Energy metabolism

Electron transport

IDP04303
(show subtarget assignments)

1

cloned

No

CPF_0251

110800905

lacA

galactoside O-acetyltransferase [Clostri...

204

conserved gene; putative drug target function;

Phase 4: April 2009

1KQA

51%

Clostridium perfringens

Cellular processes

Detoxification

IDP04304
(show subtarget assignments)

1

cloned

No

CPF_2640

110798722

sensor histidine kinase [Clostridium per...

310

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

23.5%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04305
(show subtarget assignments)

1

cloned

No

CPF_2386

110798631

ribonuclease [Clostridium perfringens AT...

480

conserved gene; putative drug target function;

Phase 4: April 2009

2BX2

27.7%

Clostridium perfringens

Cellular processes

Cell division

IDP04307
(show subtarget assignments)

1

cloned

No

CPF_1812

110799901

putative lipoprotein [Clostridium perfri...

44

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

IDP04308
(show subtarget assignments)

1

cloned

No

YPCD1.14n

40548797

hypothetical protein YPCD1.14n [Yersinia...

65

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04310
(show subtarget assignments)

1

cloned

No

BAS0231

49183264

D-alanine--D-alanine ligase, C-terminus ...

91

Proposed to be essential proteins

Phase 4: April 2009

2I80

54.9%

Bacillus anthracis

IDP04312
(show subtarget assignments)

1

cloned

No

FTT0204

56707368

purA

adenylosuccinate synthetase [Francisella...

428

conserved gene;

Phase 4: April 2009

1ADE

45.9%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04317
(show subtarget assignments)

1

cloned

No

YPO0512

218927711

putative lipoprotein [Yersinia pestis CO...

163

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cell envelope

Other

IDP04321
(show subtarget assignments)

1

cloned

No

VC0756

15640775

ndk

nucleoside diphosphate kinase [Vibrio ch...

142

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2HUR

64.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP04322
(show subtarget assignments)

1

cloned

No

VC1001

15641016

folylpolyglutamate synthase/dihydrofolat...

421

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3N2A

53.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP04327
(show subtarget assignments)

1

cloned

No

CPF_1243

110801193

sensory box histidine kinase [Clostridiu...

623

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

11.2%

Clostridium perfringens

Regulatory functions

IDP04328
(show subtarget assignments)

1

cloned

No

CPF_1452

110798743

cold shock protein [Clostridium perfring...

69

conserved gene; putative drug target function;

Phase 4: April 2009

2L15

56.3%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04332
(show subtarget assignments)

1

cloned

No

YPO2723

218929795

putative OmpA family protein [Yersinia p...

261

virulence factor; putative drug target function;

Phase 4: April 2009

2ZOV

18%

Yersinia pestis

Cell envelope

Other

IDP04333
(show subtarget assignments)

1

cloned

No

VC2483

9657062

acetolactate synthase III, large subunit...

573

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1JSC

42.8%

Vibrio cholerae

Amino acid biosynthesis

Pyruvate family

IDP04335
(show subtarget assignments)

1

cloned

No

STM1543_1_428

16764888

putative transport protein [Salmonella t...

428

Salmonella essential protein

Phase 4: April 2009

1PW4

23.4%

Salmonella enterica

IDP04337
(show subtarget assignments)

1

cloned

No

CPF_0720

110801161

splB

spore photoproduct lyase [Clostridium pe...

340

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04338
(show subtarget assignments)

1

cloned

No

CPF_1446

110801179

sodF

Mn/Fe superoxide dismutase [Clostridium ...

227

conserved gene; putative drug target function;

Phase 4: April 2009

1JR9

44.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP04340
(show subtarget assignments)

1

cloned

No

BAS0122

49183156

50S ribosomal protein L5 [Bacillus anthr...

179

Proposed to be essential proteins

Phase 4: April 2009

1IQ4

85.5%

Bacillus anthracis

IDP04342
(show subtarget assignments)

1

cloned

No

GBAA1564

47526837

panD

aspartate alpha-decarboxylase [Bacillus ...

127

conserved gene; putative drug target function;

Phase 4: April 2009

2C45

52.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04348
(show subtarget assignments)

1

cloned

No

CPF_2547

110801206

two component regulator [Clostridium per...

686

viruelnce factor;

Phase 4: April 2009

Clostridium perfringens

Unknown function

General

IDP04350
(show subtarget assignments)

1

cloned

No

STM1338_1_795

16764689

pheT

phenylalanyl-tRNA synthetase subunit bet...

795

Salmonella essential protein

Phase 4: April 2009

3PCO

92.6%

Salmonella enterica

IDP04351
(show subtarget assignments)

1

cloned

No

CPF_1213

110799898

kdpD

sensor histidine kinase KdpD [Clostridiu...

900

conserved gene; putative drug target function;

Phase 4: April 2009

2R8R

12.7%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04356
(show subtarget assignments)

1

cloned

No

YPO0509

115346318

hypothetical protein [Yersinia pestis CO...

540

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2XT4

9.3%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04358
(show subtarget assignments)

1

cloned

No

YPO0895

115346679

creC

putative histidine kinase sensor [Yersin...

472

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

14.8%

Yersinia pestis

Regulatory functions

Other

IDP04359
(show subtarget assignments)

1

cloned

No

YPO1414

218928562

pepN

aminopeptidase N [Yersinia pestis CO92]

871

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2DQ6

77.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04365
(show subtarget assignments)

1

cloned

No

CPF_1523

110798905

sensory box histidine kinase [Clostridiu...

787

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

11.6%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04367
(show subtarget assignments)

1

cloned

No

BAS3563

49186564

PTS system, fructose-specific IIABC comp...

622

Proposed to be essential proteins

Phase 4: April 2009

2R4Q

11.4%

Bacillus anthracis

IDP04370
(show subtarget assignments)

1

cloned

No

GBAA4766

47530065

iron compound ABC transporter, iron comp...

324

virulence factor; putative drug target function;

Phase 4: April 2009

3EIW

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP04373
(show subtarget assignments)

1

cloned

No

YPO3097

218930139

manB

phosphomannomutase [Yersinia pestis CO92...

457

drug target; virulence factor; putative drug target function;

Phase 4: April 2009

3UW2

37.8%

Yersinia pestis

Energy metabolism

Sugars

IDP04378
(show subtarget assignments)

1

cloned

No

CPF_2335

110799804

extracellular solute-binding protein [Cl...

482

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04380
(show subtarget assignments)

1

cloned

No

STM3713_1_404

16766998

rfaL

O-antigen ligase [Salmonella typhimurium...

404

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04386
(show subtarget assignments)

1

cloned

No

YPO3230

218930257

pepD

aminoacyl-histidine dipeptidase [Yersini...

486

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3MRU

63%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04390
(show subtarget assignments)

1

cloned

No

CPF_0618

110799563

pstS

phosphate ABC transporter, phosphate-bin...

272

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

36.4%

Clostridium perfringens

Transport and binding proteins

Anions

IDP04391
(show subtarget assignments)

1

cloned

No

CPF_1067

110798883

cotJB

spore coat protein CotJB [Clostridium pe...

83

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04392
(show subtarget assignments)

1

cloned

No

CPF_1500

110798925

putative lipoprotein [Clostridium perfri...

202

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04393
(show subtarget assignments)

1

cloned

No

CPF_1645

110798596

lonB

ATP-dependent protease LonB [Clostridium...

570

conserved gene; putative drug target function;

Phase 4: April 2009

3K1J

29.4%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04394
(show subtarget assignments)

1

cloned

No

CPF_2117

110800208

spoVD

stage V sporulation protein D [Clostridi...

695

conserved gene; putative drug target function;

Phase 4: April 2009

1PYY

24.8%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04395
(show subtarget assignments)

1

cloned

No

FTT0076

56707255

sucA

2-oxoglutarate dehydrogenase E1 componen...

941

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2JGD

47.8%

Francisella tularensis

IDP04398
(show subtarget assignments)

1

cloned

No

YPO1376

218928524

ftsK

putative cell division protein [Yersinia...

1305

drug target; putative drug target function;

Phase 4: April 2009

2IUS

33.3%

Yersinia pestis

Cellular processes

Cell division

IDP04399
(show subtarget assignments)

1

cloned

No

YPO3613

218930623

putative Rhs accessory genetic element [...

732

virulence factor; putative drug target function;

Phase 4: April 2009

2P5Z

15.8%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04400
(show subtarget assignments)

1

cloned

No

YPO2921

218929976

purL

phosphoribosylformylglycinamidine syntha...

1296

conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

82.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04402
(show subtarget assignments)

1

cloned

No

VC2254

15642252

1-deoxy-D-xylulose 5-phosphate reductois...

402

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1K5H

60.9%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04403
(show subtarget assignments)

1

cloned

No

CPF_0630

110801303

spore germination protein [Clostridium p...

374

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3N54

17.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04404
(show subtarget assignments)

1

cloned

No

VC2602

15642597

adenylosuccinate synthetase [Vibrio chol...

432

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KJX

75.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04405
(show subtarget assignments)

1

cloned

No

CPF_2987

110799346

stage 0 sporulation protein J [Clostridi...

286

conserved gene; putative drug target function;

Phase 4: April 2009

1VZ0

33.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04407
(show subtarget assignments)

1

cloned

No

CPF_0677

110799553

purH

bifunctional phosphoribosylaminoimidazol...

501

conserved gene; putative drug target function;

Phase 4: April 2009

3ZZM

41.1%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04409
(show subtarget assignments)

1

cloned

No

YPO3965

115349572

putative hybrid two-component system reg...

851

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

9.3%

Yersinia pestis

Regulatory functions

Other

IDP04410
(show subtarget assignments)

1

cloned

No

VC1047

9655512

fatty oxidation complex, alpha subunit [...

724

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1WDK

36.4%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Degradation

IDP04412
(show subtarget assignments)

1

cloned

No

CPF_0435

110799959

putative lipoprotein [Clostridium perfri...

431

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04413
(show subtarget assignments)

1

cloned

No

VC2373

15642370

glutamate synthase, large subunit [Vibri...

1530

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1LLW

44.6%

Vibrio cholerae

Amino acid biosynthesis

Glutamate family

IDP04420
(show subtarget assignments)

1

cloned

No

GBAA3308

47528594

sdhB-1

l-serine dehydratase, iron-sulfur-depend...

232

virulence factor; putative drug target function;

Phase 4: April 2009

2IQQ

15.5%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP04425
(show subtarget assignments)

1

cloned

No

GBAA4025

47529318

carB

carbamoyl phosphate synthase large subun...

1072

conserved gene; putative drug target function;

Phase 4: April 2009

1BXR

49.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04431
(show subtarget assignments)

1

cloned

No

GBAA5088

47530387

sensor histidine kinase [Bacillus anthra...

340

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

18.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04433
(show subtarget assignments)

1

cloned

No

GBAA5276

47530584

sensor histidine kinase [Bacillus anthra...

480

putative drug target function;

Phase 4: April 2009

3A0R

13.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04434
(show subtarget assignments)

1

cloned

No

YPCD1.52

16082740

yscC

outer membrane secretin precursor [Yersi...

607

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2Y9K

6.9%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04437
(show subtarget assignments)

1

cloned

No

YPO0023

115345855

glnR

Two component regulatory protein involve...

349

putative drug target function;

Phase 4: April 2009

1R62

38.4%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP04439
(show subtarget assignments)

1

cloned

No

YPO0185

115346005

ssiD

putative taurine dioxygenase [Yersinia p...

282

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GQW

75.9%

Yersinia pestis

Energy metabolism

Other

IDP04440
(show subtarget assignments)

1

cloned

No

YPO0266

115346083

secretion system apparatus protein [Yers...

682

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2X49

15.4%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04443
(show subtarget assignments)

1

cloned

No

YPO0506

218927704

clpB

putative Clp ATPase [Yersinia pestis CO9...

867

virulence factor; putative drug target function;

Phase 4: April 2009

1QVR

36.3%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04445
(show subtarget assignments)

1

cloned

No

YPO0619

115346424

putative HlyD family secretion protein [...

349

conserved gene; putative drug target function;

Phase 4: April 2009

4DK1

17.5%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04446
(show subtarget assignments)

1

cloned

No

YPO0653

115346457

glnE

glutamate-ammonia-ligase adenylyltransfe...

951

conserved gene; putative drug target function;

Phase 4: April 2009

3K7D

38.5%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP04448
(show subtarget assignments)

1

cloned

No

YPO0810

218927990

general secretion pathway protein J [Yer...

198

putative drug target function;

Phase 4: April 2009

2RET

20.2%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04449
(show subtarget assignments)

1

cloned

No

YPO0816

218927995

general secretion pathway protein D [Yer...

640

putative drug target function;

Phase 4: April 2009

3EZJ

15.6%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04450
(show subtarget assignments)

1

cloned

No

YPO0905

218928078

gcvP

glycine dehydrogenase [Yersinia pestis C...

959

conserved gene; putative drug target function;

Phase 4: April 2009

1WYT

19.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

Targets