Target   IDP00016

Stage

crystallized  

Locus Tag/Selection DB Lookup

BA_4053  

NCBI Protein Lookup

gi: 46576983   accession: Q81WC7  

Organism

Bacillus anthracis str. Ames  

Common Name

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase) (Meso-diaminopimelate-adding enzyme) (Meso-A2pm-adding enzyme) (UDP-N-acetylmuramyl-tripeptide synthetase) (UDP-MurNAc-tripeptide synthetase)  

Gene Name

 

NCBI Gene Lookup

 

NCBI Annotation

 

TIGR Main Role/Annotations

Cell envelope  

TIGR Sub Role

Biosynthesis and degradation of murein sacculus and peptidoglycan  

Comment

 

Selection Phase

Phase 1: October 2007  

Date Approved

Dec 13, 2007  

Justification for Selection

Drug Target Homolog  

Justification Codes

 

Priority

1  

Sequence Length

491  

(Subtargets)

 

pI

5.82  

Molecular Weight

53.7 kDa  

Sequence

(Check Homologs)

MKLHTLVSCL HDFPVVPKEN PEITSIEADS RKVKEGSLFV CMKGYTVDSH DFAKQAAAQG AAAIVAERPI DVDVPVVLVK NTFRSLAVLA DYFYGQPTHK LHLIGITGTN GKTTTSHIMD EIMRAHGHKT GLIGTINMKI GDETFEVKNT TPDALTLQQT FAKMVEHGVD STVMEVSSHA LDLGRVHGCD YDVAVFTNLT QDHLDYHKTM EEYKHAKGLL FAQLGNSYNH NREKYAVLNN DDAVTVEYMR STAATVVTYG IDTTSDVMAK DIAMTSGGTT FTLVTPYESV NVTMKLIGKF NVYNVLAATA AGLVSGVSLE TIIDVIKELA GVPGRFEVVD GGQNYTVIVD YAHTPDSLEN VLKTAKQFAK GDVYCIVGCG GDRDRTKRPI MASVATQYAT HAIYTSDNPR SEDPAAILDD MVHGANGNNY EVIIDRKEAI HHAITKAKAD DIIIIAGKGH ETYQIIGKDV HHFDDREVAK EAITERLNNE E  

DNA Sequence

ATGAAG TTGCAT ACACTT GTATCA TGTTTG CATGAT TTTCCA GTTGTT CCAAAA GAAAAT CCAGAA ATCACA TCTATA GAAGCT GATTCA CGTAAA GTGAAA GAGGGA AGCTTA TTTGTA TGTATG AAAGGG TATACG GTTGAT AGCCAT GATTTT GCTAAG CAAGCA GCGGCA CAAGGA GCGGCT GCTATT GTTGCG GAAAGA CCAATT GATGTT GACGTT CCAGTT GTACTT GTGAAA AACACT TTTCGT TCGTTA GCGGTT TTAGCT GATTAT TTTTAT GGTCAA CCAACA CACAAG TTACAT TTAATC GGTATT ACAGGT ACAAAT GGAAAG ACAACA ACATCG CATATT ATGGAT GAGATT ATGCGC GCACAT GGTCAT AAAACG GGGCTA ATTGGA ACGATT AATATG AAAATC GGTGAT GAAACA TTTGAG GTGAAA AATACA ACGCCA GATGCA CTAACA CTTCAA CAGACG TTTGCA AAAATG GTTGAA CACGGT GTGGAT AGCACA GTAATG GAAGTT TCATCA CATGCT TTAGAT CTTGGT CGTGTA CACGGA TGTGAT TACGAT GTAGCG GTGTTT ACAAAT TTAACA CAAGAT CATTTA GACTAC CATAAA ACGATG GAAGAA TATAAA CATGCA AAAGGG TTGCTA TTTGCA CAACTT GGCAAT AGTTAT AATCAT AATCGC GAAAAA TACGCG GTACTG AATAAC GATGAT GCTGTA ACAGTG GAATAT ATGAGA AGTACT GCAGCA ACTGTT GTAACG TATGGA ATTGAT ACAACA AGTGAT GTTATG GCCAAA GATATC GCTATG ACAAGT GGTGGA ACTACA TTTACG CTTGTA ACACCG TATGAA AGTGTA AATGTT ACGATG AAATTA ATTGGG AAATTT AATGTA TATAAT GTACTA GCTGCA ACAGCG GCAGGA CTTGTT TCTGGT GTAAGT TTGGAA ACAATC ATTGAT GTAATA AAGGAA CTAGCT GGAGTT CCTGGA CGTTTC GAAGTA GTTGAT GGTGGC CAAAAT TATACA GTTATT GTTGAT TATGCA CATACA CCAGAT AGCTTA GAAAAT GTATTG AAAACA GCAAAG CAGTTT GCAAAA GGTGAC GTATAT TGCATC GTCGGT TGTGGT GGTGAT AGAGAT CGAACG AAGAGA CCAATC ATGGCA AGTGTT GCCACA CAATAT GCAACT CACGCA ATTTAC ACTTCA GATAAT CCAAGA AGTGAA GATCCA GCGGCT ATTTTA GATGAT ATGGTA CATGGT GCAAAT GGAAAT AATTAT GAAGTG ATTATT GATAGA AAAGAA GCAATA CACCAT GCGATC ACTAAA GCGAAA GCAGAT GATATC ATTATT ATTGCT GGTAAG GGTCAT GAAACA TATCAA ATTATT GGTAAA GATGTT CATCAT TTTGAC GATCGT GAAGTC GCTAAA GAAGCA ATTACA GAGCGT TTAAAC AACGAA GAGTAA  

Inserted

Dec 19, 2007