Target   IDP02324

Stage

in_crystallization_trials  

Locus Tag/Selection DB Lookup

FTT0581  

NCBI Protein Lookup

gi: 56707709   accession: YP_169605  

Organism

Francisella tularensis subsp. tularensis SCHU S4  

Common Name

phosphopantetheine adenylyltransferase [Francisella tularensis subsp. tularensis SCHU S4]  

Gene Name

coaD  

NCBI Gene Lookup

3192516  

NCBI Annotation

Similar to COAD_LISIN (Q929W5) Phosphopantetheine adenylyltransferase from Listeria innocua (161 aa). FASTA: opt: 494 Z-score: 653.3 E(): 1.7e-28 Smith-Waterman score: 494; 50.625identity in 160 aa overlap  

TIGR Main Role/Annotations

Biosynthesis of cofactors, prosthetic groups, and carriers  

TIGR Sub Role

Pantothenate and coenzyme A  

Comment

 

Selection Phase

Phase 3: June 2008  

Date Approved

Jul 18, 2008  

Justification for Selection

Conserved; Drug target functions  

Justification Codes

 

Priority

1  

Sequence Length

162  

(Subtargets)

 

pI

8.06  

Molecular Weight

18.5 kDa  

Sequence

(Check Homologs)

MNKIAIYPGT FDPITNGHVD LVERALNIFD EIVVAVSTAY GKNTLFDIRI REQMIKEVFK DNQRVKVVSF QGLLVDTAVK HNACAIVRGL RAVSDFDYEF QMSSMNNKLN SDIQTIFLTP SEKFSCISST LVRAVAIHNY KRVDEFVPEC VFREIKLKYS KE  

DNA Sequence

ATGAAT AAGATA GCAATT TATCCA GGTACT TTTGAC CCAATT ACCAAT GGTCAT GTTGAT CTAGTA GAGCGT GCATTA AATATC TTTGAT GAAATA GTTGTT GCAGTA TCTACA GCTTAT GGTAAA AATACT CTTTTT GATATT CGTATC AGAGAG CAAATG ATAAAA GAAGTA TTCAAA GATAAT CAAAGG GTCAAA GTTGTA AGCTTT CAGGGT CTACTT GTTGAT ACAGCA GTCAAA CATAAT GCTTGT GCTATA GTTAGA GGTCTC AGAGCA GTATCT GATTTT GATTAT GAATTT CAGATG TCAAGT ATGAAT AATAAA TTAAAC AGTGAT ATTCAA ACTATA TTCTTA ACTCCG AGTGAG AAGTTT TCATGT ATTTCC TCGACA TTAGTT AGGGCT GTAGCG ATACAT AATTAT AAGCGT GTTGAT GAGTTT GTACCT GAATGT GTCTTT CGTGAG ATAAAG CTTAAA TATTCT AAGGAA TAA  

Inserted

Sep 09, 2008