Target   IDP04406

Stage

in_crystallization_trials  

Locus Tag/Selection DB Lookup

VC1053  

NCBI Protein Lookup

gi: 15641066   accession: NC_002506  

Organism

Vibrio cholerae O1 biovar El Tor str. N16961  

Common Name

adenine phosphoribosyltransferase [Vibrio cholerae O1 biovar eltor str. N16961]  

Gene Name

 

NCBI Gene Lookup

 

NCBI Annotation

catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis  

TIGR Main Role/Annotations

Purines, pyrimidines, nucleosides, and nucleotides  

TIGR Sub Role

Salvage of nucleosides and nucleotides  

Comment

 

Selection Phase

Phase 4: April 2009  

Date Approved

Jun 11, 2009  

Justification for Selection

drug target; conserved gene; putative drug target function;  

Justification Codes

 

Priority

1  

Sequence Length

181  

(Subtargets)

 

pI

4.89  

Molecular Weight

19.7 kDa  

Sequence

(Check Homologs)

MTTETLSLIK SSIKSIPDYP KKGILFRDVT SLLEDAQAYQ ATIQLLVEKY KDMGFTKVVG TEARGFLFGA PLALELGVGF VPVRKPGKLP RQTVAQSYEL EYGTDTLEIH VDAIKPGDKV LVVDDLLATG GTIEATTKLI RQLGGEVEHA AFVINLPEIG GDKRLEGLGL QVYSICEFEG H  

DNA Sequence

ATGACA ACTGAA ACTCTT TCACTG ATCAAA TCCAGC ATCAAA AGTATT CCTGAC TACCCG AAAAAA GGCATT CTGTTT CGTGAT GTGACC AGCTTG CTGGAA GATGCC CAAGCC TACCAA GCGACC ATTCAA CTTCTG GTTGAA AAGTAC AAAGAC ATGGGT TTTACC AAGGTT GTGGGC ACAGAA GCGCGT GGTTTC TTGTTT GGTGCT CCTCTG GCACTA GAACTG GGTGTC GGCTTT GTGCCT GTGCGT AAGCCG GGTAAA TTGCCG CGTCAA ACCGTC GCTCAA TCTTAT GAGCTG GAATAC GGTACT GATACG CTCGAA ATTCAT GTGGAT GCGATC AAACCG GGCGAC AAAGTA CTGGTG GTGGAT GACCTG CTGGCG ACCGGT GGTACG ATTGAA GCGACC ACTAAG CTTATC CGTCAA TTGGGT GGAGAA GTCGAG CACGCT GCCTTC GTGATC AACTTG CCAGAA ATTGGT GGTGAT AAGCGC CTTGAA GGGTTA GGCTTG CAGGTT TACAGC ATCTGT GAATTT GAAGGT CACTAA  

Inserted

Jun 26, 2009