Target   IDP04423

Stage

in_pdb   : 3M3H, 3OSC

Locus Tag/Selection DB Lookup

GBAA4021  

NCBI Protein Lookup

gi: 47529314   accession: NC_007530  

Organism

Bacillus anthracis str. 'Ames Ancestor'  

Common Name

orotate phosphoribosyltransferase [Bacillus anthracis str. 'Ames Ancestor']  

Gene Name

pyrE  

NCBI Gene Lookup

 

NCBI Annotation

involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate  

TIGR Main Role/Annotations

Purines, pyrimidines, nucleosides, and nucleotides  

TIGR Sub Role

Pyrimidine ribonucleotide biosynthesis  

Comment

 

Selection Phase

Community Interest  

Date Approved

Jun 11, 2009  

Justification for Selection

conserved gene; putative drug target function;  

Justification Codes

 

Priority

1  

Sequence Length

210  

(Subtargets)

 

pI

5.38  

Molecular Weight

22.7 kDa  

Sequence

(Check Homologs)

MKKEIASHLL EIGAVFLQPN DPFTWSSGMK SPIYCDNRLT LSYPKVRQTI AAGLEELIKE HFPTVEVIAG TATAGIAHAA WVSDRMDLPM CYVRSKAKGH GKGNQIEGKA EKGQKVVVVE DLISTGGSAI TCVEALREAG CEVLGIVSIF TYELEAGKEK LEAANVASYS LSDYSALTEV AAEKGIIGQA ETKKLQEWRK NPADEAWITA  

DNA Sequence

ATGAAA AAAGAA ATCGCA TCGCAT TTATTA GAAATT GGAGCA GTATTT TTACAA CCAAAT GATCCA TTCACA TGGTCT TCAGGT ATGAAA TCACCA ATTTAT TGTGAT AACCGT TTAACT TTATCT TATCCG AAAGTA CGCCAA ACAATT GCAGCT GGATTA GAAGAG TTAATT AAAGAG CACTTC CCAACT GTAGAA GTTATT GCAGGA ACAGCA ACTGCT GGTATT GCGCAC GCTGCA TGGGTA AGCGAT CGTATG GATTTA CCAATG TGCTAC GTACGT AGTAAA GCAAAA GGTCAT GGTAAA GGGAAC CAAATC GAAGGA AAAGCT GAAAAA GGTCAA AAAGTA GTAGTA GTAGAA GACTTA ATTTCA ACTGGT GGTAGT GCTATT ACATGT GTAGAA GCACTT CGCGAA GCTGGC TGTGAA GTATTA GGAATC GTATCA ATCTTC ACATAC GAGCTA GAAGCA GGAAAA GAAAAG CTAGAA GCAGCT AACGTA GCATCA TATTCT TTAAGT GATTAC AGTGCA TTAACT GAAGTT GCGGCA GAAAAA GGTATA ATCGGA CAAGCT GAAACG AAAAAA TTACAA GAGTGG CGTAAA AATCCA GCTGAC GAAGCT TGGATC ACAGCG TAA  

Inserted

Jun 26, 2009