Target   IDP90246

Stage

in_pdb   : 3T68, 3T6M

Locus Tag/Selection DB Lookup

VC2152  

NCBI Protein Lookup

gi: 15642151   accession: NP_231783  

Organism

Vibrio cholerae O1 biovar El Tor str. N16961  

Common Name

succinyl-diaminopimelate desuccinylase [Vibrio cholerae O1 biovar eltor str. N16961]  

Gene Name

 

NCBI Gene Lookup

2613288  

NCBI Annotation

dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.  

TIGR Main Role/Annotations

 

TIGR Sub Role

 

Comment

 

Selection Phase

Community Requests  

Date Approved

Feb 27, 2009  

Justification for Selection

These targets are similar to actual drug targets and will be used mostly for cocrystallisation with small molecules. The more information we have about the binding sites, the better are the chances to understand how the drug works and what modification can achieve.  

Justification Codes

 

Priority

8  

Sequence Length

377  

(Subtargets)

 

pI

4.76  

Molecular Weight

40.7 kDa  

Sequence

(Check Homologs)

MTDSPVLALA KELISRQSVT PADAGCQDLM IERLKALGFE IESMVFEDTT NFWARRGTQS PLFVFAGHTD VVPAGPLSQW HTPPFEPTVI DGFLHGRGAA DMKGSLACMI VAVERFIAEH PDHQGSIGFL ITSDEEGPFI NGTVRVVETL MARNELIDMC IVGEPSSTLA VGDVVKNGRR GSITGDLKVK GTQGHVAYPH LANNPVHKAL PALAELAATQ WDEGNAYFPP TSFQIPNLQA GTGASNVIPG EFDVQFNFRF STELTDEEIK RRVHSVLDAH GLDYDVKWTL SGQPFLTDTG ELLAAVVAAV EEVNHQAPAL LTTGGTSDGR FIAQMGAQVV ELGPVNATIH KVNECVRIAD LEKLTDMYQK TLNHLLG  

DNA Sequence

 

Inserted

Mar 20, 2009