Target   IDP91555

Stage

expressed  

Locus Tag/Selection DB Lookup

BAB38358  

NCBI Protein Lookup

gi: 13364411   accession: BA000007  

Organism

Escherichia coli O157:H7 str. Sakai  

Common Name

regulator of acetyl CoA synthetase [Escherichia coli O157:H7 str. Sakai]  

Gene Name

ECs4935  

NCBI Gene Lookup

 

NCBI Annotation

 

TIGR Main Role/Annotations

 

TIGR Sub Role

 

Comment

0  

Selection Phase

Community Requests  

Date Approved

Apr 12, 2011  

Justification for Selection

These targets are similar to actual drug targets and will be used mostly for cocrystallisation with small molecules. The more information we have about the binding sites, the better are the chances to understand how the drug works and what modification can achieve.  

Justification Codes

virulence/pathogenesis  

Priority

8  

Sequence Length

728  

(Subtargets)

 

pI

0.00  

Molecular Weight

82.6 kDa  

Sequence

(Check Homologs)

MITHIPRSSF SANINNTAQT NEHQTLSELF YKELEDKFSG KELATPLLKS FSENCRHNGR HIFSNKDFVI KFSISVLQAD KKEITIINKN ENTTLTQTIA PIFEEYLMEI LPQRSDALDK KELNLNSDRK EKEFPRVKLN GQCYFPGRPQ NRIVCRHIAA QYINDIYQNV DYKPHQDDYS SAEKFLTHFN KKCKNQTLAL ISSRPEGRCV AACGDFGLVM KAYFDKMESN DLSVMAAILL VDNHALTVRL RIKNTTEGCI HYVVSVYDPN VTNDKIRIMS ESKEDIKHYS LMDFMNVDYS LLKWSNDHVI NQSVAIIPAL PKEQLLMLKG TVDEITPPLS PATMNLLMAI GQNHQLKQLM IQLQKMPELH RTEMLTAYNS INLPGLYLAI NYGNADIVET IFNSLSEPGY EGLLSKKNLM HILEAKDKNG FSGLFLAISR KDKNVVTSIL NALPKLAATH HLDNEQVYKF LSAKNSTSSH VLYHVMANGD ADMLKIVLDA LSLLIRTCHL TKEQVLDLLK AKDFYGCPGL YLAMQNGHSD IVKVILEALP SLAQEINISA SDIVDLLTAK SLARDTGLFM AMQRGHMNVI NTIFNALPTL FNTFKFDKKN MKPLLLANNS NEYPGLFSAI QHKQQNVVEM VYLALSDHAR LFGFTAEDIM DFWQHKAPQK YSAFELACEL GHRVIAELIF NTLNKMAESF GFTDNPRYIA EKNYMEALLK KASPHTVR  

DNA Sequence

ATGATT ACTCAT ATTCCT CGTAGT TCTTTC TCTGCA AATATT AATAAT ACAGCC CAGACA AATGAA CACCAA ACCCTG AGTGAA TTGTTT TATAAA GAACTC GAGGAT AAATTT TCTGGC AAGGAG CTGGCG ACACCT CTATTA AAAAGC TTCTCA GAGAAC TGTAGA CACAAT GGTCGC CATATC TTTAGT AACAAG GATTTT GTCATT AAGTTT TCCATA TCTGTC TTACAA GCTGAT AAGAAA GAAATT ACGATA ATTAAT AAAAAT GAAAAC ACGACA CTCACT CAAACC ATTGCT CCAATA TTTGAA GAATAC CTAATG GAAATT TTACCT CAACGC TCAGAC GCTCTT GATAAA AAAGAA TTAAAT CTAAAC TCAGAT AGAAAA GAAAAA GAATTC CCAAGA GTTAAG CTTAAT GGTCAA TGTTAT TTTCCG GGGCGC CCCCAA AACCGT ATAGTA TGCCGA CACATT GCTGCA CAATAT ATTAAT GATATT TATCAG AATGTT GACTAC AAACCC CATCAA GATGAT TACTCT TCAGCT GAAAAA TTTCTC ACTCAC TTCAAC AAAAAA TGCAAA AACCAG ACTTTG GCGTTG ATTTCC AGCCGT CCTGAG GGGCGT TGCGTT GCTGCC TGCGGT GATTTC GGGCTA GTTATG AAGGCA TATTTT GACAAG ATGGAA TCAAAT GACCTC AGTGTT ATGGCT GCCATA TTATTG GTAGAT AACCAT GCTTTG ACGGTC CGGCTA AGAATA AAGAAC ACAACT GAAGGA TGTATC CATTAC GTGGTT TCGGTT TATGAT CCTAAT GTAACT AACGAT AAAATA AGAATC ATGAGC GAAAGT AAAGAG GATATT AAACAC TATTCA CTGATG GATTTT ATGAAT GTAGAT TATAGC CTCCTG AAATGG TCAAAT GATCAT GTTATT AACCAA TCTGTT GCAATA ATTCCA GCACTT CCAAAA GAACAG CTATTG ATGCTA AAAGGA ACTGTG GATGAA ATAACC CCTCCA TTATCA CCTGCA ACGATG AATTTG CTAATG GCAATT GGTCAG AATCAC CAACTT AAGCAA CTGATG ATTCAA CTCCAG AAAATG CCAGAA CTACAT AGAACA GAAATG TTGACT GCCTAT AATAGT ATTAAC CTCCCC GGTTTA TATTTG GCTATA AATTAT GGTAAT GCGGAT ATCGTT GAGACT ATTTTT AATTCA TTGTCA GAGCCA GGATAT GAAGGA TTACTC TCGAAA AAAAAT CTCATG CATATT CTGGAG GCAAAA GATAAA AATGGT TTTTCT GGATTA TTTTTA GCGATA TCACGT AAGGAT AAAAAT GTTGTA ACCTCG ATTCTG AACGCC TTACCT AAACTG GCCGCA ACACAT CATTTA GATAAC GAACAA GTGTAT AAATTC CTGAGT GCCAAA AATAGT ACGTCC AGCCAT GTTTTA TACCAT GTTATG GCGAAT GGTGAT GCCGAC ATGCTG AAAATT GTTTTG GACGCG TTATCT TTGTTA ATTCGC ACATGT CATTTG ACTAAA GAACAG GTACTC GATCTC CTGAAG GCAAAG GATTTT TATGGT TGCCCA GGACTA TACCTG GCGATG CAAAAT GGACAT AGCGAT ATCGTG AAAGTT ATTCTT GAAGCA TTGCCC AGCCTG GCCCAG GAAATT AACATT TCAGCT TCCGAT ATTGTA GATCTT CTGACC GCTAAA AGTCTT GCGCGC GACACG GGTTTG TTTATG GCCATG CAGCGC GGACAT ATGAAC GTTATT AATACT ATTTTT AACGCA TTACCC ACTCTG TTTAAT ACGTTT AAATTC GATAAA AAAAAT ATGAAG CCCCTC CTCCTG GCAAAT AATTCT AATGAA TACCCA GGTTTG TTTTCA GCGATA CAGCAT AAACAG CAAAAC GTTGTA GAGATG GTTTAT CTTGCT TTATCT GACCAT GCACGC CTGTTT GGATTT ACCGCT GAAGAT ATTATG GATTTT TGGCAA CACAAA GCGCCA CAAAAA TACTCT GCCTTT GAGTTG GCTTGT GAATTG GGTCAC CGGGTT ATTGCT GAATTA ATCTTT AATACA TTAAAT AAGATG GCTGAA AGCTTT GGCTTT ACGGAT AACCCT CGATAC ATTGCG GAGAAA AATTAT ATGGAA GCTTTA CTCAAA AAAGCA TCTCCC CATACC GTACGC TAA  

Inserted

Apr 12, 2011