Target   IDP91986

Stage

in_crystallization_trials  

Locus Tag/Selection DB Lookup

SpneCM_010100006694  

NCBI Protein Lookup

gi: 298255280   accession: NZ_ACNU00000000  

Organism

Streptococcus pneumoniae str. Canada MDR_19A  

Common Name

capsule biosynthesis integral membrane regulatory protein Wzg [Streptococcus pneumoniae str. Canada MDR_19A]  

Gene Name

 

NCBI Gene Lookup

 

NCBI Annotation

 

TIGR Main Role/Annotations

 

TIGR Sub Role

 

Comment

notes  

Selection Phase

Community Requests  

Date Approved

 

Justification for Selection

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19A. Target will be studied with collaborators (Scott Gray-Owen, University of Toronto) for their ability to generate immunogenic responses against S. pneumoniae infection for the purpose of generating a novel vaccine. The structures will aid in understanding the immunogenic response for further vaccine engineering.  

Justification Codes

 

Priority

8  

Sequence Length

481  

(Subtargets)

 

pI

0.00  

Molecular Weight

53.7 kDa  

Sequence

(Check Homologs)

MSRRFKKSRS QKVKRSVNIV LLTIYLLLVY FLLFLIFKYN ILAFRYLNLV VTALVLLVAL VGLLLIIYKK AEKFTIFLLV FSILVSSVSL FAVQQFVGLT NRLNATSNYS EYSISVAVLA DSEIENVTQL MSVTAPTGTD NENIQKLLAD IKSSQNTDLT VNQSSSYLAA YKSLIAGETK AIVLNSVFEN IIESEHPDYA SKIKKIYTKG FTKKVEAPKT SKDQSFNIYV SGIDTYGPIS SVSRSDVNIL MTVNRDTKKI LLTTTPRDAY VPIADGGNNQ KDKLTHAGIY GVDSSIHTLE NLYGVDINYY VRLNFTSFLK LIDLLGGVDV YNDQDFTSLH GKFHFPVGNV HLDSEQALGF VRERYSLADG DHDRGRNQQK VIAAILQKLT SSEALKNYSR IIDSLQDSIQ TNMPLETMIN LVNAQLESGG TYKVNSQDLK GMGRTDLPSY AMPDSNLYMM EINDSSLASV KTAIQDMLEG R  

DNA Sequence

ATGAGT AGACGT TTTAAA AAATCA CGTTCA CAGAAA GTGAAG CGAAGT GTTAAT ATCGTT TTGCTG ACTATT TATTTA TTGTTA GTTTAT TTTTTA TTGTTC TTAATC TTTAAG TACAAT ATCCTT GCTTTT AGATAT CTTAAC CTAGTG GTAACT GCGTTA GTCCTA CTAGTT GCCTTG GTAGGG CTACTC TTGATT ATCTAT AAAAAA GCTGAA AAGTTT ACTATT TTTCTG TTGGTG TTCTCT ATCCTT GTCAGC TCTGTG TCGCTC TTTGCA GTACAG CAGTTT GTGGGA CTGACC AATCGT TTAAAT GCGACT TCTAAT TACTCA GAATAT TCGATC AGTGTT GCTGTT TTAGCA GATAGT GAGATT GAGAAT GTTACG CAACTG ATGAGT GTGACA GCACCG ACTGGG ACTGAT AATGAA AACATT CAAAAA CTACTA GCTGAT ATCAAA TCAAGT CAGAAT ACCGAT TTGACG GTCAAT CAGAGT TCGTCT TACTTG GCAGCT TATAAG AGTTTG ATTGCA GGAGAG ACTAAG GCCATT GTCTTA AATAGT GTCTTT GAAAAT ATCATC GAATCG GAGCAT CCAGAT TACGCA TCGAAG ATAAAA AAGATT TATACC AAGGGA TTCACT AAAAAA GTAGAA GCTCCT AAGACG TCTAAG GATCAG TCTTTC AATATC TATGTT AGTGGA ATTGAT ACTTAT GGTCCG ATTAGT TCGGTG TCGCGT TCAGAT GTCAAT ATCCTG ATGACT GTCAAT CGAGAT ACCAAG AAAATT CTCTTG ACCACA ACGCCA CGTGAT GCTTAT GTACCA ATCGCA GATGGT GGGAAT AATCAA AAAGAT AAATTG ACCCAT GCGGGC ATCTAT GGAGTT GATTCG TCCATC CACACT TTAGAA AATCTC TATGGA GTGGAT ATCAAT TACTAT GTGCGA TTGAAC TTCACT TCTTTC TTGAAA TTGATC GATTTG TTGGGT GGGGTA GATGTT TATAAT GACCAA GATTTT ACATCT CTACAC GGGAAG TTCCAT TTCCCA GTTGGA AATGTC CACTTA GATTCT GAGCAG GCTCTG GGATTT GTTCGT GAGCGC TATTCC CTAGCG GATGGT GATCAT GACCGC GGGCGC AATCAA CAAAAG GTGATT GCGGCC ATCCTT CAAAAA TTAACT TCGAGC GAAGCG CTGAAA AATTAT AGTAGG ATCATT GATAGC TTGCAA GATTCT ATCCAA ACAAAC ATGCCA CTTGAG ACCATG ATAAAC TTGGTC AATGCT CAGTTA GAAAGT GGTGGA ACGTAC AAAGTG AATTCG CAAGAC TTGAAG GGTATG GGACGG ACGGAT CTTCCT TCCTAT GCGATG CCAGAT AGTAAC CTCTAT ATGATG GAAATT AACGAC AGTAGC CTTGCA TCTGTC AAAACT GCTATT CAGGAT ATGTTG GAGGGC AGATGA  

Inserted

Jan 13, 2012