Structure of IDP90195

Structure of Cowpox CPXV203 in complex with MHCI (H-2Kb)

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CSGID target
IDP90195 
PDB Id
4HKJ (NCBI MMDB) 
Authors
W.H.Mccoy Iv,D.H.Fremont,Center For Structural Genomics Of Infectious Diseases (Csgid) 
Responsible person
Chris Nelson 
Responsible lab
Washington University 
Deposition Date
Oct 15, 2012 
Release Date
Nov 14, 2012 

Annotation

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Description
Recent investigations reveal that CPXV203 binds a diverse array of classical and non-classical MHC class I proteins. CPXV203 works synergistically with the KDEL receptor to block MHC class I surface expression. CPXV203 binds MHC class I with dramatically increased affinity at the lower pH of the Golgi relative to that of the ER. Thus CPXV203 disrupts trafficking of fully assembled MHC class to the cell surface. By preventing antigen display on MHC class I, CPXV203 acts to disable adaptive immune system surveillance of infected cells. 
Functional assignment
Immune evasion 

Ligands

Ligand code Name Ligand type
MSE modified residue

Structure information

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Unit cell parameters

Space Group
P 1  
Unit Cell

a=88.31Å, b=88.25Å, c=106.42Å
α=76.18, β=69.29, γ=66.69 
Solvent content
 
Matthews coefficient
 

Refinement

Data for the highest resolution shell is in parentheses.
Resolution range
49.36-3.00Å (0.00-0.00Å)  
Rall(%)
23.1 
Rwork(%)
22.9 (0.0) 
Rfree(%)
25.3 (0.0) 
Num. observed reflections
50276 (0) 
Num. Rfree reflections
2513 (0) 
Completeness(%)
87.2 (0.0) 

Model parameters

Num Atoms
18596  
Num Waters
72  
Num Hetatoms
72  
Model mean isotropic B factor
83.320Å2  
RMSD bond length
0.000Å  
RMSD bond angle
0.000°  
Filename uploaded
cpxv203_refine_63.pdb (uploaded on Dec 04, 2013 2:09 PM)  
Inserted
Dec 04, 2013