Center for Structural Genomics of Infectious Diseases

To see full content of that page you need the activeISee plugin.
Get the latest version from here.

Structure of IDP01372

CSGID target: IDP01372
PDB Id: 3I99 (NCBI MMDB)
Authors: 'R.Zhang,M.Gu,S.Peterson,W.Anderson,A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid)'
Responsible person: Rong-guang Zhang
Responsible lab: Argonne National Laboratory
Deposition Date: Jul 10, 2009
Release Date: Oct 20, 2009

Description: The enzymes essential for bacterial peptidoglycan biosynthesis are attractive targets for antimicrobial drug development. One of these is MurB, which contains FAD as a cofactor and catalyzes the NADPH-dependent reduction of UDP-N-acetylenolpyruvylglucosamine (UDP-GlcNAcEP) to UDP-N-acetylmuramic acid. The X-ray crystal structure of the substrate FAD form of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from Vibrio cholerae O1 biovar EI Tor has been solved to 2.0 A resolution. As compared with MurB of Staphylococcus aureus, the overall structures are similar, but there are big difference in the loop regions (197-214,242-275) and also in the N and C terminals.
Functional assignment: UDP-N-acetylenolpyruvylglucosamine